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Andrew Dippel, Austin Gallegos, Vineela Aleti, Arnita Barnes, Xiaoru Chen, Elizabeth Christian, Jared Delmar, Qun Du, Reza Esfandiary, Erika Farmer, Andrew Garcia, Qing Li, Jia Lin, Weiyi Liu, LeeAnn Machiesky, Neil Mody, Arun Parupudi, Meagan Prophet, Keith Rickert, Kim Rosenthal, Song Ren, Harini Shandilya, Reena Varkey, Kevin Wons, Yuling Wu, Yueh-Ming Loo, Mark T. Esser, Nicole L. Kallewaard, Sarav Rajan, Melissa Damschroder, Weichen Xu & Gilad Kaplan. (2023) Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies. mAbs 15:1.
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Md Harunur Rashid. (2022) Full-length recombinant antibodies from Escherichia coli: production, characterization, effector function (Fc) engineering, and clinical evaluation. mAbs 14:1.
Read now
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Saki Yoneda, Tetsuo Torisu & Susumu Uchiyama. (2021) Development of syringes and vials for delivery of biologics: current challenges and innovative solutions. Expert Opinion on Drug Delivery 18:4, pages 459-470.
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Eva Germovsek, Ming Cheng & Craig Giragossian. (2021) Allometric scaling of therapeutic monoclonal antibodies in preclinical and clinical settings. mAbs 13:1.
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Inja Waldhauer, Valeria Gonzalez-Nicolini, Anne Freimoser-Grundschober, Tapan K Nayak, Linda Fahrni, Ralf J. Hosse, Danny Gerrits, Edwin J. W. Geven, Johannes Sam, Sabine Lang, Esther Bommer, Virginie Steinhart, Elisabeth Husar, Sara Colombetti, Erwin Van Puijenbroek, Markus Neubauer, J. Mark Cline, Pradeep K. Garg, Gregory Dugan, Federica Cavallo, Gonzalo Acuna, Jehad Charo, Volker Teichgräber, Stefan Evers, Otto C. Boerman, Marina Bacac, Ekkehard Moessner, Pablo Umaña & Christian Klein. (2021) Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy. mAbs 13:1.
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Lijun Xu, Shanlong Wang, Jufeng Li, Jie Li & Bingyu Li. (2020) Cancer immunotherapy based on blocking immune suppression mediated by an immune modulator LAIR-1. OncoImmunology 9:1.
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Benjamin E. Low, Gregory J. Christianson, Emily Lowell, Wenning Qin & Michael V. Wiles. (2020) Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice. mAbs 12:1.
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Brian C. Mackness, Julie A. Jaworski, Ekaterina Boudanova, Anna Park, Delphine Valente, Christine Mauriac, Olivier Pasquier, Thorsten Schmidt, Mostafa Kabiri, Abdullah Kandira, Katarina Radošević & Huawei Qiu. (2019) Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life. mAbs 11:7, pages 1276-1288.
Read now
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Marie Godar, Hans de Haard, Christophe Blanchetot & Jacobus Rasser. (2018) Therapeutic bispecific antibody formats: a patent applications review (1994-2017). Expert Opinion on Therapeutic Patents 28:3, pages 251-276.
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Flávia Sousa, Pedro Castro, Pedro Fonte, Patrick J. Kennedy, Maria Teresa Neves-Petersen & Bruno Sarmento. (2017) Nanoparticles for the delivery of therapeutic antibodies: Dogma or promising strategy?. Expert Opinion on Drug Delivery 14:10, pages 1163-1176.
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Claudia A. Castro Jaramillo, Sara Belli, Anne-Christine Cascais, Sherri Dudal, Martin R. Edelmann, Markus Haak, Marie-Elise Brun, Michael B. Otteneder, Mohammed Ullah, Christoph Funk, Franz Schuler & Silke Simon. (2017) Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms. mAbs 9:5, pages 781-791.
Read now
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Saman Soleimanpour, Tahereh Hassannia, Mahdieh Motiee, Abbas Ali Amini & S. A. R. Rezaee. (2017) Fcγ1 fragment of IgG1 as a powerful affinity tag in recombinant Fc-fusion proteins: immunological, biochemical and therapeutic properties. Critical Reviews in Biotechnology 37:3, pages 371-392.
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Melissa Y. Yeung, Steven Gabardi & Mohamed H. Sayegh. (2017) Use of polyclonal/monoclonal antibody therapies in transplantation. Expert Opinion on Biological Therapy 17:3, pages 339-352.
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Roland E. Kontermann. (2016) Half-life extended biotherapeutics. Expert Opinion on Biological Therapy 16:7, pages 903-915.
Read now
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N Hironiwa, S Ishii, S Kadono, Y Iwayanagi, F Mimoto, K Habu, T Igawa & K Hattori. (2016) Calcium-dependent antigen binding as a novel modality for antibody recycling by endosomal antigen dissociation. mAbs 8:1, pages 65-73.
Read now
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Philipp Moog & Klaus Thuermel. (2015) Spotlight on rituximab in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis: current perspectives. Therapeutics and Clinical Risk Management 11, pages 1749-1758.
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Minoru Tada, Ken-Ichiro Tatematsu, Akiko Ishii-Watabe, Akira Harazono, Daisuke Takakura, Noritaka Hashii, Hideki Sezutsu & Nana Kawasaki. (2015) Characterization of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori). mAbs 7:6, pages 1138-1150.
Read now
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Amita Datta-Mannan, Jirong Lu, Derrick R Witcher, Donmienne Leung, Ying Tang & Victor J Wroblewski. (2015) The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies. mAbs 7:6, pages 1084-1093.
Read now
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Tianlei Ying, Yanping Wang, Yang Feng, Ponraj Prabakaran, Rui Gong, Lili Wang, Karalyne Crowder & Dimiter S Dimitrov. (2015) Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn. mAbs 7:5, pages 922-930.
