Advanced search
Publication Cover
Molecular and Cellular Biology Volume 25, 2005 - Issue 9
Submit an article Journal homepage
110
Views
405
CrossRef citations to date
0
Altmetric
Gene Expression

Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Randi G. Syljuåsen1 Institute of Cancer Biology, Danish Cancer Society
,
Claus Storgaard Sørensen1 Institute of Cancer Biology, Danish Cancer Society
,
Lasse Tengbjerg Hansen2 Institute of Molecular Pathology, University of Copenhagen
,
Kasper Fugger1 Institute of Cancer Biology, Danish Cancer Society
,
Cecilia Lundin3 Department of Genetics Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
,
Fredrik Johansson3 Department of Genetics Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
,
Thomas Helleday3 Department of Genetics Microbiology and Toxicology, Stockholm University, Stockholm, Sweden;4 The Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom
,
Maxwell Sehested5 Department of Pathology, Rigshospitalet 5444, Copenhagen, Denmark
,
Jiri Lukas1 Institute of Cancer Biology, Danish Cancer Society
&
Jiri Bartek1 Institute of Cancer Biology, Danish Cancer SocietyCorrespondence[email protected]
 show all
Pages 3553-3562 | Received 12 Jul 2004, Accepted 04 Jan 2005, Published online: 27 Mar 2023

Citations (405)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (29)

Sissel Hauge, Adrian Eek Mariampillai, Gro Elise Rødland, Lilli T. E. Bay, Helga B. Landsverk & Randi G. Syljuåsen. (2023) Expanding roles of cell cycle checkpoint inhibitors in radiation oncology. International Journal of Radiation Biology 99:6, pages 941-950.
Read now
Chenghong Zhang, Sungjoon Cho, José G. Napolitano, David Russell, Christine Gu, Alan Deese, Chong Han, Yuan Chen & Shuguang Ma. (2022) Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats. Xenobiotica 52:3, pages 219-228.
Read now
Mahnoush Bahjat, Guus de Wilde, Tijmen van Dam, Chiel Maas, Timon Bloedjes, Richard J. Bende, Carel J.M. van Noesel, Dieuwertje M. Luijks, Eric Eldering, Marie José Kersten & Jeroen E.J. Guikema. (2019) The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors. Cell Cycle 18:18, pages 2307-2322.
Read now
Sissel Hauge, Libor Macurek & Randi G. Syljuåsen. (2019) p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775. Cell Cycle 18:8, pages 834-847.
Read now
Jean-Hugues Guervilly & Pierre Henri Gaillard. (2018) SLX4: multitasking to maintain genome stability. Critical Reviews in Biochemistry and Molecular Biology 53:5, pages 475-514.
Read now
Jun Yang, Ziming Hou, Changjiang Wang, Hao Wang & Hongbing Zhang. (2018) Gene expression microarray analysis reveals prognostic markers of survival in high grade astrocytomas. Neurological Research 40:9, pages 744-751.
Read now
Leslie A. Parsels, Joshua D. Parsels, Daria M. Tanska, Jonathan Maybaum, Theodore S. Lawrence & Meredith A. Morgan. (2018) The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors. Cell Cycle 17:9, pages 1076-1086.
Read now
Deborah Silvera, Amanda Ernlund, Rezina Arju, Eileen Connolly, Viviana Volta, Jinhua Wang & Robert J. Schneider. (2017) mTORC1 and -2 Coordinate Transcriptional and Translational Reprogramming in Resistance to DNA Damage and Replicative Stress in Breast Cancer Cells. Molecular and Cellular Biology 37:5.
Read now
Nandini Sakurikar & Alan Eastman. (2016) Critical reanalysis of the methods that discriminate the activity of CDK2 from CDK1. Cell Cycle 15:9, pages 1184-1188.
Read now
Leslie A. Parsels, Daria M. Tanska, Joshua D. Parsels, Sonya D. Zabludoff, Kyle C. Cuneo, Theodore S. Lawrence, Jonathan Maybaum & Meredith A. Morgan. (2016) Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry. Cell Cycle 15:5, pages 730-739.
Read now
Ann Christin Parplys, Jasna Irena Seelbach, Saskia Becker, Matthias Behr, Agnieszka Wrona, Camilla Jend, Wael Yassin Mansour, Simon Andreas Joosse, Horst-Werner Stuerzbecher, Helmut Pospiech, Cordula Petersen, Ekkehard Dikomey & Kerstin Borgmann. (2015) High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation. Cell Cycle 14:19, pages 3190-3202.
Read now
Robert Ivkov & Fred Bunz. (2015) Pathways to chromothripsis. Cell Cycle 14:18, pages 2886-2890.
Read now
G Buscemi, C Ricci, L Zannini, E Fontanella, P Plevani & D Delia. (2014) Bimodal regulation of p21waf1 protein as function of DNA damage levels. Cell Cycle 13:18, pages 2901-2912.
Read now
Neil Beeharry, Jerome Rattner, Juliane Caviston & Tim Yen. (2013) Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override. Cell Cycle 12:10, pages 1588-1597.
Read now
Halfdan Beck, Viola Nähse-Kumpf, Marie Sofie Yoo Larsen, Karen A. O'Hanlon, Sebastian Patzke, Christian Holmberg, Jakob Mejlvang, Anja Groth, Olaf Nielsen, Randi G. Syljuåsen & Claus Storgaard Sørensen. (2012) Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption. Molecular and Cellular Biology 32:20, pages 4226-4236.
Read now
Laura Carrassa, Rosaria Chilà, Monica Lupi, Francesca Ricci, Cinzia Celenza, Marco Mazzoletti, Massimo Broggini & Giovanna Damia. (2012) Combined inhibition of Chk1 and Wee1: In vitro synergistic effect translates to tumor growth inhibition in vivo. Cell Cycle 11:13, pages 2507-2517.
Read now
Alessia Errico & Vincenzo Costanzo. (2012) Mechanisms of replication fork protection: a safeguard for genome stability. Critical Reviews in Biochemistry and Molecular Biology 47:3, pages 222-235.
Read now
Deborah Wilsker, Jon H. Chung & Fred Bunz. (2012) Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells. Cell Cycle 11:8, pages 1564-1572.
Read now
Sirisha Peddibhotla, Zhubo Wei, Rao Papineni, Micheal H. Lam, Jeffrey M. Rosen & Pumin Zhang. (2011) The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression. Cell Cycle 10:4, pages 671-679.
Read now
Isabel M. Pires, Zuzana Bencokova, Chris McGurk & Ester M. Hammond. (2010) Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. Cell Cycle 9:13, pages 2502-2507.
Read now
Juan Méndez. (2009) Temporal regulation of DNA replication in mammalian cells. Critical Reviews in Biochemistry and Molecular Biology 44:5, pages 343-351.
Read now
Michalis Fragkos, Jaana Jurvansuu & Peter Beard. (2009) H2AX Is Required for Cell Cycle Arrest via the p53/p21 Pathway. Molecular and Cellular Biology 29:10, pages 2828-2840.
Read now
Ponnari Gottipati, Tobias N. Cassel, Linda Savolainen & Thomas Helleday. (2008) Transcription-Associated Recombination Is Dependent on Replication in Mammalian Cells. Molecular and Cellular Biology 28:1, pages 154-164.
Read now
Stephan Gasser. (2007) DNA damage response and development of targeted cancer treatments. Annals of Medicine 39:6, pages 457-464.
Read now
Van Leung-Pineda, Christine E. Ryan & Helen Piwnica-Worms. (2006) Phosphorylation of Chk1 by ATR Is Antagonized by a Chk1-Regulated Protein Phosphatase 2A Circuit. Molecular and Cellular Biology 26:20, pages 7529-7538.
