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COPD: Journal of Chronic Obstructive Pulmonary Disease Volume 12, 2015 - Issue 3
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Original Research

Ventilation Distribution Heterogeneity at Rest as a Marker of Exercise Impairment in Mild-to-Advanced COPD

J. Alberto NederRespiratory Investigation Unit, Queen's University & Kingston General Hospital, Kingston, Ontario, Canada;Division of Respiratory and Critical Care Medicine, Queen's University & Kingston General Hospital, Kingston, Ontario, Canada
,
Conor D.J. O’DonnellRespiratory Investigation Unit, Queen's University & Kingston General Hospital, Kingston, Ontario, Canada
,
Julia CoryRespiratory Investigation Unit, Queen's University & Kingston General Hospital, Kingston, Ontario, Canada
,
Daniel LangerRespiratory Investigation Unit, Queen's University & Kingston General Hospital, Kingston, Ontario, Canada
,
Casey E. CiavagliaRespiratory Investigation Unit, Queen's University & Kingston General Hospital, Kingston, Ontario, Canada
,
Y. LingRespiratory Investigation Unit, Queen's University & Kingston General Hospital, Kingston, Ontario, Canada
,
Katherine A. WebbRespiratory Investigation Unit, Queen's University & Kingston General Hospital, Kingston, Ontario, Canada
&
Denis E. O’DonnellRespiratory Investigation Unit, Queen's University & Kingston General Hospital, Kingston, Ontario, Canada;Division of Respiratory and Critical Care Medicine, Queen's University & Kingston General Hospital, Kingston, Ontario, CanadaCorrespondence[email protected]
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Pages 252-259 | Published online: 17 Sep 2014

Citations (30)

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Read on this site (6)

J. Alberto Neder, Juan P. de Torres & Denis E. O’Donnell. (2021) Recent Advances in the Physiological Assessment of Dyspneic Patients with Mild COPD. COPD: Journal of Chronic Obstructive Pulmonary Disease 18:3, pages 374-384.
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Weigang Dong, Yan Du & Shuping Ma. (2018) Impact of chemotherapy in the prognosis of non-small-cell lung cancer patients with severe to very severe COPD. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 3805-3812.
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Rogelio Perez-Padilla, Fernando C Wehrmeister, Maria Montes de Oca, Maria Victorina Lopez, Jose R Jardim, Adriana Muiño, Gonzalo Valdivia & Ana Maria B Menezes. (2018) Outcomes for symptomatic non-obstructed individuals and individuals with mild (GOLD stage 1) COPD in a population based cohort. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 3549-3561.
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Norihito Omote, Naozumi Hashimoto, Masahiro Morise, Koji Sakamoto, Shinichi Miyazaki, Akira Ando, Yoshio Nakahara & Yoshinori Hasegawa. (2017) Impact of mild to moderate COPD on feasibility and prognosis in non-small cell lung cancer patients who received chemotherapy. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 3541-3547.
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Suneela Zaigham, Per Wollmer & Gunnar Engström. (2017) The Association of Lung Clearance Index with COPD and FEV1 Reduction in ‘Men Born in 1914’. COPD: Journal of Chronic Obstructive Pulmonary Disease 14:3, pages 324-329.
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Amany F. Elbehairy, Azmy Faisal, Jordan A. Guenette, Dennis Jensen, Katherine A. Webb, Rashid Ahmed, J. Alberto Neder & Denis E. O'Donnell. (2017) Resting Physiological Correlates of Reduced Exercise Capacity in Smokers with Mild Airway Obstruction. COPD: Journal of Chronic Obstructive Pulmonary Disease 14:3, pages 267-275.
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Articles from other publishers (24)

