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Original Research

Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway

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Pages 5131-5141 | Published online: 05 Nov 2014

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Crossref
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Amit Kumar Singh, Prabhash Kumar Pandey, Astha Dwivedi, Amit Kumar Sharma, Akhilesh Pandey & Abhay Kumar Pandey. 2021. Nanomaterial Biointeractions at the Cellular, Organismal and System Levels. Nanomaterial Biointeractions at the Cellular, Organismal and System Levels 431 448 .
Ayse Basak Engin. 2021. Protein Kinase-mediated Decisions Between Life and Death. Protein Kinase-mediated Decisions Between Life and Death 165 193 .
Mingxiang Wang, Jin Li, Shunni Dong, Xiaobo Cai, Aili Simaiti, Xin Yang, Xinqiang Zhu, Jianhong Luo, Lin-Hua Jiang, Binyang Du, Peilin Yu & Wei Yang. (2020) Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction. Particle and Fibre Toxicology 17:1.
Crossref
Emmanuel Naveen Raj, Yu‐Wei Lin, Chien‐Hung Chen, Kuang‐Kai Liu & Jui‐I Chao. (2020) Selective Autophagy Pathway of Nanoparticles and Nanodrugs: Drug Delivery and Pathophysiological Effects. Advanced Therapeutics 3:9.
Crossref
Massimiliano G. Bianchi, Martina Chiu, Giuseppe Taurino, Roberta Ruotolo, Nelson Marmiroli, Enrico Bergamaschi, Francesco Cubadda & Ovidio Bussolati. (2020) Pyrogenic and Precipitated Amorphous Silica Nanoparticles Differentially Affect Cell Responses to LPS in Human Macrophages. Nanomaterials 10:7, pages 1395.
Crossref
Van A. Ortega, Melissa S. Cameron, James L. Stafford, Greg G. Goss, John A. Donald & Aaron G. Schultz. (2020) Polyacrylic acid coated nanoparticles elicit endothelial cell apoptosis and diminish vascular relaxation in ex vivo perfused iliac arteries of the cane toad ( Rhinella marina ) . Environmental Science: Nano 7:7, pages 1912-1926.
Crossref
Lina Zhang, Lele Hou, Zulin Liu, Siqi Huang, Zhe Meng & Liyang Liang. (2020) A mitophagic response to iron overload-induced oxidative damage associated with the PINK1/Parkin pathway in pancreatic beta cells. Journal of Trace Elements in Medicine and Biology 60, pages 126493.
Crossref
Pan Yang, Ruirui Song, Ning Li, Kun Sun, Fan Shi, Heliang Liu, Fuhai Shen, Shoufang Jiang, Lin Zhang & Yulan Jin. (2020) Silica dust exposure induces autophagy in alveolar macrophages through switching Beclin1 affinity from Bcl‐2 to PIK3C3. Environmental Toxicology 35:7, pages 758-767.
Crossref
Lu Jia, Shuang-Li Hao & Wan-Xi Yang. (2020) Nanoparticles induce autophagy via mTOR pathway inhibition and reactive oxygen species generation. Nanomedicine 15:14, pages 1419-1435.
Crossref
Yinyin Tan, Ling Yin, Zhanfang Sun, Shanshan Shao, Wenbin Chen, Xiao Man, Yifeng Du & Yan Chen. (2020) Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro. International Journal of Biological Macromolecules 153, pages 349-356.
Crossref
Haiwei Wu, Xuan Wang, Hao Liang, Jiawei Zheng, Shengyun Huang & Dongsheng Zhang. (2020) Enhanced efficacy of propranolol therapy for infantile hemangiomas based on a mesoporous silica nanoplatform through mediating autophagy dysfunction. Acta Biomaterialia 107, pages 272-285.
Crossref
Jasna Lojk, Jernej Repas, Peter Veranič, Vladimir B. Bregar & Mojca Pavlin. (2020) Toxicity mechanisms of selected engineered nanoparticles on human neural cells in vitro. Toxicology 432, pages 152364.
