Citations (100)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (17)
Radivoj Arezina, Tao Chen & Duolao Wang. (2023) Conventional, Complementary and Alternative Medicines: Mechanistic Insights into Therapeutic Landscape of Chronic Obstructive Pulmonary Disease. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 447-457.
Read now
Read now
Javier Gimeno Castillo, Francisco Javier De la Torre Gomar, Aida Menéndez Parrón & Zuriñe Martínez de Lagrán Álvarez de Arcaya. (2023) Oral roflumilast as a therapeutic option for psoriasis, what role does it have? Case report and literature review. Journal of Dermatological Treatment 34:1.
Read now
Read now
Peng Guo, Rui Li, Tie Hua Piao, Chun Lan Wang, Xiao Lu Wu & Hong Yan Cai. (2022) Pathological Mechanism and Targeted Drugs of COPD. International Journal of Chronic Obstructive Pulmonary Disease 17, pages 1565-1575.
Read now
Read now
Evgenii Skurikhin, Olga Pershina, Mariia Zhukova, Darius Widera, Edgar Pan, Angelina Pakhomova, Vyacheslav Krupin, Natalia Ermakova, Victoria Skurikhina, Lubov Sandrikina, Sergey Morozov, Aslan Kubatiev & Alexander Dygai. (2021) Spiperone Stimulates Regeneration in Pulmonary Endothelium Damaged by Cigarette Smoke and Lipopolysaccharide. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 3575-3591.
Read now
Read now
Luis Pérez de Llano, Marc Miravitlles, Rafael Golpe, Francisco Javier Alvarez-Gutiérrez, Carolina Cisneros, Carlos Almonacid, Eva Martinez-Moragon, Francisco-Javier Gonzalez-Barcala, David Ramos-Barbón, Vicente Plaza, Jose Luis Lopez-Campos, Juan Pablo de-Torres, Ciro Casanova, Juan Luis Garcia Rivero, Juan Rodriguez Hermosa, Myriam Calle Rubio, Juan Jose Soler-Cataluña & Borja G Cosio. (2020) A Proposed Approach to Chronic Airway Disease (CAD) Using Therapeutic Goals and Treatable Traits: A Look to the Future. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 2091-2100.
Read now
Read now
Aravind T Reddy, Sowmya P Lakshmi, Asoka Banno & Raju C Reddy. (2020) Glucocorticoid Receptor α Mediates Roflumilast’s Ability to Restore Dexamethasone Sensitivity in COPD. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 125-134.
Read now
Read now
Meghan Althoff & Fernando Holguin. (2020) Contemporary management techniques of asthma in obese patients. Expert Review of Respiratory Medicine 14:3, pages 249-257.
Read now
Read now
Jun Chen, Luqi Dai, Tao Wang, Junyun He, Yashu Wang & Fuqiang Wen. (2019) The elevated CXCL5 levels in circulation are associated with lung function decline in COPD patients and cigarette smoking-induced mouse model of COPD. Annals of Medicine 51:5-6, pages 314-329.
Read now
Read now
Tanveer A Wani, Ahmed H Bakheit, Mohammed Nazam Ansari, Abdul-Rahman A Al-Majed, Bakr M Al-Qahtani & Seema Zargar. (2018) Spectroscopic and molecular modeling studies of binding interaction between bovine serum albumin and roflumilast. Drug Design, Development and Therapy 12, pages 2627-2634.
Read now
Read now
Aidan Butler, Georgia May Walton & Elizabeth Sapey. (2018) Neutrophilic Inflammation in the Pathogenesis of Chronic Obstructive Pulmonary Disease. COPD: Journal of Chronic Obstructive Pulmonary Disease 15:4, pages 392-404.
Read now
Read now
Woo Ho Ban, Hyonsoo Joo, Jeong Uk Lim, Hyeon Hui Kang, Hwa Sik Moon & Sang Haak Lee. (2018) The relationship between sleep disturbance and health status in patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 2049-2055.
Read now
Read now
Henrik Watz, Nitin Bagul, Klaus F Rabe, Stephen Rennard, Vijay KT Alagappan, Jonas Román, Axel Facius & Peter MA Calverley. (2018) Use of a 4-week up-titration regimen of roflumilast in patients with severe COPD. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 813-822.
