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Journal of Toxicology: Clinical Toxicology Volume 40, 2002 - Issue 6
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Research Article

Review of Oximes in the Antidotal Treatment of Poisoning by Organophosphorus Nerve Agents

J. Kassa Purkyne Military Medical Academy, Hradec Králové, Czech Republic
Pages 803-816 | Published online: 26 Nov 2002

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Jiri Kassa, Vendula Sepsova, Lenka Matouskova, Anna Horova & Kamil Musilek. (2015) A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice. Toxicology Mechanisms and Methods 25:3, pages 229-233.
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Jiri Kassa, Jana Zdarova Karasova & Sandra Tesarova. (2011) A comparison of the neuroprotective efficacy of individual oxime (HI-6) and combinations of oximes (HI-6+trimedoxime, HI-6+K203) in soman-poisoned rats. Drug and Chemical Toxicology 34:3, pages 233-239.
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Jiri Kassa, Jana Zdarova Karasova, Ruzena Pavlikova, Kamil Musilek, Kamil Kuca, Jiri Bajgar & Young-Sik Jung. (2011) A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology Mechanisms and Methods 21:3, pages 241-245.
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Jiri Kassa, Jana Zdarova Karasova, Sandra Tesarova, Kamil Kuca & Kamil Musilek. (2010) A comparison of the ability of newly-developed bispyridinium oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) to counteract the acute neurotoxicity of soman in rats. Toxicology Mechanisms and Methods 20:8, pages 445-451.
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D.E. Lorke, M.Y. Hasan, S.M. Nurulain, K. Kuča, A. Schmitt & G.A. Petroianu. (2009) Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6. Toxicology Mechanisms and Methods 19:4, pages 327-333.
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Jiri Kassa, Jana Zdarova Karasova, Kamil Musilek, Kamil Kuca & and Young-Sik Jung. (2009) A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats. Toxicology Mechanisms and Methods 19:3, pages 232-238.
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Jiri Kassa, Jana Karasova, Kamil Musilek, Kamil Kuca & Jiri Bajgar. (2009) An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice. Clinical Toxicology 47:1, pages 72-76.
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Jiří Kassa & Vojtech Humlicek. (2008) A Comparison of the Potency of Newly Developed Oximes (K074, K075) and Currently Available Oximes (Obidoxime, Trimedoxime, Hi-6) to Counteract Acute Toxic Effects of Tabun and Cyclosarin in Mice. Drug and Chemical Toxicology 31:1, pages 127-135.
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Jiri Kassa & Jana Karasova. (2007) The Evaluation of the Neuroprotective Effects of Bispyridinium Oximes in Tabun-Poisoned Rats. Journal of Toxicology and Environmental Health, Part A 70:18, pages 1556-1567.
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Kamil Kuca, Jiri Cabal, Daniel Jun & Martina Hrabinova. (2007) Potency of Five Structurally Different Acetylcholinesterase Reactivators to Reactivate Human Brain Cholinesterases Inhibited by Cyclosarin. Clinical Toxicology 45:5, pages 512-515.
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G. A. Petroianu, M. Y. Hasan, S. M. Nurulain, N. Nagelkerke, J. Kassa & K. Kuča. (2007) New K-Oximes (K-27 and K-48) in Comparison with Obidoxime (LuH-6), HI-6, Trimedoxime (TMB-4), and Pralidoxime (2-PAM): Survival in Rats Exposed IP to the Organophosphate Paraoxon. Toxicology Mechanisms and Methods 17:7, pages 401-408.
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Jiri Kassa, Daniel Jun & Kamil Kuca. (2007) A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats. Journal of Enzyme Inhibition and Medicinal Chemistry 22:3, pages 297-300.
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Jiri Kassa & Jana Karasova. (2007) A Comparison of the Potency of Newly Developed Oximes (K074, K075) and Currently Available Oximes (Obidoxime, HI-6) to Counteract Soman-Induced Neurotoxicity in Rats. Drug and Chemical Toxicology 30:2, pages 117-131.
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Kamil Kuca, Daniel Jun & Jiri Bajgar. (2007) Currently Used Cholinesterase Reactivators Against Nerve Agent Intoxication: Comparison of Their Effectivity in Vitro. Drug and Chemical Toxicology 30:1, pages 31-40.
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Kamil Kuca, Jiri Cabal, Daniel Jun & Martina Hrabinova. (2006) In Vitro Evaluation of Acetylcholinesterase Reactivators as Potential Antidotes Against Tabun Nerve Agent Poisonings. Drug and Chemical Toxicology 29:4, pages 443-449.
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Crossref
Mai Otsuka & Hajime Miyaguchi. (2020) Evaluation of the possibility of binary synthesis of VX by theoretical calculation. Chemical Physics Letters 756, pages 137808.