Read now
Gary P. H. Ho, Steven Margossian, Toshiyasu Taniguchi & Alan D. D'Andrea. (2006) Phosphorylation of FANCD2 on Two Novel Sites Is Required for Mitomycin C Resistance. Molecular and Cellular Biology 26:18, pages 7005-7015.
Read now
Shizhou Liu, Simon Bekker-Jensen, Niels Mailand, Claudia Lukas, Jiri Bartek & Jiri Lukas. (2006) Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation. Molecular and Cellular Biology 26:16, pages 6056-6064.
Read now
Eva Petermann, Apolinar Maya-Mendoza, George Zachos, David A. F. Gillespie, Dean A. Jackson & Keith W. Caldecott. (2006) Chk1 Requirement for High Global Rates of Replication Fork Progression during Normal Vertebrate S Phase. Molecular and Cellular Biology 26:8, pages 3319-3326.
Read now
Ja-Eun Kim, Sarah A. McAvoy, David I. Smith & Junjie Chen. (2005) Human TopBP1 Ensures Genome Integrity during Normal S Phase. Molecular and Cellular Biology 25:24, pages 10907-10915.
Read now

Articles from other publishers (376)

Jinal A Patel, Camryn Zezelic, Julie Rageul, Joanne Saldanha, Arafat Khan & Hyungjin Kim. (2023) Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe. Nucleic Acids Research 51:12, pages 6246-6263.
Crossref
Mateusz Kciuk, Somdutt Mujwar, Beata Marciniak, Adrianna Gielecińska, Karol Bukowski, Mariusz Mojzych & Renata Kontek. (2023) Genotoxicity of Novel Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides in Normal and Cancer Cells In Vitro. International Journal of Molecular Sciences 24:4, pages 4053.
Crossref
Yuri Tozaki, Hiromasa Aoki, Rina Kato, Kohki Toriuchi, Saki Arame, Yasumichi Inoue, Hidetoshi Hayashi, Eiji Kubota, Hiromi Kataoka & Mineyoshi Aoyama. (2023) The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells. Cancers 15:3, pages 735.
Crossref
Anastas Gospodinov, Stefka Dzhokova, Maria Petrova & Iva Ugrinova. 2023. Control of Cell Cycle & Cell Proliferation. Control of Cell Cycle & Cell Proliferation 243 280 .
Abdol-Hossein Rezaeian, Hiroyuki Inuzuka & Wenyi Wei. 2023. Control of Cell Cycle & Cell Proliferation. Control of Cell Cycle & Cell Proliferation 179 201 .
Anya Golder, Louisa Nelson, Anthony Tighe, Bethany Barnes, Camilla Coulson-Gilmer, Robert D Morgan, Joanne C McGrail & Stephen S Taylor. (2022) Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors. NAR Cancer 4:4.
Crossref
Gijs Zonderland, Riccardo Vanzo, Sampath Amitash Gadi, Elena Martín-Doncel, Fabian Coscia, Andreas Mund, Mads Lerdrup, Jan Benada, Dominik Boos & Luis Toledo. (2022) The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition. Molecular Cell 82:18, pages 3350-3365.e7.
Crossref
Nikolay N. Kalitin, Lidia V. Ektova, Natalia S. Kostritsa, Anastasia S. Sivirinova, Alexander V. Kostarev, Galina B. Smirnova, Yulia A. Borisova, Irina S. Golubeva, Elisaveta V. Ermolaeva, Maria A. Vergun, Maria A. Babaeva, Anna A. Lushnikova & Aida F. Karamysheva. (2022) A novel glycosylated indolocarbazole derivative LCS1269 effectively inhibits growth of human cancer cells in vitro and in vivo through driving of both apoptosis and senescence by inducing of DNA damage and modulating of AKT/mTOR/S6K and ERK pathways. Chemico-Biological Interactions 364, pages 110056.
Crossref
Erkin Ozgiray, Fatma Sogutlu & Cigir Biray Avci. (2022) Chk1/2 inhibitor AZD7762 enhances the susceptibility of IDH-mutant brain cancer cells to temozolomide. Medical Oncology 39:11.
Crossref
Nadia Saeed, Ishrat Mahjabeen, Farzana Hakim, Muhammad Zahid Hussain, Azhar Mehmood, Asif Nisar, Malik Waqar Ahmed & Mahmood Akhtar Kayani. (2022) Role of Chk1 gene in molecular classification and prognosis of gastric cancer using immunohistochemistry and LORD-Q assay . Future Oncology 18:25, pages 2827-2841.
Crossref
Sandip Misra, Sougata Ghosh Chowdhury, Ginia Ghosh, Ananda Mukherjee & Parimal Karmakar. (2022) Both phosphorylation and phosphatase activity of PTEN are required to prevent replication fork progression during stress by inducing heterochromatin. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 825, pages 111800.
Crossref
Megan Perry & Gargi Ghosal. (2022) Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease. Frontiers in Molecular Biosciences 9.
Crossref
Barbara Guerra, Thomas K. Doktor, Sabrina B. Frederiksen, Kumar Somyajit & Brage S. Andresen. (2022) Essential role of CK2α for the interaction and stability of replication fork factors during DNA synthesis and activation of the S-phase checkpoint. Cellular and Molecular Life Sciences 79:6.
Crossref
Sabine Meessen, Gregoire Najjar, Anca Azoitei, Sebastian Iben, Christian Bolenz & Cagatay Günes. (2022) A Comparative Assessment of Replication Stress Markers in the Context of Telomerase. Cancers 14:9, pages 2205.
Crossref
Luisa Maresca, Barbara Stecca & Laura Carrassa. (2022) Novel Therapeutic Approaches with DNA Damage Response Inhibitors for Melanoma Treatment. Cells 11:9, pages 1466.
Crossref
Zi-Jie Long, Jun-Dan Wang, Jue-Qiong Xu, Xin-Xing Lei & Quentin Liu. (2022) cGAS/STING cross-talks with cell cycle and potentiates cancer immunotherapy. Molecular Therapy 30:3, pages 1006-1017.
Crossref
Seiji Takeuchi, Toshiro Matsuda, Mariko Tsujimoto, Takeshi Fukumoto, Ryusuke Ono & Chikako Nishigori. (2022) Replication-related genes are upregulated in XP-A cells after UV-C irradiation. Journal of Dermatological Science 105:3, pages 152-158.
Crossref
Boyang Zhao, Yiyun Rao, Scott Leighow, Edward P. O’Brien, Luke Gilbert & Justin R. Pritchard. (2022) A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments. Nature Communications 13:1.
Crossref
Seung Ho Choi, Kyoungjoo Cho, Eun Seon Kim & Hae Yong Yoo. (2022) Proline-serine-threonine-repeat region of MDC1 mediates Chk1 phosphorylation and the DNA double-strand break repair. The International Journal of Biochemistry & Cell Biology 143, pages 106152.
Crossref
Xiaoning Wu, Elena Seraia, Stephanie B. Hatch, Xiao Wan, Daniel V. Ebner, Francesca Aroldi, Yanyan Jiang, Anderson J. Ryan, Thomas Bogenrieder, Ulrike Weyer-Czernilofsky, Guillaume Rieunier & Valentine M. Macaulay. (2021) CHK1 inhibition exacerbates replication stress induced by IGF blockade. Oncogene 41:4, pages 476-488.
Crossref
Miguel A. Galindo-Campos, Nura LutfiSarah Bonnin, Carlos Martínez, Talia Velasco-Hernandez, Violeta García-Hernández, Juan Martín-CaballeroCoral AmpurdanésRamón Gimeno, Lluis ColomoGaël RouéGuillaume Guilbaud, Françoise DantzerPilar Navarro, Matilde Murga, Oscar Fernández-Capetillo, Anna Bigas, Pablo Menéndez, Julian E. SaleJosé Yélamos. (2022) Distinct roles for PARP-1 and PARP-2 in c-Myc–driven B-cell lymphoma in mice. Blood 139:2, pages 228-239.
