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Review

Avoiding hypoglycemia: a key to success for glucose-lowering therapy in type 2 diabetes

Pages 155-163 | Published online: 24 Apr 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (20)

Fawaz Albloui, James John, Osama Alghamdi, Faisal Alseraye, Abdullah Alqahtani, Waleed Tamimi, Abdullah Albloshi, Fahad M. Aldakheel, Ayesha Mateen & Rabbani Syed. (2022) Effect of hematocrit, galactose and ascorbic acid on the blood glucose readings of three point-of-care glucometers. Scandinavian Journal of Clinical and Laboratory Investigation 82:7-8, pages 563-570.
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Hirotaka Watada, Toshimasa Yamauchi, Fumiko Yamamoto, Atsushi Taniguchi, Larisa Yarush, Clemens Heilmann & Atsutaka Yasui. (2020) Safety and tolerability of empagliflozin and linagliptin combination therapy in patients with type 2 diabetes mellitus: a pooled analysis of data from five randomized, controlled clinical trials. Expert Opinion on Drug Safety 19:9, pages 1193-1202.
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Nick Freemantle, Didac Mauricio, Andrea Giaccari, Timothy Bailey, Ronan Roussel, Denise Franco, Baptiste Berthou, Valerie Pilorget, Jukka Westerbacka, Zsolt Bosnyak, Mireille Bonnemaire, Anna M. G. Cali, My-Liên Nguyên-Pascal, Alfred Penfornis, Manuel Perez-Maraver, Jochen Seufert, Sean D. Sullivan, John Wilding, Carol Wysham & Melanie Davies. (2020) Real-world outcomes of treatment with insulin glargine 300 U/mL versus standard-of-care in people with uncontrolled type 2 diabetes mellitus. Current Medical Research and Opinion 36:4, pages 571-581.
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Toshinari Asakura, Shuichi Suzuki, Toshihiko Aranishi & Zhihong Cai. (2018) Comparative usability study of the dulaglutide single-use pen versus the insulin degludec FlexTouch® among self-injection-naïve patients with type 2 diabetes mellitus in Japan. Current Medical Research and Opinion 34:6, pages 1117-1124.
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Eric L. Johnson, Juan P. Frias & Jennifer M. Trujillo. (2018) Anticipatory guidance in type 2 diabetes to improve disease management; next steps after basal insulin. Postgraduate Medicine 130:4, pages 365-374.
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Wing Bun Chan, Jung Fu Chen, Su-Yen Goh, Thi Thanh Huyen Vu, Iris Thiele Isip-Tan, Sony Wibisono Mudjanarko, Shailendra Bajpai, Maria Aileen Mabunay & Pongamorn Bunnag. (2017) Challenges and unmet needs in basal insulin therapy: lessons from the Asian experience. Diabetes, Metabolic Syndrome and Obesity 10, pages 521-532.
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Takashi Kadowaki, Kazuoki Kondo, Noriyuki Sasaki, Kyoko Miyayama, Shoko Yokota, Ryuji Terata & Maki Gouda. (2017) Efficacy and safety of teneligliptin add-on to insulin monotherapy in Japanese patients with type 2 diabetes mellitus: a 16-week, randomized, double-blind, placebo-controlled trial with an open-label period. Expert Opinion on Pharmacotherapy 18:13, pages 1291-1300.
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Jodi Strong, Davida Kruger & Lucia Novak. (2017) Insulin glargine 300 units/mL: a guide for healthcare professionals involved in the management of diabetes. Current Medical Research and Opinion 33:4, pages 785-793.
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Kristina Secnik Boye, Sarah E Curtis, Maureen J Lage & Luis-Emilio Garcia-Perez. (2016) Associations between adherence and outcomes among older, type 2 diabetes patients: evidence from a Medicare Supplemental database. Patient Preference and Adherence 10, pages 1573-1581.
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Michał Jakubczyk, Izabela Lipka, Justyna Pawęska, Maciej Niewada, Elżbieta Rdzanek, Jelka Zaletel, Antonio Ramírez de Arellano, Tomáš Doležal, Biljana Chekorova Mitreva, Bence Nagy, Guenka Petrova, Tereza Šarić, John Yfantopoulos & Marcin Czech. (2016) Cost of severe hypoglycaemia in nine European countries. Journal of Medical Economics 19:10, pages 973-982.