Crossref
Durgesh Nandini Das & Prashanta Kumar Panda. 2020. Autophagy in tumor and tumor microenvironment. Autophagy in tumor and tumor microenvironment 1 34 .
Vijaya Ravinayagam & B. Rabindran Jermy. 2020. Applications of Nanomaterials in Human Health. Applications of Nanomaterials in Human Health 249 273 .
Kyungmin Lee, Jangwook Lee, Minjeong Kwak, Young-Lai Cho, Byungtae Hwang, Min Ji Cho, Na Geum Lee, Jongjin Park, Sang-Hyun Lee, Jong-Gil Park, Yeon-Gu Kim, Jang-Seong Kim, Tae-Su Han, Hyun-Soo Cho, Young-Jun Park, Seon-Jin Lee, Hee Gu Lee, Won Kon Kim, In Cheul Jeung, Nam Woong Song, Kwang-Hee Bae & Jeong-Ki Min. (2019) Two distinct cellular pathways leading to endothelial cell cytotoxicity by silica nanoparticle size. Journal of Nanobiotechnology 17:1.
Crossref
Lihua Ren, Jianhui Liu, Jin Zhang, Ji Wang, Jialiu Wei, Yanbo Li, Caixia Guo, Zhiwei Sun & Xianqing Zhou. (2019) Silica nanoparticles induce spermatocyte cell autophagy through microRNA-494 targeting AKT in GC-2spd cells. Environmental Pollution 255, pages 113172.
Crossref
Farooq Ahmad, Xiaoyan Wang & Wanwan Li. (2019) Toxico‐Metabolomics of Engineered Nanomaterials: Progress and Challenges. Advanced Functional Materials 29:51.
Crossref
Aneetta E. Kuriakose, Nikhil Pandey, Dingying Shan, Subhash Banerjee, Jian Yang & Kytai T. Nguyen. (2019) Characterization of Photoluminescent Polylactone-Based Nanoparticles for Their Applications in Cardiovascular Diseases. Frontiers in Bioengineering and Biotechnology 7.
Crossref
Jie Kai Tee, Li Xian Yip, Eveline Sheau Tan, Supawan Santitewagun, Arun Prasath, Pu Chun Ke, Han Kiat Ho & David Tai Leong. (2019) Nanoparticles' interactions with vasculature in diseases. Chemical Society Reviews 48:21, pages 5381-5407.
Crossref
Yang Yang, Fengshou Dong, Xingang Liu, Jun Xu, Xiaohu Wu & Yongquan Zheng. (2019) Flutolanil affects circadian rhythm in zebrafish (Danio rerio) by disrupting the positive regulators. Chemosphere 228, pages 649-655.
Crossref
Bhowmira Rathore, Kyoung Sunwoo, Paramesh Jangili, Jiseon Kim, Ji Hyeon Kim, Meina Huang, Jia Xiong, Amit Sharma, Zhigang Yang, Junle Qu & Jong Seung Kim. (2019) Nanomaterial designing strategies related to cell lysosome and their biomedical applications: A review. Biomaterials 211, pages 25-47.
Crossref
Shi‐Hai Zhang, Hui‐Mei Wu, Shuai Li, Mu‐Zi Wang, Lei Fang & Rong‐Yu Liu. (2019) Melatonin enhances autophagy and decreases apoptosis induced by nanosilica in RAW264.7 cells. IUBMB Life 71:7, pages 1021-1029.
Crossref
Weizhen Liu, Changzhou Weng, Jiayi Zheng, Xiaoqian Peng, Jing Zhang & Zhang Lin. (2019) Emerging investigator series: treatment and recycling of heavy metals from nanosludge. Environmental Science: Nano 6:6, pages 1657-1673.
Crossref
Pan Luo, Fuqiang Gao, Dongsheng Niu, Xichun Sun, Qiang Song, Chongjun Guo, Yuqi Liang & Wei Sun. (2019) The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review. BioMed Research International 2019, pages 1-7.