Crossref
Ariel Gore. (2020) Broad Spectrum Treatment for Ocular Insult Induced by Organophosphate Chemical Warfare Agents. Toxicological Sciences 177:1, pages 1-10.
Crossref
Janice E. Chambers, Mary B. Dail & Edward C. Meek. (2020) Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes. Neuropharmacology 175, pages 108201.
Crossref
S. D. Varfolomeev, V. I. Bykov & S. B. Tsybenova. (2020) Kinetic modeling of dynamic processes in the cholinergic synapse. Russian Chemical Bulletin 69:8, pages 1585-1593.
Crossref
Huanglei Bi, Qin Ouyang, Zhao Wei & Zhibing Zheng. (2020) Design, synthesis and evaluation of novel nonquaternary and 3 non-oxime reactivators for acetylcholinesterase inhibited by organophosphates. Bioorganic Chemistry 100, pages 103902.
Crossref
Franz Worek, Horst Thiermann & Timo Wille. (2020) Organophosphorus compounds and oximes: a critical review. Archives of Toxicology 94:7, pages 2275-2292.
Crossref
Tamara Kranawetvogl, Dirk Steinritz, Horst Thiermann & Harald John. (2020) A novel high‐performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme‐reactivating oximes obidoxime, pralidoxime, and HI‐6 in human plasma. Drug Testing and Analysis 12:7, pages 938-947.
Crossref
Mahdieh MOUSAVI, Youbert GHOSTA & Nariman MAROOFPOUR. (2020) Insecticidal activity and sublethal effects of Beauveria bassiana (Bals.-Criv.) Vuill. isolates and essential oils against Aphis gossypii Glover, 1877 (Hemiptera: Aphididae). Acta agriculturae Slovenica 115:2.
Crossref
Christopher M. Timperley, Mike Bird, Samuel J. Gore, Christopher D. Lindsay, Helen Rice, John E.H. Tattersall, Charlotte L. Whitmore & A. Christopher Green. (2020) 3-Quinuclidinyl-α-methoxydiphenylacetate: A multi-targeted ligand with antimuscarinic and antinicotinic effects designed for the treatment of anticholinesterase poisoning. Toxicology Letters 325, pages 67-76.
Crossref
Feiyan Fu, Haibo Liu, Xiaogang Lu, Ruihua Zhang, Liqin Li, Runli Gao, Jianwei Xie, Hongmei Wang & Chengxin Pei. (2020) Identification of S419 on human serum albumin as a novel biomarker for sarin and cyclosarin exposure. Rapid Communications in Mass Spectrometry 34:9.
Crossref
Sara Bohnert, Roland M. van den Berg, John Mikler, Steven D. Klaassen & Marloes J.A. Joosen. (2020) Pharmacokinetics of Three Oximes in a Guinea Pig Model and Efficacy of Combined Oxime Therapy. Toxicology Letters 324, pages 86-94.
Crossref
Jamal Lasri, Saied M. Soliman, Sobhy E. Elsilk, Matti Haukka & Ayman El-Faham. (2020) Synthesis, crystal structure, DFT and biological activity of E-pyrene-1-carbaldehyde oxime and E-2-naphthaldehyde oxime. Journal of Molecular Structure 1207, pages 127848.
Crossref
Anne Suély Pinto Savall, Eduarda Monteiro Fidélis, Maria Eduarda Ziani Gutierrez, Bianca Barreto Martins, Vanessa Carratú Gervini, Robson Luiz Puntel, Daniel Henrique Roos, Daiana Silva Ávila & Simone Pinton. (2019) Pre‐clinical evidence of safety and protective effect of isatin and oxime derivatives against malathion‐induced toxicity. Basic & Clinical Pharmacology & Toxicology 126:4, pages 399-410.
Crossref
Raymond C. Rancourt, Jason R. Richardson, Debra L. Laskin & Jeffrey D. Laskin. 2020. Environmental Toxicants. Environmental Toxicants 261 284 .
Mohd Nor Faiz Norrrahim, Mas Amira Idayu Abdul Razak, Noor Aisyah Ahmad Shah, Herdawati Kasim, Wan Yusmawati Wan Yusoff, Norhana Abdul Halim, Siti Aminah Mohd Nor, Siti Hasnawati Jamal, Keat Khim Ong, Wan Md Zin Wan Yunus, Victor Feizal Knight & Noor Azilah Mohd Kasim. (2020) Recent developments on oximes to improve the blood brain barrier penetration for the treatment of organophosphorus poisoning: a review. RSC Advances 10:8, pages 4465-4489.
Crossref
Milan Jokanović, Miloš P. Stojiljković, Bojan Kovač & Dragana Ristić. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 1145 1159 .
