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Review

Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors

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Pages 603-617 | Published online: 15 Dec 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (25)

Romeo Romagnoli, Tiziano De Ventura, Stefano Manfredini, Erika Baldini, Claudiu T. Supuran, Alessio Nocentini, Andrea Brancale, Roberta Bortolozzi, Lorenzo Manfreda & Giampietro Viola. (2023) Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Nora Astrain-Redin, Niccolò Paoletti, Daniel Plano, Alessandro Bonardi, Paola Gratteri, Andrea Angeli, Carmen Sanmartin & Claudiu T. Supuran. (2023) Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Farhat Ramzan, Syed Ayaz Nabi, Mehak Saba Lone, Alessandro Bonardi, Aabid Hamid, Sameena Bano, Kalicharan Sharma, Syed Shafi, Mohammed Samim, Kalim Javed & Claudiu T. Supuran. (2023) Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Morteza Abdoli, Alessandro Bonardi, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Khulood H. Oudah, Walaa R. Mahmoud, Fadi M. Awadallah, Azza T. Taher, Safinaz E.-S Abbas, Heba Abdelrasheed Allam, Daniela Vullo & Claudiu T. Supuran. (2023) Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 12-23.
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Amina Merabti, Sébastien Richeter, Claudiu T. Supuran, Sébastien Clement & Jean-Yves Winum. (2023) Are tumour-associated carbonic anhydrases genuine therapeutic targets for photodynamic therapy?. Expert Opinion on Therapeutic Targets 0:0, pages 1-10.
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Claudiu T Supuran. (2023) Targeting carbonic anhydrases for the management of hypoxic metastatic tumors. Expert Opinion on Therapeutic Patents 0:0, pages 1-20.
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Claudiu T. Supuran. (2022) Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2478-2488.
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Francesco Liguori, Simone Carradori, Roberto Ronca, Sara Rezzola, Serena Filiberti, Fabrizio Carta, Marta Turati & Claudiu T. Supuran. (2022) Benzenesulfonamides with different rigidity-conferring linkers as carbonic anhydrase inhibitors: an insight into the antiproliferative effect on glioblastoma, pancreatic, and breast cancer cells. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1857-1869.
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Hossam Nada, Ahmed Elkamhawy, Magda H. Abdellattif, Andrea Angeli, Chang Hoon Lee, Claudiu T. Supuran & Kyeong Lee. (2022) 4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 994-1004.
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Alessandro Bonardi, Silvia Bua, Jacob Combs, Carrie Lomelino, Jacob Andring, Sameh Mohamed Osman, Alessandra Toti, Lorenzo Di Cesare Mannelli, Paola Gratteri, Carla Ghelardini, Robert McKenna, Alessio Nocentini & Claudiu T. Supuran. (2022) The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 930-939.
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Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Mariusz Mojzych, Beata Marciniak, Rafał Drozda & Renata Kontek. (2022) Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1278-1298.
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Mattia Mori & Claudiu T. Supuran. (2022) Acipimox inhibits human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 672-679.
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Wagdy M. Eldehna, Mohammed S. Taghour, Tarfah Al-Warhi, Alessio Nocentini, Mostafa M. Elbadawi, Hazem A. Mahdy, Mohamed A. Abdelrahman, Ohoud J. Alotaibi, Nada Aljaeed, Diaaeldin M. Elimam, Kamyar Afarinkia, Hatem A. Abdel-Aziz & Claudiu T. Supuran. (2022) Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 531-541.
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Silvia Mussi, Sara Rezzola, Paola Chiodelli, Alessio Nocentini, Claudiu T. Supuran & Roberto Ronca. (2022) Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 280-286.
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Sridhar Goud Nerella, Priti Singh, Mohammed Arifuddin & Claudiu T Supuran. (2022) Anticancer carbonic anhydrase inhibitors: a patent and literature update 2018-2022. Expert Opinion on Therapeutic Patents 32:8, pages 833-847.
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Emilie Anduran, Ludwig J Dubois, Philippe Lambin & Jean-Yves Winum. (2022) Hypoxia-activated prodrug derivatives of anti-cancer drugs: a patent review 2006 – 2021. Expert Opinion on Therapeutic Patents 32:1, pages 1-12.