Crossref
Akitoshi Nakashima, Kazuma Higashisaka, Tae Kusabiraki, Aiko Aoki, Akemi Ushijima, Yosuke Ono, Sayaka Tsuda, Tomoko Shima, Osamu Yoshino, Kazuya Nagano, Yasuo Yoshioka, Yasuo Tsutsumi & Shigeru Saito. (2019) Autophagy is a new protective mechanism against the cytotoxicity of platinum nanoparticles in human trophoblasts. Scientific Reports 9:1.
Crossref
Marco Cordani & Álvaro Somoza. (2018) Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment. Cellular and Molecular Life Sciences 76:7, pages 1215-1242.
Crossref
Xiuwei Yang, Jing Xie, Xiaoxiao Liu, Zichao Li, Kun Fang, Luying Zhang, Mei Han, Zhuang Zhang, Zhi Gong, Xuezhu Lin, Xianzhou Shi, Hui Gao & Kui Lu. (2019) Autophagy induction by xanthoangelol exhibits anti‐metastatic activities in hepatocellular carcinoma. Cell Biochemistry and Function 37:3, pages 128-138.
Crossref
Zulema Vargas-Osorio, Andrés Da Silva-Candal, Yolanda Piñeiro, Ramón Iglesias-Rey, Tomas Sobrino, Francisco Campos, José Castillo & José Rivas. (2019) Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications. Nanomaterials 9:3, pages 449.
Crossref
Jun Chen, Zhao-jie Wang, Kai-le Zhang, Yan-jun Xu, Zhi-gang Chen & Xiao-yong Hu. (2019) Selective Castration-resistant Prostate Cancer Photothermal Ablation With Copper Sulfide Nanoplates. Urology 125, pages 248-255.
Crossref
Yan Wang, Lian-Lian Liu, Yuan Tian, Yang Chen, Wen-Hui Zha, Yang Li & Fu-Ju Wu. (2019) Upregulation of DAPK2 ameliorates oxidative damage and apoptosis of placental cells in hypertensive disorder complicating pregnancy by suppressing human placental microvascular endothelial cell autophagy through the mTOR signaling pathway. International Journal of Biological Macromolecules 121, pages 488-497.
Crossref
Fujing Wei & Yixiang Duan. (2018) Crosstalk between Autophagy and Nanomaterials: Internalization, Activation, Termination. Advanced Biosystems 3:1.
Crossref
Jie Tee, Li Ng, Hannah Koh, David Leong & Han Ho. (2018) Titanium Dioxide Nanoparticles Enhance Leakiness and Drug Permeability in Primary Human Hepatic Sinusoidal Endothelial Cells. International Journal of Molecular Sciences 20:1, pages 35.
Crossref
Yang Yang, Fengshou Dong, Xingang Liu, Jun Xu, Xiaohu Wu, Wenxian Liu & Yongquan Zheng. (2018) Crosstalk of oxidative damage, apoptosis, and autophagy under endoplasmic reticulum (ER) stress involved in thifluzamide-induced liver damage in zebrafish (Danio rerio). Environmental Pollution 243, pages 1904-1911.
Crossref
Yue Chen, Meng Wang, Tianke Zhang, E. Du, Yan Liu, Shiyong Qi, Yong Xu & Zhihong Zhang. (2018) Autophagic effects and mechanisms of silver nanoparticles in renal cells under low dose exposure. Ecotoxicology and Environmental Safety 166, pages 71-77.
Crossref
Jia Lin, Jun Xia, Hua-Shan Zhao, Rui Hou, Milton Talukder, Lei Yu, Jian-Ying Guo & Jin-Long Li. (2018) Lycopene Triggers Nrf2–AMPK Cross Talk to Alleviate Atrazine-Induced Nephrotoxicity in Mice. Journal of Agricultural and Food Chemistry 66:46, pages 12385-12394.
Crossref
Collins Otieno Asweto, Hejing Hu, Shuang Liang, Lijing Wang, Mengdi Liu, Han Yang, Junchao Duan & Zhiwei Sun. (2018) Gene profiles to characterize the combined toxicity induced by low level co-exposure of silica nanoparticles and benzo[a]pyrene using whole genome microarrays in zebrafish embryos. Ecotoxicology and Environmental Safety 163, pages 47-55.