Crossref
Camilla Reiter Elbæk, Valdemaras Petrosius, Jan Benada, Louisa Erichsen, Rune Busk Damgaard & Claus Storgaard Sørensen. (2022) WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity. Cell Reports 38:3, pages 110261.
Crossref
Leslie A. Parsels, Qiang Zhang, David Karnak, Joshua D. Parsels, Kwok Lam, Henning Willers, Michael D. Green, Alnawaz Rehemtulla, Theodore S. Lawrence & Meredith A. Morgan. (2021) Translation of DNA Damage Response Inhibitors as Chemoradiation Sensitizers From the Laboratory to the Clinic. International Journal of Radiation Oncology*Biology*Physics 111:5, pages e38-e53.
Crossref
Kimberlie A Wittig, Courtney G Sansam, Tyler D Noble, Duane Goins & Christopher L Sansam. (2021) The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase. Nucleic Acids Research 49:18, pages 10507-10523.
Crossref
Francesca Esposito, Raffaella Giuffrida, Gabriele Raciti, Caterina Puglisi & Stefano Forte. (2021) Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy. International Journal of Molecular Sciences 22:19, pages 10689.
Crossref
Yandong Yin, Wei Ting Chelsea Lee, Dipika Gupta, Huijun Xue, Peter Tonzi, James A. Borowiec, Tony T. Huang, Mauro Modesti & Eli Rothenberg. (2021) A basal-level activity of ATR links replication fork surveillance and stress response. Molecular Cell 81:20, pages 4243-4257.e6.
Crossref
Diletta Ciardo, Olivier Haccard, Hemalatha Narassimprakash, Jean-Michel Arbona, Olivier Hyrien, Benjamin Audit, Kathrin Marheineke & Arach Goldar. (2021) Organization of DNA Replication Origin Firing in Xenopus Egg Extracts: The Role of Intra-S Checkpoint. Genes 12:8, pages 1224.
Crossref
Rhys M. Williams & Xiaodong Zhang. (2021) Roles of ATM and ATR in DNA double strand breaks and replication stress. Progress in Biophysics and Molecular Biology 163, pages 109-119.
Crossref
Parnia Rahnamay Farnood, Romina Danesh Pazhooh, Zatollah Asemi & Bahman Yousefi. (2021) DNA damage response and repair in pancreatic cancer development and therapy. DNA Repair 103, pages 103116.
Crossref
Hervé Técher & Philippe Pasero. (2021) The Replication Stress Response on a Narrow Path Between Genomic Instability and Inflammation. Frontiers in Cell and Developmental Biology 9.
Crossref
Fatemeh Sadoughi, Parisa Maleki Dana, Zatollah Asemi & Bahman Yousefi. (2021) DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications. DNA Repair 102, pages 103105.
Crossref
Daniel Blakemore, Nuria Vilaplana‐Lopera, Ruba Almaghrabi, Elena Gonzalez, Miriam Moya, Carl Ward, George Murphy, Agnieszka Gambus, Eva Petermann, Grant S Stewart & Paloma García. (2021) MYBL2 and ATM suppress replication stress in pluripotent stem cells. EMBO reports 22:5.
Crossref
Rhys M. Williams & Xiaodong Zhang. (2021) Roles of ATM and ATR in DNA double strand breaks and replication stress. Progress in Biophysics and Molecular Biology 161, pages 27-38.
Crossref
Nicolás Luis Calzetta, Marina Alejandra González Besteiro & Vanesa Gottifredi. (2021) PARP Activity Fine-tunes the DNA Replication Choreography of Chk1-depleted Cells. Journal of Molecular Biology 433:10, pages 166949.
Crossref
Emiliano Maiani, Giacomo Milletti, Francesca Nazio, Søs Grønbæk Holdgaard, Jirina Bartkova, Salvatore Rizza, Valentina Cianfanelli, Mar Lorente, Daniele Simoneschi, Miriam Di Marco, Pasquale D’Acunzo, Luca Di Leo, Rikke Rasmussen, Costanza Montagna, Marilena Raciti, Cristiano De Stefanis, Estibaliz Gabicagogeascoa, Gergely Rona, Nélida Salvador, Emanuela Pupo, Joanna Maria Merchut-Maya, Colin J. Daniel, Marianna Carinci, Valeriana Cesarini, Alfie O’sullivan, Yeon-Tae Jeong, Matteo Bordi, Francesco Russo, Silvia Campello, Angela Gallo, Giuseppe Filomeni, Letizia Lanzetti, Rosalie C. Sears, Petra Hamerlik, Armando Bartolazzi, Robert E. Hynds, David R. Pearce, Charles Swanton, Michele Pagano, Guillermo Velasco, Elena Papaleo, Daniela De Zio, Apolinar Maya-Mendoza, Franco Locatelli, Jiri Bartek & Francesco Cecconi. (2021) AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. Nature 592:7856, pages 799-803.
Crossref
Xiaoxue Song, Liyuan Wang, Tianci Wang, Juncheng Hu, Jingchao Wang, Rongfu Tu, Hexiu Su, Jue Jiang, Guoliang Qing & Hudan Liu. (2021) Synergistic targeting of CHK1 and mTOR in MYC-driven tumors. Carcinogenesis 42:3, pages 448-460.
Crossref
Katharine J. Herbert, Rathi Puliyadi, Remko Prevo, Gonzalo Rodriguez-Berriguete, Anderson Ryan, Kristijan Ramadan & Geoff S. Higgins. (2020) Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress. Cell Death & Differentiation 28:4, pages 1333-1346.
Crossref
Andreas Panagopoulos & Matthias Altmeyer. (2021) The Hammer and the Dance of Cell Cycle Control. Trends in Biochemical Sciences 46:4, pages 301-314.
Crossref
Pooja Gupta, Bhaskar Saha, Subrata Chattopadhyay & Birija Sankar Patro. (2021) Pharmacological targeting of differential DNA repair, radio-sensitizes WRN-deficient cancer cells in vitro and in vivo. Biochemical Pharmacology 186, pages 114450.
Crossref
Yunxiang Zhou, Lihong Liu, Sifeng Tao, Yihan Yao, Yali Wang, Qichun Wei, Anwen Shao & Yongchuan Deng. (2021) Parthanatos and its associated components: Promising therapeutic targets for cancer. Pharmacological Research 163, pages 105299.
Crossref
Zhuangzhuang Jiang, Yang Zhao, Yang Zhao, Yanqing Liu & Li Tao. (2021) Pristimerin synergizes with gemcitabine through abrogating Chk1/53BP1-mediated DNA repair in pancreatic cancer cells. Food and Chemical Toxicology 147, pages 111919.
Crossref
Fiifi Neizer-Ashun & Resham Bhattacharya. (2021) Reality CHEK: Understanding the biology and clinical potential of CHK1. Cancer Letters 497, pages 202-211.
Crossref
Rongjie Zhang, Yan Chen, Ge Zhou, Baoguo Sun, Yue Li & Zexiong Chen. (2020) Constructing the Logical Regression Model to Predict the Target of Jianpi Jiedu Decoction in the Treatment of Hepatocellular Carcinoma. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-12.
Crossref
Nicolás Luis Calzetta, Marina Alejandra González Besteiro & Vanesa Gottifredi. (2020) Mus81-Eme1–dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity. Science Advances 6:50.
Crossref
Patrycja Gralewska, Arkadiusz Gajek, Agnieszka Marczak & Aneta Rogalska. (2020) Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer. Journal of Hematology & Oncology 13:1.
Crossref
Qiliang Ding & Amnon Koren. (2020) Positive and Negative Regulation of DNA Replication Initiation. Trends in Genetics 36:11, pages 868-879.