Urelle Biapo, Alessio Ghisolfi, Geoffrey Gerer, Denis Spitzer, Valerie Keller & Thomas Cottineau. (2019) Nanostructured and functionalized cantilever for sensing organophosphorous compounds. Nanostructured and functionalized cantilever for sensing organophosphorous compounds.
Urelle Biapo, Alessio Ghisolfi, Geoffrey Gerer, Denis Spitzer, Valérie Keller & Thomas Cottineau. (2019) Functionalized TiO 2 Nanorods on a Microcantilever for the Detection of Organophosphorus Chemical Agents in Air . ACS Applied Materials & Interfaces 11:38, pages 35122-35131.
Crossref
Daniel A. Polisel, Alexandre A. de Castro, Daiana T. Mancini, Elaine F.F. da Cunha, Tanos C.C. França, Teodorico C. Ramalho & Kamil Kuca. (2019) Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects. Chemico-Biological Interactions 309, pages 108671.
Crossref
Tereza Kobrlova, Jan Korabecny & Ondrej Soukup. (2019) Current approaches to enhancing oxime reactivator delivery into the brain. Toxicology 423, pages 75-83.
Crossref
L. Muckova, N. Vanova, J. Misik, D. Herman, J. Pejchal & D. Jun. (2019) Oxidative stress induced by oxime reactivators of acetylcholinesterase in vitro. Toxicology in Vitro 56, pages 110-117.
Crossref
Christopher M. Timperley, Jonathan E. Forman, Mohammad Abdollahi, Abdullah Saeed Al-Amri, Augustin Baulig, Djafer Benachour, Veronica Borrett, Flerida A. Cariño, Michael Geist, David Gonzalez, William Kane, Zrinka Kovarik, Roberto Martínez-Álvarez, Nicia Maria Fusaro Mourão, Slawomir Neffe, Syed K. Raza, Valentin Rubaylo, Alejandra Graciela Suárez, Koji Takeuchi, Cheng Tang, Ferruccio Trifirò, Francois Mauritz van Straten, Paula S. Vanninen, Slavica Vučinić, Volodymyr Zaitsev, Muhammad Zafar-Uz-Zaman, Mongia Saïd Zina & Stian Holen. (2019) Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. On medical care and treatment of injuries from nerve agents. Toxicology 415, pages 56-69.
Crossref
Lukas Gorecki, Ondrej Soukup, Tomas Kucera, David Malinak, Daniel Jun, Kamil Kuca, Kamil Musilek & Jan Korabecny. (2018) Oxime K203: a drug candidate for the treatment of tabun intoxication. Archives of Toxicology 93:3, pages 673-691.
Crossref
Rafik Bensegueni, Mounia Guergouri, Chawki Bensouici & Mustapha Bencharif. (2019) Synthesis, antioxidant, and anti-tyrosinase activity of some aromatic oximes: an experimental and theoretical study. Journal of Reports in Pharmaceutical Sciences 8:2, pages 195.
Crossref
Lin-Na Xie, Jie Shao, Chun-Hua Huang, Feng Li, Dan Xu, Balaraman Kalyanaraman & Ben-Zhan Zhu. (2019) An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve-agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions. Free Radical Biology and Medicine 130, pages 1-7.
Crossref
Jinwoo Kim, Yashwardhan R. Malpani, Jooyun Lee, Jin Soo Shin, Soo Bong Han & Young-Sik Jung. (2018) Novel tacrine-pyridinium hybrid reactivators of organophosphorus-inhibited acetylcholinesterase: Synthesis, molecular docking, and in vitro reactivation study. Bioorganic & Medicinal Chemistry Letters 28:23-24, pages 3784-3786.
Crossref
Zhao Wei, Huanglei Bi, Yan-qin Liu, Hui-fang Nie, Lin Yao, Sheng-zheng Wang, Jun Yang, Yong-an Wang, Xueying Liu & Zhi-bing Zheng. (2018) Design, synthesis and evaluation of new classes of nonquaternary reactivators for acetylcholinesterase inhibited by organophosphates. Bioorganic Chemistry 81, pages 681-688.
Crossref
Thomas R. Hayes, Charles M. Thompson, Joseph E. Blecha, John M. Gerdes & Henry F. VanBrocklin. (2018) Radiosynthesis of O‐(1‐[ 18 F]fluoropropan‐2‐yl)‐O‐(4‐nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin . Journal of Labelled Compounds and Radiopharmaceuticals 61:14, pages 1089-1094.
Crossref
Reuel de Paula, Joyce de Almeida, Samir Cavalcante, Arlan Gonçalves, Alessandro Simas, Tanos Franca, Martin Valis, Kamil Kuca, Eugenie Nepovimova & José Granjeiro. (2018) Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon. Molecules 23:11, pages 2954.
Crossref
Jiri Kassa, Christopher M. Timperley, Mike Bird, Rebecca L. Williams, A. Christopher Green & John E.H. Tattersall. (2018) Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice. Toxicology 408, pages 95-100.