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Claudiu T. Supuran. (2021) Carbonic anhydrase inhibitors: an update on experimental agents for the treatment and imaging of hypoxic tumors. Expert Opinion on Investigational Drugs 30:12, pages 1197-1208.
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Alessio Nocentini, Clemente Capasso & Claudiu T. Supuran. (2021) Small-molecule CD73 inhibitors for the immunotherapy of cancer: a patent and literature review (2017–present). Expert Opinion on Therapeutic Patents 31:10, pages 867-876.
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Claudiu T. Supuran. (2021) Multitargeting approaches involving carbonic anhydrase inhibitors: hybrid drugs against a variety of disorders. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1702-1714.
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Claudiu T. Supuran, Alessio Nocentini, Elena Yakubova, Nikolay Savchuk, Stanislav Kalinin & Mikhail Krasavin. (2021) Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida®) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1056-1060.
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Viviana De Luca, Andrea Petreni, Vincenzo Carginale, Andrea Scaloni, Claudiu T. Supuran & Clemente Capasso. (2021) Effect of amino acids and amines on the activity of the recombinant ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territorii. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1000-1006.
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Chandra Bhushan Mishra, Raj Kumar Mongre, Amresh Prakash, Raok Jeon, Claudiu T. Supuran & Myeong-Sok Lee. (2021) Anti-breast cancer action of carbonic anhydrase IX inhibitor 4-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-benzylidene-hydrazinocarbonyl]-benzenesulfonamide (BSM-0004): in vitro and in vivo studies. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 954-963.
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Alessio Nocentini, Andrea Angeli, Fabrizio Carta, Jean-Yves Winum, Raivis Zalubovskis, Simone Carradori, Clemente Capasso, William A. Donald & Claudiu T. Supuran. (2021) Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 561-580.
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Dimitrios Tsikas & Stepan Gambaryan. (2021) Nitrous anhydrase activity of carbonic anhydrase II: cysteine is required for nitric oxide (NO) dependent phosphorylation of VASP in human platelets. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 525-534.
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Vasilisa Krivovicheva, Andrey Bubyrev, Stanislav Kalinin, Dmitry Dar'in, Maxim Gureev, Valeria Burianova, Daniella Vullo, Mikhail Krasavin & Claudiu T. Supuran. (2023) Versatile Diazomethane Sulfonamide for Expedited Exploration of Azole‐Based Carbonic Anhydrase Inhibitors via [3+2] Cycloaddition. ChemMedChem 18:10.
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Saquib Jalil, Saif Ullah, Seyed-Omar Zaraei, Rawan M. Sbenati, Afnan I. Shahin, Bilal O. AlKubaisi, Julie Pelletier, Jean Sévigny, Taleb H. Al-Tel, Jamshed Iqbal & Mohammed I. El-Gamal. (2023) Synthesis and biological evaluation of sulfamate derivatives as inhibitors of carbonic anhydrases II and IX. Medicinal Chemistry Research 32:5, pages 869-883.
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Macarena S. Le Pors, Lucía Santa Maria de la Parra, Leonardo E. Riafrecha, Daniela Vullo, Ignacio E. León, Claudiu T. Supuran & Pedro A. Colinas. (2023) Glycosyl Isoxazoles for Targeting of Tumor Microenvironment and Cancer Cells: Highly Selective Inhibitors of Carbonic Anhydrases IX and XII Showing Cytotoxic Activity. ChemistrySelect 8:11.
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Afaf El-Malah, Ehab S. Taher, Andrea Angeli, Samar S. Elbaramawi, Zeinab Mahmoud, Nour Moustafa, Claudiu T. Supuran & Tarek S. Ibrahim. (2023) Schiff bases as linker in the development of quinoline-sulfonamide hybrids as selective cancer-associated carbonic anhydrase isoforms IX/XII inhibitors: A new regioisomerism tactic. Bioorganic Chemistry 131, pages 106309.
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Heba T. Abdel‐Mohsen, Ahmed M. El Kerdawy, Andrea Petreni & Claudiu T. Supuran. (2022) Novel benzenesulfonamide‐thiouracil conjugates with a flexible N ‐ethyl acetamide linker as selective CA IX and CA XII inhibitors . Archiv der Pharmazie 356:2.