Crossref
Sera Lim, Yesol Kim, Soo-Been Lee, Hyeok-Gu Kang, Da-Hyun Kim, Jee Won Park, Daeun Chung, Hyunkyung Kong, Kyung Hyun Yoo, Yonghwan Kim, Wonshik Han, Kyung-Hee Chun & Jong Hoon Park. (2020) Inhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer. Oncogenesis 9:10.
Crossref
Stanislav Drápela, Prashant Khirsariya, Wytske M. van Weerden, Radek Fedr, Tereza Suchánková, Diana Búzová, Jan Červený, Aleš Hampl, Martin Puhr, William R. Watson, Zoran Culig, Lumír Krejčí, Kamil Paruch & Karel Souček. (2020) The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel‐resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe. Molecular Oncology 14:10, pages 2487-2503.
Crossref
Huanbo Zhu, Umang Swami, Ranjan Preet & Jun Zhang. (2020) Harnessing DNA Replication Stress for Novel Cancer Therapy. Genes 11:9, pages 990.
Crossref
Zhaojun Qiu, Pengyan Fa, Tao Liu, Chandra B. Prasad, Shanhuai Ma, Zhipeng Hong, Ernest R. Chan, Hongbing Wang, Zaibo Li, Kai He, Qi-En Wang, Terence M. Williams, Chunhong Yan, Steven T. Sizemore, Goutham Narla & Junran Zhang. (2020) A Genome-Wide Pooled shRNA Screen Identifies PPP2R2A as a Predictive Biomarker for the Response to ATR and CHK1 Inhibitors. Cancer Research 80:16, pages 3305-3318.
Crossref
Jayakumar Nair, Tzu-Ting Huang, Junko Murai, Brittany Haynes, Patricia S. Steeg, Yves Pommier & Jung-Min Lee. (2020) Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer. Oncogene 39:33, pages 5520-5535.
Crossref
Johanna C. Bendell, Helge G. Bischoff, Jimmy Hwang, Hans Christian Reinhardt, Thomas Zander, Xuejing Wang, Scott Hynes, Celine Pitou, Robert Campbell, Philip Iversen, Daphne L. Farrington, Katherine Bell-McGuinn & Michael Thomas. (2019) A phase 1 dose-escalation study of checkpoint kinase 1 (CHK1) inhibitor prexasertib in combination with p38 mitogen-activated protein kinase (p38 MAPK) inhibitor ralimetinib in patients with advanced or metastatic cancer. Investigational New Drugs 38:4, pages 1145-1155.
Crossref
Theresa E. León, Tanya Rapoz-D'Silva, Cosetta Bertoli, Sunniyat Rahman, Michael Magnussen, Brian Philip, Nadine Farah, Simon E. Richardson, Sara Ahrabi, José Afonso Guerra-Assunção, Rajeev Gupta, Elisabeth P. Nacheva, Stephen Henderson, Javier Herrero, David C. Linch, Robertus A.M. de Bruin & Marc R. Mansour. (2020) EZH2 -Deficient T-cell Acute Lymphoblastic Leukemia Is Sensitized to CHK1 Inhibition through Enhanced Replication Stress . Cancer Discovery 10:7, pages 998-1017.
Crossref
Shinya Ohashi, Osamu Kikuchi, Yukie Nakai, Tomomi Ida, Tomoki Saito, Yuki Kondo, Yoshihiro Yamamoto, Yosuke Mitani, Trang H. Nguyen Vu, Keita Fukuyama, Hiroshi Tsukihara, Norihiko Suzuki & Manabu Muto. (2020) Synthetic Lethality with Trifluridine/Tipiracil and Checkpoint Kinase 1 Inhibitor for Esophageal Squamous Cell Carcinoma. Molecular Cancer Therapeutics 19:6, pages 1363-1372.
Crossref
Zhen Guo, Youhong Wang, Yu Zhao, Yi Jin, Liang An, Heng Xu, Zhaoqian Liu, Xiaoping Chen, Honghao Zhou, Hui Wang & Wei Zhang. (2020) A functional variant in CHK1 contributes to increased risk of nasopharyngeal carcinoma in a Han Chinese population. Journal of Cellular Biochemistry 121:5-6, pages 3248-3255.
Crossref
Hannah L Smith, Lisa Prendergast & Nicola J Curtin. (2020) Exploring the Synergy between PARP and CHK1 Inhibition in Matched BRCA2 Mutant and Corrected Cells. Cancers 12:4, pages 878.
Crossref
Nicholas J. H. Warren & Alan Eastman. (2019) Comparison of the different mechanisms of cytotoxicity induced by checkpoint kinase I inhibitors when used as single agents or in combination with DNA damage. Oncogene 39:7, pages 1389-1401.
Crossref
Sona Hubackova, Eliska Davidova, Stepana Boukalova, Jaromira Kovarova, Martina Bajzikova, Ana Coelho, Mikkel G. Terp, Henrik J. Ditzel, Jakub Rohlena & Jiri Neuzil. (2020) Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors. Cell Death & Disease 11:2.
Crossref
Amaia Ercilla, Jan Benada, Sampath Amitash, Gijs Zonderland, Giorgio Baldi, Kumar Somyajit, Fena Ochs, Vincenzo Costanzo, Jiri Lukas & Luis Toledo. (2020) Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication. Cell Reports 30:7, pages 2416-2429.e7.
Crossref
Hannah L. Smith, Harriet Southgate, Deborah A. Tweddle & Nicola J. Curtin. (2020) DNA damage checkpoint kinases in cancer. Expert Reviews in Molecular Medicine 22.
Crossref
Camilla R. Elbæk, Valdemaras Petrosius & Claus S. Sørensen. (2020) WEE1 kinase limits CDK activities to safeguard DNA replication and mitotic entry. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 819-820, pages 111694.
Crossref
Abdullah A. Osman, Antje Lindemann, Li Wang, Steven J. Frank & Jeffrey N. Myers. 2020. Improving the Therapeutic Ratio in Head and Neck Cancer. Improving the Therapeutic Ratio in Head and Neck Cancer 65 88 .
Gesuino Angius, Silverio Tomao, Valeria Stati, Patrizia Vici, Vincenzo Bianco & Federica Tomao. (2019) Prexasertib, a checkpoint kinase inhibitor: from preclinical data to clinical development. Cancer Chemotherapy and Pharmacology 85:1, pages 9-20.
Crossref
Matthew T. McMillan, Theodore S. Lawrence & Meredith A. Morgan. 2020. Molecular Targeted Radiosensitizers. Molecular Targeted Radiosensitizers 191 218 .
Bennie Lemmens & Arne Lindqvist. (2019) DNA replication and mitotic entry: A brake model for cell cycle progression. Journal of Cell Biology 218:12, pages 3892-3902.
Crossref
Ina Patties, Sonja Kallendrusch, Lisa Böhme, Eva Kendzia, Henry Oppermann, Frank Gaunitz, Rolf-Dieter Kortmann & Annegret Glasow. (2019) The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment. Journal of Experimental & Clinical Cancer Research 38:1.
Crossref
Maryam Masnadi-Shirazi, Mano R. Maurya, Gerald Pao, Eugene Ke, Inder M. Verma & Shankar Subramaniam. (2019) Time varying causal network reconstruction of a mouse cell cycle. BMC Bioinformatics 20:1.
Crossref
Miguel A. Galindo-Campos, Marie Bedora-Faure, Jordi Farrés, Chloé Lescale, Lucia Moreno-Lama, Carlos Martínez, Juan Martín-Caballero, Coral Ampurdanés, Pedro Aparicio, Françoise Dantzer, Andrea Cerutti, Ludovic Deriano & José Yélamos. (2019) Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function. Cell Death & Differentiation 26:12, pages 2667-2681.
Crossref
Hisao Homma, Hitomi Nojima, Atsushi Kaida & Masahiko Miura. (2019) Induction of endomitosis-like event in HeLa cells following CHK1 inhibitor treatment. Biochemical and Biophysical Research Communications 520:2, pages 492-497.
