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Original Article

Production and Evaluation of Antibodies for the Radioimmunoassay of Gastrin

, &
Pages 221-232 | Received 22 Mar 1972, Accepted 03 Jun 1972, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (91)

Jens F. Rehfeld, Filip K. Knop & Meena Asmar. (2019) Gastrin secretion in normal subjects and diabetes patients is inhibited by glucagon-like peptide 1: a role in the gastric side effects of GLP-1-derived drugs?. Scandinavian Journal of Gastroenterology 54:12, pages 1448-1451.
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Helge L Waldum, Per M Kleveland & Reidar Fossmark. (2015) Upper gastrointestinal physiology and diseases. Scandinavian Journal of Gastroenterology 50:6, pages 649-656.
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Jens Peter Goetze, Signe Eiland, Lars Bo Svendsen, Ben Vainer, Jens Hannibal & Jens Frederik Rehfeld. (2013) Characterization of gastrins and their receptor in solid human gastric adenocarcinomas. Scandinavian Journal of Gastroenterology 48:6, pages 688-695.
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Jens F. Rehfeld & Peter Ericsson. (2012) Supersensitive gastrin assay using antibodies raised against a cholecystokinin homolog. Scandinavian Journal of Clinical and Laboratory Investigation 72:2, pages 175-179.
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Anders H. Johnsen, Fahed N. Assaad & Jens F. Rehfeld. (2011) Competitive solid-phase immunoassay of gastrin in serum using time-resolved fluorometry. Scandinavian Journal of Clinical and Laboratory Investigation 71:3, pages 216-220.
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Jens F. Rehfeld. (2008) The art of measuring gastrin in plasma: A dwindling diagnostic discipline?. Scandinavian Journal of Clinical and Laboratory Investigation 68:5, pages 353-361.
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Jens Peter Goetze, Lea I. Paloheimo, Auli Linnala, Pentti Sipponen, Carsten Palnæs Hansen & Jens F. Rehfeld. (2005) Gastrin-17 specific antibodies are too specific for gastrinoma diagnosis but stain G-cells. Scandinavian Journal of Gastroenterology 40:5, pages 596-598.
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Flemming Stadil. (2001) The measurement of gastrin. Scandinavian Journal of Clinical and Laboratory Investigation 61:234, pages 129-132.
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H.-J. Monstein, B. Ohlsson, J. Axelson. (2001) Differential Expression of Gastrin, Cholecystokinin-A and Cholecystokinin-B Receptor mRNA in Human Pancreatic Cancer Cell Lines. Scandinavian Journal of Gastroenterology 36:7, pages 738-743.
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M. Wøjdemann, B. Sternby, S. Larsen, O. Olsen. (2000) Cephalic Phase of Lipolysis Is Impaired in Pancreatic Insufficiency: Role of Gastric Lipase. Scandinavian Journal of Gastroenterology 35:2, pages 204-211.
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C. Riber, M. Wøjdemann, T. Bisgaard, H. Ingels, J. F. Rehfeld, O. Olsen. (1999) Fish Oil Reduces Gastric Acid Secretion. Scandinavian Journal of Gastroenterology 34:9, pages 845-848.
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N. R. JØRGENSEN, J. F. REHFELD, L. BARDRAM, L. HILSTED. (1998) Processing-Independent Analysis in the Diagnosis of Gastrinomas. Scandinavian Journal of Gastroenterology 33:4, pages 379-385.
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L. Rasmussen, N. Qvist, E. Øsster-Jørgensen, J. F. Rehfeld, J. J. Holst & S. A. Pedersen. (1997) A Double-Blind Placebo-Controlled Study on the Effects of Omeprazole on Gut Hormone Secretion and Gastric Emptying Rate. Scandinavian Journal of Gastroenterology 32:9, pages 900-905.
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M. Wøjdemann, O. Olsen, S. Larsen, B. Sternby & J. F. Rehfeld. (1997) Deficient Gastric Lipase Secretion in Pancreatic Insufficiency. Scandinavian Journal of Gastroenterology 32:3, pages 268-272.
