3,976
Views
275
CrossRef citations to date
0
Altmetric
Clinical Research Paper

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

, , , , , , , , , , , , , , , , , , & show all
Pages 1369-1379 | Received 21 Nov 2013, Accepted 05 May 2014, Published online: 20 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (23)

Laura M. Meyer, Sebastian E. Koschade, Jonas B. Vischedyk, Marlyn Thoelken, Andrea Gubas, Martin Wegner, Marion Basoglu, Stefan Knapp, Manuel Kaulich, Stefan Eimer, Shabnam Shaid & Christian H. Brandts. (2023) Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia. Autophagy 0:0, pages 1-15.
Read now
Eleni Karatza, George Ismailos, Markos Marangos & Vangelis Karalis. (2021) Optimization of hydroxychloroquine dosing scheme based on COVID-19 patients’ characteristics: a review of the literature and simulations. Xenobiotica 51:2, pages 127-138.
Read now
Guangzhen Wu, Yingkun Xu, Huayu Zhang, Zihao Ruan, Peizhi Zhang, Zicheng Wang, Han Gao, Xiangyu Che, Qinghua Xia & Feng Chen. (2021) A new prognostic risk model based on autophagy-related genes in kidney renal clear cell carcinoma. Bioengineered 12:1, pages 7805-7819.
Read now
Ben Loos, Daniel J. Klionsky, Andre Du Toit & Jan-Hendrik S. Hofmeyr. (2020) On the relevance of precision autophagy flux control in vivo – Points of departure for clinical translation. Autophagy 16:4, pages 750-762.
Read now
Yu Dong, Yuanjia Hu, Sovan Sarkar, Wei-Xing Zong, Min Li, Du Feng, Ju-Xian Song, Min Li, Diego L. Medina, Jieqiong Tan, Zhuohua Zhang, Zhenyu Yue & Jia-Hong Lu. (2020) Autophagy modulator scoring system: a user-friendly tool for quantitative analysis of methodological integrity of chemical autophagy modulator studies. Autophagy 16:2, pages 195-202.
Read now
Christina G. Towers & Andrew Thorburn. (2019) Circumventing autophagy inhibition. Cell Cycle 18:24, pages 3421-3431.
Read now
Yuan-yuan Zhao, Ying Tian, Lin Liu, Jian-hua Zhan, Xue Hou, Xi Chen, Ting Zhou, Yan Huang & Li Zhang. (2018) Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma. Drug Design, Development and Therapy 12, pages 2655-2663.
Read now
Joohun Ha & Joungmok Kim. (2016) Novel pharmacological modulators of autophagy: an updated patent review (2012-2015). Expert Opinion on Therapeutic Patents 26:11, pages 1273-1289.
Read now
Yang Wang, Kairong Shi, Li Zhang, Guanlian Hu, Jingyu Wan, Jiajing Tang, Sheng Yin, Jiandong Duan, Ming Qin, Neng Wang, Dandan Xie, Xinle Gao, Huile Gao, Zhirong Zhang & Qin He. (2016) Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin. Autophagy 12:6, pages 949-962.
Read now
Madhuri Chaurasia, Anant Narayan Bhatt, Asmita Das, Bilikere S. Dwarakanath & Kulbhushan Sharma. (2016) Radiation-induced autophagy: mechanisms and consequences. Free Radical Research 50:3, pages 273-290.
Read now
Romana T. Netea-Maier, Theo S. Plantinga, Frank L. van de Veerdonk, Johannes W. Smit & Mihai G. Netea. (2016) Modulation of inflammation by autophagy: Consequences for human disease. Autophagy 12:2, pages 245-260.
Read now
Yulia Haim, Matthias Blüher, Noa Slutsky, Nir Goldstein, Nora Klöting, Ilana Harman-Boehm, Boris Kirshtein, Doron Ginsberg, Martin Gericke, Esther Guiu Jurado, Julia Kovsan, Tanya Tarnovscki, Leonid Kachko, Nava Bashan, Yiftach Gepner, Iris Shai & Assaf Rudich. (2015) Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. Autophagy 11:11, pages 2074-2088.
Read now
Xuejiao Zhao, Yong Fang, Yang Yang, Yu Qin, Peng Wu, Ting Wang, Huiling Lai, Li Meng, Daowen Wang, Zhihui Zheng, Xinhua Lu, Hua Zhang, Qinglei Gao, Jianfeng Zhou & Ding Ma. (2015) Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells. Autophagy 11:10, pages 1849-1863.
Read now
Bulent Ozpolat & Doris M Benbrook. (2015) Targeting autophagy in cancer management – strategies and developments. Cancer Management and Research 7, pages 291-299.
Read now
Yuan Zhang, Zhi Liao, Li-juan Zhang & Hong-tao Xiao. (2015) The utility of chloroquine in cancer therapy. Current Medical Research and Opinion 31:5, pages 1009-1013.
Read now
Xian Zeng, Hui Zhao, Yubin Li, Jiajun Fan, Yun Sun, Shaofei Wang, Ziyu Wang, Ping Song & Dianwen Ju. (2015) Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia. Autophagy 11:2, pages 355-372.
Read now
Dan T Vogl, Edward A Stadtmauer, Kay-See Tan, Daniel F Heitjan, Lisa E Davis, Laura Pontiggia, Reshma Rangwala, Shengfu Piao, Yunyoung C Chang, Emma C Scott, Thomas M Paul, Charles W Nichols, David L Porter, Janeen Kaplan, Gayle Mallon, James E Bradner & Ravi K Amaravadi. (2014) Combined autophagy and proteasome inhibition. Autophagy 10:8, pages 1380-1390.
Read now
Devalingam Mahalingam, Monica Mita, John Sarantopoulos, Leslie Wood, Ravi K Amaravadi, Lisa E Davis, Alain C Mita, Tyler J Curiel, Claudia M Espitia, Steffan T Nawrocki, Francis J Giles & Jennifer S Carew. (2014) Combined autophagy and HDAC inhibition. Autophagy 10:8, pages 1403-1414.
Read now
Rebecca A Barnard, Luke A Wittenburg, Ravi K Amaravadi, Daniel L Gustafson, Andrew Thorburn & Douglas H Thamm. (2014) Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma. Autophagy 10:8, pages 1415-1425.
Read now
Reshma Rangwala, Yunyoung C Chang, Janice Hu, Kenneth M Algazy, Tracey L Evans, Leslie A Fecher, Lynn M Schuchter, Drew A Torigian, Jeffrey T Panosian, Andrea B Troxel, Kay-See Tan, Daniel F Heitjan, Angela M DeMichele, David J Vaughn, Maryann Redlinger, Abass Alavi, Jonathon Kaiser, Laura Pontiggia, Lisa E Davis, Peter J O’Dwyer & Ravi K Amaravadi. (2014) Combined MTOR and autophagy inhibition. Autophagy 10:8, pages 1391-1402.
Read now
Myrna R Rosenfeld, Xiaobu Ye, Jeffrey G Supko, Serena Desideri, Stuart A Grossman, Steven Brem, Tom Mikkelson, Daniel Wang, Yunyoung C Chang, Janice Hu, Quentin McAfee, Joy Fisher, Andrea B Troxel, Shengfu Piao, Daniel F Heitjan, Kay-See Tan, Laura Pontiggia, Peter J O’Dwyer, Lisa E Davis & Ravi K Amaravadi. (2014) A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy 10:8, pages 1359-1368.
Read now

Articles from other publishers (252)

Daniel L. Gustafson, Lindsey O. Viola, Christina G. Towers, Sunetra Das, Dawn L. Duval & Kristen M. Van Eaton. (2023) Sensitivity of osteosarcoma cell lines to autophagy inhibition as determined by pharmacologic and genetic manipulation. Veterinary and Comparative Oncology 21:4, pages 726-738.
Crossref
Longxiyu Meng, Jie Gao, Wenjing Mo, Baojun Wang, Hongwei Shen, Wenmin Cao, Meng Ding, Wenli Diao, Wei Chen, Qing Zhang, Jiaxin Shu, Huiqi Dai & Hongqian Guo. (2023) MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma. Redox Biology 68, pages 102956.
