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Research Article

Synthesis of new N,N′-bis[1-aryl-3-(piperidine-1-yl)propylidene]hydrazine dihydrochlorides and evaluation of their cytotoxicity against human hepatoma and breast cancer cells

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Pages 420-426 | Received 05 Mar 2013, Accepted 10 Apr 2013, Published online: 16 Jul 2013

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Read on this site (5)

Elif Unluer, Halise Inci Gul, Alkan Demirtas, Hiroshi Sakagami, Naoki Umemura, Muhammet Tanc, Cavit Kazaz & Claudiu T. Supuran. (2016) Synthesis and bioactivity studies of 1-aryl-3-(2-hydroxyethylthio)-1-propanones. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 105-109.
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Halise Inci Gul, Zehra Yazici, Muhammet Tanc & Claudiu T. Supuran. (2016) Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1540-1544.
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Dilan Ozmen Ozgun, Cem Yamali, Halise Inci Gul, Parham Taslimi, Ilhami Gulcin, Telat Yanik & Claudiu T. Supuran. (2016) Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1498-1501.
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Halise Inci Gul, Mehtap Tugrak & Hiroshi Sakagami. (2016) Synthesis of some acrylophenones with N-methylpiperazine and evaluation of their cytotoxicities. Journal of Enzyme Inhibition and Medicinal Chemistry 31:1, pages 147-151.
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Ibrahim A. Al-Suwaidan, Naglaa I. Abdel-Aziz, Adel S. El-Azab, Magda A.-A. El-Sayed, Amer M. Alanazi, Mahmoud B. El-Ashmawy & Alaa A.-M. Abdel-Aziz. (2015) Antitumor evaluation and molecular docking study of substituted 2-benzylidenebutane-1,3-dione, 2-hydrazonobutane-1,3-dione and trifluoromethyl-1H-pyrazole analogues. Journal of Enzyme Inhibition and Medicinal Chemistry 30:4, pages 679-687.
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Articles from other publishers (6)

M. Thirunavukkarasu, P. Prabakaran, A. Saral, Naiyf S. Alharbi, Shine Kadaikunnan, Aleksandr S. Kazachenko & S. Muthu. (2023) Molecular level solvent interaction (microscopic), electronic, covalent assembly (RDG, AIM & ELF), ADMET prediction and anti-cancer activity of 1-(4-Fluorophenyl)-1-propanone): Cytotoxic agent. Journal of Molecular Liquids 380, pages 121714.
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K. Kucukoglu, H. I. Gul & H. Sakagami. (2020) Evaluation of Cytotoxic Properties of N,N'-bis[(1-aryl-3-heteroaryl)propylidene]-hydrazine dihydrochlorides. Pharmaceutical Chemistry Journal 54:8, pages 784-787.
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Marco Mellado, Rafaela Sariego-Kluge, César González, Katy Díaz, Luis F. Aguilar & Manuel A. Bravo. (2020) Systematic study of the fluorescent properties of cinnamaldehyde phenylhydrazone and its interactions with metals: Synthesis and photophysical evaluation. Journal of Molecular Structure 1217, pages 128430.
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Halise Inci Gul, Mehtap Tugrak, Mustafa Gul, Sertac Mazlumoglu, Hiroshi Sakagami, Ilhami Gulcin & Claudiu T. Supuran. (2019) New phenolic Mannich bases with piperazines and their bioactivities. Bioorganic Chemistry 90, pages 103057.
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Kaan Kucukoglu, Halise Inci Gul, Parham Taslimi, Ilhami Gulcin & Claudiu T. Supuran. (2019) Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes. Bioorganic Chemistry 86, pages 316-321.
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Kaan Kucukoglu, Mustafa Gul, Halise Inci Gul, Rengul Cetin-Atalay & Bernard Geny. (2018) Cytotoxicities of novel hydrazone compounds with pyrrolidine moiety: inhibition of mitochondrial respiration may be a possible mechanism of action for the cytotoxicity of new hydrazones. Medicinal Chemistry Research 27:9, pages 2116-2124.
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