1,076
Views
70
CrossRef citations to date
0
Altmetric
Review

Recent Advances in Designing 5-Fluorouracil Delivery Systems: A Stepping Stone in the Safe Treatment of Colorectal Cancer

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 5445-5458 | Published online: 30 Jul 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Mahdi Khalilnejad, Baharak Divband, Nahideh Gharehaghaji & Tohid Mortezazadeh. (2023) Multifunctional polyethylene glycol-coated Au@MnO nanoparticles for dual-modal CT/MRI and pH-responsive 5-Fluorouracil delivery. International Journal of Polymeric Materials and Polymeric Biomaterials 72:18, pages 1480-1488.
Read now
Yalcın Bukun, Merve Zaim, Mehmet Senel, Tuğba Sagir, Bercem Yaman Kiyak & Sevim Isık. (2023) Novel fluorescein isothiocyanate (FITC) cored PAMAM dendrimers as drug delivery agent. International Journal of Polymeric Materials and Polymeric Biomaterials 0:0, pages 1-9.
Read now
Mohammad Yousefi, Mehdi Salehi Rad, Romina Shakibazadeh, Leila Ghodrati & Mehrdad Ataie Kachoie. (2022) Simulating a heteroatomic CBN fullerene-like nanocage towards the drug delivery of fluorouracil. Molecular Simulation 48:14, pages 1284-1292.
Read now
Nilufer Yuksel & Sevgi Tektas. (2022) Molecularly imprinted polymers: preparation, characterisation, and application in drug delivery systems. Journal of Microencapsulation 39:2, pages 176-196.
Read now
Mojtaba Hoseini-Ghahfarokhi, Soroush Mirkiani, Naeimeh Mozaffari, Mohamad Amin Abdolahi Sadatlu, Amir Ghasemi, Somayeh Abbaspour, Mohsen Akbarian, Fatemeh Farjadian & Mahdi Karimi. (2020) Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?. International Journal of Nanomedicine 15, pages 9469-9496.
Read now

Articles from other publishers (65)

Zhengqiao Liu, Zeran Yu, Lingfeng Zhang, Reza Tayebee, Shohre Pourmojahed, Effat Esmaeili Shahri & Xu Chen. (2023) Studying loading of 5-fluorouracil onto the surface of gold–silver nanocomposite utilizing DLS and UV–Vis spectroscopy. Chemical Papers.
Crossref
Yu-Sheng Feng, Ya-Ting Qin, Ji Zhuang, Yao-Jia Ma, Xi-Wen He, Wen-You Li & Yu-Kui Zhang. (2023) Mitochondria-Targeted Thymidylate Synthase Inhibitor Based on Fluorescent Molecularly Imprinted Polymers for Tumor Antimetabolic Therapy. ACS Applied Materials & Interfaces 15:26, pages 31139-31149.
Crossref
Daniela Predoi, Mihaela Balas, Madalina Andreea Badea, Steluta Carmen Ciobanu, Nicolas Buton & Anca Dinischiotu. (2023) Dextran-Coated Iron Oxide Nanoparticles Loaded with 5-Fluorouracil for Drug-Delivery Applications. Nanomaterials 13:12, pages 1811.
Crossref
Renu Saharan, Sarvesh K. Paliwal, Abhishek Tiwari, Varsha Tiwari, Randhir Singh, Suresh Kumar Beniwal, Preeti Dahiya & Suresh Sagadevan. (2023) Exploring graphene and its potential in delivery of drugs and biomolecules. Journal of Drug Delivery Science and Technology 84, pages 104446.
Crossref
Prabha Soundharraj, Durgalakshmi Dhinasekaran, Ajay Rakkesh Rajendran, Aruna Prakasarao & Singaravelu Ganesan. (2023) Investigation on the Drug Loading Efficacy of Protoporphyrin Functionalized Silica Precursors (Tetraethyl orthosilicate: TEOS and Biomass silica) for Enhanced Delivery of 5‐Fluorouracil. ChemistrySelect 8:20.