Crossref
Liang Ee Low, Chee Kei Kong, Wei-Hsum Yap, Sangeetaprivya P. Siva, Siew Hua Gan, Wei Sheng Siew, Long Chiau Ming, Ashley Sean Lai-Foenander, Sui Kiat Chang, Wai-Leng Lee, Yongjiang Wu, Kooi-Yeong Khaw, Yong Sze Ong, Beng Ti Tey, Sachin Kumar Singh, Kamal Dua, Dinesh Kumar Chellappan & Bey-Hing Goh. (2023) Hydroxychloroquine: Key therapeutic advances and emerging nanotechnological landscape for cancer mitigation. Chemico-Biological Interactions 386, pages 110750.
Crossref
Marthandam Asokan Shibu, Yi‐Ju Chen, Hong‐Siang Yang, Yen‐Hua He, Yun‐Hsin Lo & Wan‐Teng Lin. (2023) Principle active metabolites of Pinus morrisonicola Hayata synergistically inhibit cell proliferation and autophagy to elevate apoptosis in hepatocellular carcinoma cells . Environmental Toxicology 38:12, pages 3018-3025.
Crossref
Meena Pangarkar, Uttara Wagh & Anand Pathak. (2023) Autophagy indicators in oral squamous cell carcinoma. Pathology.
Crossref
Jian-Li Chen, Xuan Wu, Dan Yin, Xiao-Hui Jia, Xu Chen, Ze-Yun Gu & Xiao-Ming Zhu. (2023) Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines. Pharmacology & Therapeutics 249, pages 108485.
Crossref
Fatemeh Rafiei, Hojjat Zeraati, Karim Abbasi, Jahan B Ghasemi, Mahboubeh Parsaeian & Ali Masoudi-Nejad. (2023) DeepTraSynergy: drug combinations using multimodal deep learning with transformers. Bioinformatics 39:8.
Crossref
Charu Aggarwal, Alisha P Maity, Joshua M Bauml, Qi Long, Tomas Aleman, Christine Ciunci, Christopher D’Avella, Melissa Volpe, Evan Anderson, Lisa McCormick Jones, Lova Sun, Aditi P Singh, Melina E Marmarelis, Roger B Cohen, Corey J Langer & Ravi Amaravadi. (2023) A Phase II Open-Label Trial of Binimetinib and Hydroxychloroquine in Patients With Advanced KRAS -Mutant Non-Small Cell Lung Cancer . The Oncologist 28:7, pages 644-e564.
Crossref
Elisabetta Fratta, Giorgio Giurato, Roberto Guerrieri, Francesca Colizzi, Jessica Dal Col, Alessandro Weisz, Agostino Steffan & Barbara Montico. (2023) Autophagy in BRAF-mutant cutaneous melanoma: recent advances and therapeutic perspective. Cell Death Discovery 9:1.
Crossref
Juan Bautista De Sanctis, Jaime Charris, Zuleyma Blanco, Hegira Ramírez, Gricelis Patricia Martínez & Michael Rodney Mijares. (2023) Molecular Mechanisms of Chloroquine and Hydroxychloroquine Used in Cancer Therapy. Anti-Cancer Agents in Medicinal Chemistry 23:10, pages 1122-1144.
Crossref
Vaibhav Jain, Mahendra Pal Singh & Ravi K. Amaravadi. (2023) Recent advances in targeting autophagy in cancer. Trends in Pharmacological Sciences 44:5, pages 290-302.
Crossref
Hailong Pei, Yingchu Dai, Yongduo Yu, Jiaxin Tang, Zhifei Cao, Yongsheng Zhang, Bingyan Li, Jing Nie, Tom K. Hei & Guangming Zhou. (2023) The Tumorigenic Effect of lncRNA AFAP1‐AS1 is Mediated by Translated Peptide ATMLP Under the Control of m 6 A Methylation . Advanced Science 10:13.
Crossref
Hamed Bashiri & Hossein Tabatabaeian. (2023) Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma. International Journal of Molecular Sciences 24:7, pages 6019.
Crossref
Amanda J. Manea & Swapan K. Ray. (2023) Advanced Bioinformatics Analysis and Genetic Technologies for Targeting Autophagy in Glioblastoma Multiforme. Cells 12:6, pages 897.
Crossref
Yu Cui, Jinfeng Shi, Youbin Cui, Zhanpeng Zhu & Wei Zhu. (2023) The relationship between autophagy and PD-L1 and their role in antitumor therapy. Frontiers in Immunology 14.
Crossref
Yabin Zhang, Haiyan Li, Liang Lv, Kefeng Lu, Huihui Li, Wenli Zhang & Tao Cui. (2023) Autophagy: Dual roles and perspective for clinical treatment of colorectal cancer. Biochimie 206, pages 49-60.
Crossref
Petr Mlejnek. (2023) What Is the Significance of Lysosomal-Mediated Resistance to Imatinib?. Cells 12:5, pages 709.
Crossref
Ahmed M. Elshazly & David A. Gewirtz. (2023) Is Autophagy Inhibition in Combination with Temozolomide a Therapeutically Viable Strategy?. Cells 12:4, pages 535.
Crossref
Vaibhav Jain, Sandra L. Harper, Amanda M. Versace, Dylan Fingerman, Gregory Schuyler Brown, Monika Bhardwaj, Mary Ann S. Crissey, Aaron R. Goldman, Gordon Ruthel, Qin Liu, Aleksandra Zivkovic, Holgar Stark, Meenhard Herlyn, Phyllis A. Gimotty, David W. Speicher & Ravi K. Amaravadi. (2023) Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition. Cancer Discovery 13:2, pages 454-473.
Crossref
Gang Zhong, Jagadeesh K. Venkatesan, Henning Madry & Magali Cucchiarini. (2022) Advances in Human Mitochondria-Based Therapies. International Journal of Molecular Sciences 24:1, pages 608.
Crossref
Houfu Leng, Hanlin Zhang, Linsen Li, Shuhao Zhang, Yanping Wang, Selina J. Chavda, Daria Galas-Filipowicz, Hantao Lou, Adel Ersek, Emma V. Morris, Erdinc Sezgin, Yi-Hsuan Lee, Yunsen Li, Ana Victoria Lechuga-Vieco, Mei Tian, Jian-Qing Mi, Kwee Yong, Qing Zhong, Claire M. Edwards, Anna Katharina Simon & Nicole J. Horwood. (2022) Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease. Nature Communications 13:1.
Crossref
Rubayat Khan, Sudipta Panja, Ling Ding, Siyuan Tang, Weimin Tang, Ekta Kapoor, Robert G. Bennett & David Oupický. (2022) Polymeric Chloroquine as an Effective Antimigration Agent in the Treatment of Pancreatic Cancer. Molecular Pharmaceutics 19:12, pages 4631-4643.
Crossref
Daniel Eberli, Benedikt Kranzbühler, Lukas Prause, Valentin Baumgartner, Sheryl Preda, Rosa Sousa, Fabienne Lehner & Souzan Salemi. (2022) Apalutamide and autophagy inhibition in a xenograft mouse model of human prostate cancer. Journal of Cancer Research and Clinical Oncology 148:12, pages 3351-3360.
Crossref
Peng Song, Hui Li, Kuo Xu, Zi-Wei Li, Xia Ren & Xian-Jun Fu. (2022) A bibliometric and visualization-based analysis of temozolomide research hotspots and frontier evolution. Frontiers in Oncology 12.
Crossref
Mehdi Sanati, Maryam Moradi Binabaj, Seyed Sajad Ahmadi, Samaneh Aminyavari, Hossein Javid, Hamid Mollazadeh, Bahram Bibak, Elmira Mohtashami, Tannaz Jamialahmadi, Amir R. Afshari & Amirhossein Sahebkar. (2022) Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulation. Biomedicine & Pharmacotherapy 155, pages 113740.