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K. Borch, M. Stridsberg, P. Burman & J. F. Rehfeld. (1997) Basal Chromogranin a and Gastrin Concentrations in Circulation Correlate to Endocrine Cell Proliferation in Type-A Gastritis. Scandinavian Journal of Gastroenterology 32:3, pages 198-202.
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J. J. Holst, J. Fahrenkrug, F. Stadil & J. F. Rehfeld. (1996) Gastrointestinal Endocrinology. Scandinavian Journal of Gastroenterology 31:sup216, pages 27-38.
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L. Rasmussen, E. øster-Jørgensen, N. Qvist, J. J. Holst, J. F. Rehfeld, C. P. Hovendal & S. A. Pedersen. (1996) The Relationship between Gut Hormone Secretion and Gastric Emptying in Different Phases of the Migrating Motor Complex. Scandinavian Journal of Gastroenterology 31:5, pages 458-462.
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J. M. Götz, R. A. Veenendaal, I. Biemond, E. S. M. Muller, M. Veselî & C. B. H. W. Lamers. (1995) Serum Gastrin and Mucosal Somatostatin in Helicobacter pylori-Associated Gastritis. Scandinavian Journal of Gastroenterology 30:11, pages 1064-1068.
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L. Vinter-Jensen, C. Orloff Juhl, J. F. Rehfeld, S. Seier Poulsen, E. Z. Dajani & E. Nexo. (1995) Chronic Systemic Treatment with Epidermal Growth Factor Induces Hypergastrinaemia in Goettingen Minipigs. Scandinavian Journal of Gastroenterology 30:5, pages 422-427.
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J. F. Rehfeld. (1994) The Molecular Nature of Cholecystokinin in Plasma: An in vivo Immunosorption Study in Rabbits. Scandinavian Journal of Gastroenterology 29:2, pages 110-121.
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J. P. Gøtze & J. F. Rehfeld. (1994) Displaced chromatographic elution of gastrin-17 in normal human serum. Scandinavian Journal of Clinical and Laboratory Investigation 54:8, pages 673-676.
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D. Y. Graham, M. F. Go, G. M. Lew, R. M. Genta & J. F. Rehfeld. (1993) Helicobacter pylori Infection and Exaggerated Gastrin Release: Effects of Inflammation and Progastrin Processing. Scandinavian Journal of Gastroenterology 28:8, pages 690-694.
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Linda Bardram. (1990) Progastrin in Pancreas and the Zollinger-Ellison Syndrome. Scandinavian Journal of Gastroenterology 25:12, pages 1185-1195.
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L. Bardram. (1990) Gastrin in Non-Neoplastic Pancreatic Tissue from Patients with and without Gastrinomas. Scandinavian Journal of Gastroenterology 25:9, pages 935-943.
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P. Cantor, M. Boye Petersen, J. Christiansen & J. F. Rehfeld. (1990) Does Sulfation of Gastrin Influence Gastric Acid Secretion in Man?. Scandinavian Journal of Gastroenterology 25:7, pages 739-745.
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M. Sjövall, L. Lundell, J. F. Rehfeld & L. Olbe. (1989) Studies of the Release of Gastrin from the Human Duodenum Induced by Gastrin-Releasing Peptide. Scandinavian Journal of Gastroenterology 24:4, pages 445-453.
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L. Bardram & F. Stadil. (1989) Effects of Omeprazole on Acid Secretion and Acid-Related Symptoms in Patients with Zollinger-Ellison Syndrome. Scandinavian Journal of Gastroenterology 24:sup166, pages 95-100.
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L. Bardram & J. F. Rehfeld. (1989) Production and evaluation of monospecific antibodies for a processing-independent sequence of human progastrin. Scandinavian Journal of Clinical and Laboratory Investigation 49:2, pages 173-182.
