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Review

Impact of long-acting injectable antipsychotics on medication adherence and clinical, functional, and economic outcomes of schizophrenia

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Pages 1171-1180 | Published online: 13 Nov 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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Ning Ma, Lei Zhang, Wufang Zhang, Yingying He, Chong Ye & Xin Li. (2023) Long-Acting Injectable Antipsychotic Treatment for Schizophrenia in Asian Population: A Scoping Review. Neuropsychiatric Disease and Treatment 19, pages 1987-2006.
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Dusica Hadzi Boskovic, Shuting Liang, Purva Parab, Emily Wiggins & Joshua N Liberman. (2023) Real-World Evidence of Aripiprazole Tablets with Sensor: Treatment Patterns and Impacts on Psychiatric Healthcare Resource Utilization. ClinicoEconomics and Outcomes Research 15, pages 487-498.
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Stine Lassen, Thale Heintz, Tilde Pedersen, Christian Jentz, Naaja Nathanielsen, Parnuna Heilmann & Lisbeth Uhrskov Sørensen. (2023) Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients. International Journal of Circumpolar Health 82:1.
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Heidi C. Waters, Robert Stellhorn, Maelys Touya, Heather Fitzgerald, Sandipan Bhattacharjee & Leslie Citrome. (2023) The effects of early initiation of aripiprazole once-monthly on healthcare resource utilization and healthcare costs in individuals with schizophrenia: real-world evidence from US claims data. Journal of Medical Economics 26:1, pages 316-325.
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Simon Fifer, Brittany Keen, Richard Newton, Andrea Puig & Marija McGeachie. (2022) Understanding the Treatment Preferences of People Living with Schizophrenia in Australia; A Patient Value Mapping Study. Patient Preference and Adherence 16, pages 1687-1701.
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Maria Paz Garcia-Portilla, Adolfo Benito Ruiz, Felisa Gómez Robina, Marta García Dorado & Paola María López Rengel. (2022) Impact on functionality of the paliperidone palmitate three-month formulation in patients with a recent diagnosis of schizophrenia: a real-world observational prospective study. Expert Opinion on Pharmacotherapy 23:5, pages 629-638.
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Monica Zolezzi, Rawan Abouelhassan, Yassin Eltorki, Peter M Haddad & Mahtab Noorizadeh. (2021) Long-Acting Injectable Antipsychotics: A Systematic Review of Their Non-Systemic Adverse Effect Profile. Neuropsychiatric Disease and Treatment 17, pages 1917-1926.
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Francesco Pietrini, Lorenzo Tatini, Gabriele Santarelli, Dario Brugnolo, Marco Squillace, Bernardo Bozza, Andrea Ballerini, Valdo Ricca & Giulio D’Anna. (2021) Self- and caregiver-perceived disability, subjective well-being, quality of life and psychopathology improvement in long-acting antipsychotic treatments: a 2-year follow-up study. International Journal of Psychiatry in Clinical Practice 25:3, pages 307-315.
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Michael J Doane, Martha Sajatovic, Peter J Weiden, Amy K O’Sullivan, Stephen Maher, Jakob B Bjorner, Asia Sikora Kessler, Julia Carpenter-Conlin, Leona Bessonova & Dawn I Velligan. (2020) Antipsychotic Treatment Experiences of People with Schizophrenia: Patient Perspectives from an Online Survey. Patient Preference and Adherence 14, pages 2043-2054.
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Clifton Blackwood, Panna Sanga, Isaac Nuamah, Alexander Keenan, Arun Singh, Maju Mathews & Srihari Gopal. (2020) Patients’ Preference for Long-Acting Injectable versus Oral Antipsychotics in Schizophrenia: Results from the Patient-Reported Medication Preference Questionnaire. Patient Preference and Adherence 14, pages 1093-1102.
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Wagner F Gattaz, Ricardo Saracco-Alvarez, Claudiane Salles Daltio, Martinus T Van de Bilt, Jose Julian Ortegón, Sergio J Villaseñor-Bayardo, Mario Louzã, Helio Elkis, Bernardo Soares, Patricia Cabrera Jaramillo, Fabio Lawson & Leonardo Díaz-Galvis. (2020) Treatment of Patients with Recently Exacerbated Schizophrenia with Paliperidone Palmitate: A Pilot Study of Efficacy and Tolerability. Neuropsychiatric Disease and Treatment 16, pages 2063-2072.
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Francesco Pietrini, Umberto Albert, Andrea Ballerini, Paola Calò, Giuseppe Maina, Federica Pinna, Marco Vaggi, Ileana Boggian, Maria Fontana, Cesare Moro & Bernardo Carpiniello. (2019) The modern perspective for long-acting injectables antipsychotics in the patient-centered care of schizophrenia. Neuropsychiatric Disease and Treatment 15, pages 1045-1060.
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Nan Li, Jian Min Zhuo, Ibrahim Turkoz, Maju Mathews, Yu Feng & Wilson Tan. (2019) A post hoc analysis on hospitalization risk in Asian patients with schizophrenia switching to once-monthly paliperidone palmitate from oral antipsychotics. Expert Opinion on Pharmacotherapy 20:16, pages 2033-2039.
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Xue Song, Antoine C. El Khoury, Matthew Brouillette, David Smith & Kruti Joshi. (2019) Treatment discontinuation of long-acting injectables or oral atypical antipsychotics among Medicaid recipients with schizophrenia. Journal of Medical Economics 22:11, pages 1105-1112.