Crossref
Jeffrey Pradeep Raj, Nithya Jaideep Gogtay, Avaneesh Pandey, Ashish Kumar Kakkar, Nusrat Shafiq, Padmaja Mekala, Usharani Pingali, Arun Prasath Raju, Surulivelrajan Mallayasamy & Nilima Arun Kshirsagar. (2022) Population Pharmacokinetics of Hydroxychloroquine Sulfate in Healthcare Workers, Given for Prophylaxis Against Coronavirus Disease 2019 (COVID‐19) in India. The Journal of Clinical Pharmacology 62:11, pages 1403-1411.
Crossref
Amal Kamal Abdel-Aziz, Mona Kamal Saadeldin, Ahmed Hamed Salem, Safaa A. Ibrahim, Samia Shouman, Ashraf B. Abdel-Naim & Roberto Orecchia. (2022) A Critical Review of Chloroquine and Hydroxychloroquine as Potential Adjuvant Agents for Treating People with Cancer. Future Pharmacology 2:4, pages 431-443.
Crossref
Subhadip Mukhopadhyay, Kewal Kumar Mahapatra, Prakash Priyadarshi Praharaj, Shankargouda Patil & Sujit Kumar Bhutia. (2022) Recent progress of autophagy signaling in tumor microenvironment and its targeting for possible cancer therapeutics. Seminars in Cancer Biology 85, pages 196-208.
Crossref
Jin Cui, Yuta Ogasawara, Ikuko Kurata, Kazuaki Matoba, Yuko Fujioka, Nobuo N. Noda, Masakatsu Shibasaki & Takumi Watanabe. (2022) Targeting the ATG5-ATG16L1 Protein–Protein Interaction with a Hydrocarbon-Stapled Peptide Derived from ATG16L1 for Autophagy Inhibition. Journal of the American Chemical Society 144:38, pages 17671-17679.
Crossref
Pavel Spirin, Elena Shyrokova, Valeria Vedernikova, Timofey Lebedev & Vladimir Prassolov. (2022) Emetine in Combination with Chloroquine Induces Oncolytic Potential of HIV-1-Based Lentiviral Particles. Cells 11:18, pages 2829.
Crossref
Eglal Mahgoub, Jalal Taneera, Nabil Sulaiman & Maha Saber-Ayad. (2022) The role of autophagy in colorectal cancer: Impact on pathogenesis and implications in therapy. Frontiers in Medicine 9.
Crossref
Thomas B Karasic, Timothy J Brown, Charles Schneider, Ursina R Teitelbaum, Kim A Reiss, Tara C Mitchell, Ryan C Massa, Mark H O’Hara, Lisa DiCicco, Luis Garcia-Marcano, Ravi K Amaravadi & Peter J O’Dwyer. (2022) Phase I Trial of Regorafenib, Hydroxychloroquine, and Entinostat in Metastatic Colorectal Cancer. The Oncologist 27:9, pages 716-e689.
Crossref
Jinbo Li, Wenxu Cai, Jiang Yu, Shuang Zhou, Xianlu Li, Zhonggui He, Defang Ouyang, Hongzhuo Liu & Yongjun Wang. (2022) Autophagy inhibition recovers deficient ICD-based cancer immunotherapy. Biomaterials 287, pages 121651.
Crossref
Longkai He, Xiaotong Wang, Ya Jin, Weipeng Xu, Jun Lyu, Yi Guan, Jingchao Wu, Shasha Han & Guosheng Liu. (2022) A Prognostic Nomogram for Predicting Overall Survival in Pediatric Wilms Tumor Based on an Autophagy-related Gene Signature. Combinatorial Chemistry & High Throughput Screening 25:8, pages 1385-1397.
Crossref
Simone Degan, Brian L. May, Yingai J. Jin, Manel Ben Hammoda, Huiying Sun, Guoqiang Zhang, Yan Wang, Detlev Erdmann, Warren Warren & Jennifer Y. Zhang. (2022) Co-Treatment of Chloroquine and Trametinib Inhibits Melanoma Cell Proliferation and Decreases Immune Cell Infiltration. Frontiers in Oncology 12.
Crossref
Gil Awada, Julia Katharina Schwarze, Jens Tijtgat, Giuseppe Fasolino, Vibeke KruseBart Neyns. (2022) A lead-in safety study followed by a phase 2 clinical trial of dabrafenib, trametinib and hydroxychloroquine in advanced BRAFV600 mutant melanoma patients previously treated with BRAF-/MEK-inhibitors and immune checkpoint inhibitors. Melanoma Research 32:3, pages 183-191.
Crossref
Jana Jandova, Sophia L. Park, Mandi J. Corenblum, Lalitha Madhavan, Jeremy A. Snell, Liliana Rounds & Georg T. Wondrak. (2022) Mefloquine induces ER stress and apoptosis in BRAFi‐resistant A375‐BRAF V600E /NRAS Q61K malignant melanoma cells targeting intracranial tumors in a bioluminescent murine model . Molecular Carcinogenesis 61:6, pages 603-614.
Crossref
Farzana Ahmed, Hsin-Yi Tseng, Antonio Ahn, Dilini Gunatilake, Sara Alavi, Michael Eccles, Helen Rizos, Stuart J Gallagher, Jessamy C Tiffen, Peter Hersey & Abdullah Al Emran. (2022) Repurposing Melanoma Chemotherapy to Activate Inflammasomes in the Treatment of BRAF/MAPK Inhibitor Resistant Melanoma. Journal of Investigative Dermatology 142:5, pages 1444-1455.e10.
Crossref
Amanda S. Hirata, James J. La Clair, Paula C. Jimenez, Leticia Veras Costa-Lotufo & William Fenical. (2022) Preclinical Development of Seriniquinones as Selective Dermcidin Modulators for the Treatment of Melanoma. Marine Drugs 20:5, pages 301.
Crossref
Nagla Abdel Karim, Asad Ullah, Imran Ahmad, Elmustapha Bahassi, Olugbenga Olowokure, Ahmed Khaled, Harold Davis & John C. Morris. (2022) A Phase I Trial to Determine the Safety and Tolerability of Autophagy Inhibition Using Chloroquine or Hydroxychloroquine in Combination With Carboplatin and Gemcitabine in Patients With Advanced Solid Tumors. Frontiers in Oncology 12.
Crossref
Cho-Hsun Hsieh, Yi-Wei Huang & Tsen-Fang Tsai. (2022) Oral Conventional Synthetic Disease-Modifying Antirheumatic Drugs with Antineoplastic Potential: a Review. Dermatology and Therapy 12:4, pages 835-860.
Crossref
Reui‐Liang Yan & Ruey‐Hwa Chen. (2021) Autophagy and cancer metabolism—The two‐way interplay. IUBMB Life 74:4, pages 281-295.
Crossref
Janice M. Mehnert, Tara C. Mitchell, Alexander C. Huang, Tomas S. Aleman, Benjamin J. Kim, Lynn M. Schuchter, Gerald P. Linette, Giorgos C. Karakousis, Sheryl Mitnick, Lydia Giles, Mary Carberry, Noelle Frey, Andrew Kossenkov, Roman Groisberg, Leonel F. Hernandez-Aya, George Ansstas, Ann W. Silk, Sunandana Chandra, Jeffrey A. Sosman, Phyllis A. Gimotty, Rosemarie Mick & Ravi K. Amaravadi. (2022) BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600 -mutant Melanoma . Clinical Cancer Research 28:6, pages 1098-1106.
Crossref
Samiha Mohsen, Philip T. Sobash, Ghada Fahad Algwaiz, Noor Nasef, Safaa Abed Al-Zeidaneen & Nagla Abdel Karim. (2022) Autophagy Agents in Clinical Trials for Cancer Therapy: A Brief Review. Current Oncology 29:3, pages 1695-1708.
Crossref
Mei Wang, Ling Zeng, Ping Su, Ling Ma, Ming Zhang & Yuan zhen Zhang. (2022) Autophagy: a multifaceted player in the fate of sperm. Human Reproduction Update 28:2, pages 200-231.