Crossref
Maja Katalinić, Goran Šinko, Nikolina Maček Hrvat, Tamara Zorbaz, Anita Bosak & Zrinka Kovarik. (2018) Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations. Toxicology 406-407, pages 104-113.
Crossref
Carlos A. Valdez, Mira K. Marchioretto, Roald N. Leif & Saphon Hok. (2018) Efficient derivatization of methylphosphonic and aminoethylsulfonic acids related to nerve agents simultaneously in soils using trimethyloxonium tetrafluoroborate for their enhanced, qualitative detection and identification by EI-GC–MS and GC–FPD. Forensic Science International 288, pages 159-168.
Crossref
Shibaji Ghosh, Kalyanashis Jana & Bishwajit Ganguly. (2018) Influence of gauche effect on uncharged oxime reactivators for the reactivation of tabun-inhibited AChE: quantum chemical and steered molecular dynamics studies. Journal of Computer-Aided Molecular Design 32:7, pages 793-807.
Crossref
Jiri Kassa, Christopher M. Timperley, Mike Bird, Rebecca L. Williams, A. Christopher Green & John E. H. Tattersall. (2018) Evaluation of the Influence of Three Newly Developed Bispyridinium Anti-nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice. Basic & Clinical Pharmacology & Toxicology 122:4, pages 429-435.
Crossref
Jamal Lasri, Katherine Chulvi & Naser Eltaher Eltayeb. (2018) Crystal structures of ( E )-1-naphthaldehyde oxime and ( E )-phenanthrene-9-carbaldehyde oxime . Acta Crystallographica Section E Crystallographic Communications 74:3, pages 332-336.
Crossref
Jiri Kassa, Jan Korabecny, Eugenie Nepovimova & Daniel Jun. (2018) The influence of modulators of acetylcholinesterase on the resistance of mice against soman and on the effectiveness of antidotal treatment of soman poisoning in mice. Journal of Applied Biomedicine 16:1, pages 10-14.
Crossref
Karla Alejo-González, Erik Hanson-Viana & Rafael Vazquez-Duhalt. (2018) Enzymatic detoxification of organophosphorus pesticides and related toxicants有機リン系殺虫剤よび関連毒物の酵素的無毒化. Journal of Pesticide Science 43:1, pages 1-9.
Crossref
Karla Alejo-González, Katrin Quester, Erik Hanson, Ismael Secundino, Yvonne Rosenstein, Alejandro Huerta-Saquero & Rafael Vazquez-Duhalt. (2017) PEGylation of cytochrome P450 enhances its biocatalytic performance for pesticide transformation. International Journal of Biological Macromolecules 105, pages 163-170.
Crossref
Zhao Wei, Yan-qin Liu, Sheng-zheng Wang, Lin Yao, Hui-fang Nie, Yong-an Wang, Xue-Ying Liu, Zhi-bing Zheng & Song Li. (2017) Conjugates of salicylaldoximes and peripheral site ligands: Novel efficient nonquaternary reactivators for nerve agent-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry 25:16, pages 4497-4505.
Crossref
Shibaji Ghosh, Nellore Bhanu Chandar, Kalyanashis Jana & Bishwajit Ganguly. (2017) Revealing the importance of linkers in K-series oxime reactivators for tabun-inhibited AChE using quantum chemical, docking and SMD studies. Journal of Computer-Aided Molecular Design 31:8, pages 729-742.
Crossref
Manos Gkikas, Reginald K. Avery, Carolyn E. Mills, Ramanathan Nagarajan, Eugene Wilusz & Bradley D. Olsen. (2016) Hydrogels That Actuate Selectively in Response to Organophosphates. Advanced Functional Materials 27:6, pages 1602784.
Crossref
Jiří Kassa & Jan Korábečný. (2017) Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice. Acta Medica (Hradec Kralove, Czech Republic) 60:4, pages 140-145.
Crossref
Jiří Kassa, Jan Korábečný & Eugenie Nepovimová. (2017) The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice. Acta Medica (Hradec Kralove, Czech Republic) 60:1, pages 37-43.
Crossref
Jiri Kassa, Vendula Sepsova, Anna Horova & Kamil Musilek. (2017) A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K305, K307) with the oxime K203 and trimedoxime in tabun-poisoned rats and mice. Journal of Applied Biomedicine 15:1, pages 49-53.
Crossref
Erin Gallagher, Il Minn, Janice E. Chambers & Peter C. Searson. (2016) In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs). Fluids and Barriers of the CNS 13:1.
Crossref
Lukas Gorecki, Jan Korabecny, Kamil Musilek, David Malinak, Eugenie Nepovimova, Rafael Dolezal, Daniel Jun, Ondrej Soukup & Kamil Kuca. (2016) SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides. Archives of Toxicology 90:12, pages 2831-2859.