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Louise Watson, Romita Das, Ruth Farquhar, Haya Langerman & Anthony H. Barnett. (2016) Consequences of delaying treatment intensification in type 2 diabetes: evidence from a UK database. Current Medical Research and Opinion 32:9, pages 1465-1475.
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Daisuke Yabe & Yutaka Seino. (2016) Alogliptin for the treatment of type 2 diabetes: a drug safety evaluation. Expert Opinion on Drug Safety 15:2, pages 249-264.
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Elizabeth L Eby, Kate Van Brunt, Cynthia Brusko, Bradley Curtis & Maureen J Lage. (2015) Dosing of U-100 insulin and associated outcomes among Medicare enrollees with type 1 or type 2 diabetes. Clinical Interventions in Aging 10, pages 991-1001.
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André J Scheen. (2015) Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes. Expert Opinion on Drug Safety 14:4, pages 505-524.
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André J Scheen. (2015) A review of gliptins for 2014. Expert Opinion on Pharmacotherapy 16:1, pages 43-62.
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Anja Schweizer, Serge Halimi & Sylvie Dejager. (2014) Experience with DPP-4 inhibitors in the management of patients with type 2 diabetes fasting during Ramadan. Vascular Health and Risk Management 10, pages 15-24.
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John B. Buse, Jenny Han, Stephan Miller, Leigh MacConell, Richard Pencek & Matthew Wintle. (2014) Addition of exenatide BID to insulin glargine: a post-hoc analysis of the effect on glycemia and weight across a range of insulin titration. Current Medical Research and Opinion 30:7, pages 1209-1218.
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Karoline von Websky, Christoph Reichetzeder & Berthold Hocher. (2013) Linagliptin as add-on therapy to insulin for patients with type 2 diabetes. Vascular Health and Risk Management 9, pages 681-694.
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Christian Göbl, Micaela Morettini, Benedetta Salvatori, Wathik Alsalim, Hana Kahleova, Bo Ahrén & Andrea Tura. (2022) Temporal Patterns of Glucagon and Its Relationships with Glucose and Insulin following Ingestion of Different Classes of Macronutrients. Nutrients 14:2, pages 376.
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Tatiana Valente & Alberto K. Arbex. (2021) Glycemic Variability, Oxidative Stress, and Impact on Complications Related to Type 2 Diabetes Mellitus. Current Diabetes Reviews 17:7.
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Anders L. Carlson, Lauren M. Huyett, Jay Jantz, Albert Chang, Todd Vienneau & Trang T. Ly. (2021) Improved glycemic control in 3,592 adults with type 2 diabetes mellitus initiating a tubeless insulin management system. Diabetes Research and Clinical Practice 174, pages 108735.
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Ahmed Elshebiny, Hassan Alali, Zainab Alamer, Yasmin Alsultan, Hashim Alkhalaf, Abdullah Alkishi & Mohammed Alsuwaylih. (2021) The incidence of hypoglycemia and its risk factors among diabetic patients in the Eastern Province of Saudi Arabia. International Journal of Medicine in Developing Countries, pages 614-621.
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Amme Mardulate Tshabalala, Adedayo Tunde Ajidahun, Treginah Mkhabela, Phemelo Bapela, Constance Majumane & Tshepo Msimango. (2021) Prevalence and factors associated with fear of hypoglycaemia among adults with Type 1 diabetes mellitus at an academic hospital in South Africa. International Journal of Africa Nursing Sciences 15, pages 100367.
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Takashi Kadowaki, Guang Wang, Julio Rosenstock, Daisuke Yabe, Yongde Peng, Keizo Kanasaki, Yiming Mu, Michaela Mattheus, Annett Keller, Tomoo Okamura, Odd Erik Johansen & Nikolaus Marx. (2020) Effect of linagliptin, a dipeptidyl peptidase-4 inhibitor, compared with the sulfonylurea glimepiride on cardiovascular outcomes in Asians with type 2 diabetes: subgroup analysis of the randomized CAROLINA® trial. Diabetology International 12:1, pages 87-100.