Crossref
Kim Klapan, Dagmar Simon, Alexander Karaulov, Marina Gomzikova, Albert Rizvanov, Shida Yousefi & Hans-Uwe Simon. (2022) Autophagy and Skin Diseases. Frontiers in Pharmacology 13.
Crossref
V. T. AnjaliFeroze Kaliyadan. (2022) Immunotherapy in skin cancers - A narrative review. Journal of Skin and Sexually Transmitted Diseases 4, pages 11-18.
Crossref
Silvina Odete Bustos, Nathalia Leal Santos, Roger Chammas & Luciana Nogueira de Sousa Andrade. (2022) Secretory Autophagy Forges a Therapy Resistant Microenvironment in Melanoma. Cancers 14:1, pages 234.
Crossref
Diana Duarte & Nuno Vale. (2022) Combining repurposed drugs to treat colorectal cancer. Drug Discovery Today 27:1, pages 165-184.
Crossref
Silvia Vega-Rubín-de-Celis. 2022. Autophagy in Health and Disease. Autophagy in Health and Disease 361 384 .
Elisabetta Iessi, Rosa Vona, Camilla Cittadini & Paola Matarrese. (2021) Targeting the Interplay between Cancer Metabolic Reprogramming and Cell Death Pathways as a Viable Therapeutic Path. Biomedicines 9:12, pages 1942.
Crossref
Yomna S. Abd El-Aziz, Lionel Y. W. Leck, Patric J. Jansson & Sumit Sahni. (2021) Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma. Cancers 13:24, pages 6152.
Crossref
Fatima Baker, Ibrahim H. Polat, Khalil Abou-El-Ardat, Islam Alshamleh, Marlyn Thoelken, Daniel Hymon, Andrea Gubas, Sebastian E. Koschade, Jonas B. Vischedyk, Manuel Kaulich, Harald Schwalbe, Shabnam Shaid & Christian H. Brandts. (2021) Metabolic Rewiring Is Essential for AML Cell Survival to Overcome Autophagy Inhibition by Loss of ATG3. Cancers 13:23, pages 6142.
Crossref
Aileen R. Ariosa, Vikramjit Lahiri, Yuchen Lei, Ying Yang, Zhangyuan Yin, Zhihai Zhang & Daniel J. Klionsky. (2021) A perspective on the role of autophagy in cancer. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867:12, pages 166262.
Crossref
Yuchen Lei & Daniel J. Klionsky. (2021) The Emerging Roles of Autophagy in Human Diseases. Biomedicines 9:11, pages 1651.
Crossref
Ingo Ganzleben, Markus F. Neurath & Christoph Becker. (2021) Autophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances. Cancers 13:21, pages 5575.
Crossref
Maria Scuto, Angela Trovato Salinaro, Isabella Caligiuri, Maria Laura Ontario, Valentina Greco, Nello Sciuto, Roberto Crea, Edward J. Calabrese, Flavio Rizzolio, Vincenzo Canzonieri & Vittorio Calabrese. (2021) Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology. Mechanisms of Ageing and Development 199, pages 111551.
Crossref
Meng-Chao Xiao, Hui Qian, Chen-Kai Huang, Bai-Nan Zheng, Fang-Zhi Yan, Fang Liu, Xin Zhang, Shi-Jie Chen, Cheng Luo & Wei-Fen Xie. (2021) Imatinib inhibits the malignancy of hepatocellular carcinoma by suppressing autophagy. European Journal of Pharmacology 906, pages 174217.
Crossref
Alyssa Gabrielle Apilan & Carmel Mothersill. (2021) Targeted and Non-Targeted Mechanisms for Killing Hypoxic Tumour Cells—Are There New Avenues for Treatment?. International Journal of Molecular Sciences 22:16, pages 8651.
Crossref
Min Sik Choi, Yoon-Jee Chae, Ji Woong Choi & Ji-Eun Chang. (2021) Potential Therapeutic Approaches through Modulating the Autophagy Process for Skin Barrier Dysfunction. International Journal of Molecular Sciences 22:15, pages 7869.
Crossref
Heyang Cui, Yongjia Weng, Ning Ding, Chen Cheng, Longlong Wang, Yong Zhou, Ling Zhang, Yongping Cui & Weimin Zhang. (2021) Autophagy-Related Three-Gene Prognostic Signature for Predicting Survival in Esophageal Squamous Cell Carcinoma. Frontiers in Oncology 11.
Crossref
Mona Foth & Martin McMahon. (2021) Autophagy Inhibition in BRAF-Driven Cancers. Cancers 13:14, pages 3498.
Crossref
Houjun Xia, Douglas R. Green & Weiping Zou. (2021) Autophagy in tumour immunity and therapy. Nature Reviews Cancer 21:5, pages 281-297.
Crossref
Fei Wang, Aftab Ullah, Xuelian Fan, Zhou Xu, Rongling Zong, Xuewen Wang & Gang Chen. (2021) Delivery of nanoparticle antigens to antigen-presenting cells: from extracellular specific targeting to intracellular responsive presentation. Journal of Controlled Release 333, pages 107-128.
Crossref
Kaitlyn M. Dykstra, Hannah R. S. Fay, Ashish C. Massey, Neng Yang, Matthew Johnson, Scott Portwood, Monica L. Guzman & Eunice S. Wang. (2021) Inhibiting autophagy targets human leukemic stem cells and hypoxic AML blasts by disrupting mitochondrial homeostasis. Blood Advances 5:8, pages 2087-2100.
Crossref
Anna Chmurska, Karolina Matczak & Agnieszka Marczak. (2021) Two Faces of Autophagy in the Struggle against Cancer. International Journal of Molecular Sciences 22:6, pages 2981.
Crossref
Nienke Visser, Harm Jan Lourens, Gerwin Huls, Edwin Bremer & Valerie R. Wiersma. (2021) Inhibition of Autophagy Does Not Re-Sensitize Acute Myeloid Leukemia Cells Resistant to Cytarabine. International Journal of Molecular Sciences 22:5, pages 2337.
Crossref
Carolina Mendonça Gorgulho, Anuradha Krishnamurthy, Anastasia Lanzi, Jérôme Galon, Franck Housseau, Ramon Kaneno & Michael T. Lotze. (2021) Gutting it Out: Developing Effective Immunotherapies for Patients With Colorectal Cancer. Journal of Immunotherapy 44:2, pages 49-62.
Crossref
Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Chandra Sekhar Bhol, Srimanta Patra, Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Amruta Singh, Shankargouda Patil & Sujit Kumar Bhutia. (2021) Mitochondrial rewiring through mitophagy and mitochondrial biogenesis in cancer stem cells: A potential target for anti-CSC cancer therapy. Cancer Letters 498, pages 217-228.
Crossref
Chao‐Yen Ho, An‐Chen Chang, Chung‐Hua Hsu, Te‐Fu Tsai, Yi‐Chia Lin, Kuang‐Yu Chou, Hung‐En Chen, Ji‐Fan Lin, Po‐Chun Chen & Thomas I‐Sheng Hwang. (2020) Miconazole induces protective autophagy in bladder cancer cells. Environmental Toxicology 36:2, pages 185-193.
Crossref
Lili Zhao, Wenxi Li, Xu Luo & Surui Sheng. (2020) The multifaceted roles of nucleophagy in cancer development and therapy. Cell Biology International 45:2, pages 246-257.
Crossref
Timothy Marsh, Bhairavi Tolani & Jayanta Debnath. (2021) The pleiotropic functions of autophagy in metastasis. Journal of Cell Science 134:2.
Crossref
PA Shantanu, NP Syamprasad, Bishal Rajdev, Basveshwar Gawali, AvdheshKumar Rai, Tashnin Rahman & VG M. Naidu. (2021) Delineating the role of autophagy in driving the resistance to cancer chemotherapy. Annals of Oncology Research and Therapy 1:2, pages 78.
Crossref
Xiang-ling Chen, Peng Liu, Wei-liang Zhu & Li-guang Lou. (2020) DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer. Acta Pharmacologica Sinica 42:1, pages 132-141.