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J. Poulsen, N. A. Lovgreen & E. Amdrup. (1986) Fasting and Food-Stimulated Serum Gastrin Concentration in 151 Duodenal Ulcer Patients and 41 Non-Dyspeptic Volunteers: Significant Sex Differences. Scandinavian Journal of Gastroenterology 21:7, pages 881-885.
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L. Bardram & F. Stadil. (1986) Omeprazole in the Zollinger-Ellison Syndrome. Scandinavian Journal of Gastroenterology 21:3, pages 374-378.
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K. Borch, H. Renvall, G. Liedberg & B. N. Andersen. (1986) Relations between Circulating Gastrin and Endocrine Cell Proliferation in the Atrophic Gastric Fundic Mucosa. Scandinavian Journal of Gastroenterology 21:3, pages 357-363.
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Helge L. Waldum & Per M. Kleveland. (1986) Gastrointestinal Regulatory Peptides: Radioimmunoassay and Biological Activity. Scandinavian Journal of Gastroenterology 21:9, pages 1025-1028.
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Oli Jacobsen, Linda Bardram & Jens F. Rehfeld. (1986) The requirement for gastrin measurements. Scandinavian Journal of Clinical and Laboratory Investigation 46:5, pages 423-426.
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A. P. N. Majumdar & H. Nielsen. (1985) Influence of Glucocorticoids on Prenatal Development of the Gut and Pancreas in Rats. Scandinavian Journal of Gastroenterology 20:1, pages 65-71.
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K. C. Christensen. (1984) Specific Beta-Adrenergic Mechanisms in the Hypoglycaemic Activation of Gastrin and Gastric Acid Secretion. Scandinavian Journal of Gastroenterology 19:3, pages 339-342.
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L. A. Christiansen. (1984) The Metabolism of Gastrin-34, Gastrin-17, and Gastrin-14 in the Isolated Perfused Pig Liver. Scandinavian Journal of Gastroenterology 19:2, pages 131-138.
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B. Petersen. (1984) Abnormally processed gastrins in active duodenal ulcer disease. Scandinavian Journal of Clinical and Laboratory Investigation 44:sup168, pages 25-44.
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B. Petersen, J. Steen & J. Christiansen. (1983) Variations in the Release of the NH2-Terminal Fragment of Gastrin-17 in the Course of Duodenal Ulcer Disease. Scandinavian Journal of Gastroenterology 18:8, pages 1101-1107.
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B. Petersen & B. Nyboe Andersen. (1983) Increased Concentrations of the NH2-Terminal Fragment of Gastrin-17 in Acute Duodenal Ulcer and Acute Gastritis. Scandinavian Journal of Gastroenterology 18:5, pages 635-641.
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B. Petersen. (1983) Metabolism of the NH2-Terminal Tridecapeptide of Gastrin-17 in Normal Subjects and Duodenal Ulcer Patients. Scandinavian Journal of Gastroenterology 18:5, pages 613-617.
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B. Nyboe Andersen, B. Petersen, K. Borch & J. F. Rehfeld. (1983) Variations in the Sulfation of Circulating Gastrins in Gastrointestinal Diseases. Scandinavian Journal of Gastroenterology 18:4, pages 565-569.
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J. Steen & L. Westergaard. (1983) Gastrin and Gastrointestinal Dyspepsia in Pregnancy. Acta Obstetricia et Gynecologica Scandinavica 62:2, pages 155-156.
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P. Kirkegaard, B. Petersen, P. Skov Olsen, S. S. Poulsen & J. Christiansen. (1982) The Mechanism of Gastrin Release in Cysteamine-Induced Duodenal Ulcer. Scandinavian Journal of Gastroenterology 17:5, pages 609-612.
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P. Kirkegaard, J. Christiansen, B. Petersen & P. Skov Olsen. (1982) Calcium and Stimulus-Secretion Coupling in Gastric Fundic Mucosa. Scandinavian Journal of Gastroenterology 17:4, pages 533-538.