Read now
Read now
Raju Bishwakarma, Wei Zhang, Yu-Li Lin, Yong-Fang Kuo, Victor J Cardenas & Gulshan Sharma. (2018) Metformin use and health care utilization in patients with coexisting chronic obstructive pulmonary disease and diabetes mellitus. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 793-800.
Read now
Read now
Peter M. A. Calverley, Helgo Magnussen, Marc Miravitlles & Jadwiga A. Wedzicha. (2017) Triple Therapy in COPD: What We Know and What We Don't. COPD: Journal of Chronic Obstructive Pulmonary Disease 14:6, pages 648-662.
Read now
Read now
Dave Singh, Massimo Corradi, Monica Spinola, Alberto Papi, Omar S Usmani, Mario Scuri, Stefano Petruzzelli & Jørgen Vestbo. (2017) Triple therapy in COPD: new evidence with the extrafine fixed combination of beclomethasone dipropionate, formoterol fumarate, and glycopyrronium bromide. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 2917-2928.
Read now
Read now
David MG Halpin, Marc Miravitlles, Norbert Metzdorf & Bartolomé Celli. (2017) Impact and prevention of severe exacerbations of COPD: a review of the evidence. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 2891-2908.
Read now
Read now
Amany F. Elbehairy, Grace Parraga, Katherine A. Webb, J Alberto Neder & Denis E. O’Donnell. (2017) Mild chronic obstructive pulmonary disease: why spirometry is not sufficient!. Expert Review of Respiratory Medicine 11:7, pages 549-563.
Read now
Read now
Articles from other publishers (83)
Yazdan Hasani Nourian, Jafar Salimian, Ali Ahmadi, Zahra Salehi, Mehrdad Karimi, Alireza Emamvirdizadeh, Sadegh Azimzadeh Jamalkandi & Mostafa Ghanei. (2023) cAMP-PDE signaling in COPD: Review of cellular, molecular and clinical features. Biochemistry and Biophysics Reports 34, pages 101438.
Crossref
Crossref
Jonathan I. Silverberg, Lars E. French, Richard B. Warren, Bruce Strober, Kim Kjøller, Morten O. A. Sommer, Philippe Andres, Jakob Felding, Anne Weiss, Deniz Tutkunkardas, Tine Skak‐Nielsen & Emma Guttman. (2023) Pharmacology of orismilast, a potent and selective PDE4 inhibitor. Journal of the European Academy of Dermatology and Venereology 37:4, pages 721-729.
Crossref
Crossref
Hye Jeong Yun & Ho-Young Lee. (2023) The novel TAK1 inhibitor handelin inhibits NF-κB and AP-1 activity to alleviate elastase-induced emphysema in mice. Life Sciences 319, pages 121388.
Crossref
Crossref
Clémence Martin, Guillaume Chassagnon, Sven Günther, Stéfanie Habib, Jean Pastré, Pierre-Régis Burgel & Nicolas Roche. 2023. Asthma in the 21st Century. Asthma in the 21st Century
195
216
.
Emad H.M. Hassanein, Wafaa R. Mohamed, Osama S. Ahmed, Mohamed M. Abdel-Daim & Ahmed M. Sayed. (2022) The role of inflammation in cadmium nephrotoxicity: NF-κB comes into view. Life Sciences 308, pages 120971.
Crossref
Crossref
Emanuela F. Craparo, Marta Cabibbo, Cinzia Scialabba, Gaetano Giammona & Gennara Cavallaro. (2022) Inhalable Formulation Based on Lipid–Polymer Hybrid Nanoparticles for the Macrophage Targeted Delivery of Roflumilast. Biomacromolecules 23:8, pages 3439-3451.
Crossref
Crossref
Letizia Crocetti, Giuseppe Floresta, Agostino Cilibrizzi & Maria Paola Giovannoni. (2022) An Overview of PDE4 Inhibitors in Clinical Trials: 2010 to Early 2022. Molecules 27:15, pages 4964.
Crossref
Crossref
Aurélie Moniot, Julien Braux, Renaud Siboni, Christine Guillaume, Sandra Audonnet, Ingrid Allart-Simon, Janos Sapi, Rabindra Tirouvanziam, Stéphane Gérard, Sophie C. Gangloff & Frédéric Velard. (2022) Inhibition of Recruitment and Activation of Neutrophils by Pyridazinone-Scaffold-Based Compounds. International Journal of Molecular Sciences 23:13, pages 7226.