Crossref
Janice E. Chambers, Howard W. Chambers, Kristen E. Funck, Edward C. Meek, Ronald B. Pringle & Matthew K. Ross. (2016) Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX. Chemico-Biological Interactions 259, pages 154-159.
Crossref
Helen Rice, Tom M. Mann, Stuart J. Armstrong, Matthew E. Price, A. Chris Green & John E.H. Tattersall. (2016) The potential role of bioscavenger in the medical management of nerve-agent poisoned casualties. Chemico-Biological Interactions 259, pages 175-181.
Crossref
Gabriel Amitai, Rellie Gez, Lily Raveh, Nira Bar-Ner, Ettie Grauer & Shira Chapman. (2016) Novel bifunctional hybrid small molecule scavengers for mitigating nerve agents toxicity. Chemico-Biological Interactions 259, pages 187-204.
Crossref
Janice E. Chambers, Edward C. Meek & Howard W. Chambers. (2016) Novel brain‐penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates. Annals of the New York Academy of Sciences 1374:1, pages 52-58.
Crossref
Jeffrey A. Koenig, Thuy L. Dao, Robert K. Kan & Tsung‐Ming Shih. (2016) Zebrafish as a model for acetylcholinesterase‐inhibiting organophosphorus agent exposure and oxime reactivation. Annals of the New York Academy of Sciences 1374:1, pages 68-77.
Crossref
Kyeong Eun Yang, Hyun‐Jin Jang, In‐Hu Hwang, Young‐Ho Chung, Jong‐Soon Choi, Tae‐Hoon Lee, Yun‐Jo Chung, Min‐Seung Lee, Mi Young Lee, Eui‐Ju Yeo & Ik‐Soon Jang. (2015) Phenyl 2‐pyridyl ketoxime induces cellular senescence‐like alterations via nitric oxide production in human diploid fibroblasts. Aging Cell 15:2, pages 245-255.
Crossref
Jan Bures, Jaroslav Kvetina, Ilja Tacheci, Michal Pavlik, Martin Kunes, Stanislav Rejchrt, Kamil Kuca & Marcela Kopacova. (2015) The effect of different doses of atropine on gastric myoelectrical activity in fasting experimental pigs. Journal of Applied Biomedicine 13:4, pages 273-277.
Crossref
Trond Myhrer, Espen Mariussen, Siri Enger & Pål Aas. (2015) Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats. NeuroToxicology 50, pages 142-148.
Crossref
Jiří Bajgar & Jiří Kassa. (2015) DEPARTMENT OF TOXICOLOGY AND MILITARY PHARMACY - IMPORTANT PART OF THE FACULTY OF MILITARY HEALTH SCIENCES OF THE UNIVERSITY OF DEFENCE. Military Medical Science Letters 84:2, pages 57-66.
Crossref
Jiri Kassa, Vendula Sepsova, Martina Tumova, Anna Horova & Kamil Musilek. (2015) A Comparison of the Reactivating and Therapeutic Efficacy of Two Newly Developed Oximes (K727 and K733) with Oxime K203 and Trimedoxime in Tabun-Poisoned Rats and Mice. Basic & Clinical Pharmacology & Toxicology 116:4, pages 367-371.
Crossref
Rupa Iyer, Brian Iken & Alex Leon. (2015) Developments in alternative treatments for organophosphate poisoning. Toxicology Letters 233:2, pages 200-206.
Crossref
Carolyn Chambers, Chunyuan Luo, Min Tong, Yerie Yang & Ashima Saxena. (2015) Probing the role of amino acids in oxime-mediated reactivation of nerve agent-inhibited human acetylcholinesterase. Toxicology in Vitro 29:2, pages 408-414.
Crossref
G. Sundararajan, D. Rajaraman, T. Srinivasan, D. Velmurugan & K. Krishnasamy. (2015) Synthesis, characterization, computational calculation and biological studies of some 2,6-diaryl-1-(prop-2-yn-1-yl)piperidin-4-one oxime derivatives. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 139, pages 108-118.
Crossref
Pooja Pooja, S. Aggarwal, A. K. Tiwari, V. Kumar, R. Pratap, G. Singh & A. K. Mishra. (2015) Novel pyridinium oximes: synthesis, molecular docking and in vitro reactivation studies. RSC Advances 5:30, pages 23471-23480.
Crossref
Apurba K. Bhattacharjee, Elizabeth Marek, Ha Thu Le, Ruthie Ratcliffe, James C. DeMar, Dmitry Pervitsky & Richard K. Gordon. (2015) Discovery of non-oxime reactivators using an in silico pharmacophore model of reactivators for DFP-inhibited acetylcholinesterase. European Journal of Medicinal Chemistry 90, pages 209-220.
Crossref
Milan Jokanović. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 1057 1070 .