Crossref
Samson A. Adeyemi, Zardad Az-Zamakhshariy & Yahya E. Choonara. (2023) In Vitro Prototyping of a Nano-Organogel for Thermo-Sonic Intra-Cervical Delivery of 5-Fluorouracil-Loaded Solid Lipid Nanoparticles for Cervical Cancer. AAPS PharmSciTech 24:5.
Crossref
Yichuan Jiang, Yueyao Jiang, Min Li & Qian Yu. (2023) Will nanomedicine become a good solution for the cardiotoxicity of chemotherapy drugs?. Frontiers in Pharmacology 14.
Crossref
Aylin M. Deliormanlı, Begüm Rahman, Sibel Oguzlar & Merve Zeyrek Ongun. (2023) Investigation of the structural, photoluminescence properties, bioactivity and 5-fluorouracil delivery behavior of Dy3+ and Dy:Eu3+-doped bioactive glasses. Journal of Alloys and Compounds 944, pages 169153.
Crossref
Faezeh Ghazali, Sharieh Hosseini & Sepideh Ketabi. (2022) DFT and Molecular Simulation Study of Gold Clusters as Effective Drug Delivery Systems for 5-Fluorouracil Anticancer Drug. Journal of Cluster Science 34:3, pages 1499-1509.
Crossref
Soraia I. Falcão, Diana Duarte, Moustapha Diallo, Joana Santos, Eduarda Ribeiro, Nuno Vale & Miguel Vilas-Boas. (2023) Improvement of the In Vitro Cytotoxic Effect on HT-29 Colon Cancer Cells by Combining 5-Fluorouacil and Fluphenazine with Green, Red or Brown Propolis. Molecules 28:8, pages 3393.
Crossref
Sheng-Nan Ren, Zhan-Yi Zhang, Rui-Jie Guo, Da-Ren Wang, Fang-Fang Chen, Xue-Bo Chen & Xue-Dong Fang. (2023) Application of nanotechnology in reversing therapeutic resistance and controlling metastasis of colorectal cancer. World Journal of Gastroenterology 29:13, pages 1911-1941.
Crossref
Geza Lazar, Fran Nekvapil, Branko Glamuzina, Tudor Tamaș, Lucian Barbu-Tudoran, Maria Suciu & Simona Cinta Pinzaru. (2023) pH-Dependent Behavior of Novel 5-FU Delivery System in Environmental Conditions Comparable to the Gastro-Intestinal Tract. Pharmaceutics 15:3, pages 1011.
Crossref
Athar Mahdieh, Hamid Yeganeh, Sverre Arne Sande & Bo Nyström. (2023) Design of novel polyurethane-based ionene nanocarriers for cancer therapy: Synthesis, in-vitro, and in-vivo studies. International Journal of Pharmaceutics 635, pages 122768.
Crossref
Haiping Ma, Naping Zhao, Suxia Luo, Yanqiao Zhang, Zhijun Yuan, Hao Sun, Shen Gao, Xianbao Zhan & Li Zhang. (2023) Pharmacokinetic and bioequivalence study of two capecitabine tablets in Chinese patients with breast, colorectal or gastric cancer under fed condition: A multicentric, randomized, open-label, single-dose, two-period, two-way crossover clinical trial. European Journal of Pharmaceutical Sciences 182, pages 106373.
Crossref
Sylwia Milewska, Gabriela Siemiaszko, Agnieszka Zofia Wilczewska, Iwona Misztalewska-Turkowicz, Karolina Halina Markiewicz, Dawid Szymczuk, Diana Sawicka, Halina Car, Ryszard Lazny & Katarzyna Niemirowicz-Laskowska. (2023) Folic-Acid-Conjugated Thermoresponsive Polymeric Particles for Targeted Delivery of 5-Fluorouracil to CRC Cells. International Journal of Molecular Sciences 24:2, pages 1364.
Crossref
Sneha Shriparna Satpathy, Satya Narayan Sahu & Chandana Mohanty. A computational therapeutic evaluation of 5-Fluorouracil and different phytochemicals in view of dynamic behavior with native and mutated protein related to colon cancer. A computational therapeutic evaluation of 5-Fluorouracil and different phytochemicals in view of dynamic behavior with native and mutated protein related to colon cancer.