Crossref
Crossref
Dennis Williams. (2020) The Role of the Pharmacist in Optimizing Outcomes With Roflumilast, a PDE4 Inhibitor for the Treatment of COPD. Journal of Pharmacy Practice 35:3, pages 445-454.
Crossref
Crossref
MANIKANDAN VELSITHARTH, HOFMANN BRIDGER & NAVUKKARASU RAJENDRAN AATTRALARASU. (2022) PREDICTING MORTALITY OF COVID PATIENTS WITH COMORBIDITIES (Review Article). EXPERIMENTAL & CLINICAL MEDICINE GEORGIA.
Crossref
Crossref
Mun-Ock Kim, Jae-Won Lee, Jae Kyoung Lee, Yu Na Song, Eun Sol Oh, Hyunju Ro, Dahye Yoon, Yun-Hwa Jeong, Ji-Yoon Park, Sung-Tae Hong, Hyung Won Ryu, Su Ui Lee & Dae Young Lee. (2022) Black Ginseng Extract Suppresses Airway Inflammation Induced by Cigarette Smoke and Lipopolysaccharides In Vivo. Antioxidants 11:4, pages 679.
Crossref
Crossref
Mitsugi Ookawara & Yasunori Nio. (2022) Phosphodiesterase 4 inhibitors in diabetic nephropathy. Cellular Signalling 90, pages 110185.
Crossref
Crossref
Do Young Kim, Jehyun Nam, Joo-seop Chung, Sang-Woo Kim & Ho-Jin Shin. (2022) Role of Roflumilast Combined with ESHAP Chemotherapy in Relapsed/Refractory Patients with Diffuse Large B-Cell Lymphoma. Cancer Research and Treatment 54:1, pages 301-313.
Crossref
Crossref
Evgenii Skurikhin, Olga Pershina, Mariia Zhukova, Darius Widera, Natalia Ermakova, Edgar Pan, Angelina Pakhomova, Sergey Morozov, Aslan Kubatiev & Alexander Dygai. (2021) Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer. Frontiers in Cell and Developmental Biology 9.
Crossref
Crossref
Malvika Kaul, Sai Sunkara, Matthew J. Major, Keith E. Gordon & Israel Rubinstein. (2021) Proposed novel treatment paradigm of aberrant gait and balance kinematics in patients with severe COPD. Respirology 26:10, pages 914-916.
Crossref
Crossref
Chuang Xiao, Sha Cheng, Haochang Lin, Zhiying Weng, Peihua Peng, Deyou Zeng, Xiaohua Du, Xiujuan Zhang, Yaqing Yang, Yaping Liang, Rong Huang, Chen Chen, Lueli Wang, Hongxiang Wu, Runfeng Li, Xinhua Wang, Rongping Zhang, Zifeng Yang, Xian Li, Xue Cao & Weimin Yang. (2021) Isoforskolin, an adenylyl cyclase activator, attenuates cigarette smoke-induced COPD in rats. Phytomedicine 91, pages 153701.
Crossref
Crossref
Noorul Hasan, Saima Zameer, Abul Kalam Najmi, Suhel Parvez, Mohammad Shahar Yar & Mohd Akhtar. (2021) RETRACTED ARTICLE: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular Aβ1–42 rat model of Alzheimer’s disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway. Pharmacological Reports 73:5, pages 1287-1302.
Crossref
Crossref
Licia Totani, Concetta Amore, Antonio Piccoli, Giuseppe Dell’Elba, Angelo Di Santo, Roberto Plebani, Romina Pecce, Nicola Martelli, Alice Rossi, Serena Ranucci, Ida De Fino, Paolo Moretti, Alessandra Bragonzi, Mario Romano & Virgilio Evangelista. (2021) Type-4 Phosphodiesterase (PDE4) Blockade Reduces NETosis in Cystic Fibrosis. Frontiers in Pharmacology 12.
Crossref
Crossref
Nina Sicker & Christoph Fisser. (2021) 64/m mit progredienter Dyspnoe und vermehrten Exazerbationen bei chronisch obstruktiver Lungenerkrankung64/m—Progressive dyspnea and increased exacerbations in chronic obstructive pulmonary disease. Der Internist 62:S4, pages 400-405.
Crossref
Crossref
Binu Sasi, Purushoth Ethiraj, Jamie Myers, An-Ping Lin, Shoulei Jiang, Zhijun Qiu, Kenneth N. Holder & Ricardo C. T. Aguiar. (2020) Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression. Leukemia 35:7, pages 1990-2001.