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Wagdy M. Eldehna, Mahmoud A. El Hassab, Nahla A. Abdelshafi, Rana A. Eissa, Nadeen H. Diab, Ekram H. Mohamed, Mamdouh A. Oraby, Sara T. Al-Rashood, Rana G. Eissa, Zainab M. Elsayed, Alessio Nocentini, Claudiu T. Supuran, Mahmoud Elsabahy & Noura G. Eissa. (2023) Development of potent nanosized carbonic anhydrase inhibitor for targeted therapy of hypoxic solid tumors. International Journal of Pharmaceutics 631, pages 122537.
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Claudiu T. Supuran. 2022. Flavonoids and Phenolics. Flavonoids and Phenolics 298 329 .
Petr Heneberg. (2022) Lactic Acidosis in Patients with Solid Cancer. Antioxidants & Redox Signaling 37:16-18, pages 1130-1152.
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Pavitra S. Thacker, Vaishnavi Newaskar, Andrea Angeli, Dilep Kumar Sigalapalli, Nerella Sridhar Goud, Hepsibha Chirra, Afzal B. Shaik, Mohammed Arifuddin & Claudiu T. Supuran. (2022) Synthesis and biological evaluation of coumarin‐thiazole hybrids as selective carbonic anhydrase IX and XII inhibitors. Archiv der Pharmazie 355:12.
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Heba T. Abdel‐Mohsen, Mohamed A. Omar, Andrea Petreni & Claudiu T. Supuran. (2022) Novel 2‐substituted thioquinazoline‐benzenesulfonamide derivatives as carbonic anhydrase inhibitors with potential anticancer activity. Archiv der Pharmazie 355:12.
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Claudiu T. Supuran. (2022) Carbonic Anhydrase Inhibitors from Marine Natural Products. Marine Drugs 20:11, pages 721.
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B. S. Star, C. K. Boahen, E. C. van der Slikke, V. M. Quinten, J. C. ter Maaten, R. H. Henning, V. Kumar & H. R. Bouma. (2022) Plasma proteomic characterization of the development of acute kidney injury in early sepsis patients. Scientific Reports 12:1.
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Babatunde Samuel Obadawo, Oluwatoba Emmanuel Oyeneyin, Adesoji Alani Olanrewaju, Damilohun Samuel Metibemu, Sunday Adeola Emaleku, Taoreed Olakunle Owolabi & Nureni Ipinloju. (2022) Predicting the Anticancer Activity of 2-alkoxycarbonylallyl Esters against MDA-MB-231 Breast Cancer - QSAR, Machine Learning and Molecular Docking. Current Drug Discovery Technologies 19:6.
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Heba T. Abdel‐Mohsen, Andrea Petreni & Claudiu T. Supuran. (2022) Investigation of the carbonic anhydrase inhibitory activity of benzenesulfonamides incorporating substituted fused‐pyrimidine tails. Archiv der Pharmazie 355:11.
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Phuong Linh Nguyen, Ahmed Elkamhawy, Young Hee Choi, Chang Hoon Lee, Kyeong Lee & Jungsook Cho. (2022) Suppression of Tumor Growth and Cell Migration by Indole-Based Benzenesulfonamides and Their Synergistic Effects in Combination with Doxorubicin. International Journal of Molecular Sciences 23:17, pages 9903.
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Lisa Hiepp, Doris Mayr, Kathrin Gärtner, Elisa Schmoeckel, Frederick Klauschen, Alexander Burges, Sven Mahner, Reinhard Zeidler & Bastian Czogalla. (2022) Carbonic anhydrase XII as biomarker and therapeutic target in ovarian carcinomas. PLOS ONE 17:7, pages e0271630.
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Giulia Arrighi, Adrián Puerta, Andrea Petrini, Francisco J. Hicke, Alessio Nocentini, Miguel X. Fernandes, José M. Padrón, Claudiu T. Supuran, José G. Fernández-Bolaños & Óscar López. (2022) Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations. International Journal of Molecular Sciences 23:14, pages 7685.
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Nazanin Tatari, Xiaoyu Zhang, Shawn C. Chafe, Dillon McKenna, Keith A. Lawson, Minomi Subapanditha, Muhammad Vaseem Shaikh, Mathieu Seyfrid, Neil Savage, Chitra Venugopal, Jason Moffat & Sheila K. Singh. (2022) Dual Antigen T Cell Engagers Targeting CA9 as an Effective Immunotherapeutic Modality for Targeting CA9 in Solid Tumors. Frontiers in Immunology 13.