Crossref
Tatiana N. Moiseeva, Chenao QianNorie SugitaniHatice U. Osmanbeyoglu & Christopher J. Bakkenist. (2019) WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells. Proceedings of the National Academy of Sciences 116:48, pages 23891-23893.
Crossref
Kalindi Parmar, Bose S. Kochupurakkal, Jean-Bernard Lazaro, Zhigang C. Wang, Sangeetha Palakurthi, Paul T. Kirschmeier, Chunyu Yang, Larissa A. Sambel, Anniina Färkkilä, Elizaveta Reznichenko, Hunter D. Reavis, Connor E. Dunn, Lee Zou, Khanh T. Do, Panagiotis A. Konstantinopoulos, Ursula A. Matulonis, Joyce F. Liu, Alan D. D'Andrea & Geoffrey I. Shapiro. (2019) The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition. Clinical Cancer Research 25:20, pages 6127-6140.
Crossref
Kyle C. Cuneo, Meredith A. Morgan, Vaibhav Sahai, Matthew J. Schipper, Leslie A. Parsels, Joshua D. Parsels, Theresa Devasia, Mahmoud Al-Hawaray, Clifford S. Cho, Hari Nathan, Jonathan Maybaum, Mark M. Zalupski & Theodore S. Lawrence. (2019) Dose Escalation Trial of the Wee1 Inhibitor Adavosertib (AZD1775) in Combination With Gemcitabine and Radiation for Patients With Locally Advanced Pancreatic Cancer. Journal of Clinical Oncology 37:29, pages 2643-2650.
Crossref
Jone Michelena, Marco Gatti, Federico Teloni, Ralph Imhof & Matthias Altmeyer. (2019) Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions. Journal of Cell Biology 218:9, pages 2865-2875.
Crossref
Junko Murai, Anish Thomas, Markku Miettinen & Yves Pommier. (2019) Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies. Pharmacology & Therapeutics 201, pages 94-102.
Crossref
Marina A González Besteiro, Nicolás L Calzetta, Sofía M Loureiro, Martín Habif, Rémy Bétous, Marie‐Jeanne Pillaire, Antonio Maffia, Simone Sabbioneda, Jean‐Sébastien Hoffmann & Vanesa Gottifredi. (2019) Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing. The EMBO Journal 38:16.
Crossref
Alice BourgeoisSébastien BonnetSandra Breuils-BonnetKarima HabboutRenée ParadisEve TremblayMarie-Claude LampronMark E. OrcholskiFrancois PotusThomas BerteroThibaut PeterliniStephen Y. ChanKaren A NorrisRoxane PaulinSteeve ProvencherOlivier Boucherat. (2019) Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology 39:8, pages 1667-1681.
Crossref
Baki Akgül, Matthias Kirschberg, Alan Storey & Martin Hufbauer. (2019) Human papillomavirus type 8 oncoproteins E6 and E7 cooperate in downregulation of the cellular checkpoint kinase-1. International Journal of Cancer 145:3, pages 797-806.
Crossref
Swagata Halder, Ignacio Torrecilla, Martin D. Burkhalter, Marta Popović, John Fielden, Bruno Vaz, Judith Oehler, Domenic Pilger, Davor Lessel, Katherine Wiseman, Abhay Narayan Singh, Iolanda Vendrell, Roman Fischer, Melanie Philipp & Kristijan Ramadan. (2019) SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication. Nature Communications 10:1.
Crossref
Tatiana N. Moiseeva, Yandong YinMichael J. CalderonChenao QianSandra Schamus-HaynesNorie SugitaniHatice U. OsmanbeyogluEli RothenbergSimon C. WatkinsChristopher J. Bakkenist. (2019) An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication. Proceedings of the National Academy of Sciences 116:27, pages 13374-13383.
Crossref
Nicholas J. H. Warren, Katelyn L. Donahue & Alan Eastman. (2019) Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38. ACS Pharmacology & Translational Science 2:3, pages 168-182.
Crossref
Emilie Lukášová, Martina Řezáčová, Alena Bačíková, Ludmila Šebejová, Jiřina Vávrová & Stanislav Kozubek. (2019) Distinct cellular responses to replication stress leading to apoptosis or senescence. FEBS Open Bio 9:5, pages 870-890.
Crossref
Benoît Falquet & Ulrich Rass. (2019) Structure-Specific Endonucleases and the Resolution of Chromosome Underreplication. Genes 10:3, pages 232.
Crossref
Nisha Pillay, Anthony Tighe, Louisa Nelson, Samantha Littler, Camilla Coulson-Gilmer, Nourdine Bah, Anya Golder, Bjorn Bakker, Diana C.J. Spierings, Dominic I. James, Kate M. Smith, Allan M. Jordan, Robert D. Morgan, Donald J. Ogilvie, Floris Foijer, Dean A. Jackson & Stephen S. Taylor. (2019) DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Cancer Cell 35:3, pages 519-533.e8.
Crossref
Nicholas J.H. Warren & Alan Eastman. (2019) Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe. Journal of Biological Chemistry 294:6, pages 1763-1778.
Crossref
Sukrit Mahajan, Komal Raina, Shalini Verma & B.J. Rao. (2019) Human RAD52 protein regulates homologous recombination and checkpoint function in BRCA2 deficient cells. The International Journal of Biochemistry & Cell Biology 107, pages 128-139.
Crossref
Diletta Ciardo, Arach Goldar & Kathrin Marheineke. (2019) On the Interplay of the DNA Replication Program and the Intra-S Phase Checkpoint Pathway. Genes 10:2, pages 94.
Crossref
Thomas Grellety, Celine Callens, Elodie Richard, Adrien Briaux, Valérie Vélasco, Marina Pulido, Anthony Gonçalves, Pierre Gestraud, Gaetan MacGrogan, Hervé Bonnefoi & Bruno Cardinaud. (2019) Enhancing Abiraterone Acetate Efficacy in Androgen Receptor–positive Triple-negative Breast Cancer: Chk1 as a Potential Target. Clinical Cancer Research 25:2, pages 856-867.
Crossref
Vanesa Lafarga, Hsu‐Min Sung, Katharina Haneke, Lea Roessig, Anne‐Laure Pauleau, Marius Bruer, Sara Rodriguez‐Acebes, Andres J Lopez‐Contreras, Oliver J Gruss, Sylvia Erhardt, Juan Mendez, Oscar Fernandez‐Capetillo & Georg Stoecklin. (2018) TIAR marks nuclear G2/M transition granules and restricts CDK 1 activity under replication stress . EMBO reports 20:1.
Crossref
Hidemasa Goto, Toyoaki Natsume, Masato T. Kanemaki, Aika Kaito, Shujie Wang, Esteban C. Gabazza, Masaki Inagaki & Akira Mizoguchi. (2019) Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell-cycle progression. Journal of Cell Science.
Crossref
Pepijn M. Schoonen, Sergi Guerrero Llobet & Marcel A.T.M. van Vugt. 2019. DNA Repair. DNA Repair 157 201 .
Kim Hjorth-Jensen, Apolinar Maya-Mendoza, Nanna Dalgaard, Jón O Sigurðsson, Jiri Bartek, Diego Iglesias-Gato, Jesper V Olsen & Amilcar Flores-Morales. (2018) SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability. Nucleic Acids Research 46:18, pages 9484-9495.
Crossref
Hongwei Liao, Fang Ji, Thomas Helleday & Songmin Ying. (2018) Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments. EMBO reports 19:9.
Crossref
Emilio Lecona & Oscar Fernandez-Capetillo. (2018) Targeting ATR in cancer. Nature Reviews Cancer 18:9, pages 586-595.