Anai A. Valencia-Lazcano, Dilawar Hassan, Mehrab Pourmadadi, Amin shamsabadipour, Razieh Behzadmehr, Abbas Rahdar, Dora I. Medina & Ana M. Díez-Pascual. (2023) 5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy. European Journal of Medicinal Chemistry 246, pages 114995.
Crossref
Mahmoud H. Abu Elella, Emad S. Goda, Mariam M. Abady, Dina Mohammed & Heba M. Abdallah. 2023. Carbon Nanostructures in Biomedical Applications. Carbon Nanostructures in Biomedical Applications 67 93 .
Kajal Ghosal, Shreya Chatterjee, Sabu Thomas & Poulomi Roy. (2022) A Detailed Review on Synthesis, Functionalization, Application, Challenges, and Current Status of Magnetic Nanoparticles in the Field of Drug Delivery and Gene Delivery System. AAPS PharmSciTech 24:1.
Crossref
Farhat Jubeen, Sana Ijaz, Ishrat Jabeen, Usman Aftab, Wajeeha Mehdi, Awais Altaf, Siham A. Alissa, Hanan A. Al-Ghulikah, Safa Ezzine, Imen Bejaoui & Munawar Iqbal. (2022) Anticancer potential of novel 5-Fluorouracil co-crystals against MCF7 breast and SW480 colon cancer cell lines along with docking studies. Arabian Journal of Chemistry 15:12, pages 104299.
Crossref
Fatemeh Farjadian, Maryam Moghadam, Mohammad Monfared & Soliman Mohammadi‐Samani. (2022) Mesoporous silica nanostructure modified with azo gatekeepers for colon targeted delivery of 5‐fluorouracil. AIChE Journal 68:12.
Crossref
Kerong Guo, Xin Ma, Jian Li, Chong Zhang & Liqiang Wu. (2022) Recent advances in combretastatin A-4 codrugs for cancer therapy. European Journal of Medicinal Chemistry 241, pages 114660.
Crossref
Ehsan Shakerzadeh, Elham Tahmasebi, Long Van Duong & Minh Tho Nguyen. 2022. Characteristics and Applications of Boron. Characteristics and Applications of Boron.
Diana Duarte, Inês Guerreiro & Nuno Vale. (2022) Novel Strategies for Cancer Combat: Drug Combination Using Repurposed Drugs Induces Synergistic Growth Inhibition of MCF-7 Breast and HT-29 Colon Cancer Cells. Current Issues in Molecular Biology 44:10, pages 4930-4949.
Crossref
Diana Duarte, Mariana Nunes, Sara Ricardo & Nuno Vale. (2022) Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action. Biomolecules 12:10, pages 1490.
Crossref
Sonia López, Ignacio Gracia, Rodrigo Plaza-Pedroche, Juan Francisco Rodríguez, José Manuel Pérez-Ortiz, Julián Rodríguez-López & María Jesús Ramos. (2022) In Vitro Antioxidant and Pancreatic Anticancer Activity of Novel 5-Fluorouracil-Coumarin Conjugates. Pharmaceutics 14:10, pages 2152.
Crossref
Buhle Buyana, Tobeka Naki, Sibusiso Alven & Blessing Atim Aderibigbe. (2022) Nanoparticles Loaded with Platinum Drugs for Colorectal Cancer Therapy. International Journal of Molecular Sciences 23:19, pages 11261.
Crossref
Fatemeh Farjadian, Soheila Ghasemi, Mohsen Akbarian, Mojtaba Hoseini-Ghahfarokhi, Mohsen Moghoofei & Mohammad Doroudian. (2022) Physically stimulus-responsive nanoparticles for therapy and diagnosis. Frontiers in Chemistry 10.
Crossref
Jungwon Kong, Sung Soo Park & Chang-Sik Ha. (2022) pH-Sensitive Polyacrylic Acid-Gated Mesoporous Silica Nanocarrier Incorporated with Calcium Ions for Controlled Drug Release. Materials 15:17, pages 5926.