Crossref
Jia Liu, Xiaoxuan Wang, Ming Zheng & Qingxian Luan. (2018) Lipopolysaccharide from Porphyromonas gingivalis promotes autophagy of human gingival fibroblasts through the PI3K/Akt/mTOR signaling pathway. Life Sciences 211, pages 133-139.
Crossref
Jing Li, Chuxiong Zeng, Beishi Zheng, Chun Liu, Min Tang, Yan Jiang, Yizhong Chang, Weiping Song, Yingxin Wang & Changqing Yang. (2018) HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis. Clinical Science 132:15, pages 1645-1667.
Crossref
Liangjiao Chen, Jia Liu, Yanli Zhang, Guilan Zhang, Yiyuan Kang, Aijie Chen, Xiaoli Feng & Longquan Shao. (2018) The toxicity of silica nanoparticles to the immune system. Nanomedicine 13:15, pages 1939-1962.
Crossref
Lotte M.P. Vermeulen, Toon Brans, Stefaan C. De Smedt, Katrien Remaut & Kevin Braeckmans. (2018) Methodologies to investigate intracellular barriers for nucleic acid delivery in non-viral gene therapy. Nano Today 21, pages 74-90.
Crossref
Guangyi Qin, Ping Li & Zhuowei Xue. (2018) Triptolide induces protective autophagy and apoptosis in human cervical cancer cells by downregulating Akt/mTOR activation. Oncology Letters.
Crossref
Caixia Guo, Ji Wang, Li Jing, Ru Ma, Xiaoying Liu, Lifang Gao, Lige Cao, Junchao Duan, Xianqing Zhou, Yanbo Li & Zhiwei Sun. (2018) Mitochondrial dysfunction, perturbations of mitochondrial dynamics and biogenesis involved in endothelial injury induced by silica nanoparticles. Environmental Pollution 236, pages 926-936.
Crossref
Xiaowei Ma, Lin Zhong, Hongbo Guo, Yifeng Wang, Ningqiang Gong, Yuqing Wang, Jun Cai & Xing‐Jie Liang. (2018) Multiwalled Carbon Nanotubes Induced Hypotension by Regulating the Central Nervous System. Advanced Functional Materials 28:11.
Crossref
Tao Jia, Jungyoon Choi, Jéremy Ciccione, Maxime Henry, Ahmad Mehdi, Jean Martinez, Béatrice Eymin, Gilles Subra & Jean-Luc Coll. (2018) Heteromultivalent targeting of integrin αvβ3 and neuropilin 1 promotes cell survival via the activation of the IGF-1/insulin receptors. Biomaterials 155, pages 64-79.
Crossref
Ayse Basak Engin & A Wallace Hayes. (2018) The impact of immunotoxicity in evaluation of the nanomaterials safety. Toxicology Research and Application 2, pages 239784731875557.
Crossref
Yubin Li & Dianwen Ju. 2018. Cellular and Molecular Toxicology of Nanoparticles. Cellular and Molecular Toxicology of Nanoparticles 71 84 .
Yi Cao. 2018. Cellular and Molecular Toxicology of Nanoparticles. Cellular and Molecular Toxicology of Nanoparticles 59 69 .
Juan Du, Zhi Xu, Qian Liu, Yu Yang, Hang Qian, Mingdong Hu, Ye Fan, Qi Li, Wei Yao, Hongli Li, Guisheng Qian, Binfeng He, Deshan Zhou, Chengde Mao & Guansong Wang. (2017) ATG101 Single-Stranded Antisense RNA-Loaded Triangular DNA Nanoparticles Control Human Pulmonary Endothelial Growth via Regulation of Cell Macroautophagy. ACS Applied Materials & Interfaces 9:49, pages 42544-42555.
Crossref
Uche C. Anozie & Paul Dalhaimer. (2017) Molecular links among non-biodegradable nanoparticles, reactive oxygen species, and autophagy. Advanced Drug Delivery Reviews 122, pages 65-73.