Crossref
Jacqueline A. Brinkman, Yue Liu & Stephen J. Kron. (2021) Small-molecule drug repurposing to target DNA damage repair and response pathways. Seminars in Cancer Biology 68, pages 230-241.
Crossref
Waleska Kerllen Martins, Maryana do Nascimento da Silva, Kiran Pandey, Ikuko Maejima, Ercília Ramalho, Vania Claudia Olivon, Susana Nogueira Diniz & Daniel Grasso. (2021) Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions. Current Research in Pharmacology and Drug Discovery 2, pages 100033.
Crossref
Nipa H. Patel, Sarah Bloukh, Enas Alwohosh, Ahmad Alhesa, Tareq Saleh & David A. Gewirtz. 2021. Autophagy and Senescence in Cancer Therapy. Autophagy and Senescence in Cancer Therapy 1 74 .
Dong Wook Shin. (2020) Dual Roles of Autophagy and Their Potential Drugs for Improving Cancer Therapeutics. Biomolecules & Therapeutics 28:6, pages 503-511.
Crossref
Mohd Ishaq, Rani Ojha, Aditya P. Sharma & Shrawan K. Singh. (2020) Autophagy in cancer: Recent advances and future directions. Seminars in Cancer Biology 66, pages 171-181.
Crossref
Zahra Mohammadalipour, Marveh Rahmati, Alireza Khataee & Mohammad A. Moosavi. (2020) Differential effects of N‐TiO 2 nanoparticle and its photo‐activated form on autophagy and necroptosis in human melanoma A375 cells . Journal of Cellular Physiology 235:11, pages 8246-8259.
Crossref
Xinmiao Ji, Xin Zhang & Zhiyuan Li. (2020) ULK1 inhibitor induces spindle microtubule disorganization and inhibits phosphorylation of Ser10 of histone H3. FEBS Open Bio 10:11, pages 2452-2463.
Crossref
Gricelis P. Martinez, Mercedes E. Zabaleta, Camilo Di Giulio, Jaime E. Charris & Michael R. Mijares. (2020) The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases. Current Pharmaceutical Design 26:35, pages 4467-4485.
Crossref
Qian Li, Min Wang, Yan Zhang, Liuqian Wang, Wei Yu, Xiaomin Bao, Biyun Zhang, Yanghong Xiang & Anchun Deng. (2020) BIX-01294-enhanced chemosensitivity in nasopharyngeal carcinoma depends on autophagy-induced pyroptosis. Acta Biochimica et Biophysica Sinica 52:10, pages 1131-1139.
Crossref
Ali Bagherian, Rajab Mardani, Bostan Roudi, Mohsen Taghizadeh, Hamid Reza Banfshe, Amir Ghaderi, Amirhossein Davoodvandi, Samane Shamollaghamsari, Michael R. Hamblin & Hamed Mirzaei. (2020) Combination Therapy with Nanomicellar-Curcumin and Temozolomide for In Vitro Therapy of Glioblastoma Multiforme via Wnt Signaling Pathways. Journal of Molecular Neuroscience 70:10, pages 1471-1483.
Crossref
Fleury Augustin Nsole Biteghe, Nyangone Ekome Toung Chalomie, Neelakshi Mungra, Guillaume Vignaux, Nan Gao, Aurelia Vergeade, Ambrose Okem, Krupa Naran, Jean De La Croix Ndong & Stefan Barth. (2020) Antibody-Based Immunotherapy: Alternative Approaches for the Treatment of Metastatic Melanoma. Biomedicines 8:9, pages 327.
Crossref
Yan Li, Mi Hyeon Cho, Seon Sook Lee, Dong-Eun Lee, Heesun Cheong & Yongdoo Choi. (2020) Hydroxychloroquine-loaded hollow mesoporous silica nanoparticles for enhanced autophagy inhibition and radiation therapy. Journal of Controlled Release 325, pages 100-110.
Crossref
Guiqin Hou, Ang Jia, Li Yang, Yu Zhao, Yi Hu, Wuduo Zhao, Wen Zhao, Hong-Min Liu & Zhaoming Lu. (2020) OP16 induces deadly autophagy and apoptosis of cells by inhibiting Akt in esophageal squamous cell carcinoma. Molecular and Cellular Biochemistry 472:1-2, pages 219-230.
Crossref
Maria Garcia‐Cremades, Belen P. Solans, Emma Hughes, Jacqueline P. Ernest, Erika Wallender, Francesca Aweeka, Anne F. Luetkemeyer & Radojka M. Savic. (2020) Optimizing Hydroxychloroquine Dosing for Patients With COVID‐19: An Integrative Modeling Approach for Effective Drug Repurposing. Clinical Pharmacology & Therapeutics 108:2, pages 253-263.
Crossref
José Manuel García-Heredia & Amancio Carnero. (2020) Role of Mitochondria in Cancer Stem Cell Resistance. Cells 9:7, pages 1693.
Crossref
Laurel Chandler, Imran Yusuf, Michelle McClements, Alun Barnard, Robert MacLaren & Kanmin Xue. (2020) Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy. International Journal of Molecular Sciences 21:14, pages 4972.
Crossref
Kai Wang, Yanbei Tu, Jian-Bo Wan, Meiwan Chen & Chengwei He. (2020) Synergistic anti-breast cancer effect of pulsatilla saponin D and camptothecin through interrupting autophagic–lysosomal function and promoting p62-mediated ubiquitinated protein aggregation. Carcinogenesis 41:6, pages 804-816.
Crossref
Susanna Ambrosio & Barbara Majello. (2020) Autophagy Roles in Genome Maintenance. Cancers 12:7, pages 1793.
Crossref
G. A. Horne, J. Stobo, C. Kelly, A. Mukhopadhyay, A. L. Latif, J. Dixon-Hughes, L. McMahon, P. Cony-Makhoul, J. Byrne, G. Smith, S. Koschmieder, T. H. BrÜmmendorf, P. Schafhausen, P. Gallipoli, F. Thomson, W. Cong, R. E. Clark, D. Milojkovic, G. V. Helgason, L. Foroni, F. E. Nicolini, T. L. Holyoake & M. Copland. (2020) A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease. Leukemia 34:7, pages 1775-1786.
Crossref
Jan Hraběta, Marie Belhajová, Hana Šubrtová, Miguel Angel Merlos Rodrigo, Zbyněk Heger & Tomáš Eckschlager. (2020) Drug Sequestration in Lysosomes as One of the Mechanisms of Chemoresistance of Cancer Cells and the Possibilities of Its Inhibition. International Journal of Molecular Sciences 21:12, pages 4392.
Crossref
Maria Condello, Giovanna Mancini & Stefania Meschini. (2020) The Exploitation of Liposomes in the Inhibition of Autophagy to Defeat Drug Resistance. Frontiers in Pharmacology 11.
Crossref
Tuhina Khan, Nicola Relitti, Margherita Brindisi, Stefania Magnano, Daniela Zisterer, Sandra Gemma, Stefania Butini & Giuseppe Campiani. (2019) Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas. Medicinal Research Reviews 40:3, pages 1002-1060.
Crossref
Ferda Kaleağasıoğlu, Doaa M. Ali & Martin R. Berger. (2020) Multiple Facets of Autophagy and the Emerging Role of Alkylphosphocholines as Autophagy Modulators. Frontiers in Pharmacology 11.
Crossref
Ting Liu, Jing Zhang, Kangdi Li, Lingnan Deng & Hongxiang Wang. (2020) Combination of an Autophagy Inducer and an Autophagy Inhibitor: A Smarter Strategy Emerging in Cancer Therapy. Frontiers in Pharmacology 11.
Crossref
Nestor Ishimwe, Wenbin Zhang, Jieying Qian, Yunjiao Zhang & Longping Wen. (2020) Autophagy regulation as a promising approach for improving cancer immunotherapy. Cancer Letters 475, pages 34-42.
