1,543
Views
67
CrossRef citations to date
0
Altmetric
Author's View

Trial Watch

Toll-like receptor agonists in oncological indications

, , , , , , , , , & show all
Article: e29179 | Received 07 May 2014, Accepted 09 May 2014, Published online: 01 Aug 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (19)

Assia Hijazi, Carlotta Antoniotti, Chiara Cremolini & Jérôme Galon. (2023) Light on life: immunoscore immune-checkpoint, a predictor of immunotherapy response. OncoImmunology 12:1.
Read now
Julie Le Naour, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer & Erika Vacchelli. (2020) Trial watch: TLR3 agonists in cancer therapy. OncoImmunology 9:1.
Read now
Hiroaki Shime, Akira Maruyama, Sumito Yoshida, Yohei Takeda, Misako Matsumoto & Tsukasa Seya. (2018) Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells. OncoImmunology 7:1.
Read now
Martina Sanlorenzo, Igor Vujic, Fabrizio Carnevale-Schianca, Pietro Quaglino, Loretta Gammaitoni, Maria Teresa Fierro, Massimo Aglietta & Dario Sangiolo. (2017) Role of interferon in melanoma: old hopes and new perspectives. Expert Opinion on Biological Therapy 17:4, pages 475-483.
Read now
Erika Vacchelli, Norma Bloy, Fernando Aranda, Aitziber Buqué, Isabelle Cremer, Sandra Demaria, Alexander Eggermont, Silvia Chiara Formenti, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2016) Trial Watch: Immunotherapy plus radiation therapy for oncological indications. OncoImmunology 5:9.
Read now
Aitziber Buqué, Norma Bloy, Fernando Aranda, Isabelle Cremer, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2016) Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy. OncoImmunology 5:6.
Read now
Kristina Iribarren, Norma Bloy, Aitziber Buqué, Isabelle Cremer, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Špíšek, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2016) Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy. OncoImmunology 5:3.
Read now
Jonathan Pol, Aitziber Buqué, Fernando Aranda, Norma Bloy, Isabelle Cremer, Alexander Eggermont, Philippe Erbs, Jitka Fucikova, Jérôme Galon, Jean-Marc Limacher, Xavier Preville, Catherine Sautès-Fridman, Radek Spisek, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2016) Trial Watch—Oncolytic viruses and cancer therapy. OncoImmunology 5:2.
Read now
Erika Vacchelli, Fernando Aranda, Norma Bloy, Aitziber Buqué, Isabelle Cremer, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2016) Trial Watch—Immunostimulation with cytokines in cancer therapy. OncoImmunology 5:2.
Read now
Tsukasa Seya, Yohei Takeda & Misako Matsumoto. (2016) Tumor vaccines with dsRNA adjuvant ARNAX induces antigen-specific tumor shrinkage without cytokinemia. OncoImmunology 5:2.
Read now
Lorenzo Galluzzi, Alexander Eggermont & Guido Kroemer. (2016) Doubling the blockade for melanoma immunotherapy. OncoImmunology 5:1.
Read now
Sonia Domingos-Pereira, Rim Hojeij, Erica Reggi, Laurent Derré, Mathieu F Chevalier, Pedro Romero, Patrice Jichlinski & Denise Nardelli-Haefliger. (2015) Local Salmonella immunostimulation recruits vaccine-specific CD8 T cells and increases regression of bladder tumor. OncoImmunology 4:7.
Read now
Norma Bloy, Aitziber Buqué, Fernando Aranda, Francesca Castoldi, Alexander Eggermont, Isabelle Cremer, Catherine Sautès-Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2015) Trial watch: Naked and vectored DNA-based anticancer vaccines. OncoImmunology 4:5.
Read now
Aitziber Buqué, Norma Bloy, Fernando Aranda, Francesca Castoldi, Alexander Eggermont, Isabelle Cremer, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Aurélien Marabelle, Radek Spisek, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2015) Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications. OncoImmunology 4:4.
Read now
Lorenzo Galluzzi, Guido Kroemer & Alexander Eggermont. (2014) Novel immune checkpoint blocker approved for the treatment of advanced melanoma. OncoImmunology 3:11.
Read now
Norma Bloy, Jonathan Pol, Fernando Aranda, Alexander Eggermont, Isabelle Cremer, Wolf Hervé Fridman, Jitka Fučíková, Jérôme Galon, Eric Tartour, Radek Spisek, Madhav V. Dhodapkar, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2014) Trial watch: Dendritic cell-based anticancer therapy. OncoImmunology 3:11.
Read now
Oliver Kepp, Laura Senovilla, Ilio Vitale, Erika Vacchelli, Sandy Adjemian, Patrizia Agostinis, Lionel Apetoh, Fernando Aranda, Vincenzo Barnaba, Norma Bloy, Laura Bracci, Karine Breckpot, David Brough, Aitziber Buqué, Maria G. Castro, Mara Cirone, Maria I. Colombo, Isabelle Cremer, Sandra Demaria, Luciana Dini, Aristides G. Eliopoulos, Alberto Faggioni, Silvia C. Formenti, Jitka Fučíková, Lucia Gabriele, Udo S. Gaipl, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Nathalia A. Giese, Zong Sheng Guo, Akseli Hemminki, Martin Herrmann, James W. Hodge, Stefan Holdenrieder, Jamie Honeychurch, Hong-Min Hu, Xing Huang, Tim M. Illidge, Koji Kono, Mladen Korbelik, Dmitri V. Krysko, Sherene Loi, Pedro R. Lowenstein, Enrico Lugli, Yuting Ma, Frank Madeo, Angelo A. Manfredi, Isabelle Martins, Domenico Mavilio, Laurie Menger, Nicolò Merendino, Michael Michaud, Gregoire Mignot, Karen L. Mossman, Gabriele Multhoff, Rudolf Oehler, Fabio Palombo, Theocharis Panaretakis, Jonathan Pol, Enrico Proietti, Jean-Ehrland Ricci, Chiara Riganti, Patrizia Rovere-Querini, Anna Rubartelli, Antonella Sistigu, Mark J. Smyth, Juergen Sonnemann, Radek Spisek, John Stagg, Abdul Qader Sukkurwala, Eric Tartour, Andrew Thorburn, Stephen H. Thorne, Peter Vandenabeele, Francesca Velotti, Samuel T. Workenhe, Haining Yang, Wei-Xing Zong, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2014) Consensus guidelines for the detection of immunogenic cell death. OncoImmunology 3:9.
Read now
Norma Bloy, Jonathan Pol, Gwenola Manic, Ilio Vitale, Alexander Eggermont, Jérôme Galon, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2014) Trial Watch: Radioimmunotherapy for oncological indications. OncoImmunology 3:9.
Read now
Erika Vacchelli, Fernando Aranda, Alexander Eggermont, Catherine Sautès-Fridman, Eric Tartour, Eugene P Kennedy, Michael Platten, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2014) Trial watch: IDO inhibitors in cancer therapy. OncoImmunology 3:10.
Read now