Crossref
Yi Cao, Yu Gong, Liangliang Liu, Yiwei Zhou, Xin Fang, Cao Zhang, Yining Li & Juan Li. (2017) The use of human umbilical vein endothelial cells (HUVECs) as an in vitro model to assess the toxicity of nanoparticles to endothelium: a review . Journal of Applied Toxicology 37:12, pages 1359-1369.
Crossref
Jianbo Che, Bing Liang, Yuan Zhang, Yi Wang, Jianyu Tang & Gongning Shi. (2017) Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of autophagy via inhibiting PI3K/Akt/mTOR pathway in human endothelial cells. Cardiovascular Pathology 31, pages 57-62.
Crossref
Moataz Dowaidar, Maxime Gestin, Carmine Pasquale Cerrato, Mohammed Hakim Jafferali, Helerin Margus, Paula Ann Kivistik, Kariem Ezzat, Einar Hallberg, Margus Pooga, Mattias Hällbrink & Ülo Langel. (2017) Role of autophagy in cell-penetrating peptide transfection model. Scientific Reports 7:1.
Crossref
Junchao Duan, Hejing Hu, Lin Feng, Xiaozhe Yang & Zhiwei Sun. (2017) Silica nanoparticles inhibit macrophage activity and angiogenesis via VEGFR2-mediated MAPK signaling pathway in zebrafish embryos. Chemosphere 183, pages 483-490.
Crossref
Sivakumar Murugadoss, Dominique Lison, Lode Godderis, Sybille Van Den Brule, Jan Mast, Frederic Brassinne, Noham Sebaihi & Peter H. Hoet. (2017) Toxicology of silica nanoparticles: an update. Archives of Toxicology 91:9, pages 2967-3010.
Crossref
Rafał Krętowski, Magdalena Kusaczuk, Monika Naumowicz, Joanna Kotyńska, Beata Szynaka & Marzanna Cechowska-Pasko. (2017) The Effects of Silica Nanoparticles on Apoptosis and Autophagy of Glioblastoma Cell Lines. Nanomaterials 7:8, pages 230.
Crossref
R. Björkenheim, G. Strömberg, J. Pajarinen, M. Ainola, P. Uppstu, L. Hupa, T. O. Böhling & N. C. Lindfors. (2017) Polymer-coated bioactive glass S53P4 increases VEGF and TNF expression in an induced membrane model in vivo. Journal of Materials Science 52:15, pages 9055-9065.
Crossref
Zeng-Ying Qiao, Wen-Jia Lai, Yao-Xin Lin, Dan Li, Xiao-Hui Nan, Yi Wang, Hao Wang & Qiao-Jun Fang. (2017) Polymer– KLAK Peptide Conjugates Induce Cancer Cell Death through Synergistic Effects of Mitochondria Damage and Autophagy Blockage . Bioconjugate Chemistry 28:6, pages 1709-1721.
Crossref
Annette Kraegeloh & Klaus Unfried. 2017. Nanomaterials Handbook. Nanomaterials Handbook 629 662 .
Shasha Zhu, Jiqian Zhang, Li Zhang, Wentao Ma, Na Man, Yiming Liu, Wei Zhou, Jun Lin, Pengfei Wei, Peipei Jin, Yunjiao Zhang, Yi Hu, Erwei Gu, Xianfu Lu, Zhilai Yang, Xuesheng Liu, Li Bai & Longping Wen. (2017) Inhibition of Kupffer Cell Autophagy Abrogates Nanoparticle‐Induced Liver Injury. Advanced Healthcare Materials 6:9.
Crossref
Haijian Sun, Xuexue Zhu, Weiwei Cai & Liying Qiu. (2017) Hypaphorine Attenuates Lipopolysaccharide-Induced Endothelial Inflammation via Regulation of TLR4 and PPAR-γ Dependent on PI3K/Akt/mTOR Signal Pathway. International Journal of Molecular Sciences 18:4, pages 844.