Read now
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Colby A Souders, Stuart C Nelson, Yang Wang, Andrew R Crowley, Mark S Klempner & William Thomas$suffix/text()$suffix/text(). (2015) A novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life. mAbs 7:5, pages 912-921.
Read now
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Ranajoy Majumdar, Reza Esfandiary, Steven M Bishop, Hardeep S Samra, C Russell Middaugh, David B Volkin & David D Weis. (2015) Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life. mAbs 7:1, pages 84-95.
Read now
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Jan Stracke, Thomas Emrich, Petra Rueger, Tilman Schlothauer, Lothar Kling, Alexander Knaupp, Hubert Hertenberger, Andreas Wolfert, Christian Spick, Wilma Lau, Georg Drabner, Ulrike Reiff, Hans Koll & Apollon Papadimitriou. (2014) A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies. mAbs 6:5, pages 1229-1242.
Read now
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Tobias Neuber, Katrin Frese, Jan Jaehrling, Sebastian Jäger, Daniela Daubert, Karin Felderer, Mechthild Linnemann, Anne Höhne, Stefan Kaden, Johanna Kölln, Thomas Tiller, Bodo Brocks, Ralf Ostendorp & Stefan Pabst. (2014) Characterization and screening of IgG binding to the neonatal Fc receptor. mAbs 6:4, pages 928-942.
Read now
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Yuan Wang, Zehua Tian, Diraviyam Thirumalai & Xiaoying Zhang. (2014) Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering. Journal of Drug Targeting 22:4, pages 269-278.
Read now
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Céline Monnet, Sylvie Jorieux, Nathalie Souyris, Ouafa Zaki, Alexandra Jacquet, Nathalie Fournier, Fabien Crozet, Christophe de Romeuf, Khalil Bouayadi, Rémi Urbain, Christian K Behrens, Philippe Mondon & Alexandre Fontayne. (2014) Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody. mAbs 6:2, pages 422-436.
Read now
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Thomas List & Dario Neri. (2013) Immunocytokines: a review of molecules in clinical development for cancer therapy. Clinical Pharmacology: Advances and Applications 5:sup1, pages 29-45.
Read now
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Josée Golay, Gianpietro Semenzato, Alessandro Rambaldi, Robin Foà, Gianluca Gaidano, Enrica Gamba, Fabrizio Pane, Antonello Pinto, Giorgina Specchia, Francesco Zaja & Mario Regazzi. (2013) Lessons for the clinic from rituximab pharmacokinetics and pharmacodynamics. mAbs 5:6, pages 826-837.
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Maria Laura Belladonna & Ursula Grohmann. (2013) Bioengineering heterodimeric cytokines: turning promiscuous proteins into therapeutic agents. Biotechnology and Genetic Engineering Reviews 29:2, pages 149-174.
Read now
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Matthew J. Bernett, Seung Y. Chu, Irene Leung, Gregory L. Moore, Sung-Hyung Lee, Erik Pong, Hsing Chen, Sheryl Phung, Umesh S. Muchhal, Holly M. Horton, Greg A. Lazar, John R Desjarlais & David E. Szymkowski. (2013) Immune suppression in cynomolgus monkeys by XPro9523. mAbs 5:3, pages 384-396.
Read now
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Isidro Hötzel, Frank-Peter Theil, Lisa J. Bernstein, Saileta Prabhu, Rong Deng, Leah Quintana, Jeff Lutman, Renuka Sibia, Pamela Chan, Daniela Bumbaca, Paul Fielder, Paul J. Carter & Robert F. Kelley. (2012) A strategy for risk mitigation of antibodies with fast clearance. mAbs 4:6, pages 753-760.
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Yong Fu, Renhong Tang & Xiaofeng Zhao. (2023) Engineering cytokines for cancer immunotherapy: a systematic review. Frontiers in Immunology 14.
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Crossref
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Christoph Q. Schmidt & Richard J. H. Smith. (2022) Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system. Immunological Reviews 313:1, pages 376-401.
Crossref
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Crossref
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Crossref
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Patty A. Culp, Jeremiah D. Degenhardt, Danielle E. Dettling & Chad May. 2022. Cancer Immunology and Immunotherapy. Cancer Immunology and Immunotherapy
267
319
.
Giovana Onzi, Silvia S. Guterres, Adriana R. Pohlmann & Luiza Abrahão Frank. 2022. The ADME Encyclopedia. The ADME Encyclopedia
68
80
.
Ian Wilkinson, Stephen Anderson, Jeremy Fry, Louis Alex Julien, David Neville, Omar Qureshi, Gary Watts & Geoff Hale. (2021) Fc-engineered antibodies with immune effector functions completely abolished. PLOS ONE 16:12, pages e0260954.
Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Crossref
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Crossref
Crossref
Samvedna Saini & Yatender Kumar. 2021. Translational Biotechnology. Translational Biotechnology
233
266
.
Giovana Onzi, Silvia S. Guterres, Adriana R. Pohlmann & Luiza Abrahão Frank. 2021. The ADME Encyclopedia. The ADME Encyclopedia
1
13
.
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Crossref
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Crossref
Crossref
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Crossref
Crossref
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Crossref
Crossref
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Crossref
Crossref
Susanna K. ElledgeHai L. Tran, Alec H. ChristianVeronica SteriByron HannF. Dean Toste, Christopher J. ChangJames A. Wells. (2020) Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation. Proceedings of the National Academy of Sciences 117:11, pages 5733-5740.
Crossref
Crossref
John S. Ruano-Salguero & Kelvin H. Lee. (2020) Antibody transcytosis across brain endothelial-like cells occurs nonspecifically and independent of FcRn. Scientific Reports 10:1.
Crossref
Crossref
Ruksana Huda. (2020) New Approaches to Targeting B Cells for Myasthenia Gravis Therapy. Frontiers in Immunology 11.
Crossref
Crossref
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Crossref
Crossref
Hanna Wabnitz, Ramsha Khan & Alan H. Lazarus. (2020) The use of IVIg in fetal and neonatal alloimmune thrombocytopenia— Principles and mechanisms. Transfusion and Apheresis Science 59:1, pages 102710.