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Bruno Emond, Antoine C. El Khoury, Charmi Patel, Dominic Pilon, Laura Morrison, Maryia Zhdanava, Patrick Lefebvre, Neeta Tandon & Kruti Joshi. (2019) Real-world outcomes post-transition to once-every-3-months paliperidone palmitate in patients with schizophrenia within US commercial plans. Current Medical Research and Opinion 35:3, pages 407-416.
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Antoine C. El Khoury, Dominic Pilon, Laura Morrison, Nina Shak, Maude Vermette-Laforme, Tony B. Amos, Edward Kim & Patrick Lefebvre. (2019) The prospective economic impact of once monthly paliperidone palmitate versus oral atypical antipsychotics in Medicaid patients with schizophrenia. Current Medical Research and Opinion 35:3, pages 395-405.
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Martha Sajatovic, Ruth Ross, Susan N Legacy, Christoph U Correll, John M Kane, Faith DiBiasi, Heather Fitzgerald & Matthew Byerly. (2018) Identifying patients and clinical scenarios for use of long-acting injectable antipsychotics – expert consensus survey part 1. Neuropsychiatric Disease and Treatment 14, pages 1463-1474.
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Wenjie Zhang, Tony B Amos, Stephen W Gutkin, Nicole Lodowski, Emma Giegerich & Kruti Joshi. (2018) A systematic literature review of the clinical and health economic burden of schizophrenia in privately insured patients in the United States. ClinicoEconomics and Outcomes Research 10, pages 309-320.
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Eduard Parellada, Miquel Bioque, Manuel Serrano, Berta Herrera & Marta García Dorado. (2018) An open-treatment six-week study of the clinical effectiveness of Paliperidone Palmitate in schizophrenia: data from acute units in Spain (SHADOW study). International Journal of Psychiatry in Clinical Practice 22:3, pages 191-199.
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Rosaria Di Lorenzo, Michela Cameli, Chiara Piemonte, Marisa Bolondi, Giulia Landi, Gabriella Pollutri, Ludovica Spattini, Valentina Moretti & Paola Ferri. (2018) Clinical improvement, relapse and treatment adherence with paliperidone palmitate 1-month formulation: 1-year treatment in a naturalistic outpatient setting. Nordic Journal of Psychiatry 72:3, pages 214-220.
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Solomon Nuhoho, Abdallah Saad, Goretti Saumell, Daniel Ribes & Antoine C. El Khoury. (2018) Economic evaluation of paliperidone palmitate once monthly for treating chronic schizophrenia patients in the United Arab Emirates. Current Medical Research and Opinion 34:4, pages 601-611.
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Dominic Pilon, Matthew Alcusky, Yongling Xiao, Philippe Thompson-Leduc, Marie-Hélène Lafeuille, Patrick Lefebvre & Carmela Benson. (2018) Adherence, persistence, and inpatient utilization among adult schizophrenia patients using once-monthly versus twice-monthly long-acting atypical antipsychotics. Journal of Medical Economics 21:2, pages 135-143.
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Jingping Zhao, Lehua Li, Jianguo Shi, Yi Li, Xiufeng Xu, Keqing Li, Lili Zhang, Shangli Cai, Yu Feng, Jianmin Zhuo, Weihong Liu & Huafei Lu. (2017) Safety and efficacy of paliperidone palmitate 1-month formulation in Chinese patients with schizophrenia: a 25-week, open-label, multicenter, Phase IV study. Neuropsychiatric Disease and Treatment 13, pages 2045-2056.
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Eva G Katz, Brett Hauber, Srihari Gopal, Angie Fairchild, Amy Pugh, Rachel B Weinstein & Bennett S Levitan. (2016) Physician and patient benefit–risk preferences from two randomized long-acting injectable antipsychotic trials. Patient Preference and Adherence 10, pages 2127-2139.
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Andrea de Bartolomeis, Andrea Fagiolini, Marco Vaggi & Claudio Vampini. (2016) Targets, attitudes, and goals of psychiatrists treating patients with schizophrenia: key outcome drivers, role of quality of life, and place of long-acting antipsychotics. Neuropsychiatric Disease and Treatment 12, pages 99-108.
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Thomas R. Einarson, Hanna Pudas, Pushpendra Goswami, Kristel van Impe & Basil G. Bereza. (2016) Pharmacoeconomics of long-acting atypical antipsychotics for acutely relapsed chronic schizophrenia in Finland. Journal of Medical Economics 19:2, pages 121-130.
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Franck Jean Baylé, Arnaud Tessier, Sophie Bouju & David Misdrahi. (2015) Medication adherence in patients with psychotic disorders: an observational survey involving patients before they switch to long-acting injectable risperidone. Patient Preference and Adherence 9, pages 1333-1341.
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Carmela J. Benson, Kruti Joshi, Kate L. Lapane & John Fastenau. (2015) Evaluation of a comprehensive information and assistance program for patients with schizophrenia treated with long-acting injectable antipsychotics. Current Medical Research and Opinion 31:7, pages 1437-1448.
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Francesco Pietrini, Mattia Spadafora, Gabriela Alina Talamba, Lucia Godini, Lorenzo Lelli, Susanna Arcabasso, Mara Manetti & Andrea Ballerini. (2015) The effects of switching from oral to LAI antipsychotic treatment on subjective experience of schizophrenic and schizoaffective patients: Preliminary results. International Journal of Psychiatry in Clinical Practice 19:2, pages 106-113.
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