Crossref
Haijun Liu, Yusi Cheng, Jian Yang, Wei Wang, Shencun Fang, Wei Zhang, Bing Han, Zewei Zhou, Honghong Yao, Jie Chao & Hong Liao. (2017) BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis. Cell Death & Disease 8:3, pages e2657-e2657.
Crossref
Ji‐Qian Zhang, Wei Zhou, Sha‐Sha Zhu, Jun Lin, Peng‐Fei Wei, Fen‐Fen Li, Pei‐Pei Jin, Han Yao, Yun‐Jiao Zhang, Yi Hu, Yi‐Ming Liu, Ming Chen, Zheng‐Quan Li, Xue‐sheng Liu, Li Bai & Long‐ping Wen. (2016) Persistency of Enlarged Autolysosomes Underscores Nanoparticle‐Induced Autophagy in Hepatocytes. Small 13:7.
Crossref
Hussein Traboulsi, Necola Guerrina, Matthew Iu, Dusica Maysinger, Parisa Ariya & Carolyn Baglole. (2017) Inhaled Pollutants: The Molecular Scene behind Respiratory and Systemic Diseases Associated with Ultrafine Particulate Matter. International Journal of Molecular Sciences 18:2, pages 243.
Crossref
Huai Guan, Hua Piao, Zhiqiang Qian, Xueying Zhou, Yijie Sun, Chenxue Gao, Shuangyue Li & Fengyuan Piao. (2017) 2,5-Hexanedione induces autophagic death of VSC4.1 cells via a PI3K/Akt/mTOR pathway. Molecular BioSystems 13:10, pages 1993-2005.
Crossref
Sushma Sushma, Hridyesh Kumar, Iqbal Ahmad & Pradip Kumar Dutta. (2017) Evaluation of the DNA damaging potential of indigenous health hazardous quartz nanoparticles on the cultured lung cells. Toxicology Research 6:2, pages 152-161.
Crossref
M.I. Hermanns, C. Freese, L. Anspach, V. Grützner, C. Pohl, R.E. Unger & C.J. Kirkpatrick. 2017. Comprehensive Biomaterials II. Comprehensive Biomaterials II 295 334 .
Lizhen Jiang, Yongbo Yu, Yang Li, Yang Yu, Junchao Duan, Yang Zou, Qiuling Li & Zhiwei Sun. (2016) Oxidative Damage and Energy Metabolism Disorder Contribute to the Hemolytic Effect of Amorphous Silica Nanoparticles. Nanoscale Research Letters 11:1.
Crossref
Mingyi Zhao, Ping Zhu, Masayuki Fujino, Yoshiaki Nishio, Jimei Chen, Hidenori Ito, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Lingling Zhao, Jian Zhuang & Xiao-Kang Li. (2016) 5-Aminolevulinic acid with sodium ferrous citrate induces autophagy and protects cardiomyocytes from hypoxia-induced cellular injury through MAPK-Nrf-2-HO-1 signaling cascade. Biochemical and Biophysical Research Communications 479:4, pages 663-669.
Crossref
Luocheng Li, Zhiwei Wang, Xiaoping Hu, Ting Wan, Hongbing Wu, Wanli Jiang & Rui Hu. (2016) Human aortic smooth muscle cell-derived exosomal miR-221/222 inhibits autophagy via a PTEN/Akt signaling pathway in human umbilical vein endothelial cells. Biochemical and Biophysical Research Communications 479:2, pages 343-350.
Crossref
Junchao Duan, Hejing Hu, Qiuling Li, Lizhen Jiang, Yang Zou, Yapei Wang & Zhiwei Sun. (2016) Combined toxicity of silica nanoparticles and methylmercury on cardiovascular system in zebrafish (Danio rerio) embryos. Environmental Toxicology and Pharmacology 44, pages 120-127.
Crossref
Ryan F. Russell, Jacqueline U. McDonald, Laura Lambert & John S. Tregoning. (2016) Use of the Microparticle Nanoscale Silicon Dioxide as an Adjuvant To Boost Vaccine Immune Responses against Influenza Virus in Neonatal Mice. Journal of Virology 90:9, pages 4735-4744.