Crossref
Crossref
Ninad Varkhede, Rupesh Bommana, Christian Schöneich & M. Laird Forrest. (2020) Proteolysis and Oxidation of Therapeutic Proteins After Intradermal or Subcutaneous Administration. Journal of Pharmaceutical Sciences 109:1, pages 191-205.
Crossref
Crossref
Terence L. Kirley, Andrew B. Norman & Hanna N. Wetzel. (2020) A novel differential scanning fluorimetry analysis of a humanized anti-cocaine mAb and its ligand binding characteristics. Journal of Immunological Methods 476, pages 112676.
Crossref
Crossref
Hideki Watanabe, Chuya Yoshida, Ayako Ooishi, Yasuto Nakai, Momoko Ueda, Yutaka Isobe & Shinya Honda. (2019) Histidine-Mediated Intramolecular Electrostatic Repulsion for Controlling pH-Dependent Protein–Protein Interaction. ACS Chemical Biology 14:12, pages 2729-2736.
Crossref
Crossref
Kyungbo Kim, Pereira Araujo, Nikhil Hebbar, Ziyuan Zhou, Xirong Zheng, Fang Zheng, Vivek M Rangnekar & Chang-Guo Zhan. (2019) Development of a novel prostate apoptosis response-4 (Par-4) protein entity with an extended duration of action for therapeutic treatment of cancer. Protein Engineering, Design and Selection 32:3, pages 159-166.
Crossref
Crossref
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Crossref
Crossref
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Crossref
Crossref
Dongfen Yuan, Frederik Rode & Yanguang Cao. (2019) A systems pharmacokinetic/pharmacodynamic model for concizumab to explore the potential of anti-TFPI recycling antibodies. European Journal of Pharmaceutical Sciences 138, pages 105032.
Crossref
Crossref
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Crossref
Crossref
Keith J. Arlotta & Shawn C. Owen. (2019) Antibody and antibody derivatives as cancer therapeutics. WIREs Nanomedicine and Nanobiotechnology 11:5.
Crossref
Crossref
Yao-Yun Fan, Vahid Farrokhi, Teresa Caiazzo, Mengmeng Wang, Denise M. O’Hara & Hendrik Neubert. (2019) Human FcRn Tissue Expression Profile and Half-Life in PBMCs. Biomolecules 9:8, pages 373.
Crossref
Crossref
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Crossref
Crossref
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Crossref
Crossref
Justin K. Murray, Bin Wu, Christopher M. Tegley, Thomas E. Nixey, James R. Falsey, Brad Herberich, Li Yin, Kelvin Sham, Jason Long, Jennifer Aral, Yuan Cheng, Chawita Netirojjanakul, Liz Doherty, Charles Glaus, Tayo Ikotun, Hongyan Li, Linh Tran, Marcus Soto, Hossein Salimi-Moosavi, Joseph Ligutti, Shanti Amagasu, Kristin L. Andrews, Xuhai Be, Min-Hwa Jasmine Lin, Robert S. Foti, Christopher P. Ilch, Beth Youngblood, Thomas J. Kornecook, Margaret Karow, Kenneth W. Walker, Bryan D. Moyer, Kaustav Biswas & Les P. Miranda. (2019)
Engineering Na
V
1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics
. ACS Chemical Biology 14:4, pages 806-818.
Crossref
Crossref
Subhabrata Majumder, Wei Wang & Arun Alphonse Ignatius. (2019) Impact of Buffers on Colloidal Property and Aggregation Propensities of a Bispecific Antibody. Journal of Pharmaceutical Sciences 108:3, pages 1139-1147.
Crossref
Crossref
Yvonne J. Rosenberg, George K. Lewis, David C. Montefiori, Celia C. LaBranche, Mark G. Lewis, Lori A. Urban, Jonathan P. Lees, Lingjun Mao & Xiaoming Jiang. (2019) Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques. PLOS ONE 14:2, pages e0212649.
Crossref
Crossref
Kenta Haraya, Tatsuhiko Tachibana & Tomoyuki Igawa. (2019) Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering. Drug Metabolism and Pharmacokinetics 34:1, pages 25-41.
Crossref
Crossref
Cornelia Hutmacher & Dario Neri. (2019) Antibody-cytokine fusion proteins: Biopharmaceuticals with immunomodulatory properties for cancer therapy. Advanced Drug Delivery Reviews 141, pages 67-91.
Crossref
Crossref
Andrew T. Lucas, Ryan Robinson, Allison N. Schorzman, Joseph A. Piscitelli, Juan F. Razo & William C. Zamboni. (2019) Pharmacologic Considerations in the Disposition of Antibodies and Antibody-Drug Conjugates in Preclinical Models and in Patients. Antibodies 8:1, pages 3.
Crossref
Crossref
Chen Wang, Qingshan Zheng, Mingqiang Zhang & Hong Lu. (2018) Lack of ethnic differences in the pharmacokinetics and pharmacodynamics of evolocumab between Caucasian and Asian populations. British Journal of Clinical Pharmacology 85:1, pages 114-125.
Crossref
Crossref
Dorien De Vlieger, Marlies Ballegeer, Iebe Rossey, Bert Schepens & Xavier Saelens. (2018) Single-Domain Antibodies and Their Formatting to Combat Viral Infections. Antibodies 8:1, pages 1.
Crossref
Crossref
Niyanta N. Kumar, Michelle E. Pizzo, Geetika Nehra, Brynna Wilken-Resman, Sam Boroumand & Robert G. Thorne. (2018) Passive Immunotherapies for Central Nervous System Disorders: Current Delivery Challenges and New Approaches. Bioconjugate Chemistry 29:12, pages 3937-3966.
Crossref
Crossref
Tiziana Alberio, Greta Forlani, Marta Lualdi, Giovanna Tosi, Roberto S. Accolla & Mauro Fasano. (2018) Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells. Journal of Translational Medicine 16:1.