Crossref
Mayla Gabriela Silva Borba, Fernando Fonseca Almeida Val, Vanderson Souza Sampaio, Marcia Almeida Araújo Alexandre, Gisely Cardoso Melo, Marcelo Brito, Maria Paula Gomes Mourão, José Diego Brito-Sousa, Djane Baía-da-Silva, Marcus Vinitius Farias Guerra, Ludhmila Abrahão Hajjar, Rosemary Costa Pinto, Antonio Alcirley Silva Balieiro, Antônio Guilherme Fonseca Pacheco, James Dean Oliveira SantosJrJr, Felipe Gomes Naveca, Mariana Simão Xavier, André Machado Siqueira, Alexandre Schwarzbold, Júlio Croda, Maurício Lacerda Nogueira, Gustavo Adolfo Sierra Romero, Quique Bassat, Cor Jesus Fontes, Bernardino Cláudio Albuquerque, Cláudio-Tadeu Daniel-Ribeiro, Wuelton Marcelo Monteiro & Marcus Vinícius Guimarães Lacerda. (2020) Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. JAMA Network Open 3:4, pages e208857.
Crossref
Eva Schrezenmeier & Thomas Dörner. (2020) Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nature Reviews Rheumatology 16:3, pages 155-166.
Crossref
Jean M. Mulcahy Levy & Andrew Thorburn. (2019) Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients. Cell Death & Differentiation 27:3, pages 843-857.
Crossref
Young Hyun Cho, Seung-Hwan Lee, Sook-Jeong Lee, Ha Na Kim & Jae-Young Koh. (2020) A role of metallothionein-3 in radiation-induced autophagy in glioma cells. Scientific Reports 10:1.
Crossref
Lucy Brazil, Angela L Swampillai, Ka Man Mak, Darren Edwards, Pavlina Mesiri, Laura Clifton-Hadley, Richard Shaffer, Joanne Lewis, Colin Watts, Sarah Jeffries, Pinelopi Gkogkou, Anthony J Chalmers, Naomi L Fersht, Allan Hackshaw & Susan C Short. (2020) Hydroxychloroquine and short-course radiotherapy in elderly patients with newly diagnosed high-grade glioma: a randomized phase II trial. Neuro-Oncology Advances 2:1.
Crossref
Benjamin Bonavida. 2020. Autophagy in Immune Response: Impact on Cancer Immunotherapy. Autophagy in Immune Response: Impact on Cancer Immunotherapy 9 27 .
Dipanwita Das Mukherjee, Satabdi Datta Choudhury & Gopal Chakrabarti. 2020. Autophagy in tumor and tumor microenvironment. Autophagy in tumor and tumor microenvironment 249 264 .
Grace Nehme & Nancy Gordon. 2020. Current Advances in the Science of Osteosarcoma. Current Advances in the Science of Osteosarcoma 167 175 .
Mei Lan Tan, Heng Kean Tan & Tengku Sifzizul Tengku Muhammad. 2020. Cancer Immunology. Cancer Immunology 355 402 .
Gloriane Schnabolk, Elisabeth Obert & Bärbel Rohrer. 2020. Retinal Pigment Epithelium in Health and Disease. Retinal Pigment Epithelium in Health and Disease 185 201 .
Sunandana Chandra, Grant A. McArthur & Jeffrey Sosman. 2020. Cutaneous Melanoma. Cutaneous Melanoma 1087 1108 .
Agrotis & Ketteler. (2019) On ATG4B as Drug Target for Treatment of Solid Tumours—The Knowns and the Unknowns. Cells 9:1, pages 53.
Crossref
Jing Liu, Shuaiyu Long, Huanan Wang, Nannan Liu, Chuchu Zhang, Lingling Zhang & Yingjie Zhang. (2019) Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth. Cancer Cell International 19:1.
Crossref
Christina G. Towers, Darya Wodetzki & Andrew Thorburn. (2019) Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations. The Journal of Cell Biology, pages jcb.201909033.
Crossref
Marta Pérez-Hernández, Alain Arias, David Martínez-García, Ricardo Pérez-Tomás, Roberto Quesada & Vanessa Soto-Cerrato. (2019) Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization. Cancers 11:10, pages 1599.
Crossref
Evangelos Koustas, Panagiotis Sarantis, Stamatios Theoharis, Angelica A. Saetta, Ilenia Chatziandreou, Georgia Kyriakopoulou, Ioanna Giannopoulou, Maria Michelli, Dimitrios Schizas, Athanasios G. Papavassiliou & Michalis V. Karamouzis. (2019) Autophagy-related Proteins as a Prognostic Factor of Patients With Colorectal Cancer. American Journal of Clinical Oncology 42:10, pages 767-776.
Crossref
Janice M. Mehnert, Amanda D. Kaveney, Jyoti Malhotra, Kristen Spencer, Daniella Portal, Susan Goodin, Antoinette R. Tan, Joseph Aisner, Rebecca A. Moss, Hongxia Lin, Joseph R. Bertino, Darlene Gibbon, Laurence A. Doyle, Eileen P. White & Mark N. Stein. (2019) A phase I trial of MK-2206 and hydroxychloroquine in patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology 84:4, pages 899-907.
Crossref
Francesca Cuomo, Lucia Altucci & Gilda Cobellis. (2019) Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy. Cancers 11:10, pages 1465.
Crossref
Tavakol, Ashrafizadeh, Deng, Azarian, Abdoli, Motavaf, Poormoghadam, Khanbabaei, Afshar, Mandegary, Pardakhty, Yap, Mohammadinejad & Kumar. (2019) Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems. Biomolecules 9:10, pages 530.
Crossref
Guadalupe Rojas-Sanchez, Israel Cotzomi-Ortega, Nidia G. Pazos-Salazar, Julio Reyes-Leyva & Paola Maycotte. (2019) Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive. Biology 8:4, pages 71.
Crossref
Ravi K. Amaravadi, Alec C. Kimmelman & Jayanta Debnath. (2019) Targeting Autophagy in Cancer: Recent Advances and Future Directions. Cancer Discovery 9:9, pages 1167-1181.
Crossref
Christina G. Towers, Brent E. Fitzwalter, Daniel Regan, Andrew Goodspeed, Michael J. Morgan, Chang-Wei Liu, Daniel L. Gustafson & Andrew Thorburn. (2019) Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition. Developmental Cell 50:6, pages 690-703.e6.
Crossref
Saei & Eichhorn. (2019) Adaptive Responses as Mechanisms of Resistance to BRAF Inhibitors in Melanoma. Cancers 11:8, pages 1176.
Crossref
Nicholas Howard, Marco Clementino, Donghern Kim, Lei Wang, Angela Verma, Xianglin Shi, Zhuo Zhang & Robert S. DiPaola. (2019) New developments in mechanisms of prostate cancer progression. Seminars in Cancer Biology 57, pages 111-116.
Crossref
Jiraporn Paha, Phongthon Kanjanasirirat, Bamroong Munyoo, Patoomratana Tuchinda, Naravut Suvannang, Chanin Nantasenamat, Kanokthip Boonyarattanakalin, Prasat Kittakoop, Sirawit Srikor, Gunganist Kongklad, Noppawan Rangkasenee, Suradej Hongeng, Pongsak Utaisincharoen, Suparerk Borwornpinyo & Marisa Ponpuak. (2019) A novel potent autophagy inhibitor ECDD-S27 targets vacuolar ATPase and inhibits cancer cell survival. Scientific Reports 9:1.
Crossref
Xiaoju Wang, Wenxin Li, Ni Zhang, Xiaoli Zheng & Zhao Jing. (2019) Opportunities and challenges of co‑targeting epidermal growth factor receptor and autophagy signaling in non‑small cell lung cancer (Review). Oncology Letters.
Crossref
Liliana Torres-López, Paola Maycotte, Andrómeda Liñán-Rico, Liliana Liñán-Rico, Luis Donis-Maturano, Iván Delgado-Enciso, Carmen Meza-Robles, Clemente Vásquez-Jiménez, Arturo Hernández-Cruz & Oxana Dobrovinskaya. (2019) Tamoxifen induces toxicity, causes autophagy, and partially reverses dexamethasone resistance in Jurkat T cells. Journal of Leukocyte Biology 105:5, pages 983-998.