Christopher M. Timperley & John Tattersall. 2015. Best Synthetic Methods. Best Synthetic Methods 1 89 .
Jiri Kassa, Jan Korabecny, Vendula Sepsova & Martina Tumova. (2014) The Evaluation of Prophylactic Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase in Soman-Poisoned Mice - A Comparison with Commonly Used Pyridostigmine. Basic & Clinical Pharmacology & Toxicology 115:6, pages 571-576.
Crossref
Christina M. Wilhelm, Thomas H. Snider, Michael C. Babin, David A. Jett, Gennady E. PlatoffJr.Jr. & David T. Yeung. (2014) A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides. Toxicology and Applied Pharmacology 281:3, pages 254-265.
Crossref
Zhao Wei, Yan-qin Liu, Xin-bo Zhou, Yuan Luo, Chun-qian Huang, Yong-an Wang, Zhi-bing Zheng & Song Li. (2014) New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters 24:24, pages 5743-5748.
Crossref
HuaZhi Ding, ShuZhen Liao, FuBing Xiao, GuoLi Shen, RuQin Yu & ZhaoYang Wu. (2014) Acetylcholinesterase liquid crystal biosensor for identification of AChE inhibitors by a reactivator. Science China Chemistry 57:11, pages 1589-1595.
Crossref
Xiangjiang Tang, Tingting Zhang, Bo Liang, Dongfei Han, Lingxing Zeng, Cheng Zheng, Tie Li, Mingdeng Wei & Aihua Liu. (2014) Sensitive electrochemical microbial biosensor for p-nitrophenylorganophosphates based on electrode modified with cell surface-displayed organophosphorus hydrolase and ordered mesopore carbons. Biosensors and Bioelectronics 60, pages 137-142.
Crossref
William Rea & Kalpana Patel. 2014. Reversibility of Chronic Disease and Hypersensitivity,Volume 2. Reversibility of Chronic Disease and Hypersensitivity,Volume 2 555 690 .
Edna F. R. Pereira, Yasco Aracava, Louis J. DeTollaJr.Jr., E. Jeffrey Beecham, G. William BasingerJr.Jr., Edgar J. Wakayama & Edson X. Albuquerque. (2014) Animal Models That Best Reproduce the Clinical Manifestations of Human Intoxication with Organophosphorus Compounds. Journal of Pharmacology and Experimental Therapeutics 350:2, pages 313-321.
Crossref
Jiri Kassa, Vendula Sepsova & Martina Tumova. (2014) A comparison of the reactivating and therapeutic efficacy of two novel oximes K378 and K458 with currently available oximes in rats and mice poisoned with sarin. Journal of Applied Biomedicine 12:3, pages 155-160.
Crossref
Dajana Gašo-Sokač, Valentina Bušić, Mario Cetina & Marijana Jukić. (2014) An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation. Molecules 19:6, pages 7610-7620.
Crossref
Tingting Zhang, Lingxing Zeng, Lei Han, Tie Li, Cheng Zheng, Mingdeng Wei & Aihua Liu. (2014) Ultrasensitive electrochemical sensor for p-nitrophenyl organophosphates based on ordered mesoporous carbons at low potential without deoxygenization. Analytica Chimica Acta 822, pages 23-29.
Crossref
Shuai Wang, Jing Nie, Yan Zheng & Jun-An Ma. (2014) A Direct Copper-Promoted Three-Component Entry to Trifluoromethylketoximes. Organic Letters 16:6, pages 1606-1609.
Crossref
Uday K Killi, Vladimir Wsol, Ondrej Soukup, Kamil Kuca, Michael Winder & Gunnar Tobin. (2014) In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat . Clinical and Experimental Pharmacology and Physiology 41:2, pages 139-146.
Crossref
Yoon Jeong Jang, Olga G. Tsay, Dhiraj P. Murale, Jeong A. Jeong, Aviv Segev & David G. Churchill. (2014) Novel and selective detection of Tabun mimics. Chem. Commun. 50:56, pages 7531-7534.
Crossref
Mohammad Moshiri, Anahita Alizadeh & Mahdi Balali-Mood. 2014. Basic and Clinical Toxicology of Organophosphorus Compounds. Basic and Clinical Toxicology of Organophosphorus Compounds 177 212 .
Trond Myhrer, Siri Enger, Espen Mariussen & Pål Aas. (2013) Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility. Toxicology 314:2-3, pages 221-228.
Crossref
Manjinder Singh, Maninder Kaur, Hitesh Kukreja, Rajan Chugh, Om Silakari & Dhandeep Singh. (2013) Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection. European Journal of Medicinal Chemistry 70, pages 165-188.
Crossref
Miroslav Pohanka. (2013) HI-6 modulates immunization efficacy in a BALB/c mouse model. Environmental Toxicology and Pharmacology 36:3, pages 801-806.