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Sujoy Ghosh & Romik Ghosh. (2020) Glargine-300: An updated literature review on randomized controlled trials and real-world studies. World Journal of Diabetes 11:4, pages 100-114.
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NC Tan, S Goh, EY Khoo, R Dalan, A Koong, CM, Khoo, TS Tan, AB Jain, AV Gadekar & YM Bee. (2020) Self-reported hypoglycaemia in insulin-treated patients with diabetes mellitus: results from the Singapore cohort of the International Operations Hypoglycaemia Assessment Tool study. Singapore Medical Journal 61:3, pages 129-136.
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Koji Nakashima, Nobuhiro Okamura, Hayato Sanefuji & Hideaki Kaneto. (2020) Practical application of short-term intensive insulin therapy based on the concept of “treat to target” to reduce hypoglycaemia in routine clinical site. Scientific Reports 10:1.
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Young-Hoon Lee. (2020) Sociodemographic Factors Associated with Participation in Diabetes Education among Community-Dwelling Adults with Diabetes. Yonsei Medical Journal 61:2, pages 169.
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Gashayeneh Genetu Tiruneh, Nurilign Abebe & Getenet Dessie. (2019) Self-reported hypoglycemia in adult diabetic patients in East Gojjam, Northwest Ethiopia: institution based cross-sectional study. BMC Endocrine Disorders 19:1.
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Johan Farngren & Bo Ahrén. (2019) Incretin-based medications (GLP-1 receptor agonists, DPP-4 inhibitors) as a means to avoid hypoglycaemic episodes. Metabolism 99, pages 25-31.
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Amanda K. Kitten, Meghan Kamath, Laurajo Ryan & Kelly R. Reveles. (2019) National ambulatory care non-insulin antidiabetic medication prescribing trends in the United States from 2009 to 2015. PLOS ONE 14:8, pages e0221174.
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Noor Syaffinaz Noor Mohamad Zin, Nooraain Hashim, Nurdiana Samsulrizal & Nur Syimal'ain Azmi. (2019) The protective effect of Azadirachta excelsa leaves extract and quercetin treatment on the learning and memory impairments in relation with insulin and amylin levels in the brain of streptozotocin-induced diabetic rats. Journal of King Saud University - Science 31:3, pages 299-307.
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Fang L. Zhou, Charlie Nicholls, Lin Xie, Yuexi Wang, Neel Vaidya & Luigi F. Meneghini. (2019) Hypoglycaemia and treatment patterns among insulin‐treated patients with type 2 diabetes who switched to insulin glargine 300 units/mL versus other basal insulin in a real‐world setting. Endocrinology, Diabetes & Metabolism 2:3.
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Luigi F. Meneghini, Didac Mauricio, Emanuela Orsi, Nebojsa M. Lalic, Anna M.G. Cali, Jukka Westerbacka, Peter Stella, Christophe Candelas, DEA, Valerie Pilorget, Riccardo Perfetti & Kamlesh Khunti. (2019) The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes: Achieving HbA1c targets with basal insulin in a real‐world setting. Diabetes, Obesity and Metabolism 21:6, pages 1429-1436.
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H. A. Dissanayake, G. S. P. Keerthisena, K. K. K. Gamage, J. H. Liyanage, I. R. H. S. Ihalagama, W. M. U. A. Wijetunga, T. A. D. Tillekaratne, G. W. Katulanda & P. Katulanda. (2018) Hypoglycaemia in diabetes: do we think enough of the cause? An observational study on prevalence and causes of hypoglycaemia among patients with type 2 diabetes in an out-patient setting in Sri Lanka. BMC Endocrine Disorders 18:1.
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David Nathanson, Ugne Sabale, Jan W. Eriksson, Thomas Nyström, Anna Norhammar, Urban Olsson & Johan Bodegård. (2017) Healthcare Cost Development in a Type 2 Diabetes Patient Population on Glucose-Lowering Drug Treatment: A Nationwide Observational Study 2006–2014. PharmacoEconomics - Open 2:4, pages 393-402.
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