Crossref
Crossref
Ruby E. Dawson, Brendan J. Jenkins & Mohamed I. Saad. (2021) IL-6 family cytokines in respiratory health and disease. Cytokine 143, pages 155520.
Crossref
Crossref
H. Burke & T.M.A. Wilkinson. (2021) Unravelling the mechanisms driving multimorbidity in COPD to develop holistic approaches to patient-centred care. European Respiratory Review 30:160, pages 210041.
Crossref
Crossref
Dipak R. Patel, Shweta Urva, Stephen Ho, Cody J. Buckman, Yanfei Ma, Jean Lim, Sean E. Sissons, Mary S. Zuniga, Diane Philips, Karen Cox & Daniel J. Dairaghi. (2021) Characterization of LY2775240, a selective phosphodiesterase‐4 inhibitor, in nonclinical models and in healthy subjects. Clinical and Translational Science 14:3, pages 1037-1048.
Crossref
Crossref
Maxine J. Roberts, Lauren T. May, Alastair C. Keen, Bonan Liu, Terrance Lam, Steven J. Charlton, Elizabeth M. Rosethorne & Michelle L. Halls. (2021) Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus. Frontiers in Pharmacology 12.
Crossref
Crossref
Won Seok Choi, Hyun Sik Kang, Hong Jo Kim, Wang Tae Lee, Uy Dong Sohn & Ji-Yun Lee. (2021) Vinpocetine alleviates lung inflammation via macrophage inflammatory protein-1β inhibition in an ovalbumin-induced allergic asthma model. PLOS ONE 16:4, pages e0251012.
Crossref
Crossref
Lijuan Gao, Ni Zeng, Zhicheng Yuan, Tao Wang, Lei Chen, Deqing Yang, Dan Xu, Chun Wan, Fuqiang Wen & Yongchun Shen. (2021) Knockout of Formyl Peptide Receptor-1 Attenuates Cigarette Smoke–Induced Airway Inflammation in Mice. Frontiers in Pharmacology 12.
Crossref
Crossref
Kun Zhou, Hong-Yan Hao, Yang-Jie Mao, Qiu-Zi Wu, Lei Chen, Shuang Wang, Wu Jin, Zhen-Yuan Xu, Shao-Jie Lou & Dan-Qian Xu. (2021) Solvent-less Dehydrogenative C–H Etherification with Alcohols Using Mechanochemistry. ACS Sustainable Chemistry & Engineering 9:12, pages 4433-4439.
Crossref
Crossref
Anna Maria Spera. (2021) Are nucleotide inhibitors, already used for treating hepatitis C virus infection, a potential option for the treatment of COVID-19 compared with standard of care? A literature review. World Journal of Virology 10:2, pages 53-61.
Crossref
Crossref
Rachana Mandru, Christine Y. Zhou, Rachel Pauley & Robert M. Burkes. (2021) Considerations for and Mechanisms of Adjunct Therapy in COPD. Journal of Clinical Medicine 10:6, pages 1225.
Crossref
Crossref
Chunyuan Zhang, Zeting Xing, Meiyun Tan, Yanwen Wu & Wei Zeng. (2021)
Roflumilast Ameliorates Isoflurane-Induced Inflammation in Astrocytes
via
the CREB/BDNF Signaling Pathway
. ACS Omega 6:6, pages 4167-4174.
Crossref
Crossref
Jooyeon Lee & Se-Ran Yang. (2021) Lung organoids: target cells for understanding respiratory diseases. Organoid 1, pages e4.
Crossref
Crossref
Matthias H. Urban, Nicole Kreibich, Andreas Gleiss, Georg‐Christian Funk, Sylvia Hartl & Otto C. Burghuber. (2020)
Effects of roflumilast on arterial stiffness in
COPD
(
ELASTIC
): A randomized trial
. Respirology 26:2, pages 153-160.
Crossref
Crossref
Sugin Lal Jabaris S & Ranju V. (2021) Scope of adjuvant therapy using roflumilast, a PDE-4 inhibitor against COVID-19. Pulmonary Pharmacology & Therapeutics 66, pages 101978.