Crossref
Crossref
Alexander Falkenhagen & Sadhna Joshi. (2018) HIV Entry and Its Inhibition by Bifunctional Antiviral Proteins. Molecular Therapy - Nucleic Acids 13, pages 347-364.
Crossref
Crossref
Yanli Zhuang, Di Chen, Amarnath Sharma & Zhenhua Xu. (2018) Risk-Based Comparability Assessment for Monoclonal Antibodies During Drug Development: A Clinical Pharmacology Perspective. The AAPS Journal 20:6.
Crossref
Crossref
Meric Ovacik & Kedan Lin. (2018) Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development. Clinical and Translational Science 11:6, pages 540-552.
Crossref
Crossref
Dinen D. Shah, Jingming Zhang, Ming-ching Hsieh, Shanmuuga Sundaram, Haripada Maity & Krishna M.G. Mallela. (2018) Effect of Peroxide- Versus Alkoxyl-Induced Chemical Oxidation on the Structure, Stability, Aggregation, and Function of a Therapeutic Monoclonal Antibody. Journal of Pharmaceutical Sciences 107:11, pages 2789-2803.
Crossref
Crossref
Marcela Helena Gambim Fonseca, Gilvan Pessoa Furtado, Marcus Rafael Lobo Bezerra, Larissa Queiroz Pontes & Carla Freire Celedonio Fernandes. (2018) Boosting half-life and effector functions of therapeutic antibodies by Fc-engineering: An interaction-function review. International Journal of Biological Macromolecules 119, pages 306-311.
Crossref
Crossref
Kayoko Hayashihara, Kanta Enomoto & Susumu Uchiyama. (2018) Analysis of Primary and Higher Order Structures of Biopharmaceuticals Including Antibody Drugs by Mass Spectrometry質量分析法による抗体医薬などのバイオ医薬品の一次および高次構造解析. Journal of the Mass Spectrometry Society of Japan 66:4, pages 161-163.
Crossref
Crossref
Shridhar C. Ghagane, Sridevi I. Puranik, Siew Hua Gan, Murigendra B. Hiremath, R.B. Nerli & M.V. Ravishankar. (2018) Frontiers of monoclonal antibodies: Applications in medical practices. Human Antibodies 26:3, pages 135-142.
Crossref
Crossref
Holm SchneiderFlorian FaschingbauerSonia Schuepbach-MallepellIris KörberSigrun WohlfartAngela DickMandy WahlbuhlChristine Kowalczyk-QuintasMichele VigoloNeil KirbyCorinna TannertOliver RompelWolfgang RascherMatthias W. BeckmannPascal Schneider. (2018) Prenatal Correction of X-Linked Hypohidrotic Ectodermal Dysplasia. New England Journal of Medicine 378:17, pages 1604-1610.
Crossref
Crossref
Peter Ulrich, Guenter Blaich, Andreas Baumann, Rajni Fagg, Adam Hey, Andrea Kiessling, Sven Kronenberg, Rikke Hvid Lindecrona, Silke Mohl, Wolfgang F. Richter, Jay Tibbitts, Flavio Crameri & Lucinda Weir. (2018) Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing. Regulatory Toxicology and Pharmacology 94, pages 91-100.
Crossref
Crossref
Andrew Lucas, Lauren Price, Allison Schorzman, Mallory Storrie, Joseph Piscitelli, Juan Razo & William Zamboni. (2018) Factors Affecting the Pharmacology of Antibody–Drug Conjugates. Antibodies 7:1, pages 10.
Crossref
Crossref
Martin R. Gaudinski, Emily E. Coates, Katherine V. Houser, Grace L. Chen, Galina Yamshchikov, Jamie G. Saunders, LaSonji A. Holman, Ingelise Gordon, Sarah Plummer, Cynthia S. Hendel, Michelle Conan-Cibotti, Margarita Gomez Lorenzo, Sandra Sitar, Kevin Carlton, Carolyn Laurencot, Robert T. Bailer, Sandeep Narpala, Adrian B. McDermott, Aryan M. Namboodiri, Janardan P. Pandey, Richard M. Schwartz, Zonghui Hu, Richard A. Koup, Edmund Capparelli, Barney S. Graham, John R. Mascola & Julie E. Ledgerwood. (2018) Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults. PLOS Medicine 15:1, pages e1002493.
Crossref
Crossref
Christian Fercher, Sahar Keshvari, Michael A McGuckin & Ross T Barnard. (2017) Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins. Experimental Biology and Medicine 243:2, pages 166-183.
Crossref
Crossref
Marco Cavaco, Miguel A. R. B. Castanho & Vera Neves. (2018) Peptibodies: An elegant solution for a long-standing problem. Peptide Science 110:1, pages e23095.
Crossref
Crossref
Moon Soo Gil, Jinhwan Cho, Thavasyappan Thambi, V.H. Giang Phan, Inchan Kwon & Doo Sung Lee. (2017) Bioengineered robust hybrid hydrogels enrich the stability and efficacy of biological drugs. Journal of Controlled Release 267, pages 119-132.
Crossref
Crossref
Valderilio Azevedo, Thomas Dörner, Robert Strohal, John Isaacs, Gilberto Castañeda-Hernández, João Gonçalves & Iain McInnes. (2017) Biosimilars: considerations for clinical practice. Considerations in Medicine 1:1, pages 13-18.
Crossref
Crossref
Michael J. E. Marshall, Richard J. Stopforth & Mark S. Cragg. (2017) Therapeutic Antibodies: What Have We Learnt from Targeting CD20 and Where Are We Going?. Frontiers in Immunology 8.
Crossref
Crossref
Jon A. Kenniston, Brandy M. Taylor, Gregory P. Conley, Janja Cosic, Kris J. Kopacz, Allison P. Lindberg, Stephen R. Comeau, Kateri Atkins, Jameson Bullen, Christopher TenHoor, Burt A. Adelman, Daniel J. Sexton, Thomas E. Edwards & Andrew E. Nixon. (2017) Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody. Journal of Biological Chemistry 292:42, pages 17449-17460.