Crossref
Naomi B. Haas, Leonard J. Appleman, Mark Stein, Maryann Redlinger, Melissa Wilks, Xiaowei Xu, Angelique Onorati, Anusha Kalavacharla, Taehyong Kim, Chao Jie Zhen, Sabah Kadri, Jeremy P. Segal, Phyllis A. Gimotty, Lisa E. Davis & Ravi K. Amaravadi. (2019) Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma. Clinical Cancer Research 25:7, pages 2080-2087.
Crossref
Mitsunobu Takeda, Jun Koseki, Hidekazu Takahashi, Norikatsu Miyoshi, Naohiro Nishida, Junichi Nishimura, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori & Naotsugu Haraguchi. (2019) Disruption of Endolysosomal RAB5/7 Efficiently Eliminates Colorectal Cancer Stem Cells. Cancer Research 79:7, pages 1426-1437.
Crossref
Pablo Baquero, Amy Dawson & Gudmundur Vignir Helgason. (2018) Autophagy and mitochondrial metabolism: insights into their role and therapeutic potential in chronic myeloid leukaemia. The FEBS Journal 286:7, pages 1271-1283.
Crossref
Jurgen Kriel & Ben Loos. (2019) The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death. Cell Death & Differentiation 26:4, pages 640-652.
Crossref
Pablo Baquero, Amy Dawson, Arunima Mukhopadhyay, Elodie M. Kuntz, Rebecca Mitchell, Orianne Olivares, Angela Ianniciello, Mary T. Scott, Karen Dunn, Michael C. Nicastri, Jeffrey D. Winkler, Alison M. Michie, Kevin M. Ryan, Christina Halsey, Eyal Gottlieb, Erin P. Keaney, Leon O. Murphy, Ravi K. Amaravadi, Tessa L. Holyoake & G. Vignir Helgason. (2018) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia 33:4, pages 981-994.
Crossref
Alexandra G Smith & Kay F Macleod. (2019) Autophagy, cancer stem cells and drug resistance. The Journal of Pathology 247:5, pages 708-718.
Crossref
Marco B. Schaaf, Diede Houbaert, Odeta Meçe, San Kit To, Maarten Ganne, Hannelore Maes & Patrizia Agostinis. (2019) Lysosomal Pathways and Autophagy Distinctively Control Endothelial Cell Behavior to Affect Tumor Vasculature. Frontiers in Oncology 9.
Crossref
Rushika M. PereraChiara Di Malta & Andrea Ballabio. (2019) MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer. Annual Review of Cancer Biology 3:1, pages 203-222.
Crossref
Anne Vehlow, Erik Klapproth, Sha Jin, Ricarda Hannen, Maria Hauswald, Jörg-Walter Bartsch, Christopher Nimsky, Achim Temme, Birgit Leitinger & Nils Cordes. (2019) Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity. Cell Reports 26:13, pages 3672-3683.e7.
Crossref
Hendrik Folkerts, Susan Hilgendorf, Edo Vellenga, Edwin Bremer & Valerie R. Wiersma. (2018) The multifaceted role of autophagy in cancer and the microenvironment. Medicinal Research Reviews 39:2, pages 517-560.
Crossref
Vito W. Rebecca, Michael C. Nicastri, Colin Fennelly, Cynthia I. Chude, Julie S. Barber-Rotenberg, Amruta Ronghe, Quentin McAfee, Noel P. McLaughlin, Gao Zhang, Aaron R. Goldman, Rani Ojha, Shengfu Piao, Estela Noguera-Ortega, Alessandra Martorella, Gretchen M. Alicea, Jennifer J. Lee, Lynn M. Schuchter, Xiaowei Xu, Meenhard Herlyn, Ronen Marmorstein, Phyllis A. Gimotty, David W. Speicher, Jeffrey D. Winkler & Ravi K. Amaravadi. (2019) PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. Cancer Discovery 9:2, pages 220-229.
Crossref
Afshan Fathima Nawas, Ragini Mistry, Shrinath Narayanan, Shayna Elizabeth Thomas‐Jardin, Janani Ramachandran, Jananisree Ravichandran, Ebin Neduvelil, Krisha Luangpanh & Nikki Ayanna Delk. (2018) IL‐1 induces p62/SQSTM1 and autophagy in ERα + /PR + BCa cell lines concomitant with ERα and PR repression, conferring an ERα − /PR − BCa‐like phenotype . Journal of Cellular Biochemistry 120:2, pages 1477-1491.
Crossref
Juan Sironi, Evelyn Aranda, Lars Ulrik Nordstrøm & Edward L. Schwartz. (2019) Lysosome Membrane Permeabilization and Disruption of the Molecular Target of Rapamycin (mTOR)-Lysosome Interaction Are Associated with the Inhibition of Lung Cancer Cell Proliferation by a Chloroquinoline Analog. Molecular Pharmacology 95:1, pages 127-138.
Crossref
Emmanuel K. CudjoeJr.Jr., S. Lauren Kyte, Tareq Saleh, Joseph W. Landry & David A. Gewirtz. 2019. Targeting Cell Survival Pathways to Enhance Response to Chemotherapy. Targeting Cell Survival Pathways to Enhance Response to Chemotherapy 259 273 .
Sunandana Chandra, Grant McArthur & Jeffrey Sosman. 2019. Cutaneous Melanoma. Cutaneous Melanoma 1 22 .
Kamran Abri & Adil I. Daud. 2019. Melanoma. Melanoma 687 697 .
Lei Zhan, Jun Li & Bing Wei. (2018) Autophagy therapeutics: preclinical basis and initial clinical studies. Cancer Chemotherapy and Pharmacology 82:6, pages 923-934.
Crossref
Evangelos Koustas, Athanasios G. Papavassiliou & Michalis V. Karamouzis. (2018) The role of autophagy in the treatment of BRAF mutant colorectal carcinomas differs based on microsatellite instability status. PLOS ONE 13:11, pages e0207227.
Crossref
O.A. Garden, S.W. Volk, N.J. Mason & J.A. Perry. (2018) Companion animals in comparative oncology: One Medicine in action. The Veterinary Journal 240, pages 6-13.
Crossref
Sheng Yin, Chunyu Xia, Yashi Wang, Dandan Wan, Jingdong Rao, Xian Tang, Jiaojie Wei, Xuhui Wang, Man Li, Zhirong Zhang, Ji Liu & Qin He. (2018) Dual receptor recognizing liposomes containing paclitaxel and hydroxychloroquine for primary and metastatic melanoma treatment via autophagy-dependent and independent pathways. Journal of Controlled Release 288, pages 148-160.
Crossref
Jiale Liu, Xiaoxuan Liu, Yanfeng Han, Jing Zhang, Dan Liu, Guilei Ma, Chen Li, Lanxia Liu & Deling Kong. (2018) Nanovaccine Incorporated with Hydroxychloroquine Enhances Antigen Cross-Presentation and Promotes Antitumor Immune Responses. ACS Applied Materials & Interfaces 10:37, pages 30983-30993.
Crossref
Michael J. MorganBrent E. FitzwalterCharles R. OwensRani K. Powers, Joseph L. SottnikGraciela GamezJames C. Costello, Dan TheodorescuAndrew Thorburn. (2018) Metastatic cells are preferentially vulnerable to lysosomal inhibition. Proceedings of the National Academy of Sciences 115:36.
Crossref
Angelique V. Onorati, Matheus Dyczynski, Rani Ojha & Ravi K. Amaravadi. (2018) Targeting autophagy in cancer. Cancer 124:16, pages 3307-3318.
Crossref
Jingwen Xu, Nipa H. Patel, Tareq Saleh, Emmanuel K. Cudjoe, Moureq Alotaibi, Yingliang Wu, Santiago Lima, Adam M. Hawkridge & David A. Gewirtz. (2018) Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy. Radiation Research 190:5, pages 538.