Crossref
Jiri Kassa, Jan Misik & Jana Z. Karasova. (2013) Evaluation of the Potency of Two Novel Bispyridinium Oximes (K456, K458) in Comparison with Oxime K203 and Trimedoxime to Counteract Tabun-Induced Neurotoxicity in Rats. Basic & Clinical Pharmacology & Toxicology 113:3, pages 201-208.
Crossref
Imtiyaz H. Lone, Khaliquz Z. Khan, Bharat I. Fozdar & Fida Hussain. (2013) Synthesis antimicrobial and antioxidant studies of new oximes of steroidal chalcones. Steroids 78:9, pages 945-950.
Crossref
Hyo-Jeong Hong, Jieun Lee, Ae Ri Bae & Ik-Hwan Um. (2013) Kinetics and Reaction Mechanism for Alkaline Hydrolysis of Y-Substituted-Phenyl Diphenylphosphinates. Bulletin of the Korean Chemical Society 34:7, pages 2001-2005.
Crossref
Yuki C. Tse, Claire R. Sharp & Timothy Evans. (2013) Mechanical ventilation in a dog with acetylcholinesterase inhibitor toxicosis. Journal of Veterinary Emergency and Critical Care 23:4, pages 442-446.
Crossref
Xin Li, Chen Yang, Jia‐Lu Jin, Xiao‐Song Xue & Jin‐Pei Cheng. (2013) Synthesis of Optically Enriched Spirocyclic Benzofuran‐2‐ones by Bifunctional Thiourea‐Base Catalyzed Double‐Michael Addition of Benzofuran‐2‐ones to Dienones. Chemistry – An Asian Journal 8:5, pages 997-1003.
Crossref
Martina Šrajer Gajdošik, Dajana Gašo-Sokač, Hrvoje Pavlović, James Clifton, Lucas Breen, Lulu Cao, Jasminka Giacometti & Djuro Josic. (2013) Sample preparation and further proteomic investigation of the inhibitory activity of pyridinium oximes to Gram-positive and Gram-negative food pathogens. Food Research International 51:1, pages 46-52.
Crossref
O. Soukup, D. Jun, G. Tobin & K. Kuca. (2012) The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors. Archives of Toxicology 87:4, pages 711-719.
Crossref
Jiří Kassa, Jana Žďárová Karasová & Markéta Krejčiová. (2013) Therapeutic efficacy of a novel bispyridinium oxime K203 and commonly used oximes (HI-6, obidoxime, trimedoxime, methoxime) in soman-poisoned male rats and mice. Journal of Applied Biomedicine 11:1, pages 7-13.
Crossref
Julien Renou, Guillaume Mercey, Tristan Verdelet, Emilia Păunescu, Emilie Gillon, Mélanie Arboléas, Mélanie Loiodice, Maria Kliachyna, Rachid Baati, Florian Nachon, Ludovic Jean & Pierre-Yves Renard. (2013) Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents. Chemico-Biological Interactions 203:1, pages 81-84.
Crossref
Guillaume Mercey, Julien Renou, Tristan Verdelet, Maria Kliachyna, Rachid Baati, Emilie Gillon, Mélanie Arboléas, Mélanie Loiodice, Florian Nachon, Ludovic Jean & Pierre-Yves Renard. (2012) Phenyltetrahydroisoquinoline–Pyridinaldoxime Conjugates as Efficient Uncharged Reactivators for the Dephosphylation of Inhibited Human Acetylcholinesterase. Journal of Medicinal Chemistry 55:23, pages 10791-10795.
Crossref
Mohammd Moshiri, Emadodin Darchini-Maragheh & Mahdi Balali-Mood. (2012) Advances in toxicology and medical treatment of chemical warfare nerve agents. DARU Journal of Pharmaceutical Sciences 20:1.
Crossref
Jiri Kassa, Jan Misik & Jana Zdarova Karasova. (2012) A Comparison of the Potency of a Novel Bispyridinium Oxime K203 and currently available Oximes (Obidoxime, HI ‐6) to Counteract the Acute Neurotoxicity of Sarin in Rats . Basic & Clinical Pharmacology & Toxicology 111:5, pages 333-338.
Crossref
Hongjun Jing, Yadong Jiang & Xiaosong Du. (2012) Screen-printed single-walled carbon nanotube networks and their use for dimethyl methylphosphonate detection. Journal of Materials Science: Materials in Electronics 23:10, pages 1823-1829.
Crossref
Sebastian Wertz & Armido Studer. (2012) Metal‐Free 2,2,6,6‐Tetramethylpiperidin‐1‐yloxy Radical (TEMPO) Catalyzed Aerobic Oxidation of Hydroxylamines and Alkoxyamines to Oximes and Oxime Ethers. Helvetica Chimica Acta 95:10, pages 1758-1772.