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Simone Giovannuzzi, Clemente Capasso, Alessio Nocentini & Claudiu T. Supuran. (2022) Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII. Molecules 27:13, pages 4076.
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Amina Merabti, Maxime Roger, Christophe Nguyen, Alessio Nocentini, Philippe Gerbier, Sébastien Richeter, Magali Gary‐Bobo, Claudiu T. Supuran, Sébastien Clément & Jean‐Yves Winum. (2022) Carbonic Anhydrase Inhibitors Featuring a Porphyrin Scaffold: Synthesis, Optical and Biological Properties. European Journal of Organic Chemistry 2022:21.
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Samar A. El-Kalyoubi, Ehab S. Taher, Tarek S. Ibrahim, Mohammed Farrag El-Behairy & Amany M. M. Al-Mahmoudy. (2022) Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors. Pharmaceuticals 15:5, pages 494.
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Anna Di Fiore, Claudiu T. Supuran, Andrea Scaloni & Giuseppina De Simone. (2021) Post-translational modifications in tumor-associated carbonic anhydrases. Amino Acids 54:4, pages 543-558.
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Zihe Huo, Remo Bilang, Claudiu T. Supuran, Nicolas von der Weid, Elisabeth Bruder, Stefan Holland-Cunz, Ivan Martin, Manuele G. Muraro & Stephanie J. Gros. (2022) Perfusion-Based Bioreactor Culture and Isothermal Microcalorimetry for Preclinical Drug Testing with the Carbonic Anhydrase Inhibitor SLC-0111 in Patient-Derived Neuroblastoma. International Journal of Molecular Sciences 23:6, pages 3128.
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Heba T. Abdel-Mohsen, Ahmed M. El Kerdawy, Mohamed A. Omar, Andrea Petreni, Rasha M. Allam, Hoda I. El Diwani & Claudiu T. Supuran. (2022) Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine–Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors. European Journal of Medicinal Chemistry 228, pages 114004.
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Simone Giovannuzzi, Mario D’Ambrosio, Cristina Luceri, Sameh Mohamed Osman, Marco Pallecchi, Gianluca Bartolucci, Alessio Nocentini & Claudiu T. Supuran. (2021) Aromatic Sulfonamides including a Sulfonic Acid Tail: New Membrane Impermeant Carbonic Anhydrase Inhibitors for Targeting Selectively the Cancer-Associated Isoforms. International Journal of Molecular Sciences 23:1, pages 461.
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Giacomo Biagiotti, Andrea Angeli, Arianna Giacomini, Gianluca Toniolo, Luca Landini, Gianluca Salerno, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Tommaso Mello, Silvia Mussi, Cosetta Ravelli, Marcello Marelli, Stefano Cicchi, Enzo Menna, Roberto Ronca, Claudiu T. Supuran & Barbara Richichi. (2021) Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells. ACS Applied Nano Materials 4:12, pages 14153-14160.
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Yang Zhou, Ya-Jiao Wu, Lei Wang, Juan Han, Jia-Cong Wu, Chun-Mei Li & Yun Wang. (2021) Natural deep eutectic solvents as green and biocompatible reaction medium for carbonic anhydrase catalysis. International Journal of Biological Macromolecules 190, pages 206-213.
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Mária Bodnár Mikulová, Dáša Kružlicová, Daniel Pecher, Andrea Petreni, Claudiu T. Supuran & Peter Mikuš. (2021) Synthesis and Inhibition Activity Study of Triazinyl-Substituted Amino(alkyl)-benzenesulfonamide Conjugates with Polar and Hydrophobic Amino Acids as Inhibitors of Human Carbonic Anhydrases I, II, IV, IX, and XII. International Journal of Molecular Sciences 22:20, pages 11283.
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Dmitry Dar'in, Grigory Kantin, Stanislav Kalinin, Tatiana Sharonova, Alexander Bunev, Gennady I. Ostapenko, Alessio Nocentini, Vladimir Sharoyko, Claudiu T. Supuran & Mikhail Krasavin. (2021) Investigation of 3-sulfamoyl coumarins against cancer-related IX and XII isoforms of human carbonic anhydrase as well as cancer cells leads to the discovery of 2-oxo-2H-benzo[h]chromene-3-sulfonamide – A new caspase-activating proapoptotic agent. European Journal of Medicinal Chemistry 222, pages 113589.