Crossref
Crossref
Bence Szikora, László Hiripi, Balázs Bender, Imre Kacskovics & Attila Iliás. (2017) Characterization of the interactions of rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG isotypes. PLOS ONE 12:9, pages e0185662.
Crossref
Crossref
Kaustav Biswas, Thomas E. Nixey, Justin K. Murray, James R. Falsey, Li Yin, Hantao Liu, Jacinthe Gingras, Brian E. Hall, Brad Herberich, Jerry Ryan Holder, Hongyan Li, Joseph Ligutti, Min-Hwa Jasmine Lin, Dong Liu, Brian D. Soriano, Marcus Soto, Linh Tran, Christopher M. Tegley, Anrou Zou, Kannan Gunasekaran, Bryan D. Moyer, Liz Doherty & Les P. Miranda. (2017)
Engineering Antibody Reactivity for Efficient Derivatization to Generate Na
V
1.7 Inhibitory GpTx-1 Peptide–Antibody Conjugates
. ACS Chemical Biology 12:9, pages 2427-2435.
Crossref
Crossref
Yijun Shen, Hua Li, Li Zhao, Gang Li, Ben Chen, Qingsong Guo, Bei Gao, Jinsong Wu, Tong Yang, Li Jin & Yong Su. (2017) Increased half-life and enhanced potency of Fc-modified human PCSK9 monoclonal antibodies in primates. PLOS ONE 12:8, pages e0183326.
Crossref
Crossref
Kenta Haraya, Tatsuhiko Tachibana & Junichi Nezu. (2017) Quantitative prediction of therapeutic antibody pharmacokinetics after intravenous and subcutaneous injection in human. Drug Metabolism and Pharmacokinetics 32:4, pages 208-217.
Crossref
Crossref
Martin Klinger. (2017) A role for macromolecular crowding in off-target binding of therapeutic antibodies. Protein Engineering, Design and Selection 30:7, pages 489-494.
Crossref
Crossref
Sari Latvala, Bjoern Jacobsen, Michael B. Otteneder, Annika Herrmann & Sven Kronenberg. (2017) Distribution of FcRn Across Species and Tissues. Journal of Histochemistry & Cytochemistry 65:6, pages 321-333.
Crossref
Crossref
Tarianna Stewart, William T. Koval, Samuel A. Molina, Suzanne M. Bock, James W. LillardJr.Jr., Russell F. Ross, Tejal A. Desai & Michael Koval. (2017) Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway. Experimental Cell Research 355:2, pages 153-161.
Crossref
Crossref
David M. Francis & Susan N. Thomas. (2017) Progress and opportunities for enhancing the delivery and efficacy of checkpoint inhibitors for cancer immunotherapy. Advanced Drug Delivery Reviews 114, pages 33-42.
Crossref
Crossref
John P. Gibbs, J. Greg Slatter, Ogo Egbuna, Michelle Geller, Lisa Hamilton, Clapton S. Dias, Ren Y. Xu, Jessica Johnson, Scott M. Wasserman & Maurice G. Emery. (2017) Evaluation of Evolocumab (AMG 145), a Fully Human Anti-PCSK9 IgG2 Monoclonal Antibody, in Subjects With Hepatic Impairment. The Journal of Clinical Pharmacology 57:4, pages 513-523.
Crossref
Crossref
Eva M. del Amo, Anna-Kaisa Rimpelä, Emma Heikkinen, Otto K. Kari, Eva Ramsay, Tatu Lajunen, Mechthild Schmitt, Laura Pelkonen, Madhushree Bhattacharya, Dominique Richardson, Astrid Subrizi, Tiina Turunen, Mika Reinisalo, Jaakko Itkonen, Elisa Toropainen, Marco Casteleijn, Heidi Kidron, Maxim Antopolsky, Kati-Sisko Vellonen, Marika Ruponen & Arto Urtti. (2017) Pharmacokinetic aspects of retinal drug delivery. Progress in Retinal and Eye Research 57, pages 134-185.
Crossref
Crossref
K. John MorrowJr.Jr.. 2016. Biosimilars of Monoclonal Antibodies. Biosimilars of Monoclonal Antibodies
565
590
.
Young Woo Choi, Moon Cheol Kang, Yong Bok Seo, Hong Namkoong, Yunji Park, Dong-Hoon Choi, You Suk Suh, Seung-Woo Lee, Young Chul Sung & Hyun-Tak Jin. (2016) Intravaginal Administration of Fc-Fused IL7 Suppresses the Cervicovaginal Tumor by Recruiting HPV DNA Vaccine-Induced CD8 T Cells. Clinical Cancer Research 22:23, pages 5898-5908.
Crossref
Crossref
L.H. Laws, C.E. Parker, G. Cherala, Y. Koguchi, A. Waisman, M.K. Slifka, M.H. Oberbarnscheidt, J.S. Obhrai, M.Y. Yeung & L.V. Riella. (2016) Inflammation Causes Resistance to Anti-CD20–Mediated B Cell Depletion. American Journal of Transplantation 16:11, pages 3139-3149.
Crossref
Crossref
Jingjie Mo, Qingrong Yan, Chi Kwong So, Tam Soden, Michael J. Lewis & Ping Hu. (2016) Understanding the Impact of Methionine Oxidation on the Biological Functions of IgG1 Antibodies Using Hydrogen/Deuterium Exchange Mass Spectrometry. Analytical Chemistry 88:19, pages 9495-9502.
Crossref
Crossref
Eszter Lázár-Molnár & Julio C Delgado. (2016) Immunogenicity Assessment of Tumor Necrosis Factor Antagonists in the Clinical Laboratory. Clinical Chemistry 62:9, pages 1186-1198.
