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Review

Emerging molecular targets in oncology: clinical potential of MET/hepatocyte growth-factor inhibitors

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Pages 1001-1014 | Published online: 12 Jun 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Janakiraman Subramanian & Ossama Tawfik. (2021) Detection of MET exon 14 skipping mutations in non-small cell lung cancer: overview and community perspective. Expert Review of Anticancer Therapy 21:8, pages 877-886.
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Lei Huang, Kun Xie, Hongwen Li, Ruiqin Wang, Xiaoqing Xu, Kaiming Chen, Hua Gu & Jianmin Fang. (2020) Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody. Drug Design, Development and Therapy 14, pages 3201-3214.
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Johan Filip Vansteenkiste, Charlotte Van De Kerkhove, Els Wauters & Pierre Van Mol. (2019) Capmatinib for the treatment of non-small cell lung cancer. Expert Review of Anticancer Therapy 19:8, pages 659-671.
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Alessandro Granito, Elena Guidetti & Laura Gramantieri. (2015) c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma. Journal of Hepatocellular Carcinoma 2, pages 29-38.
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Dongheon Lee, Eun-Sil Sung, Jin-Hyung Ahn, Sungwon An, Jiwon Huh & Weon-Kyoo You. (2015) Development of antibody-based c-Met inhibitors for targeted cancer therapy. ImmunoTargets and Therapy 4, pages 35-44.
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Camillo Porta, Palma Giglione, Alessandra Ferrari, Francesca Reversi, Wanda Liguigli, Ilaria Imarisio & Carlo Ganini. (2015) Tivantinib (ARQ197) in hepatocellular carcinoma. Expert Review of Anticancer Therapy 15:6, pages 615-622.
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Qiang Zhen, Jun-Feng Liu, Jia-Bao Liu, Ren-Feng Wang, Wei-Wei Chu, Ya-Xiao Zhang, Guo-Liang Tan, Xiao-Jian Zhao & Bao-Lei Lv. (2015) Endothelial PAS domain-containing protein 1 confers TKI-resistance by mediating EGFR and MET pathways in non-small cell lung cancer cells. Cancer Biology & Therapy 16:4, pages 549-557.
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Articles from other publishers (75)