Crossref
Saswati Ghosh, Sayoni Nag, Krishna Das Saha & Biswadip Banerji. (2022) S ‐Benzyl cysteine based cyclic dipeptide super hydrogelator: Enhancing efficacy of an anticancer drug via sustainable release . Journal of Peptide Science 28:8.
Crossref
Chenmala Karthika, Md. Habibur Rahman, Raman Sureshkumar, Rokeya Akter, Azmat Ali Khan, Amer M. Alanazi, Abul Kalam Azad, Paritosh Barai & Hasi Rani Barai. (2022) 5-Fluorouracil and Curcumin Combination Coated with Pectin and Its Strategy towards Titanium Dioxide, Dimethylhydrazine Colorectal Cancer Model with the Evaluation of the Blood Parameters. Polymers 14:14, pages 2868.
Crossref
Mohammad Hasan Kamel Attar Kar & Mohammad Yousefi. (2022) Interaction of a conical carbon scaffold with the thio-substituted model of fluorouracil towards approaching the drug delivery purposes. Main Group Chemistry 21:2, pages 725-735.
Crossref
Mohammad Hasan Kamel Attar Kar & Mohammad Yousefi. (2022) Investigating drug delivery of 5-fluorouracil by assistance of an iron-modified graphene scaffold: Computational studies. Main Group Chemistry 21:2, pages 651-658.
Crossref
Zaynab Fatfat, Maamoun Fatfat & Hala Gali-Muhtasib. (2022) Micelles as potential drug delivery systems for colorectal cancer treatment. World Journal of Gastroenterology 28:25, pages 2867-2880.
Crossref
Ehsan Shakerzadeh, Krzysztof K. Zborowski, Ernesto Chigo Anota & Minh Tho Nguyen. (2022) Pristine and alkali and alkaline earth metals encapsulated B 36 N 36 nanoclusters as prospective delivery agents and detectors for 5‐fluorouracil anticancer drug . Applied Organometallic Chemistry 36:7.
Crossref
Khadije Fasihi, Forouzan Amerizadeh, Reihaneh Sabbaghzadeh, Maryam Heydari, Farzad Rahmani, Asma Mostafapour, Majid Khazaei, Elisa Rasouli, Seyed Mahdi Hassanian, Gordon A. Ferns, Majid Rezayi & Amir Avan. (2022) The therapeutic potential of γ-Al2O3 nanoparticle containing 5-fluorouracil in the treatment of colorectal cancer. Tissue and Cell 76, pages 101755.
Crossref
Sarah I. Othman, Alyaa Adlii, Ahmed A. Allam, Haifa A. Alqhtani, Ali A. AlHammadi & Mostafa R. Abukhadra. (2022) Characterization of MgO/CaO hybrid nanorods as an enhanced inorganic carrier of 5-Fluorouracil drug; loading, release, and cytotoxicity studies. Journal of Inorganic and Organometallic Polymers and Materials 32:6, pages 2322-2331.
Crossref
Mehdi Hadjianfar, Dariush Semnani, Jaleh Varshosaz, Sajad MohammadiSayed Pedram Rezazadeh Tehrani. (2021) 5FU-loaded PCL/Chitosan/Fe 3 O 4 Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System . Advanced Pharmaceutical Bulletin 12:3, pages 568-582.
Crossref
Zahra Pourmanouchehri, Sayeh Ebrahimi, Mazdak Limoee, Fereshteh Jalilian, Sajad Janfaza, Amirhossein Vosoughi & Leila Behbood. (2022) Controlled release of 5-fluorouracil to melanoma cells using a hydrogel/micelle composites based on deoxycholic acid and carboxymethyl chitosan. International Journal of Biological Macromolecules 206, pages 159-166.
Crossref
Arem Qayum, Asmita Magotra, Syed Mohmad Shah, Utpal Nandi, P.R. Sharma, Bhahwal Ali Shah & Shashank Kumar Singh. (2022) Synergistic combination of PMBA and 5-fluorouracil (5-FU) in targeting mutant KRAS in 2D and 3D colorectal cancer cells. Heliyon 8:4, pages e09103.