Crossref
Miiko Sokka, Dennis Koalick, Peter Hemmerich, Juhani Syväoja & Helmut Pospiech. (2018) The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase. International Journal of Molecular Sciences 19:8, pages 2376.
Crossref
Blanca Gómez-Escoda & Pei-Yun Jenny Wu. (2018) The organization of genome duplication is a critical determinant of the landscape of genome maintenance. Genome Research 28:8, pages 1179-1192.
Crossref
Sara Rodriguez-Acebes, Silvana Mourón & Juan Méndez. (2018) Uncoupling fork speed and origin activity to identify the primary cause of replicative stress phenotypes. Journal of Biological Chemistry 293:33, pages 12855-12861.
Crossref
Leighton H. Daigh, Chad Liu, Mingyu Chung, Karlene A. Cimprich & Tobias Meyer. (2018) Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates. Cell Systems 7:1, pages 17-27.e3.
Crossref
A. Lindemann, H. Takahashi, A.A. Patel, A.A. Osman & J.N. Myers. (2018) Targeting the DNA Damage Response in OSCC with TP 53 Mutations . Journal of Dental Research 97:6, pages 635-644.
Crossref
Xiaosong Yang, You Pan, Zhaojun Qiu, Zhanwen Du, Yao Zhang, Pengyan Fa, Shashank Gorityala, Shanhuai Ma, Shunqiang Li, Ceshi Chen, Hongbing Wang, Yan Xu, Chunhong Yan, Keri Ruth, Zhefu Ma & Junran Zhang. (2018) RNF126 as a Biomarker of a Poor Prognosis in Invasive Breast Cancer and CHEK1 Inhibitor Efficacy in Breast Cancer Cells. Clinical Cancer Research 24:7, pages 1629-1643.
Crossref
Ruixue Yuan, Harmjan R Vos, Robert M van Es, Jing Chen, Boudewijn MT Burgering, Bart Westendorp & Alain de Bruin. (2018) Chk1 and 14‐3‐3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest. The EMBO Journal 37:5.
Crossref
Zhaojun Qiu, Nancy L. Oleinick & Junran Zhang. (2018) ATR/CHK1 inhibitors and cancer therapy. Radiotherapy and Oncology 126:3, pages 450-464.
Crossref
Mayur A. Gadhikar, Jiexin Zhang, Li Shen, Xiayu Rao, Jing Wang, Mei Zhao, Nene N. Kalu, Faye M. Johnson, Lauren A. Byers, John Heymach, Walter N. Hittelman, Durga Udayakumar, Raj K. Pandita, Tej K. Pandita, Curtis R. Pickering, Abena B. Redwood, Helen Piwnica-Worms, Katharina Schlacher, Mitchell J. Frederick & Jeffrey N. Myers. (2018) CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition . Cancer Research 78:3, pages 781-797.
Crossref
Junko Murai, Sai-Wen Tang, Elisabetta Leo, Simone A. Baechler, Christophe E. Redon, Hongliang Zhang, Muthana Al Abo, Vinodh N. Rajapakse, Eijiro Nakamura, Lisa M. Miller Jenkins, Mirit I. Aladjem & Yves Pommier. (2018) SLFN11 Blocks Stressed Replication Forks Independently of ATR. Molecular Cell 69:3, pages 371-384.e6.
Crossref
Francesco Cucco, Elisa Palumbo, Serena Camerini, Barbara D’Alessio, Valentina Quarantotti, Maria Luisa Casella, Ilaria Maria Rizzo, Dubravka Cukrov, Domenico Delia, Antonella Russo, Marco Crescenzi & Antonio Musio. (2018) Separase prevents genomic instability by controlling replication fork speed. Nucleic Acids Research 46:1, pages 267-278.
Crossref
Emilio Lecona & Oscar Fernández-Capetillo. 2018. Targeting the DNA Damage Response for Anti-Cancer Therapy. Targeting the DNA Damage Response for Anti-Cancer Therapy 35 61 .
Fabian Doerr, Julie George, Anna Schmitt, Filippo Beleggia, Tim Rehkämper, Sarah Hermann, Vonn Walter, Jean-Philip Weber, Roman K. Thomas, Maike Wittersheim, Reinhard Büttner, Thorsten Persigehl & H. Christian Reinhardt. (2017) Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer. Scientific Reports 7:1.
Crossref
Tatiana Moiseeva, Brian Hood, Sandy Schamus, Mark J. O’Connor, Thomas P. Conrads & Christopher J. Bakkenist. (2017) ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1. Nature Communications 8:1.
Crossref
Chun-Hua Dai, Yi Wang, Ping Chen, Qian Jiang, Ting Lan, Mei-Yu Li, Jin-Yu Su, Yan Wu & Jian Li. (2017) Suppression of the FA pathway combined with CHK1 inhibitor hypersensitize lung cancer cells to gemcitabine. Scientific Reports 7:1.
Crossref
Marcelo S. da Silva, Raphael S. Pavani, Jeziel D. Damasceno, Catarina A. Marques, Richard McCulloch, Luiz Ricardo Orsini Tosi & Maria Carolina Elias. (2017) Nuclear DNA Replication in Trypanosomatids: There Are No Easy Methods for Solving Difficult Problems. Trends in Parasitology 33:11, pages 858-874.
Crossref
Laura Carrassa & Giovanna Damia. (2017) DNA damage response inhibitors: Mechanisms and potential applications in cancer therapy. Cancer Treatment Reviews 60, pages 139-151.
Crossref
Cen Li, Soyoung Park, Xiaowen Zhang, Leonard M. Eisenberg, Hong Zhao, Zbigniew Darzynkiewicz & Dazhong Xu. (2017) Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase–dependent mechanism. Journal of Biological Chemistry 292:40, pages 16746-16759.
Crossref
Hervé Técher, Stéphane Koundrioukoff, Alain Nicolas & Michelle Debatisse. (2017) The impact of replication stress on replication dynamics and DNA damage in vertebrate cells. Nature Reviews Genetics 18:9, pages 535-550.
Crossref
Satya Narayan, Aruna S. Jaiswal, Ritika Sharma, Akbar Nawab, Lizette Vila Duckworth, Brian K. Law, Maria Zajac-Kaye, Thomas J. George, Jay Sharma, Arun K. Sharma & Robert A. Hromas. (2017) NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations. Oncotarget 8:34, pages 57246-57264.
Crossref
Junko Murai. (2017) Targeting DNA repair and replication stress in the treatment of ovarian cancer. International Journal of Clinical Oncology 22:4, pages 619-628.
Crossref
Pauline Rimmelé, Michela Esposito, Laure Delestré, Jean-Hugues Guervilly, Maya Ridinger-Saison, Emmanuelle Despras, Françoise Moreau-Gachelin, Filippo Rosselli & Christel Guillouf. (2017) The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia. Oncotarget 8:23, pages 37104-37114.
Crossref
Luis Toledo, Kai John Neelsen & Jiri Lukas. (2017) Replication Catastrophe: When a Checkpoint Fails because of Exhaustion. Molecular Cell 66:6, pages 735-749.
Crossref
Yipin Lu, Mark Knapp, Kenneth Crawford, Robert Warne, Robert Elling, Kelly Yan, Michael Doyle, Gwynn Pardee, Li Zhang, Sylvia Ma, Mulugeta Mamo, Elizabeth Ornelas, Yue Pan, Dirksen Bussiere, Johanna Jansen, Isabel Zaror, Albert Lai, Paul Barsanti & Janet Sim. (2017) Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. Journal of Molecular Biology 429:11, pages 1684-1704.
Crossref
Jeffrey R. Infante, Antoine Hollebecque, Sophie Postel-Vinay, Todd M. Bauer, Elizabeth M. Blackwood, Marie Evangelista, Sami Mahrus, Franklin V. Peale, Xuyang Lu, Srikumar Sahasranaman, Rui Zhu, Yuan Chen, Xiao Ding, Elaine R. Murray, Jennifer L. Schutzman, Jennifer O. Lauchle, Jean-Charles Soria & Patricia M. LoRusso. (2017) Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors. Clinical Cancer Research 23:10, pages 2423-2432.