Crossref
Ana M. Costero, Margarita Parra, Salvador Gil, Raúl Gotor, Ramón Martínez‐Mañez, Félix Sancenón & Santiago Royo. (2012) Selective Detection of Nerve Agent Simulants by Using Triarylmethanol‐Based Chromogenic Chemodosimeters. European Journal of Organic Chemistry 2012:26, pages 4937-4946.
Crossref
O. Soukup, Z. Kristofikova, D. Jun, V. Tambor, D. Ripova & K. Kuca. (2012) The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers. Toxicology Letters 212:3, pages 315-319.
Crossref
Mario Cetina, Ante Nagl, Dajana Gašo-Sokač, Spomenka Kovač, Valentina Bušić & Dijana Saftić. (2012) Extensive Intramolecular and Intermolecular Interactions in Two Quaternary Salts of the Pyridoxal Oxime. Journal of Chemical Crystallography 42:7, pages 752-758.
Crossref
Yun Chen. (2012) Organophosphate-induced brain damage: Mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies. NeuroToxicology 33:3, pages 391-400.
Crossref
Jiri Kassa, Kamil Musilek, Marketa Koomlova & Jiri Bajgar. (2011) A Comparison of the Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase with Commonly Used Pyridostigmine as Pharmacological Pre‐Treatment of Soman‐Poisoned Mice. Basic & Clinical Pharmacology & Toxicology 110:4, pages 322-326.
Crossref
Miroslav Pohanka. (2012) Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology. International Journal of Molecular Sciences 13:2, pages 2219-2238.
Crossref
Jiří Kassa, Jana Zdarová Karasová, Růžena Pavlíková, Filip Caisberger & Jiří Bajgar. (2012) The Ability of Oxime Mixtures to Increase the Reactivating and Therapeutic Efficacy of Antidotal Treatment of Cyclosarin Poisoning in Rats and Mice. Acta Medica (Hradec Kralove, Czech Republic) 55:1, pages 27-31.
Crossref
Christopher M. Timperley, Mike Bird, Christopher Green, Matthew E. Price, John E. Chad, Simon R. Turner & John E. H. Tattersall. (2012) 1,1′-(Propane-1,3-diyl)bis(4-tert-butylpyridinium) di(methanesulfonate) protects guinea pigs from soman poisoning when used as part of a combined therapy. Med. Chem. Commun. 3:3, pages 352-356.
Crossref
. 2012. Nerve Agents Poisoning and its Treatment in Schematic Figures and Tables. Nerve Agents Poisoning and its Treatment in Schematic Figures and Tables 77 81 .
Vendula Šepsová, Jana Žďárová Karasová, Filip Zemek, Brian J. Bennion & Kamil Kuča. (2011) OXIMES AS INHIBITORS OF ACETYLHOLINESTERASE - A STRUCTURE-ACTIVITY RELATIONSHIP (SAR) STUDY. Military Medical Science Letters 80:4, pages 178-186.
Crossref
Jiri Kassa, Jana Zdarova Karasova, Vendula Sepsova, Filip Caisberger & Jiri Bajgar. (2011) A Comparison of the Reactivating and Therapeutic Efficacy of Chosen Combinations of Oximes With Individual Oximes Against VX in Rats and Mice. International Journal of Toxicology 30:5, pages 562-567.
Crossref
Meltem Uzunhisarcikli & Yusuf Kalender. (2011) Protective effects of vitamins C and E against hepatotoxicity induced by methyl parathion in rats. Ecotoxicology and Environmental Safety 74:7, pages 2112-2118.
Crossref
Halil Gökce & Semiha Bahçeli. (2011) A study on quantum chemical calculations of 3-, 4-nitrobenzaldehyde oximes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 79:5, pages 1783-1793.
Crossref
O. SOUKUP, J. KRŮŠEK, M. KANIAKOVÁ, U. K. KUMAR, M. OZ, D. JUN, J. FUSEK, K. KUČA & G. TOBIN. (2011) Oxime Reactivators and Their in Vivo and in Vitro Effects on Nicotinic Receptors. Physiological Research, pages 679-686.
Crossref
Jiří Kassa, Jana Žďárová Karasová, Vendula Šepsová & Jiří Bajgar. (2011) A comparison of the reactivating and therapeutic efficacy of the newly developed bispyridinium oxime K203 with currently available oximes, in sarin poisoned rats and mice. Journal of Applied Biomedicine 9:4, pages 225-230.
Crossref
Jiri Kassa, Jana Zdarova Karasova, Vendula Sepsova & Filip Caisberger. (2011) The Benefit of Combinations of Oximes for the Reactivating and Therapeutic Efficacy of Antidotal Treatment of Sarin Poisoning in Rats and Mice. Basic & Clinical Pharmacology & Toxicology 109:1, pages 30-34.
Crossref

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