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Accelerated aging in the tumor microenvironment

Connecting aging, inflammation and cancer metabolism with personalized medicine

, , , , , & show all
Pages 2059-2063 | Published online: 01 Jul 2011

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Read on this site (12)

Michael P Lisanti, Kimberly Reeves, Maria Peiris-Pagès, Amy L Chadwick, Rosa Sanchez-Alvarez, Anthony Howell, Ubaldo E. Martinez-Outschoorn & Federica Sotgia. (2014) JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention. Cell Cycle 13:4, pages 580-599.
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Michael P. Lisanti, Ubaldo E. Martinez-Outschoorn & Federica Sotgia. (2013) Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery. Cell Cycle 12:17, pages 2723-2732.
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Ubaldo E Martinez-Outschoorn, Joseph M Curry, Ying-Hui Ko, Zhao Lin, Madalina Tuluc, David Cognetti, Ruth C Birbe, Edmund Pribitkin, Alessandro Bombonati, Richard G Pestell, Anthony Howell, Federica Sotgia & Michael P Lisanti. (2013) Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment. Cell Cycle 12:16, pages 2580-2597.
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Mazhar Al-Zoubi, Ahmed F. Salem, Ubaldo E. Martinez-Outschoorn, Diana Whitaker-Menezes, Rebecca Lamb, James Hulit, Anthony Howell, Ricardo Gandara, Marina Sartini, Hwyda Arafat, Generoso Bevilacqua, Federica Sotgia & Michael P. Lisanti. (2013) Creating a tumor-resistant microenvironment: Cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo. Cell Cycle 12:3, pages 480-490.
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Claudia Capparelli, Barbara Chiavarina, Diana Whitaker-Menezes, Timothy G. Pestell, Richard G. Pestell, James Hulit, Sebastiano Andò, Anthony Howell, Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle 11:19, pages 3599-3610.
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Claudia Capparelli, Carmela Guido, Diana Whitaker-Menezes, Gloria Bonuccelli, Renee Balliet, Timothy G. Pestell, Allison F. Goldberg, Richard G. Pestell, Anthony Howell, Sharon Sneddon, Ruth Birbe, Aristotelis Tsirigos, Ubaldo Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production. Cell Cycle 11:12, pages 2285-2302.
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Federica Sotgia, Diana Whitaker-Menezes, Ubaldo E. Martinez-Outschoorn, Neal Flomenberg, Ruth Birbe, Agnieszka K. Witkiewicz, Anthony Howell, Nancy J. Philp, Richard G. Pestell & Michael P. Lisanti. (2012) Mitochondrial metabolism in cancer metastasis. Cell Cycle 11:7, pages 1445-1454.
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Agnieszka K. Witkiewicz, Diana Whitaker-Menezes, Abhijit Dasgupta, Nancy J. Philp, Zhao Lin, Ricardo Gandara, Sharon Sneddon, Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) Using the “reverse Warburg effect” to identify high-risk breast cancer patients. Cell Cycle 11:6, pages 1108-1117.
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Adam Ertel, Aristotelis Tsirigos, Diana Whitaker-Menezes, Ruth Birbe, Stephanos Pavlides, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Federica Sotgia & Michael P. Lisanti. (2012) Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism. Cell Cycle 11:2, pages 253-263.
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Renee M. Balliet, Claudia Capparelli, Carmela Guido, Timothy G. Pestell, Ubaldo E. Martinez-Outschoorn, Zhao Lin, Diana Whitaker-Menezes, Barbara Chiavarina, Richard G. Pestell, Anthony Howell, Federica Sotgia & Michael P. Lisanti. (2011) Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth. Cell Cycle 10:23, pages 4065-4073.
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Michael P Lisanti, Ubaldo E. Martinez-Outschoorn, Zhao Lin, Stephanos Pavlides, Diana Whitaker-Menezes, Richard G. Pestell, Anthony Howell & Federica Sotgia. (2011) Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis. Cell Cycle 10:15, pages 2440-2449.
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Ubaldo E. Martinez-Outschoorn, Zhao Lin, Ying-Hui Ko, Allison Goldberg, Neal Flomenberg, Chenguang Wang, Stephanos Pavlides, Richard G. Pestell, Anthony Howell, Federica Sotgia & Michael P. Lisanti. (2011) Understanding the metabolic basis of drug resistance. Cell Cycle 10:15, pages 2521-2528.
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