Crossref
Crossref
Salman Muzammil, John R. Mabus, Philip R. Cooper, Randall J. Brezski, Courtney B. Bement, Rob Perkinson, Norman D. Huebert, Suzanne Thompson, Dalia Levine, Connie Kliwinski, Dino Bradley & Pamela J. Hornby. (2016) FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric‐coated capsules in cynomolgus macaques. Pharmacology Research & Perspectives 4:3.
Crossref
Crossref
João Pedro Martins, Patrick J. Kennedy, Hélder A. Santos, Cristina Barrias & Bruno Sarmento. (2016) A comprehensive review of the neonatal Fc receptor and its application in drug delivery. Pharmacology & Therapeutics 161, pages 22-39.
Crossref
Crossref
Jeanne S. Geiser, Michael A. Heathman, Xuewei Cui, Jennifer Martin, Corina Loghin, Jenny Y. Chien & Amparo de la Pe?a. (2015) Clinical Pharmacokinetics of Dulaglutide in Patients with Type?2 Diabetes: Analyses of Data from Clinical Trials. Clinical Pharmacokinetics 55:5, pages 625-634.
Crossref
Crossref
Diego Moricoli, Damiano Cosimo Carbonella, Sabrina Dominici, Valentina Fiori, Maria Cristina Balducci, Clara Guerzoni, Maria Cristina Manara, Michela Pasello, Maria Elena Laguardia, Maurizio Cianfriglia, Katia Scotlandi & Mauro Magnani. (2015) Process development of a human recombinant diabody expressed in E. coli: engagement of CD99-induced apoptosis for target therapy in Ewing’s sarcoma. Applied Microbiology and Biotechnology 100:9, pages 3949-3963.
Crossref
Crossref
Daria A. Burmistrova, Sergey V. Tillib, Dmitry V. Shcheblyakov, Inna V. Dolzhikova, Dmitry N. Shcherbinin, Olga V. Zubkova, Tatiana I. Ivanova, Amir I. Tukhvatulin, Maxim M. Shmarov, Denis Y. Logunov, Boris S. Naroditsky & Aleksandr L. Gintsburg. (2016) Genetic Passive Immunization with Adenoviral Vector Expressing Chimeric Nanobody-Fc Molecules as Therapy for Genital Infection Caused by Mycoplasma hominis. PLOS ONE 11:3, pages e0150958.
Crossref
Crossref
Amano Masato, Fukui Kiichi & Susumu Uchiyama. (2016) Suppression of Methionine Oxidation of a Pharmaceutical Antibody Stored in a Polymer-Based Syringe. Journal of Pharmaceutical Sciences 105:2, pages 623-629.
Crossref
Crossref
David Ternant, Christophe Arnoult, Martine Pugnière, Christine Dhommée, Daniel Drocourt, Eric Perouzel, Christophe Passot, Nadine Baroukh, Denis Mulleman, Gérard Tiraby, Hervé Watier, Gilles Paintaud & Valérie Gouilleux-Gruart. (2016) IgG1 Allotypes Influence the Pharmacokinetics of Therapeutic Monoclonal Antibodies through FcRn Binding. The Journal of Immunology 196:2, pages 607-613.
Crossref
Crossref
Jean W Lee. (2016) Generic method approaches for monoclonal antibody therapeutics analysis using both ligand binding and LC–MS/MS techniques. Bioanalysis 8:1, pages 19-27.
Crossref
Crossref
. (2016) Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives: Chapter 5 Human Albumin - Revised. Transfusion Medicine and Hemotherapy 43:3, pages 223-232.
Crossref
Crossref
Naomi S. Sta Maria, Samuel R. Barnes, Michael R. Weist, David Colcher, Andrew A. Raubitschek & Russell E. Jacobs. (2015) Low Dose Focused Ultrasound Induces Enhanced Tumor Accumulation of Natural Killer Cells. PLOS ONE 10:11, pages e0142767.
Crossref
Crossref
Lei ZhengMark Milton. 2015. Monoclonal Antibodies: Development, Delivery and Applications. Monoclonal Antibodies: Development, Delivery and Applications
58
82
.
Adriana Bajardi-Taccioli, Andrew Blum, Chongfeng Xu, Zoran Sosic, Svetlana Bergelson & Marina Feschenko. (2015) Effect of protein aggregates on characterization of FcRn binding of Fc-fusion therapeutics. Molecular Immunology 67:2, pages 616-624.
Crossref
Crossref
K. Fujimoto, H. Ida, Y. Hirota, M. Ishigai, J. Amano & Y. Tanaka. (2015) Intracellular Dynamics and Fate of a Humanized Anti-Interleukin-6 Receptor Monoclonal Antibody, Tocilizumab. Molecular Pharmacology 88:4, pages 660-675.
Crossref
Crossref
Jonathan T. Sockolosky & Francis C. Szoka. (2015) The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy. Advanced Drug Delivery Reviews 91, pages 109-124.
Crossref
Crossref
Kevin O. Saunders, Amarendra Pegu, Ivelin S. Georgiev, Ming Zeng, M. Gordon Joyce, Zhi-Yong Yang, Sung-Youl Ko, Xuejun Chen, Stephen D. Schmidt, Ashley T. Haase, John-Paul Todd, Saran Bao, Peter D. Kwong, Srinivas S. Rao, John R. Mascola & Gary J. Nabel. (2015) Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection. Journal of Virology 89:11, pages 5895-5903.
Crossref
Crossref
Chao Han, George R. Gunn, Joseph C. Marini, Gopi Shankar, Helen Han Hsu & Hugh M. Davis. (2015) Pharmacokinetics and Immunogenicity Investigation of a Human Anti-Interleukin-17 Monoclonal Antibody in Non-Naïve Cynomolgus Monkeys. Drug Metabolism and Disposition 43:5, pages 762-770.
Crossref
Crossref
Qiang Wu, Ho Young Lee, Pin Yee Wong, Guoying Jiang & Hélène Gazzano-Santoro. (2015) Development and applications of AlphaScreen-based FcRn binding assay to characterize monoclonal antibodies. Journal of Immunological Methods 420, pages 31-37.