Crossref
Crossref
Jaebeom Cho, Hye-Young Min, Ho Jin Lee, Seung Yeob Hyun, Jeong Yeon Sim, Myungkyung Noh, Su Jung Hwang, Shin-Hyung Park, Hye-Jin Boo, Hyo-Jong Lee, Sungyoul Hong, Rang-Woon Park, Young Kee Shin, Mien-Chie Hung & Ho-Young Lee. (2021) RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse. Journal of Clinical Investigation 131:1.
Crossref
Crossref
O. V. Zhukova & A. L. Khokhlov. (2020) Analysis of the long-term effectiveness of a drug in the treatment of a chronic disease is the basis of rational pharmacotherapy (on the example of the use of roflumilast in the treatment of chronic obstructive pulmonary disease). Kachestvennaya klinicheskaya praktika:3, pages 35-39.
Crossref
Crossref
Marcus May & Stefan Engeli. (2020) Gewichtsänderung als unerwünschte Arzneimittelwirkung. Adipositas - Ursachen, Folgeerkrankungen, Therapie 14:03, pages 133-139.
Crossref
Crossref
Lal Jabaris S Sugin, Arumugam Murugesan, Menon Bindu & K Narayan Sunil. (2020) Roflumilast: A potential drug for the treatment of cognitive impairment?. Neuroscience Letters 736, pages 135281.
Crossref
Crossref
Giuseppe Pascarella, Alessandro Strumia, Chiara Piliego, Federica Bruno, Romualdo Del Buono, Fabio Costa, Simone Scarlata & Felice Eugenio Agrò. (2020) COVID‐19 diagnosis and management: a comprehensive review. Journal of Internal Medicine 288:2, pages 192-206.
Crossref
Crossref
Wupeng Liao, Albert Y. H. Lim, W. S. Daniel Tan, John Abisheganaden & W. S. Fred Wong. (2020) Restoration of HDAC2 and Nrf2 by andrographolide overcomes corticosteroid resistance in chronic obstructive pulmonary disease. British Journal of Pharmacology 177:16, pages 3662-3673.
Crossref
Crossref
Dan Mei, W.S. Daniel Tan, Yvonne Tay, Amartya Mukhopadhyay & W.S. Fred Wong. (2020) Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease. Trends in Pharmacological Sciences 41:7, pages 475-486.
Crossref
Crossref
Jeferson Machado Batista Sohn, Suzen Tortato Furtado de Souza, Ana Maria Raymundi, Jéssica Bonato, Rúbia Maria Weffort de Oliveira, Jos Prickaerts & Cristina Aparecida Stern. (2020) Persistence of the extinction of fear memory requires late-phase cAMP/PKA signaling in the infralimbic cortex. Neurobiology of Learning and Memory 172, pages 107244.
Crossref
Crossref
Hye-Jin Boo, So Jung Park, Myungkyung Noh, Hye-Young Min, Lak Shin Jeong & Ho-Young Lee. (2020) LJ-2698, an Adenosine A3 Receptor Antagonist, Alleviates Elastase-Induced Pulmonary Emphysema in Mice. Biomolecules & Therapeutics 28:3, pages 250-258.
Crossref
Crossref
Xi Chen, Teng Wang, Xinghua Qiu, Chengli Que, Hanxiyue Zhang, Lina Zhang & Tong Zhu. (2020) Susceptibility of individuals with chronic obstructive pulmonary disease to air pollution exposure in Beijing, China: A case-control panel study (COPDB). Science of The Total Environment 717, pages 137285.
Crossref
Crossref
Hye-Jin Boo, So Jung Park, Myungkyung Noh, Hye-Young Min, Lak Shin Jeong & Ho-Young Lee. (2020) LJ-529, a partial peroxisome proliferator-activated receptor gamma (PPARγ) agonist and adenosine A3 receptor agonist, ameliorates elastase-induced pulmonary emphysema in mice. Archives of Pharmacal Research 43:5, pages 540-552.
Crossref
Crossref
Sadia Janjua, Rebecca Fortescue & Phillippa Poole. (2020) Phosphodiesterase-4 inhibitors for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2020:5.
Crossref
Crossref
Chin Kook Rhee & Deog Kyeom Kim. (2020) Role of phosphodiesterase-4 inhibitors in chronic obstructive pulmonary disease. The Korean Journal of Internal Medicine 35:2, pages 276-283.