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J. Steen, N. Steen, M. Herning & P. M. Christiansen. (1982) Basal Serum Gastrin Concentration Related to Complications, Blood Groups, and Season in Duodenal Ulcer. Scandinavian Journal of Gastroenterology 17:4, pages 529-532.
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Örjan Selking, K. Borch, H. Johansson, S. Ljunghall & L. Wide. (1982) Evaluation of Parathyroid Function in Patients with Hypergastrinaemia and Pernicious Anaemia. Upsala Journal of Medical Sciences 87:3, pages 215-222.
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H. F. Helander, G. Liedberg & J. F. Rehfeld. (1982) Quantitative Electron Microscopical Studies of Parietal Cells after Antral Exclusion in the Rat. Scandinavian Journal of Gastroenterology 17:1, pages 141-143.
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L. A. Christiansen, S. Keiding & K. Winkler. (1982) Hepatic Elimination of Endogenous Gastrin in Pigs. Scandinavian Journal of Gastroenterology 17:1, pages 113-120.
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B. Petersen, J. H. Henriksen, J. F. Rehfeld & J. Christiansen. (1981) Removal of Endogenous Gastrin in Man. Scandinavian Journal of Gastroenterology 16:6, pages 727-730.
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B. Petersen, J. Christiansen & J. F. Rehfeld. (1981) Acid Secretory Potency and Elimination of the 15-Leucine Gastrin-17 Analogue in Man. Scandinavian Journal of Gastroenterology 16:3, pages 437-440.
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H. Overgaard Nielsen, K. Lauritsen & L. A. Christiansen. (1981) The Human Stomach after Antrectomy. Scandinavian Journal of Gastroenterology 16:3, pages 353-356.
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Jens F. Rehfeld. (1981) A unique high-titer antiserum to gastrin. Scandinavian Journal of Clinical and Laboratory Investigation 41:8, pages 723-727.
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J. Steen, M. Herning, P. M. Christiansen & J. F. Rehfeld. (1980) Relationship Between Basal Serum Gastrin Concentrations and Gastric Acid Secretion in Peptic Ulcer Disease. Scandinavian Journal of Gastroenterology 15:8, pages 949-952.
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H. Overgaard Nielsen, P. E. Rørbák Madsen & L. A. Christiansen. (1980) The Parietal Cells in Duodenal Ulcer Patients. Scandinavian Journal of Gastroenterology 15:7, pages 793-797.
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L. A. Christiansen & S. Lindkaer Jensen. (1980) Gastrin Release in Pigs during Intestinal Pouch Stimulation with Meat Extract. Scandinavian Journal of Gastroenterology 15:5, pages 577-580.
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H. L. Waldum & P. G. Burhol. (1980) The Effect of Somatostatin on Serum Group I Pepsinogens (PG I), Serum Gastrin, and Gastric H+ and Pepsin Secretion in Man. Scandinavian Journal of Gastroenterology 15:4, pages 425-431.
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B. Petersen & J. F. Rehfeld. (1980) The NH2-Terminal Tridecapeptide Fragment of Gastrin-17 in Serum from Duodenal Ulcer Patients. Scandinavian Journal of Gastroenterology 15:1, pages 29-31.
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F. W. Henriksen, L. A. Christiansen & F. Stadil. (1979) Serum Disappearance Rate of Gastrin-17 after Vagotomy. Scandinavian Journal of Gastroenterology 14:7, pages 791-796.
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H. L. Waldum, P. G. Burhol & B. K. Straume. (1979) Serum Group I Pepsinogens During Prolonged Infusion of Pentagastrin and Secretin in Man. Scandinavian Journal of Gastroenterology 14:6, pages 761-768.
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B. Stenquist, G. Nilsson, J. F. Rehfeld & L. Olbe. (1979) Plasma Gastrin Concentrations following Sham Feeding in Duodenal Ulcer Patients. Scandinavian Journal of Gastroenterology 14:3, pages 305-311.