Crossref
Crossref
Arjan van der Flier, Zhan Liu, Siyuan Tan, Kai Chen, Douglas Drager, Tongyao Liu, Susannah Patarroyo-White, Haiyan Jiang & David R. Light. (2015) FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes. PLOS ONE 10:4, pages e0124930.
Crossref
Crossref
Alison J. Smith. (2015) New Horizons in Therapeutic Antibody Discovery: Opportunities and Challenges versus Small-Molecule Therapeutics. SLAS Discovery 20:4, pages 437-453.
Crossref
Crossref
K. R. Henne, B. Ason, M. Howard, W. Wang, J. Sun, J. Higbee, J. Tang, K. C. Matsuda, R. Xu, L. Zhou, J. C. Y. Chan, C. King, D. E. Piper, R. R. Ketchem, M. L. Michaels, S. M. Jackson & M. W. Retter. (2015) Anti-PCSK9 Antibody Pharmacokinetics and Low-Density Lipoprotein-Cholesterol Pharmacodynamics in Nonhuman Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to Neonatal Fc Receptor-Binding Enhancement. Journal of Pharmacology and Experimental Therapeutics 353:1, pages 119-131.
Crossref
Crossref
Céline Monnet, Sylvie Jorieux, Rémi Urbain, Nathalie Fournier, Khalil Bouayadi, Christophe De Romeuf, Christian K. Behrens, Alexandre Fontayne & Philippe Mondon. (2015) Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions. Frontiers in Immunology 6.
Crossref
Crossref
Yubo Zhang. (2015) Understanding the impact of Fc glycosylation on its conformational changes by molecular dynamics simulations and bioinformatics. Molecular BioSystems 11:12, pages 3415-3424.
Crossref
Crossref
Uli Binder & Arne Skerra. 2015. Biobetters. Biobetters
269
311
.
RABI’ATUL ‘ADAWIYAH BINTE MINHAT & THILO HAGEN. (2015) A POSSIBLE APPROACH FOR ORAL DRUG DELIVERY OF NANOPARTICLES. COSMOS 10:01, pages 13-16.
Crossref
Crossref
Justin K.H. Liu. (2014) The history of monoclonal antibody development – Progress, remaining challenges and future innovations. Annals of Medicine and Surgery 3:4, pages 113-116.
Crossref
Crossref
Philip R. Cooper, Connie M. Kliwinski, Robert A. Perkinson, Edwin Ragwan, John R. Mabus, Gordon D. Powers, Haimanti Dorai, Jill Giles-Komar & Pamela J. Hornby. (2014) The contribution of cell surface FcRn in monoclonal antibody serum uptake from the intestine in suckling rat pups. Frontiers in Pharmacology 5.
Crossref
Crossref
Sang Taek Jung, Tae Hyun Kang & Dong-il Kim. (2014) Engineering an aglycosylated Fc variant for enhanced FcγRI engagement and pH-dependent human FcRn binding. Biotechnology and Bioprocess Engineering 19:5, pages 780-789.
Crossref
Crossref
Masato Amano, Naoki Kobayashi, Masayuki Yabuta, Susumu Uchiyama & Kiichi Fukui. (2014) Detection of Histidine Oxidation in a Monoclonal Immunoglobulin Gamma (IgG) 1 Antibody. Analytical Chemistry 86:15, pages 7536-7543.
Crossref
Crossref
Lei Diao, Shuanglian Li, Thomas Ludden, Jogarao Gobburu, Ivan Nestorov & Haiyan Jiang. (2014) Population Pharmacokinetic Modelling of Recombinant Factor IX Fc Fusion Protein (rFIXFc) in Patients with Haemophilia B. Clinical Pharmacokinetics 53:5, pages 467-477.
Crossref
Crossref
Tianlei Ying, Tina W. Ju, Yanping Wang, Ponraj Prabakaran & Dimiter S. Dimitrov. (2014) Interactions of IgG1 CH2 and CH3 Domains with FcRn. Frontiers in Immunology 5.
Crossref
Crossref
Pamela J. Hornby, Philip R. Cooper, Connie Kliwinski, Edwin Ragwan, John R. Mabus, Benjamin Harman, Suzanne Thompson, Amanda L. Kauffman, Zhengyin Yan, Susan H. Tam, Haimanti Dorai, Gordon D. Powers & Jill Giles-Komar. (2013) Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis. Pharmaceutical Research 31:4, pages 908-922.
Crossref
Crossref
Luca Fornelli, Daniel Ayoub, Konstantin Aizikov, Alain Beck & Yury O. Tsybin. (2014) Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry. Analytical Chemistry 86:6, pages 3005-3012.
Crossref
Crossref
Susan Lorey, Erik Fiedler, Anja Kunert, Jörg Nerkamp, Christian Lange, Markus Fiedler, Eva Bosse-Doenecke, Maren Meysing, Manja Gloser, Chris Rundfeldt, Una Rauchhaus, Ilka Hänssgen, Thomas Göttler, Arnd Steuernagel, Ulrike Fiedler & Ulrich Haupts. (2014) Novel Ubiquitin-derived High Affinity Binding Proteins with Tumor Targeting Properties. Journal of Biological Chemistry 289:12, pages 8493-8507.
Crossref
Crossref
Jody D. Berry. 2014. Therapeutic Fc‐Fusion Proteins. Therapeutic Fc‐Fusion Proteins
217
232
.
Ole Haagen Nielsen, Cynthia Maxwell & Jakob Hendel. (2013) IBD medications during pregnancy and lactation. Nature Reviews Gastroenterology & Hepatology 11:2, pages 116-127.
Crossref
Crossref
Yasuhiro Uno, Masahiro Utoh & Kazuhide Iwasaki. (2014) Polymorphisms of Neonatal Fc Receptor in Cynomolgus and Rhesus Macaques. Drug Metabolism and Pharmacokinetics 29:5, pages 427-430.
Crossref
Crossref
Gabriele Proetzel & Derry C. Roopenian. (2014) Humanized FcRn mouse models for evaluating pharmacokinetics of human IgG antibodies. Methods 65:1, pages 148-153.