Crossref
Doaa Hussein Zineldeen, Noha Mohamed Shafik & Sheng Fan Li. (2017) Alternative Chk1-independent S/M checkpoint in somatic cells that prevents premature mitotic entry. Medical Oncology 34:4.
Crossref
Collins Asweto, Jing Wu, Hejing Hu, Lin Feng, Xiaozhe Yang, Junchao Duan & Zhiwei Sun. (2017) Combined Effect of Silica Nanoparticles and Benzo[a]pyrene on Cell Cycle Arrest Induction and Apoptosis in Human Umbilical Vein Endothelial Cells. International Journal of Environmental Research and Public Health 14:3, pages 289.
Crossref
Divya Iyer & Nicholas Rhind. (2017) The Intra-S Checkpoint Responses to DNA Damage. Genes 8:2, pages 74.
Crossref
Sissel Hauge, Christian Naucke, Grete Hasvold, Mrinal Joel, Gro Elise Rødland, Petras Juzenas, Trond Stokke & Randi G. Syljuåsen. (2016) Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading. Oncotarget 8:7, pages 10966-10979.
Crossref
Sergio Muñoz & Juan Méndez. (2016) DNA replication stress: from molecular mechanisms to human disease. Chromosoma 126:1, pages 1-15.
Crossref
Erin George, Hyoung Kim, Clemens Krepler, Brandon Wenz, Mehran Makvandi, Janos L. Tanyi, Eric Brown, Rugang Zhang, Patricia Brafford, Stephanie Jean, Robert H. Mach, Yiling Lu, Gordon B. Mills, Meenhard Herlyn, Mark Morgan, Xiaochen Zhang, Robert Soslow, Ronny Drapkin, Neil Johnson, Ying Zheng, George Cotsarelis, Katherine L. Nathanson & Fiona Simpkins. (2017) A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers. JCI Insight 2:1.
Crossref
Hui-Ju Hsieh & Guang Peng. (2017) Cellular responses to replication stress: Implications in cancer biology and therapy. DNA Repair 49, pages 9-20.
Crossref
Joanne Wayne, Teresa Brooks & Andrew J. Massey. (2016) Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase. Oncotarget 7:51, pages 85033-85048.
Crossref
Joelle A. Desmarais, Christian Unger, Ivan Damjanov, Mark Meuth & Peter Andrews. (2016) Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress. Stem Cell Research & Therapy 7:1.
Crossref
Nnennaya Kanu, Maria Antonietta Cerone, Gerald Goh, Lykourgos-Panagiotis Zalmas, Jirina Bartkova, Michelle Dietzen, Nicholas McGranahan, Rebecca Rogers, Emily K. Law, Irina Gromova, Maik Kschischo, Michael I. Walton, Olivia W. Rossanese, Jiri Bartek, Reuben S. Harris, Subramanian Venkatesan & Charles Swanton. (2016) DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer. Genome Biology 17:1.
Crossref
Andrew J. Massey. (2016) Inhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy. Cancer Letters 383:1, pages 41-52.
Crossref
Jing Li, Yang Tang, Liu Huang, Qian-qian Yu, Guang-yuan Hu, Chao Chen, Peng Zhang & Xiang-lin Yuan. (2016) Genetic variants in CHEK1 gene are associated with the prognosis of thoracic esophageal squamous cell carcinoma patients treated with radical resection. Journal of Huazhong University of Science and Technology [Medical Sciences] 36:6, pages 828-833.
Crossref
Stephanie A. YazinskiLee Zou. (2016) Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway. Annual Review of Genetics 50:1, pages 155-173.
Crossref
Kathleen A. Bridges, Xingxing Chen, Huifeng Liu, Crosby Rock, Thomas A. Buchholz, Stuart D. Shumway, Heath D. Skinner & Raymond E. Meyn. (2016) MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Oncotarget 7:44, pages 71660-71672.
Crossref
Holly E. Barker, Radhika Patel, Martin McLaughlin, Ulrike Schick, Shane Zaidi, Christopher M. Nutting, Katie L. Newbold, Shreerang Bhide & Kevin J. Harrington. (2016) CHK1 Inhibition Radiosensitizes Head and Neck Cancers to Paclitaxel-Based Chemoradiotherapy. Molecular Cancer Therapeutics 15:9, pages 2042-2054.
Crossref
Martin R. Gill, Siti Norain Harun, Swagata Halder, Ramon A. Boghozian, Kristijan Ramadan, Haslina Ahmad & Katherine A. Vallis. (2016) A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition. Scientific Reports 6:1.
Crossref
Jun Zhang, Qun Dai, Dongkyoo Park & Xingming Deng. (2016) Targeting DNA Replication Stress for Cancer Therapy. Genes 7:8, pages 51.
Crossref
Jianyun Zhao, Xiaojia Niu, Xinyu Li, Holly Edwards, Guan Wang, Yue Wang, Jeffrey W Taub, Hai Lin & Yubin Ge. (2016) Inhibition of CHK1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells. Oncotarget 7:23, pages 34785-34799.
Crossref
Yao Zhang, Jinzhi Lai, Zhanwen Du, Jinnan Gao, Shuming Yang, Shashank Gorityala, Xiahui Xiong, Ou Deng, Zhefu Ma, Chunhong Yan, Gonzalo Susana, Yan Xu & Junran Zhang. (2016) Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget 7:23, pages 34688-34702.
Crossref
Amaia Ercilla, Alba Llopis, Sonia Feu, Sergi Aranda, Patrik Ernfors, Raimundo Freire & Neus Agell. (2016) New origin firing is inhibited by APC/C Cdh1 activation in S-phase after severe replication stress . Nucleic Acids Research 44:10, pages 4745-4762.
Crossref
Anne-Sophie Boyer, David Walter & Claus Storgaard Sørensen. (2016) DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities. Seminars in Cancer Biology 37-38, pages 16-25.
Crossref
Mathieu von Joest, Sabela Búa Aguín & Han Li. (2016) Genomic stability during cellular reprogramming: Mission impossible?. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 788, pages 12-16.
Crossref
Ranjan Preet, Sumit Siddharth, Shakti Ranjan Satapathy, Sarita Das, Anmada Nayak, Dipon Das, Michael D. Wyatt & Chanakya Nath Kundu. (2016) Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade. Biochemical Pharmacology 105, pages 23-33.
Crossref
Hervé Técher, Stéphane Koundrioukoff, Sandra Carignon, Therese Wilhelm, Gaël A. Millot, Bernard S. Lopez, Olivier Brison & Michelle Debatisse. (2016) Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage. Cell Reports 14:5, pages 1114-1127.
Crossref
Yunpeng Feng, Arsenios Vlassis, Céline Roques, Marie‐Eve Lalonde, Cristina González‐Aguilera, Jean‐Philippe Lambert, Sung‐Bau Lee, Xiaobei Zhao, Constance Alabert, Jens V Johansen, Eric Paquet, Xiang‐Jiao Yang, Anne‐Claude Gingras, Jacques Côté & Anja Groth. (2015) BRPF 3‐ HBO 1 regulates replication origin activation and histone H3K14 acetylation . The EMBO Journal 35:2, pages 176-192.
Crossref
Nandini Sakurikar, Ruth Thompson, Ryan Montano & Alan Eastman. (2015) A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase. Oncotarget 7:2, pages 1380-1394.
Crossref
Andrew J. Massey, Peter Stephens, Rebecca Rawlinson, Lauren McGurk, Ruth Plummer & Nicola J. Curtin. (2016) mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition. Molecular Oncology 10:1, pages 101-112.