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Mudasir Nabi Peerzada, Ernest Hamel, Ruoli Bai, Claudiu T. Supuran & Amir Azam. (2021) Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development. Pharmacology & Therapeutics 225, pages 107860.
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Iryna Antal, Martina Koneracka, Martina Kubovcikova, Vlasta Zavisova, Alena Jurikova, Iryna Khmara, Maria Omastova, Matej Micusik, Monika Barathova, Lenka Jelenska, Ivana Kajanova, Miriam Zatovicova & Silvia Pastorekova. (2021) Targeting of carbonic anhydrase IX-positive cancer cells by glycine-coated superparamagnetic nanoparticles. Colloids and Surfaces B: Biointerfaces 205, pages 111893.
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Antje Güttler, Yvonne Eiselt, Anne Funtan, Andreas Thiel, Marina Petrenko, Jacqueline Keßler, Iris Thondorf, Reinhard Paschke, Dirk Vordermark & Matthias Bache. (2021) Betulin Sulfonamides as Carbonic Anhydrase Inhibitors and Anticancer Agents in Breast Cancer Cells. International Journal of Molecular Sciences 22:16, pages 8808.
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Andrea Angeli, Mariana Pinteala, Stelian S. Maier, Alessandra Toti, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Silvia Selleri, Fabrizio Carta & Claudiu T. Supuran. (2021) Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity. Bioorganic & Medicinal Chemistry Letters 45, pages 128147.
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Francesca Mancuso, Anna Di Fiore, Laura De Luca, Andrea Angeli, Giuseppina De Simone, Claudiu T. Supuran & Rosaria Gitto. (2021) Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII. Bioorganic & Medicinal Chemistry 44, pages 116279.
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Ebru Temiz, Ismail Koyuncu, Mustafa Durgun, Murat Caglayan, Ataman Gonel, Eray Metin Güler, Abdurrahim Kocyigit & Claudiu T. Supuran. (2021) Inhibition of Carbonic Anhydrase IX Promotes Apoptosis through Intracellular pH Level Alterations in Cervical Cancer Cells. International Journal of Molecular Sciences 22:11, pages 6098.
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Tatiana Sharonova, Polina Paramonova, Stanislav Kalinin, Alexander Bunev, Rovshan Е. Gasanov, Alessio Nocentini, Vladimir Sharoyko, Tatiana B. Tennikova, Dmitry Dar’in, Claudiu T. Supuran & Mikhail Krasavin. (2021) Insertion of metal carbenes into the anilinic N–H bond of unprotected aminobenzenesulfonamides delivers low nanomolar inhibitors of human carbonic anhydrase IX and XII isoforms. European Journal of Medicinal Chemistry 218, pages 113352.
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Claudiu T. Supuran. (2021) Emerging role of carbonic anhydrase inhibitors. Clinical Science 135:10, pages 1233-1249.
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Zuo-Peng Zhang, Ye Zhong, Zhen-Bin Han, Lin Zhou, Hua-Sheng Su, Jian Wang, Yang Liu & Mao-Sheng Cheng. (2021) Synthesis, Molecular Docking Analysis and Biological Evaluations of Saccharide-Modified Thiadiazole Sulfonamide Derivatives. International Journal of Molecular Sciences 22:11, pages 5482.
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Utpal K. Mondal, Kate Doroba, Ahmed M. Shabana, Rachel Adelberg, Md. Raqibul Alam, Claudiu T. Supuran & Marc A. Ilies. (2021) PEG Linker Length Strongly Affects Tumor Cell Killing by PEGylated Carbonic Anhydrase Inhibitors in Hypoxic Carcinomas Expressing Carbonic Anhydrase IX. International Journal of Molecular Sciences 22:3, pages 1120.
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Claudiu T. Supuran. 2021. New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications. New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications 115 131 .
Geetha Venkateswaran, Shawn C. Chafe, Wells S. Brown, Zachary J. Gerbec, Paul C. McDonald, Shannon Awrey, Seth J. Parker & Shoukat Dedhar. (2022) A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells. SSRN Electronic Journal.
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