Paola Rogliani, Dejan Radovanovic, Josuel Ora, Nadia Starc, Stefano Verri, Elena Pistocchini & Luigino Calzetta. (2023) Assessing the relationship between cardiovascular and small airway disease and acute events in COPD: The ARCADIA study protocol. Pulmonary Pharmacology & Therapeutics 82, pages 102231.
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Larisa D. Kiryukhina, Elena V. Kokorina, Pavel V. Gavrilov, Nina V. Denisova, Liudmila I. Archakova & Petr K. Yablonskiy. (2023) Gas Exchange in Patients with Pulmonary Tuberculosis: Relationships with Pulmonary Poorly Communicating Fraction and Alveolar Volume. Journal of Respiration 3:2, pages 107-117.
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O. I. Savushkina, A. V. Fokin, L. U. Komolova & A. A. Zaytsev. (2022) The role of functional tests in the diagnosis of paresis of the diaphragm. Clinical Medicine (Russian Journal) 100:6, pages 310-313.
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O. I. Savushkina & A. V. Cherniak. (2022) Methods for diagnosing dysfunction of small airways and uniformity of lung ventilation: their use after a novel coronavirus infection. Bulletin Physiology and Pathology of Respiration 1:84, pages 137-143.
Crossref
J. Alberto Neder, Danilo C. Berton, Devin B. Phillips & Denis E. O'Donnell. (2021) Exertional ventilation/carbon dioxide output relationship in COPD: from physiological mechanisms to clinical applications. European Respiratory Review 30:161, pages 200190.
Crossref
Devin B. Phillips, Matthew D. James, Amany F. Elbehairy, Kathryn M. Milne, Sandra G. Vincent, Nicolle J. Domnik, Juan P. de‐Torres, J. Alberto Neder & Denis E. O'Donnell. (2021) Reduced exercise tolerance in mild chronic obstructive pulmonary disease: The contribution of combined abnormalities of diffusing capacity for carbon monoxide and ventilatory efficiency. Respirology.
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Roberta Pisi, Marina Aiello, Luigino Calzetta, Annalisa Frizzelli, Veronica Alfieri, Giuseppina Bertorelli, Giovanna Pisi & Alfredo Chetta. (2021) Ventilation Heterogeneity in Asthma and COPD: The Value of the Poorly Communicating Fraction as the Ratio of Total Lung Capacity to Alveolar Volume. Respiration 100:5, pages 404-410.
Crossref
J. Alberto Neder, Danilo C. Berton & Denis E. O'Donnell. (2020) The Lung Function Laboratory to Assist Clinical Decision-making in Pulmonology. Chest 158:4, pages 1629-1643.
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J. Alberto Neder, Juan P. de-Torres, Kathryn M. Milne & Denis E. O'Donnell. (2020) Lung Function Testing in Chronic Obstructive Pulmonary Disease. Clinics in Chest Medicine 41:3, pages 347-366.
Crossref
Weigang Dong, Yaqian Zhu, Yan Du, Lina Wang, Xue Feng & Shuping Ma. (2020) Impact of severe‐to‐very severe chronic obstructive pulmonary disease on the prognosis of patients with non‐small cell lung cancer who received chemotherapy. The Clinical Respiratory Journal 14:4, pages 345-352.
Crossref
José Alberto Neder, Danilo Cortozi Berton & Denis E O’Donnell. (2020) Integrating measurements of pulmonary gas exchange to answer clinically relevant questions. Jornal Brasileiro de Pneumologia 46:1.
Crossref
Amany F. Elbehairy, Conor D. O'Donnell, Asmaa Abd Elhameed, Sandra G. Vincent, Kathryn M. Milne, Matthew D. James, Katherine A. Webb, J. Alberto Neder & Denis E. O’Donnell. (2019) Low resting diffusion capacity, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease. Journal of Applied Physiology 127:4, pages 1107-1116.
Crossref
Surya P. Bhatt, Sandeep Bodduluri, Vrishank Raghav, Nirav R. Bhakta, Carla G. Wilson, Young-il Kim, Michael Eberlein, Frank C. Sciurba, MeiLan K. Han, Mark T. Dransfield & Arie Nakhmani. (2019) The Peak Index: Spirometry Metric for Airflow Obstruction Severity and Heterogeneity. Annals of the American Thoracic Society 16:8, pages 982-989.
Crossref
J. Alberto Neder, Danilo C. Berton, Paulo T. Muller & Denis E. O’Donnell. (2019) Incorporating Lung Diffusing Capacity for Carbon Monoxide in Clinical Decision Making in Chest Medicine. Clinics in Chest Medicine 40:2, pages 285-305.
Crossref
J. Alberto Neder, Mathieu Marillier, Anne-Catherine Bernard & Denis E. O'Donnell. (2019) Transfer coefficient of the lung for carbon monoxide and the accessible alveolar volume: clinically useful if used wisely. Breathe 15:1, pages 69-76.
Crossref
Dejan Radovanovic, Pierachille Santus, Francesco Blasi, Giovanni Sotgiu, Francesca D'Arcangelo, Edoardo Simonetta, Martina Contarini, Elisa Franceschi, Pieter C. Goeminne, James D. Chalmers & Stefano Aliberti. (2018) A comprehensive approach to lung function in bronchiectasis. Respiratory Medicine 145, pages 120-129.
Crossref
J. Alberto Neder, Danilo C. Berton, Flavio F. Arbex, Maria Clara Alencar, Alcides Rocha, Priscila A. Sperandio, Paolo Palange & Denis E. O'Donnell. (2017) Physiological and clinical relevance of exercise ventilatory efficiency in COPD. European Respiratory Journal 49:3, pages 1602036.
Crossref
B. Degano. (2017) Synthèse N° 2 : Évaluation fonctionnelle d’un trouble ventilatoire obstructif. Revue des Maladies Respiratoires Actualités 9:1, pages 64-72.
Crossref
Denis E. O'Donnell, Amany F. Elbehairy, Azmy Faisal, Katherine A. Webb, J. Alberto Neder & Donald A. Mahler. (2016) Exertional dyspnoea in COPD: the clinical utility of cardiopulmonary exercise testing. European Respiratory Review 25:141, pages 333-347.
Crossref
Sean B. Fain & Ronald L. Sorkness. (2016) Using MRI to Reveal (and Resolve) the Complexity of Obstructive Lung Disease. Academic Radiology 23:4, pages 393-395.
Crossref
Christopher Davis, Khadija Sheikh, Damien Pike, Sarah Svenningsen, David G. McCormack, Denis O'Donnell, J. Alberto Neder & Grace Parraga. (2016) Ventilation Heterogeneity in Never-smokers and COPD:. Academic Radiology 23:4, pages 398-405.
Crossref
Pierachille Santus, Dejan Radovanovic, Giovanni Balzano, Matteo Pecchiari, Rita Raccanelli, Nicola Sarno, Fabiano Di Marco, Paul W. Jones & Mauro Carone. (2016) Improvements in Lung Diffusion Capacity following Pulmonary Rehabilitation in COPD with and without Ventilation Inhomogeneity. Respiration 92:5, pages 295-307.
Crossref
Denis E. O’Donnell, Katherine A. Webb & J. Alberto Neder. (2015) Lung hyperinflation in COPD: applying physiology to clinical practice. COPD Research and Practice 1:1.
Crossref
Pierachille Santus, Dejan Radovanovic, Fabiano Di Marco, Rita Raccanelli, Vincenzo Valenti & Stefano Centanni. (2015) Faster reduction in hyperinflation and improvement in lung ventilation inhomogeneity promoted by aclidinium compared to glycopyrronium in severe stable COPD patients. A randomized crossover study. Pulmonary Pharmacology & Therapeutics 35, pages 42-49.
Crossref

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