Crossref
Eshraq Ahmed Abdullah. (2022) Theoretical study of a single-walled carbon nanotube and a cellulose biofiber as 5-fluorouracil anti-cancer drug carriers. European Journal of Chemistry 13:1, pages 69-77.
Crossref
Bakry Ibrahim, Omar Y Mady, Murtaza M Tambuwala & Yusuf A Haggag. (2022) pH-sensitive nanoparticles containing 5-fluorouracil and leucovorin as an improved anti-cancer option for colon cancer. Nanomedicine 17:6, pages 367-381.
Crossref
Karim Kheiri, Negin Sohrabi, Reza Mohammadi & Mohammad Sadegh Amini-Fazl. (2022) Preparation and characterization of magnetic nanohydrogel based on chitosan for 5-fluorouracil drug delivery and kinetic study. International Journal of Biological Macromolecules 202, pages 191-198.
Crossref
Diana Duarte, Soraia I. Falcão, Iouraouine El Mehdi, Miguel Vilas-Boas & Nuno Vale. (2022) Honeybee Venom Synergistically Enhances the Cytotoxic Effect of CNS Drugs in HT-29 Colon and MCF-7 Breast Cancer Cell Lines. Pharmaceutics 14:3, pages 511.
Crossref
Carmen Stavarache, Mircea Vinatoru & Timothy Mason. (2022) Transport of Magnetic Polyelectrolyte Capsules in Various Environments. Coatings 12:2, pages 259.
Crossref
Matheus Lohan-Codeço, Maria Luísa Barambo-Wagner, Luiz Eurico Nasciutti, Luis Felipe Ribeiro Pinto, Nathalia Meireles Da Costa & Antonio PalumboJrJr. (2022) Molecular mechanisms associated with chemoresistance in esophageal cancer. Cellular and Molecular Life Sciences 79:2.
Crossref
Junzong Chen, Miaojuan Qiu, Shiqiang Zhang, Binbin Li, Dong Li, Xiuyu Huang, Zhirong Qian, Jing Zhao, Zhiyong Wang & Di Tang. (2022) A calcium phosphate drug carrier loading with 5-fluorouracil achieving a synergistic effect for pancreatic cancer therapy. Journal of Colloid and Interface Science 605, pages 263-273.
Crossref
Jonaid Ahmad Malik, Sakeel Ahmed, Bisma Jan, Onur Bender, Turki Al Hagbani, Aali Alqarni & Sirajudheen Anwar. (2022) Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges. Biomedicine & Pharmacotherapy 145, pages 112375.
Crossref
Galal H. Elgemeie & Reham A. Mohamed-Ezzat. 2022. New Strategies Targeting Cancer Metabolism. New Strategies Targeting Cancer Metabolism 107 142 .
Seung-On Lee, Ah-Won Kwak, Mee-Hyun Lee, Ji-Hye Seo, Seung-Sik Cho, Goo Yoon, Jung-Il Chae, Sang Hoon Joo & Jung-Hyun Shim. (2021) Picropodophyllotoxin Induces G1 Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway. Journal of Microbiology and Biotechnology 31:12, pages 1615-1623.
Crossref
Valeria Ciaffaglione, Maria N. Modica, Valeria Pittalà, Giuseppe Romeo, Loredana Salerno & Sebastiano Intagliata. (2021) Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs. ChemMedChem 16:23, pages 3496-3512.
Crossref
Khatereh Zarkesh, Elaheh Entezar-Almahdi, Parisa Ghasemiyeh, Mohsen Akbarian, Marzieh Bahmani, Shahrzad Roudaki, Rahil Fazlinejad, Soliman Mohammadi-Samani, Negar Firouzabadi, Majid Hosseini & Fatemeh Farjadian. (2021) Drug-based therapeutic strategies for COVID-19-infected patients and their challenges. Future Microbiology 16:18, pages 1415-1451.
Crossref
Manisha Pandey, Hira Choudhury, Bapi Gorain, Shao Qin Tiong, Grace Yee Seen Wong, Kai Xin Chan, Xuan They & Wei Shen Chieu. (2021) Site-Specific Vesicular Drug Delivery System for Skin Cancer: A Novel Approach for Targeting. Gels 7:4, pages 218.