Crossref
Crossref
Buğra Kerget, Ömer Araz, Ferhan Kerget, Hüseyin Serkan Erol, Sevilay Özmen, Zekai Halıcı & Metin Akgün. (2020) Evaluation of the Roflumilast Effect Supplemented with Linezolid in Pleural Empyema in Rats Caused by Intrapleural <i>Staphylococcus aureus</i> Inoculation. Japanese Journal of Infectious Diseases 73:1, pages 1-7.
Crossref
Crossref
Aishath Fazleen & Tom Wilkinson. (2020) Early COPD: current evidence for diagnosis and management. Therapeutic Advances in Respiratory Disease 14, pages 175346662094212.
Crossref
Crossref
Veronica Ann Varney, Helen Parnell, Chandrarshekar Malapanjudi Jagadish & Ziyad Abubacker. (2020) Longstanding tracheobronchomalacia: A forgotten cause of severe cough and its response to roflumilast. Respiratory Medicine Case Reports 31, pages 101247.
Crossref
Crossref
Ariadna Fernández-Calvet, Begoña Euba, Lucía Caballero, Roberto Díez-Martínez, Margarita Menéndez, Carlos Ortiz de Solórzano, José Leiva, Vicente Micol, Enrique Barrajón-Catalán & Junkal Garmendia. (2019) Preclinical Evaluation of the Antimicrobial-Immunomodulatory Dual Action of Xenohormetic Molecules against Haemophilus influenzae Respiratory Infection. Biomolecules 9:12, pages 891.
Crossref
Crossref
Radhika Joshi, Dong Yan, Omar Hamed, Mahmoud M. Mostafa, Taruna Joshi, Robert Newton & Mark A. Giembycz. (2019) Impact of Phosphodiesterase 4 Inhibition on the Operational Efficacy, Response Maxima, and Kinetics of Indacaterol-Induced Gene Expression Changes in BEAS-2B Airway Epithelial Cells: A Global Transcriptomic Analysis. Molecular Pharmacology 96:1, pages 56-72.
Crossref
Crossref
Rajnikanth Sunke, Ramudu Bankala, B. Thirupataiah, E.V.V. Shivaji Ramarao, Jetta Sandeep Kumar, Hari Maduri Doss, Raghavender Medishetti, Pushkar Kulkarni, Ravi Kumar Kapavarapu, Mahaboobkhan Rasool, Jayesh Mudgal, Jessy E. Mathew, Gautham G. Shenoy, Kishore V.L. Parsa & Manojit Pal. (2019) InCl3 mediated heteroarylation of indoles and their derivatization via C H activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis. European Journal of Medicinal Chemistry 174, pages 198-215.
Crossref
Crossref
Víctor M. Muñoz-Pérez, Mario I. Ortiz, Raquel Cariño-Cortés, Eduardo Fernández-Martínez, Leticia Rocha-Zavaleta & Mirandeli Bautista-Ávila. (2019) Preterm Birth, Inflammation and Infection: New Alternative Strategies for their Prevention. Current Pharmaceutical Biotechnology 20:5, pages 354-365.
Crossref
Crossref
Adrián Matencio, Samanta Hernández-García, Francisco García-Carmona & José Manuel López-Nicolás. (2019) A Way to Increase the Bioaccesibility and Photostability of Roflumilast, a COPD Treatment, by Cyclodextrin Monomers. Polymers 11:5, pages 801.
Crossref
Crossref
Michael B. Fessler. (2019) Drugging the Mighty Neutrophil in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory Cell and Molecular Biology 60:4, pages 382-383.
Crossref
Crossref
Maggie Lam, Emma Lamanna & Jane E. Bourke. 2019. Smooth Muscle Spontaneous Activity. Smooth Muscle Spontaneous Activity
381
422
.
Kate H. Regan & Adam T. Hill. (2018) Emerging therapies in adult and paediatric bronchiectasis. Respirology 23:12, pages 1127-1137.
Crossref
Crossref
MeiLan K Han. (2018) Roflumilast for eosinophilic chronic obstructive pulmonary disease?. The Lancet Respiratory Medicine 6:11, pages 802-803.
Crossref
Crossref
Shireen Mirza, Ryan D. Clay, Matthew A. Koslow & Paul D. Scanlon. (2018) COPD Guidelines: A Review of the 2018 GOLD Report. Mayo Clinic Proceedings 93:10, pages 1488-1502.