Mandy Sakamoto & Tejas Patil. (2023) MET alterations in advanced non-small cell lung cancer. Lung Cancer 178, pages 254-268.
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Elena Michaels & Christine M. Bestvina. (2022) Meeting an un-MET need: Targeting MET in non-small cell lung cancer. Frontiers in Oncology 12.
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Han Yao, Yuanyuan Ren, Jun Yan, Jiadai Liu, Jinhui Hu, Ming Yan & Xingshu Li. (2022) Design, Synthesis, and Evaluation of New Mesenchymal–Epithelial Transition Factor (c-Met) Kinase Inhibitors with Dual Chiral Centers. Molecules 27:17, pages 5359.
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Amandeep Thakur, Chetna Faujdar, Ram Sharma, Sachin Sharma, Basant Malik, Kunal Nepali & Jing Ping Liou. (2022) Glioblastoma: Current Status, Emerging Targets, and Recent Advances. Journal of Medicinal Chemistry 65:13, pages 8596-8685.
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Nisha S Ramani, Ajaykumar C Morani & Shengle Zhang. (2022) MET Gene High Copy Number (Amplification/Polysomy) Identified in Melanoma for Potential Targeted Therapy . American Journal of Clinical Pathology 157:4, pages 502-505.
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Niamh Coleman, Alice Harbery, Sara Heuss, Igor Vivanco & Sanjay Popat. (2022) Targeting un-MET needs in advanced non-small cell lung cancer. Lung Cancer 164, pages 56-68.
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Anqi Wang, Wen Yang, Yue Li, Yang Zhang, Jieqi Zhou, Ruochen Zhang, Weijie Zhang, Jianjie Zhu, Yuanyuan Zeng, Zeyi Liu & Jian-an Huang. (2022) CPNE1 promotes non-small cell lung cancer progression by interacting with RACK1 via the MET signaling pathway. Cell Communication and Signaling 20:1.
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Leylah M. Drusbosky, Richa Dawar, Estelamari Rodriguez & Chukwuemeka V. Ikpeazu. (2021) Therapeutic strategies in METex14 skipping mutated non-small cell lung cancer. Journal of Hematology & Oncology 14:1.
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Mark A. Socinski, Nathan A. Pennell & Kurtis D. Davies. (2021) MET Exon 14 Skipping Mutations in Non–Small-Cell Lung Cancer: An Overview of Biology, Clinical Outcomes, and Testing Considerations . JCO Precision Oncology:5, pages 653-663.
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Qiang Lu, Yunfeng Ni, Wuping Wang, Lei Wang, Tao Jiang & Lei Shang. (2021) Dynamin 3 Inhibits the Proliferation of Non-small-Cell Lung Cancer Cells by Suppressing c-MET–GBR2–STAT3 Complex Formation. Frontiers in Cell and Developmental Biology 9.
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Hao-Xin Gui, Jun Peng, Ze-Ping Yang, Lu-Yao Chen, Hong Zeng, Yu-Ting Shao, Xi Mu, Qian Hao, Yang Yang, Su An, Xiao-Xi Guo, Tian-Rui Xu & Ying Liu. (2021) HDAC1–Smad3–mSin3A complex is required for Smad3-induced transcriptional inhibition of hepatocyte growth factor receptor in human lung cancers. Carcinogenesis 42:4, pages 587-600.
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Yi-Long Wu, Egbert F. Smit & Todd M. Bauer. (2021) Capmatinib for patients with non-small cell lung cancer with MET exon 14 skipping mutations: A review of preclinical and clinical studies. Cancer Treatment Reviews 95, pages 102173.
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Yangbing Jin, Zehui Zhang, Siyi Zou, Fanlu Li, Hao Chen, Chenghong Peng, Xiaxing Deng, Chenlei Wen, Baiyong Shen & Qian Zhan. (2021) A Novel c-MET-Targeting Antibody-Drug Conjugate for Pancreatic Cancer. Frontiers in Oncology 11.
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Meet Patel, Adam Eckburg, Shahina Gantiwala, Zachary Hart, Joshua Dein, Katie Lam & Neelu Puri. (2021) Resistance to Molecularly Targeted Therapies in Melanoma. Cancers 13:5, pages 1115.
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Hironori Tsujimoto, Minako Kobayashi, Hidekazu Sugasawa, Satoshi Ono, Yoji Kishi & Hideki Ueno. (2021) Potential mechanisms of tumor progression associated with postoperative infectious complications. Cancer and Metastasis Reviews 40:1, pages 285-296.
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Kinan El Husseini, Nouha Chaabane, Audrey Mansuet-Lupo, Karen Leroy, Marie-Pierre Revel & Marie Wislez. (2020) Capmatinib-induced interstitial lung disease: A case report. Current Problems in Cancer: Case Reports 2, pages 100024.
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Ulrike Glaenzel, Yi Jin, Regine Hansen, Kirsten Schroer, Gholamreza Rahmanzadeh, Ulrike Pfaar, Jan Jaap van Lier, Hubert Borell, Axel Meissner, Gian Camenisch & Sylvia Zhao. (2020) Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite. Drug Metabolism and Disposition 48:10, pages 873-885.
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Yubo Wang, Panwen Tian, Lei Xia, Li Li, Rui Han, Mengxiao Zhu, Analyn Lizaso, Tian Qin, Min Li, Bing Yu, Xinru Mao, Han Han-Zhang & Yong He. (2020) The clinical efficacy of combinatorial therapy of EGFR-TKI and crizotinib in overcoming MET amplification-mediated resistance from prior EGFR-TKI therapy. Lung Cancer 146, pages 165-173.
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Qian Qian, Changping Wu, Jianping Chen & Weibing Wang. (2020) Relationship between IL10 and PD-L1 in Liver Hepatocellular Carcinoma Tissue and Cell Lines. BioMed Research International 2020, pages 1-14.
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