Crossref
Luis M.P. Verissimo, Inês Cabral, Ana M.T.D.P.V. Cabral, Gianluca Utzeri, Francisco J.B. Veiga, Artur J.M. Valente & Ana C.F. Ribeiro. (2021) Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics. The Journal of Chemical Thermodynamics 161, pages 106533.
Crossref
Shang-Der Chen, Jenq-Lin Yang, Yi-Heng Hsieh, Tsu-Kung Lin, Yi-Chun Lin, A-Ching Chao & Ding-I Yang. (2021) Potential Roles of Sestrin2 in Alzheimer’s Disease: Antioxidation, Autophagy Promotion, and Beyond. Biomedicines 9:10, pages 1308.
Crossref
Hyocheol Bae, Woonghee Lee, Jisoo Song, Taeyeon Hong, Myung Hyun Kim, Jiyeon Ham, Gwonhwa Song & Whasun Lim. (2021) Polydatin Counteracts 5-Fluorouracil Resistance by Enhancing Apoptosis via Calcium Influx in Colon Cancer. Antioxidants 10:9, pages 1477.
Crossref
Tz-Feng Lin & Shih-Hsuan Yeh. (2021) Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers. Polymers 13:16, pages 2705.
Crossref
Adam Kasiński, Monika Zielińska-Pisklak, Sebastian Kowalczyk, Andrzej Plichta, Anna Zgadzaj, Ewa Oledzka & Marcin Sobczak. (2021) Synthesis and Characterization of New Biodegradable Injectable Thermosensitive Smart Hydrogels for 5-Fluorouracil Delivery. International Journal of Molecular Sciences 22:15, pages 8330.
Crossref
Diana Duarte, Armando Cardoso & Nuno Vale. (2021) Synergistic Growth Inhibition of HT-29 Colon and MCF-7 Breast Cancer Cells with Simultaneous and Sequential Combinations of Antineoplastics and CNS Drugs. International Journal of Molecular Sciences 22:14, pages 7408.
Crossref
Kangkang Ying, Bingjun Bai, Xing Gao, Yuzi Xu, Hangxiang Wang & Binbin Xie. (2021) Orally Administrable Therapeutic Nanoparticles for the Treatment of Colorectal Cancer. Frontiers in Bioengineering and Biotechnology 9.
Crossref
Adil Muala Dhumad, Hatem Jameel Majeed, Hasan Zandi & Kun Harismah. (2021) FeC19 cage vehicle for fluorouracil anticancer drug delivery: DFT approach. Journal of Molecular Liquids 333, pages 115905.
Crossref
Cláudia Camacho, Helena Tomás & João Rodrigues. (2021) Use of Half-Generation PAMAM Dendrimers (G0.5–G3.5) with Carboxylate End-Groups to Improve the DACHPtCl2 and 5-FU Efficacy as Anticancer Drugs. Molecules 26:10, pages 2924.
Crossref
Elaheh Entezar-Almahdi, Reza Heidari, Soheila Ghasemi, Soliman Mohammadi-Samani & Fatemeh Farjadian. (2021) Integrin receptor mediated pH-responsive nano-hydrogel based on histidine-modified poly(aminoethyl methacrylamide) as targeted cisplatin delivery system. Journal of Drug Delivery Science and Technology 62, pages 102402.
Crossref
Adam Kasiński, Monika Zielińska-Pisklak, Ewa Oledzka, Grzegorz Nałęcz-Jawecki, Agata Drobniewska & Marcin Sobczak. (2020) Hydrogels Based on Poly(Ether-Ester)s as Highly Controlled 5-Fluorouracil Delivery Systems—Synthesis and Characterization. Materials 14:1, pages 98.
Crossref
Fatemeh Farjadian, Amin Reza Akbarizadeh & Lobat Tayebi. (2020) Synthesis of novel reducing agent for formation of metronidazole-capped silver nanoparticle and evaluating antibacterial efficiency in gram-positive and gram-negative bacteria. Heliyon 6:8, pages e04747.
Crossref