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Research Article

Synthesis and carbonic anhydrase inhibitory properties of amino acid – coumarin/quinolinone conjugates incorporating glycine, alanine and phenylalanine moieties

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Pages 1198-1202 | Received 13 Oct 2015, Accepted 23 Oct 2015, Published online: 19 Nov 2015

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Claudiu T. Supuran. (2020) Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery. Expert Opinion on Drug Discovery 15:6, pages 671-686.
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Hasan Küçükbay, Zeynep Gönül, F. Zehra Küçükbay, Andrea Angeli, Gianluca Bartolucci & Claudiu T. Supuran. (2020) Preparation, carbonic anhydrase enzyme inhibition and antioxidant activity of novel 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives incorporating mono or dipeptide moiety. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1021-1026.
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Hasan Küçükbay, Nesrin Buğday, F. Zehra Küçükbay, Andrea Ageli, Gianluca Bartolucci & Claudiu T. Supuran. (2020) Synthesis and human carbonic anhydrase I, II, VA, and XII inhibition with novel amino acid–sulphonamide conjugates. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 489-497.
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Alessio Nocentini & Claudiu T. Supuran. (2019) Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery. Expert Opinion on Drug Discovery 14:11, pages 1175-1197.
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Deniz Üzeroğlu Payaz, F. Zehra Küçükbay, Hasan Küçükbay, Andrea Angeli & Claudiu T. Supuran. (2019) Synthesis carbonic anhydrase enzyme inhibition and antioxidant activity of novel benzothiazole derivatives incorporating glycine, methionine, alanine, and phenylalanine moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 343-349.
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E. Nazarshodeh, R. Sheikhpour, S. Gharaghani & M. A. Sarram. (2018) A novel proteochemometrics model for predicting the inhibition of nine carbonic anhydrase isoforms based on supervised Laplacian score and k-nearest neighbour regression. SAR and QSAR in Environmental Research 29:6, pages 419-437.
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F. Zehra Küçükbay, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran. (2016) Synthesis and carbonic anhydrase I, II, IV and XII inhibitory properties of N-protected amino acid – sulfonamide conjugates. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1476-1483.
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Fiby N. Takla, Sumera Zaib, Waleed A. Bayoumi, Kiran Shehzadi, Shahenda M. El-Messery, Sharjeel Anjum, Amir Faisal & Magda N.A. Nasr. (2023) Targeting Carbonic Anhydrases II/ IX/ XII with Novel Series of Coumarin-Based Compounds: Synthesis, Biological Activity and Molecular Dynamics Analysis. Journal of Molecular Structure, pages 137277.
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Mariangela Agamennone, Marialuigia Fantacuzzi, Simone Carradori, Anél Petzer, Jacobus P. Petzer, Andrea Angeli, Claudiu T. Supuran & Grazia Luisi. (2022) Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl Appendages: In Vitro and Computational Studies. Molecules 27:22, pages 7884.
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Hasan Küçükbay, Zeynep Gönül, Fatümetüzzehra Zehra Küçükbay, Zehra Tekin, Andrea Angeli, Gianluca Bartolucci, Claudiu T. Supuran, Eray Tatlıcı, Elif Apohan & Özfer Yeşilada. (2021) Synthesis of new 7‐amino‐3,4‐dihydroquinolin‐2(1 H )‐one‐peptide derivatives and their carbonic anhydrase enzyme inhibition, antioxidant, and cytotoxic activities . Archiv der Pharmazie 354:11.
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Maharajan Abirami, Senniappan Thamarai Selvi & Vetrivel Nadaraj. (2021) Microwave Irradiation: Synthesis and Characterization of Substituted Pyranoquinolines. Letters in Organic Chemistry 18:2, pages 156-159.
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Claudiu T. Supuran. 2021. New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications. New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications 115 131 .
Muthu Suresh, Vadivel Siva, Sultan Asath Bahadur & Shunmuganarayanan Athimoolam. (2020) Structural elucidation, hydrogen bonding motifs and solid state properties of p-toluenesulfonate salt of β-alaninine for optoelectronic device application. Journal of Molecular Structure 1221, pages 128820.
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Lokesh Kumar, Kashmiri Lal, Pinki Yadav, Ashwani Kumar & Avijit Kumar Paul. (2020) Synthesis, characterization, α-glucosidase inhibition and molecular modeling studies of some pyrazoline-1H-1,2,3-triazole hybrids. Journal of Molecular Structure 1216, pages 128253.
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Tarek S. Ibrahim, Israa A. Seliem, Siva S. Panda, Amany M. M. Al-Mahmoudy, Zakaria K. M. Abdel-Samii, Nabil A. Alhakamy, Hani Z. Asfour & Mohamed Elagawany. (2020) An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry. Molecules 25:11, pages 2501.
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Razieh Sheikhpour, Sajjad Gharaghani & Elmira Nazarshodeh. (2020) Sparse feature selection in multi-target modeling of carbonic anhydrase isoforms by exploiting shared information among multiple targets. Chemometrics and Intelligent Laboratory Systems 200, pages 104000.
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Ashraf Farouq Wasfy, Aly A. Aly, Mohamed S. Behalo & Noura S. Mohamed. (2019) Synthesis of novel phthalazine derivatives as pharmacological activities. Journal of Heterocyclic Chemistry 57:1, pages 12-25.
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Kartsev, Geronikaki, Bua, Nocentini, Petrou, Lichitsky, Frasinyuk, Leitans, Kazaks, Tars & Supuran. (2019) Extending the Inhibition Profiles of Coumarin-Based Compounds Against Human Carbonic Anhydrases: Synthesis, Biological, and In Silico Evaluation. Molecules 24:19, pages 3580.
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Murat Boztas, Parham Taslimi, Mirali Akbar Yavari, Ilhami Gulcin, Ertan Sahin & Abdullah Menzek. (2019) Synthesis and biological evaluation of bromophenol derivatives with cyclopropyl moiety: Ring opening of cyclopropane with monoester. Bioorganic Chemistry 89, pages 103017.
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Hasan Küçükbay, Nesrin Buğday, F. Zehra Küçükbay, Emanuela Berrino, Gianluca Bartolucci, Sonia Del Prete, Clemente Capasso & Claudiu T. Supuran. (2019) Synthesis and carbonic anhydrase inhibitory properties of novel 4-(2-aminoethyl)benzenesulfonamide-dipeptide conjugates. Bioorganic Chemistry 83, pages 414-423.
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Claudiu T. Supuran & Andrea Scozzafava. 2019. Carbonic Anhydrases. Carbonic Anhydrases 245 255 .
Claudiu T. Supuran, Vincenzo Alterio, Anna Di Fiore, Katia D’ Ambrosio, Fabrizio Carta, Simona Maria Monti & Giuseppina De Simone. (2018) Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one. Medicinal Research Reviews 38:6, pages 1799-1836.
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Niccolò Chiaramonte, Maria Romanelli, Elisabetta Teodori & Claudiu Supuran. (2018) Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors. Metabolites 8:2, pages 36.
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Aikaterini Peperidou, Silvia Bua, Murat Bozdag, Dimitra Hadjipavlou-Litina & Claudiu Supuran. (2018) Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX. Molecules 23:1, pages 153.
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