Crossref
Timothy M Hall, Marie-Pier Tétreault, Kathryn E Hamilton & Kelly A Whelan. (2018) Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma. Current Opinion in Pharmacology 41, pages 12-19.
Crossref
Vivian Adamski, Christina Schmitt, Florian Ceynowa, Rainer Adelung, Ralph Lucius, Michael Synowitz, Kirsten Hattermann & Janka Held-Feindt. (2018) Effects of sequentially applied single and combined temozolomide, hydroxychloroquine and AT101 treatment in a long-term stimulation glioblastoma in vitro model. Journal of Cancer Research and Clinical Oncology 144:8, pages 1475-1485.
Crossref
Jurgen Kriel, Kristian Müller-Nedebock, Gerald Maarman, Siyasanga Mbizana, Edward Ojuka, Bert Klumperman & Ben Loos. (2018) Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics. Scientific Reports 8:1.
Crossref
David A. Gewirtz, Liliya Tyutyunyk-Massey & Joseph W. Landry. (2018) The potentially conflicting cell autonomous and cell non-autonomous functions of autophagy in mediating tumor response to cancer therapy. Biochemical Pharmacology 153, pages 46-50.
Crossref
Elizabeth A. Hall, Jon E. Ramsey, Zhihua Peng, Davit Hayrapetyan, Viacheslav Shkepu, Bruce O'Rourke, William Geiger, Kevin Lam & Claire F. Verschraegen. (2018) Novel organometallic chloroquine derivative inhibits tumor growth. Journal of Cellular Biochemistry 119:7, pages 5921-5933.
Crossref
Payel Sil, Sing-Wai Wong & Jennifer Martinez. (2018) More Than Skin Deep: Autophagy Is Vital for Skin Barrier Function. Frontiers in Immunology 9.
Crossref
Keagan P. Collins, Kristen M. Jackson & Daniel L. Gustafson. (2018) Hydroxychloroquine: A Physiologically-Based Pharmacokinetic Model in the Context of Cancer-Related Autophagy Modulation. Journal of Pharmacology and Experimental Therapeutics 365:3, pages 447-459.
Crossref
Jaroslav Zelenka, Martina Koncošová & Tomáš Ruml. (2018) Targeting of stress response pathways in the prevention and treatment of cancer. Biotechnology Advances 36:3, pages 583-602.
Crossref
Hussein F. Aqbi, Liliya Tyutyunyk-Massey, Rebecca C. Keim, Savannah E. Butler, Theresa Thekkudan, Supriya Joshi, Timothy M. Smith, Dipankar Bandyopadhyay, Michael O. Idowu, Harry D. Bear, Kyle K. Payne, David A. Gewirtz & Masoud H. Manjili. (2018) Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy. Oncotarget 9:31, pages 22113-22122.
Crossref
Ana Serrano-Puebla & Patricia Boya. (2018) Lysosomal membrane permeabilization as a cell death mechanism in cancer cells. Biochemical Society Transactions 46:2, pages 207-215.
Crossref
Andrew Thorburn. (2018) Autophagy and disease. Journal of Biological Chemistry 293:15, pages 5425-5430.
Crossref
Elzbieta Pawlowska, Joanna Szczepanska, Magdalena Szatkowska & Janusz Blasiak. (2018) An Interplay between Senescence, Apoptosis and Autophagy in Glioblastoma Multiforme—Role in Pathogenesis and Therapeutic Perspective. International Journal of Molecular Sciences 19:3, pages 889.
Crossref
Annan Yang, Grit Herter-Sprie, Haikuo Zhang, Elaine Y. Lin, Douglas Biancur, Xiaoxu Wang, Jiehui Deng, Josephine Hai, Shenghong Yang, Kwok-Kin Wong & Alec C. Kimmelman. (2018) Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms. Cancer Discovery 8:3, pages 276-287.
Crossref
Wei Yang, Sarah R. Hosford, Nicole A. Traphagen, Kevin Shee, Eugene Demidenko, Stephanie Liu & Todd W. Miller. (2018) Autophagy promotes escape from phosphatidylinositol 3‐kinase inhibition in estrogen receptor‐positive breast cancer. The FASEB Journal 32:3, pages 1222-1235.
Crossref
Siew-Li Lai, Mohd Rais Mustafa & Pooi-Fong Wong. (2018) Panduratin A induces protective autophagy in melanoma via the AMPK and mTOR pathway. Phytomedicine 42, pages 144-151.
Crossref
Roberta Ranieri, Elena Ciaglia, Giuseppina Amodio, Paola Picardi, Maria Chiara Proto, Patrizia Gazzerro, Chiara Laezza, Paolo Remondelli, Maurizio Bifulco & Simona Pisanti. (2017) N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux. Cell Death & Differentiation 25:2, pages 353-367.
Crossref
Janice M. Santiago-O’Farrill, Eugenie S. Kleinerman, Mario G. Hollomon, Andrew Livingston, Wei-Lien Wang, Jen-Wei Tsai & Nancy B. Gordon. (2017) Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy. Oncotarget 9:2, pages 1602-1616.
Crossref
Fernanda Antunes, Adolfo Garcia Erustes, Angélica Jardim Costa, Ana Carolina Nascimento, Claudia Bincoletto, Rodrigo Portes Ureshino, Gustavo José Silva Pereira & Soraya Soubhi Smaili. (2018) Autophagy and intermittent fasting: the connection for cancer therapy?. Clinics 73, pages e814s.
Crossref
Xuhui Wang, Yue Qiu, Qianwen Yu, Hui Li, Xiaoxiao Chen, Man Li, Yang Long, Yayuan Liu, Libao Lu, Jiajing Tang, Zhirong Zhang & Qin He. (2018) Enhanced glioma therapy by synergistic inhibition of autophagy and tyrosine kinase activity. International Journal of Pharmaceutics 536:1, pages 1-10.
Crossref
Punya Bhat, Jurgen Kriel, Babu Shubha Priya, Basappa, Nanjunda Swamy Shivananju & Ben Loos. (2018) Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization. Biochemical Pharmacology 147, pages 170-182.
Crossref
Kamran Abri & Adil I. Daud. 2017. Melanoma. Melanoma 1 11 .
MATHILDE CHERAY, GAËLLE BÉGAUD, ELISE DELUCHE, ALEXANDRE NIVET, SERGE BATTU, FABRICE LALLOUÉ, MIREILLE VERDIER & BARBARA BESSETTE. 2017. Glioblastoma. Glioblastoma 59 71 .
Jean M. Mulcahy Levy, Christina G. Towers & Andrew Thorburn. (2017) Targeting autophagy in cancer. Nature Reviews Cancer 17:9, pages 528-542.
Crossref
Aysa Rezabakhsh, Soheila Montazersaheb, Elahe Nabat, Mehdi Hassanpour, Azadeh Montaseri, Hassan Malekinejad, Ali Akbar Movassaghpour, Reza Rahbarghazi & Alireza Garjani. (2017) Effect of hydroxychloroquine on oxidative/nitrosative status and angiogenesis in endothelial cells under high glucose condition. BioImpacts 7:4, pages 219-226.
Crossref
Ammar Kurdi, Matthias Cleenewerck, Christel Vangestel, Sophie Lyssens, Wim Declercq, Jean-Pierre Timmermans, Sigrid Stroobants, Koen Augustyns, Guido R.Y. De Meyer, Pieter Van Der Veken & Wim Martinet. (2017) ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice. Biochemical Pharmacology 138, pages 150-162.
Crossref
Li Min, Edwin Choy, Raphael E. Pollock, Chongqi Tu, Francis Hornicek & Zhenfeng Duan. (2017) Autophagy as a potential target for sarcoma treatment. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868:1, pages 40-50.
Crossref
Hendrik Folkerts, Susan Hilgendorf, Albertus T J Wierenga, Jennifer Jaques, André B Mulder, Paul J Coffer, Jan Jacob Schuringa & Edo Vellenga. (2017) Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia. Cell Death & Disease 8:7, pages e2927-e2927.
Crossref

Displaying 200 of 275 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list