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P. Hesselfeldt, J. Christiansen, J. F. Rehfeld & O. Backer. (1979) Meal-stimulated Gastric Acid and Gastrin Secretion before and after Jejuno-ileal Shunt Operation in Obese Patients. Scandinavian Journal of Gastroenterology 14:1, pages 13-16.
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V. Kruse. (1979) Dissociation rate constants and fractional binding of tracer estimated for three antibody populations in unstripped and stripped antiserum. Scandinavian Journal of Clinical and Laboratory Investigation 39:3, pages 215-221.
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H. L. Waldum, P. G. Burhol & B. K. Straume. (1978) Serum Group I Pepsinogens and Gastrin in Relation to Gastric H+ and Pepsin Outputs before and after Subcutaneous Injection of Pentagastrin. Scandinavian Journal of Gastroenterology 13:8, pages 943-946.
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G. Bodemar, A. Walan & G. Lundquist. (1978) Food-Stimulated Acid Secretion Measured by Intragastric Titration with Bicarbonate in Patients with Duodenal and Gastric Ulcer Disease and in Controls. Scandinavian Journal of Gastroenterology 13:8, pages 911-918.
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R. Stave, D. Gedde-Dahl & E. Gjone. (1978) Fasting and Food-stimulated Serum Gastrin Concentrations in Relation to the Antral G-cell Population. Scandinavian Journal of Gastroenterology 13:7, pages 845-849.
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F. B. Loud, D. Froberg, J. Reichardt, J. J. Holst, J. F. Rehfeld & J. Christiansen. (1978) Inhibition of Meal-stimulated Gastric Acid Secretion in Man by Exogenous and Endogenous Pancreatic Glucagon. Scandinavian Journal of Gastroenterology 13:7, pages 795-798.
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L. A. Christiansen, S. Lindkaer Jensen, J. F. Rehfeld, F. Stadil & K. C. Christensen. (1978) Antral Content and Secretion of Gastrins in Pigs. Scandinavian Journal of Gastroenterology 13:6, pages 719-725.
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J. G. Stage, F. Stadil, J. F. Rehfeld, J. Fahrenkrug & O. B. Schaffalitzky De Muckadell. (1978) Secretin and the Zollinger-Ellison Syndrome: Reliability of Secretin Tests and Pathogenetic Role of Secretin. Scandinavian Journal of Gastroenterology 13:4, pages 501-511.
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K. C. Christensen, F. Stadil, J. Malmström & J. F. Rehfeld. (1978) The Effect of Beta-Adrenergic and Cholinergic Blockade on the Circadian Rhythm of Gastrins in Serum. Scandinavian Journal of Gastroenterology 13:3, pages 263-272.
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L.-I. Larsson, J. F. Rehfeld & N. Goltermann. (1977) Gastrin in the Human Fetus. Scandinavian Journal of Gastroenterology 12:7, pages 869-872.
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H. A. El Munshid, F. Sundler & R. Håkanson. (1977) Effects of Bilateral Nephrectomy on Endocrine Cells of Rat Stomach. Scandinavian Journal of Gastroenterology 12:7, pages 849-856.
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L. Grimelius, H. Johansson, G. Lundqvist, A. Olazabal, J. H. Polak & A. G. E. Pearse. (1977) The Parathyroid Glands in Experimentally Induced Hypergastrinemia in the Rat. Scandinavian Journal of Gastroenterology 12:6, pages 739-744.
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R. Stockbrügger, L. Angervall & G. Lundqvist. (1976) Serum Gastrin and Atrophic Gastritis in Achlorhydric Patients with and without Pernicious Anemia. Scandinavian Journal of Gastroenterology 11:7, pages 713-719.
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J. Christiansen, J. F. Rehfeld & F. Stadil. (1976) Effect of Intrajejunal Fat on Meal-stimulated Acid and Gastrin Secretion in Man. Scandinavian Journal of Gastroenterology 11:7, pages 673-676.