Crossref
Kumar Sanjiv, Anna Hagenkort, José Manuel Calderón-Montaño, Tobias Koolmeister, Philip M. Reaper, Oliver Mortusewicz, Sylvain A. Jacques, Raoul V. Kuiper, Niklas Schultz, Martin Scobie, Peter A. Charlton, John R. Pollard, Ulrika Warpman Berglund, Mikael Altun & Thomas Helleday. (2016) Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities. Cell Reports 14:2, pages 298-309.
Crossref
William F. Osorio-Zambrano & Scott Davey. (2015) Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling. PLOS ONE 10:12, pages e0144434.
Crossref
Ilaria Iacobucci, Andrea Ghelli Luserna Di Rorà, Maria Vittoria Verga Falzacappa, Claudio Agostinelli, Enrico Derenzini, Anna Ferrari, Cristina Papayannidis, Annalisa Lonetti, Simona Righi, Enrica Imbrogno, Silvia Pomella, Claudia Venturi, Viviana Guadagnuolo, Federica Cattina, Emanuela Ottaviani, Maria Chiara Abbenante, Antonella Vitale, Loredana Elia, Domenico Russo, Pier Luigi Zinzani, Stefano Pileri, Pier Giuseppe Pelicci & Giovanni Martinelli. (2015) In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia. Journal of Hematology & Oncology 8:1.
Crossref
Gry Irene Magnussen, Elisabeth Emilsen, Karianne Giller Fleten, Birgit Engesæter, Viola Nähse-Kumpf, Roar Fjær, Ana Slipicevic & Vivi Ann Flørenes. (2015) Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma. BMC Cancer 15:1.
Crossref
Xing-Hua Liao, Li Zheng, Hong-Peng He, De-Liang Zheng, Zhao-Qiang Wei, Nan Wang, Jian Dong, Wen-Jian Ma & Tong-Cun Zhang. (2015) STAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cells. Cellular Signalling 27:11, pages 2285-2295.
Crossref
Silvia Emma Rossi, Arta Ajazi, Walter Carotenuto, Marco Foiani & Michele Giannattasio. (2015) Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress. Cell Reports 13:1, pages 80-92.
Crossref
Constance King, H. Bruce Diaz, Samuel McNeely, Darlene Barnard, Jack Dempsey, Wayne Blosser, Richard Beckmann, David Barda & Mark S. Marshall. (2015) LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Molecular Cancer Therapeutics 14:9, pages 2004-2013.
Crossref
Rémi Buisson, Jessica L. Boisvert, Cyril H. Benes & Lee Zou. (2015) Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase. Molecular Cell 59:6, pages 1011-1024.
Crossref
Sergio Ruiz, Andres J. Lopez-Contreras, Mathieu Gabut, Rosa M. Marion, Paula Gutierrez-Martinez, Sabela Bua, Oscar Ramirez, Iñigo Olalde, Sara Rodrigo-Perez, Han Li, Tomas Marques-Bonet, Manuel Serrano, Maria A. Blasco, Nizar N. Batada & Oscar Fernandez-Capetillo. (2015) Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells. Nature Communications 6:1.
Crossref
Pedro Zuazua-Villar, Anil Ganesh, Geraldine Phear, Mary E. Gagou & Mark Meuth. (2015) Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells. Nucleic Acids Research, pages gkv835.
Crossref
YACHAO ZHAO, ZHENG XIAO, WENNA CHEN, JINSHENG YANG, TAO LI & BO FAN. (2015) Disulfiram sensitizes pituitary adenoma cells to temozolomide by regulating O6-methylguanine-DNA methyltransferase expression. Molecular Medicine Reports 12:2, pages 2313-2322.
Crossref
J Farrés, L Llacuna, J Martin-Caballero, C Martínez, J J Lozano, C Ampurdanés, A J López-Contreras, L Florensa, J Navarro, E Ottina, F Dantzer, V Schreiber, A Villunger, O Fernández-Capetillo & J Yélamos. (2014) PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors. Cell Death & Differentiation 22:7, pages 1144-1157.
Crossref
Marie Platel, Arach Goldar, Jennifer M. Wiggins, Pedro Barbosa, Pierre Libeau, Pierre Priam, Hemalatha Narassimprakash, Xenia Grodzenski & Kathrin Marheineke. (2015) Tight Chk1 Levels Control Replication Cluster Activation in Xenopus. PLOS ONE 10:6, pages e0129090.
Crossref
L M Sarmento, V Póvoa, R Nascimento, G Real, I Antunes, L R Martins, C Moita, P M Alves, M Abecasis, L F Moita, R M E Parkhouse, J P P Meijerink & J T Barata. (2014) CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress. Oncogene 34:23, pages 2978-2990.
Crossref
Michalis Fragkos, Olivier Ganier, Philippe Coulombe & Marcel Méchali. (2015) DNA replication origin activation in space and time. Nature Reviews Molecular Cell Biology 16:6, pages 360-374.
Crossref
Matthias Dobbelstein & Claus Storgaard Sørensen. (2015) Exploiting replicative stress to treat cancer. Nature Reviews Drug Discovery 14:6, pages 405-423.
Crossref
Priyanka Saini, Yizhu Li & Matthias Dobbelstein. (2015) Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress. Oncotarget 6:15, pages 13072-13087.
Crossref
W-T Wang, J W F Catto & M Meuth. (2014) Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors. Oncogene 34:22, pages 2887-2896.
Crossref
Andrea Lunardi, Shohreh Varmeh, Ming Chen, Riccardo Taulli, Jlenia Guarnerio, Ugo Ala, Nina Seitzer, Tomoki Ishikawa, Brett S. Carver, Robin M. Hobbs, Valentina Quarantotti, Christopher Ng, Alice H. Berger, Caterina Nardella, Laura Poliseno, Rodolfo Montironi, Mireia Castillo-Martin, Carlos Cordon-Cardo, Sabina Signoretti & Pier Paolo Pandolfi. (2015) Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis . Cancer Discovery 5:5, pages 550-563.
Crossref
Xiangzi Han, Franklin Mayca Pozo, Jacob N. Wisotsky, Benlian Wang, James W. Jacobberger & Youwei Zhang. (2015) Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation. Journal of Biological Chemistry 290:19, pages 12370-12378.
Crossref
Julio Vera, Yvonne Raatz, Olaf Wolkenhauer, Tina Kottek, Animesh Bhattacharya, Jan C. Simon & Manfred Kunz. (2015) Chk1 and Wee1 control genotoxic-stress induced G2–M arrest in melanoma cells. Cellular Signalling 27:5, pages 951-960.
Crossref
Randi G. Syljuåsen, Grete Hasvold, Sissel Hauge & Åslaug Helland. (2015) Targeting lung cancer through inhibition of checkpoint kinases. Frontiers in Genetics 6.
Crossref
Manoj B. Parmar, Hamidreza Montazeri Aliabadi, Parvin Mahdipoor, Cezary Kucharski, Robert Maranchuk, Judith C. Hugh & Hasan UludaÄŸ. (2015) Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines. Frontiers in Bioengineering and Biotechnology 3.
Crossref
Cai Guo, Akiko Kumagai, Katharina Schlacher, Anna Shevchenko, Andrej Shevchenko & William G. Dunphy. (2015) Interaction of Chk1 with Treslin Negatively Regulates the Initiation of Chromosomal DNA Replication. Molecular Cell 57:3, pages 492-505.
Crossref
Franziska Schmidt, Meike Kunze, Ann-Christine Loock & Matthias Dobbelstein. (2014) Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells. Oncotarget 6:2, pages 617-632.
Crossref
Hidemasa Goto, Kousuke Kasahara & Masaki Inagaki. (2015) Novel Insights into Chk1 Regulation by Phosphorylation. Cell Structure and Function 40:1, pages 43-50.
Crossref

Displaying 200 of 405 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.