Crossref
Crossref
Alex J. Mackay, Konstantinos Kostikas, Lindsey Murray, Fernando J. Martinez, Marc Miravitlles, Gavin Donaldson, Donald Banerji, Francesco Patalano & Jadwiga A. Wedzicha. (2018) Patient-reported Outcomes for the Detection, Quantification, and Evaluation of Chronic Obstructive Pulmonary Disease Exacerbations. American Journal of Respiratory and Critical Care Medicine 198:6, pages 730-738.
Crossref
Crossref
Øyvind Nicolay Ulland Salvesen, Jesper Rømhild Davidsen, Anton Pottegård & Daniel Pilsgaard Henriksen. (2018) Roflumilast Usage from 2010 to 2016: A Danish Nationwide Drug Utilization Study. Basic & Clinical Pharmacology & Toxicology 123:3, pages 314-319.
Crossref
Crossref
Esther Barreiro, Ester Puig-Vilanova, Anna Salazar-Degracia, Sergi Pascual-Guardia, Carme Casadevall & Joaquim Gea. (2018) The phosphodiesterase-4 inhibitor roflumilast reverts proteolysis in skeletal muscle cells of patients with COPD cachexia. Journal of Applied Physiology 125:2, pages 287-303.
Crossref
Crossref
Axel Facius, Eleonora Marostica, Philip Gardiner, Henrik Watz & Gezim Lahu. (2018) Pharmacokinetic and Pharmacodynamic Modelling to Characterize the Tolerability of Alternative Up-Titration Regimens of Roflumilast in Patients with Chronic Obstructive Pulmonary Disease. Clinical Pharmacokinetics 57:8, pages 1029-1038.
Crossref
Crossref
Ibrahim A. Janahi, Abdul Rehman & Noor Ul-Ain Baloch. 2018. Corticosteroids. Corticosteroids.
Peter M A Calverley, Antonio R Anzueto, Kerstine Carter, Lars Grönke, Christoph Hallmann, Christine Jenkins, Jadwiga Wedzicha & Klaus F Rabe. (2018) Tiotropium and olodaterol in the prevention of chronic obstructive pulmonary disease exacerbations (DYNAGITO): a double-blind, randomised, parallel-group, active-controlled trial. The Lancet Respiratory Medicine 6:5, pages 337-344.
Crossref
Crossref
Tiago Torres & Luis Puig. (2017) Apremilast: A Novel Oral Treatment for Psoriasis and Psoriatic Arthritis. American Journal of Clinical Dermatology 19:1, pages 23-32.
Crossref
Crossref
Derek G. Waller & Anthony P. Sampson. 2018. Medical Pharmacology and Therapeutics. Medical Pharmacology and Therapeutics
193
209
.
Laura Carzaniga, Gabriele Amari, Andrea Rizzi, Carmelida Capaldi, Renato De Fanti, Eleonora Ghidini, Gino Villetti, Chiara Carnini, Nadia Moretto, Fabrizio Facchinetti, Paola Caruso, Gessica Marchini, Loredana Battipaglia, Riccardo Patacchini, Valentina Cenacchi, Roberta Volta, Francesco Amadei, Alice Pappani, Silvia Capacchi, Valentina Bagnacani, Maurizio Delcanale, Paola Puccini, Silvia Catinella, Maurizio Civelli & Elisabetta Armani. (2017) Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases. Journal of Medicinal Chemistry 60:24, pages 10026-10046.
Crossref
Crossref
Asger Reinstrup Bihlet, Morten Asser Karsdal, Jannie Marie Bülow Sand, Diana Julie Leeming, Mustimbo Roberts, Wendy White & Russell Bowler. (2017) Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD. Respiratory Research 18:1.
Crossref
Crossref
Chang Dong Yeo, Young Ae Kim, Hwa Young Lee, Jin Woo Kim, Seung Joon Kim, Sang Haak Lee & Young Kyoon Kim. (2017) Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model. European Journal of Pharmacology 812, pages 189-195.