Crossref
Yongxin Li, Xigang Geng, Haichen Wang, Gesheng Cheng & Suochun Xu. (2016) CTRP9 Ameliorates Pulmonary Arterial Hypertension Through Attenuating Inflammation and Improving Endothelial Cell Survival and Function. Journal of Cardiovascular Pharmacology 67:5, pages 394-401.
Crossref
Laura Hulea, Zoran Markovic, Ivan Topisirovic, Thomas Simmet & Vladimir Trajkovic. (2016) Biomedical Potential of mTOR Modulation by Nanoparticles. Trends in Biotechnology 34:5, pages 349-353.
Crossref
Jennifer Mytych, Maciej Wnuk & Suresh I.S. Rattan. (2016) Low doses of nanodiamonds and silica nanoparticles have beneficial hormetic effects in normal human skin fibroblasts in culture. Chemosphere 148, pages 307-315.
Crossref
Chen Xi, Jie Zhou, Shuzhang Du & Shaojun Peng. (2016) Autophagy upregulation promotes macrophages to escape mesoporous silica nanoparticle (MSN)-induced NF-κB-dependent inflammation. Inflammation Research 65:4, pages 325-341.
Crossref
Lu Zhang, XueQin Wang, YiMing Miao, ZhiQiang Chen, PengFei Qiang, LiuQing Cui, Hongjuan Jing & YuQi Guo. (2016) Magnetic ferroferric oxide nanoparticles induce vascular endothelial cell dysfunction and inflammation by disturbing autophagy. Journal of Hazardous Materials 304, pages 186-195.
Crossref
Xiaohong Wang, Guoxiong Zhou, Chun Liu, Ronglong Wei, Shunxing Zhu, Yuefen Xu, Mengjie Wu & Qing Miao. (2016) Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats . Mediators of Inflammation 2016, pages 1-12.
Crossref
Qiuling Li, Hejing Hu, Lizhen Jiang, Yang Zou, Junchao Duan & Zhiwei Sun. (2016) Cytotoxicity and autophagy dysfunction induced by different sizes of silica particles in human bronchial epithelial BEAS-2B cells. Toxicology Research 5:4, pages 1216-1228.
Crossref
Hejing Hu, Qiuling Li, Lizhen Jiang, Yang Zou, Junchao Duan & Zhiwei Sun. (2016) Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos. Toxicology Research 5:2, pages 609-620.
Crossref
Peilin Yu, Jin Li, Jialin Jiang, Zunquan Zhao, Zhaoyuan Hui, Jun Zhang, Yifan Zheng, Daishun Ling, Lie Wang, Lin-Hua Jiang, Jianhong Luo, Xinqiang Zhu & Wei Yang. (2015) A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles. Scientific Reports 5:1.
Crossref
Sayan Mullick Chowdhury, Justin Fang & Balaji Sitharaman. (2015) Interaction of graphene nanoribbons with components of the blood vascular system. Future Science OA 1:3.
Crossref
Puja Khanna, Cynthia Ong, Boon Bay & Gyeong Baeg. (2015) Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death. Nanomaterials 5:3, pages 1163-1180.
Crossref
Ning Meng, Lei Han, XiaoHong Pan, Le Su, Zheng Jiang, Zhang Lin, Jing Zhao, ShangLi Zhang, Yun Zhang, BaoXiang Zhao & JunYing Miao. (2015) Nano-Mg(OH)2-induced proliferation inhibition and dysfunction of human umbilical vein vascular endothelial cells through caveolin-1-mediated endocytosis. Cell Biology and Toxicology 31:1, pages 15-27.
Crossref
Lizhen Jiang, Yanbo Li, Yang Li, Caixia Guo, Yongbo Yu, Yang Zou, Yumei Yang, Yang Yu, Junchao Duan, Weijia Geng, Qiuling Li & Zhiwei Sun. (2015) Silica nanoparticles induced the pre-thrombotic state in rats via activation of coagulation factor XII and the JNK-NF-κB/AP-1 pathway. Toxicology Research 4:6, pages 1453-1464.
Crossref