Crossref
Crossref
Diego Moricoli, Maria Elena Laguardia, Damiano Cosimo Carbonella, Maria Cristina Balducci, Sabrina Dominici, Valentina Fiori, Giordano Serafini, Michela Flego, Maurizio Cianfriglia & Mauro Magnani. (2014) Isolation of a new human scFv antibody recognizing a cell surface binding site to CEACAM1. Large yield production, purification and characterization in E. coli expression system. Protein Expression and Purification 93, pages 38-45.
Crossref
Crossref
Roy Jefferis. 2014. Antibody Fc. Antibody Fc
297
316
.
Vasco Filipe, Ivo Que, John F. Carpenter, Clemens Löwik & Wim Jiskoot. (2013) In Vivo Fluorescence Imaging of IgG1 Aggregates After Subcutaneous and Intravenous Injection in Mice. Pharmaceutical Research 31:1, pages 216-227.
Crossref
Crossref
Lauren Martz. (2013) Oral nanoparticles. Science-Business eXchange 6:48.
Crossref
Crossref
Gabriel J. Robbie, Ryan Criste, William F. Dall'Acqua, Kathryn Jensen, Nita K. Patel, Genevieve A. Losonsky & M. Pamela Griffin. (2013) A Novel Investigational Fc-Modified Humanized Monoclonal Antibody, Motavizumab-YTE, Has an Extended Half-Life in Healthy Adults. Antimicrobial Agents and Chemotherapy 57:12, pages 6147-6153.
Crossref
Crossref
Eric M. PridgenFrank AlexisTimothy T. KuoEtgar Levy-NissenbaumRohit KarnikRichard S. BlumbergRobert LangerOmid C. Farokhzad. (2013) Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery. Science Translational Medicine 5:213.
Crossref
Crossref
Michael M. Schmidt, Sharon A. Townson, Amy J. Andreucci, Bracken M. King, Emily B. Schirmer, Alec J. Murillo, Christian Dombrowski, Alison W. Tisdale, Patricia A. Lowden, Allyson L. Masci, Joseph T. Kovalchin, David V. Erbe, K. Dane Wittrup, Eric S. Furfine & Thomas M. Barnes. (2013) Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface. Structure 21:11, pages 1966-1978.
Crossref
Crossref
Jean W Lee. (2013) ADME of monoclonal antibody biotherapeutics: knowledge gaps and emerging tools. Bioanalysis 5:16, pages 2003-2014.
Crossref
Crossref
Eric Ezan. (2013) Pharmacokinetic studies of protein drugs: Past, present and future. Advanced Drug Delivery Reviews 65:8, pages 1065-1073.
Crossref
Crossref
Dmitrij Hristodorov, Rainer Fischer & Lars Linden. (2012) With or Without Sugar? (A)glycosylation of Therapeutic Antibodies. Molecular Biotechnology 54:3, pages 1056-1068.
Crossref
Crossref
Kai-Ting Shade & Robert Anthony. (2013) Antibody Glycosylation and Inflammation. Antibodies 2:4, pages 392-414.
Crossref
Crossref
Velin Z. Spassov & Lisa Yan. (2013)
p
H‐selective mutagenesis of protein–protein interfaces:
In silico
design of therapeutic antibodies with prolonged half‐life
. Proteins: Structure, Function, and Bioinformatics 81:4, pages 704-714.
Crossref
Crossref
Amita Datta-Mannan, Benjamin Yaden, Venkatesh Krishnan, Bryan E. Jones & Johnny E. Croy. (2013) An Engineered Human Follistatin Variant: Insights into the Pharmacokinetic and Pharmocodynamic Relationships of a Novel Molecule with Broad Therapeutic Potential. Journal of Pharmacology and Experimental Therapeutics 344:3, pages 616-623.
Crossref
Crossref
C. Kliwinski, P. R. Cooper, R. Perkinson, J. R. Mabus, S. H. Tam, T. M. Wilkinson, J. Giles-Komar, B. Scallon, G. D. Powers & P. J. Hornby. (2013) Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice. American Journal of Physiology-Gastrointestinal and Liver Physiology 304:3, pages G262-G270.
Crossref
Crossref
Edmund A. Rossi, Chien-Hsing Chang, Thomas M. Cardillo & David M. Goldenberg. (2012) Optimization of Multivalent Bispecific Antibodies and Immunocytokines with Improved in Vivo Properties. Bioconjugate Chemistry 24:1, pages 63-71.
Crossref
Crossref
Alain Beck, Elsa Wagner-Rousset, Daniel Ayoub, Alain Van Dorsselaer & Sarah Sanglier-Cianférani. (2012) Characterization of Therapeutic Antibodies and Related Products. Analytical Chemistry 85:2, pages 715-736.
Crossref
Crossref
Timo Rath, Timothy T. Kuo, Kristi Baker, Shuo-Wang Qiao, Kanna Kobayashi, Masaru Yoshida, Derry Roopenian, Edda Fiebiger, Wayne I. Lencer & Richard S. Blumberg. (2012) The Immunologic Functions of the Neonatal Fc Receptor for IgG. Journal of Clinical Immunology 33:S1, pages 9-17.
Crossref
Crossref
Kristi Baker, Timo Rath & Richard S. Blumberg. 2013. Molecular and Cellular Mechanisms of Antibody Activity. Molecular and Cellular Mechanisms of Antibody Activity
189
219
.
Xin Xu & Yulia Vugmeyster. (2012) Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics. The AAPS Journal 14:4, pages 781-791.
Crossref
Crossref
S. P. Hogan. (2012) Neonatal Fc receptor (FcRn) and maternal-to-newborn IgE absorption. Clinical & Experimental Allergy 42:12, pages 1656-1659.
Crossref
Crossref
Katrin L. Gutbrodt & Dario Neri. (2012) Immunocytokines. Antibodies 1:1, pages 70-87.
Crossref
Crossref