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S. Asnæs, B. Bjerregaard, J. Malmström, O. H. Hansen, F. Hardt & Aa. Johansen. (1976) Antral Gastrin Cells. Scandinavian Journal of Gastroenterology 11:5, pages 471-474.
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F. Stadil, J. F. Rehfeld, L. A. Christiansen & J. Malmström. (1975) Patterns of Gastrin Components in Serum during Feeding in Normal Subjects and Duodenal Ulcer Patients. Scandinavian Journal of Gastroenterology 10:8, pages 863-868.
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J. Malmström & F. Stadil. (1975) Measurement of Immunoreactive Gastrin in Gastric Mucosa. Scandinavian Journal of Gastroenterology 10:4, pages 433-439.
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O. Kronborg, T. Pedersen, F. Stadil & J. F. Rehfeld. (1974) The Effect of Beta-Adrenergic Blockade upon Gastric Acid Secretion and Gastrin Secretion during Hypoglycaemia before and after Vagotomy. Scandinavian Journal of Gastroenterology 9:2, pages 173-176.
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F. Stadil & J. F. Rehfeld. (1974) Effect of Insulin Injection on Serum Gastrin Concentrations in Duodenal Ulcer Patients and Normal Subjects. Scandinavian Journal of Gastroenterology 9:2, pages 143-147.
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Dagfinn Gedde-Dahl. (1974) Radioimmunoassay of Gastrin. Fasting Serum Levels in Humans with Normal and High Gastric Acid Secretion. Scandinavian Journal of Gastroenterology 9:1, pages 41-47.
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Henry Johansson, Urban Krause, Folke Nilsson & Gudmar Lundqvist. (1974) The Influence of Hypercalcemia on Gastric Secretion and Serum Gastrin Concentration in Intact and Thyro-parathyroidectomized Rats. Upsala Journal of Medical Sciences 79:3, pages 161-163.
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Henry Johansson, Bengt Furberg, Urban Krause, Gudmar Lundqvist & Åke Rimsten. (1974) Gastric Secretion in Hyperparathyroid Subjects before and after Parathyroid Surgery. Upsala Journal of Medical Sciences 79:3, pages 155-160.
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Jens F. Rehfeld. (1973) Gastrins in Serum. Scandinavian Journal of Gastroenterology 8:7, pages 577-583.
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O. Kronborg, F. Stadil, J. Rehfeld & P. M. Christiansen. (1973) Relationship between Serum Gastrin Concentrations and Gastric Acid Secretion in Duodenal Ulcer Patients before and after Selective and Highly Selective Vagotomy. Scandinavian Journal of Gastroenterology 8:6, pages 491-496.
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J. F. Rehfeld & F. Stadil. (1973) Radioimmunoassay for Gastrin Employing Immunosorbent. Scandinavian Journal of Clinical and Laboratory Investigation 31:4, pages 459-464.
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F. Stadil & J. F. Rehfeld. (1972) Hypoglycaemic Release of Gastrin in Man. Scandinavian Journal of Gastroenterology 7:6, pages 509-514.
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F. Stadil & J. F. Rehfeld. (1972) Preparation of 125I-Labelled Synthetic Human Gastrin I for Radioimmunoanalysis. Scandinavian Journal of Clinical and Laboratory Investigation 30:4, pages 361-368.
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C B H Lamers & J H M Van Tongeren. (1979) Postprandial serum gastrin levels in patients with combined hypergastrinaemia and hyperchlorhydria. British Journal of Surgery 66:8, pages 547-549.
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J Malmstrøm, F Stadil & K C Christensen. (1977) Effect of truncal vagotomy on gastroduodenal content of gastrin. British Journal of Surgery 64:1, pages 34-38.
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F Stadil, J F Rehfeld, P M Christiansen & O Kronborg. (1974) Gastrin response to food in duodenal ulcer patients before and after selective or highly selective vagotomy. British Journal of Surgery 61:11, pages 884-888.
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