Crossref
Crossref
Frederico Leon Arrabal Fernandes, Alberto Cukier, Aquiles Assunção Camelier, Carlos Cezar Fritscher, Cláudia Henrique da Costa, Eanes Delgado Barros Pereira, Irma Godoy, José Eduardo Delfini Cançado, José Gustavo Romaldini, Jose Miguel Chatkin, José Roberto Jardim, Marcelo Fouad Rabahi, Maria Cecília Nieves Maiorano de Nucci, Maria da Penha Uchoa Sales, Maria Vera Cruz de Oliveira Castellano, Miguel Abidon Aidé, Paulo José Zimermann Teixeira, Renato Maciel, Ricardo de Amorim Corrêa, Roberto Stirbulov, Rodrigo Abensur Athanazio, Rodrigo Russo, Suzana Tanni Minamoto & Fernando Luiz Cavalcanti Lundgren. (2017) Recommendations for the pharmacological treatment of COPD: questions and answers. Jornal Brasileiro de Pneumologia 43:4, pages 290-301.
Crossref
Crossref
Klaus F. Rabe, Peter M.A. Calverley, Fernando J. Martinez & Leonardo M. Fabbri. (2017) Effect of roflumilast in patients with severe COPD and a history of hospitalisation. European Respiratory Journal 50:1, pages 1700158.
Crossref
Crossref
Shireen Mirza & Roberto Benzo. (2017) Chronic Obstructive Pulmonary Disease Phenotypes: Implications for Care. Mayo Clinic Proceedings 92:7, pages 1104-1112.
Crossref
Crossref
Vijay Bharathi Arumugham & Cosima T Baldari. (2017) cAMP: a multifaceted modulator of immune synapse assembly and T cell activation. Journal of Leukocyte Biology 101:6, pages 1301-1316.
Crossref
Crossref
Andrea Rossi, Riccardo M. Inciardi, Andrea Rossi, Pier Luigi Temporelli, Donata Lucci, Lucio Gonzini, Roberto Marchioli, Gian Luigi Nicolosi & Luigi Tavazzi. (2017) Prognostic effects of rosuvastatin in patients with co-existing chronic obstructive pulmonary disease and chronic heart failure: A sub-analysis of GISSI-HF trial. Pulmonary Pharmacology & Therapeutics 44, pages 16-23.
Crossref
Crossref
Valentina Sala, Jean Piero Margaria, Alessandra Murabito, Fulvio Morello, Alessandra Ghigo & Emilio Hirsch. (2017) Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF). Current Heart Failure Reports 14:3, pages 187-196.
Crossref
Crossref
Brijeshkumar S. Patel, Md. Mostafizur Rahman, Gina Baehring, Dikaia Xenaki, Francesca Su-May Tang, Brian G. Oliver & Alaina J. Ammit. (2017)
Roflumilast
N
-Oxide in Combination with Formoterol Enhances the Antiinflammatory Effect of Dexamethasone in Airway Smooth Muscle Cells
. American Journal of Respiratory Cell and Molecular Biology 56:4, pages 532-538.
Crossref
Crossref
Wupeng Liao, Jinrui Dong, Hong Peh, Lay Tan, Kah Lim, Li Li & Wai-Shiu Wong. (2017) Oligonucleotide Therapy for Obstructive and Restrictive Respiratory Diseases. Molecules 22:1, pages 139.
Crossref
Crossref
Nicholas J. Gross & Peter J. Barnes. (2017) New Therapies for Asthma and Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine 195:2, pages 159-166.
Crossref
Crossref
Seong Yong Lim. 2017. COPD. COPD
219
242
.
Marc Miravitlles, Anthony D’Urzo, Dave Singh & Vladimir Koblizek. (2016) Pharmacological strategies to reduce exacerbation risk in COPD: a narrative review. Respiratory Research 17:1.
Crossref
Crossref
Gopalan Balasubramanian, Sukunath Narayanan, Lavanya Andiappan, Thirunavukkarasu Sappanimuthu, Saravanan Thirunavukkarasu, Shamundeeswari Sundaram, Saravanakumar Natarajan, Naresh Sivaraman, Sridharan Rajagopal, Fakrudeen Ali Ahamed Nazumudeen, Sanjeev Saxena, Santosh L. Vishwakarma, Shridhar Narayanan, Ganapavarapu V.R. Sharma, Chidambaram V. Srinivasan & Narasimhan Kilambi. (2016) In vivo effective dibenzo[b,d]furan-1-yl-thiazoles as novel PDE-4 inhibitors. Bioorganic & Medicinal Chemistry 24:22, pages 5702-5716.
Crossref
Crossref
D. Spina & C. P. Page. 2017. Pharmacology and Therapeutics of Asthma and COPD. Pharmacology and Therapeutics of Asthma and COPD
63
91
.