Articles from other publishers (48)

Christian Rolfo, Elisa Giovannetti, Pablo Martinez, Shannon McCue & Aung Naing. (2023) Applications and clinical trial landscape using Toll-like receptor agonists to reduce the toll of cancer. npj Precision Oncology 7:1.
Crossref
Michelle L. Bookstaver, Qin Zeng, Robert S. Oakes, Senta M. Kapnick, Vikas Saxena, Camilla Edwards, Nishedhya Venkataraman, Sheneil K. Black, Xiangbin Zeng, Eugene Froimchuk, Thomas Gebhardt, Jonathan S. Bromberg & Christopher M. Jewell. (2022) Self‐Assembly of Immune Signals to Program Innate Immunity through Rational Adjuvant Design. Advanced Science 10:1.
Crossref
Jiaojiao Liu, Cong Ding, Xiaolong Wang, Lu Yang, Xin Liu & Qiaozhen Kang. (2022) TLR agonist rMBP-NAP inhibits B16 melanoma tumor growth via induction of DCs maturation and T-cells cytotoxic response. Cytotechnology 74:4, pages 459-467.
Crossref
Zhou Tian, Baojian Hong, Jianzhong Chen & Zhe Tang. (2022) Combination of Radiofrequency Ablation With Resiquimod to Treat Hepatocellular Carcinoma Via Inflammation of Tumor Immune Microenvironment and Suppression of Angiogenesis. Frontiers in Oncology 12.
Crossref
Mengyue Pei, Huiyang Li, Yingwei Zhu, Jian Lu & Chuangnian Zhang. (2022) In vitro evidence of oncofetal antigen and TLR-9 agonist co-delivery by alginate nanovaccines for liver cancer immunotherapy . Biomaterials Science 10:11, pages 2865-2876.
Crossref
RuYan Li, QingHua Zheng, QiuPing Deng, Yi Wang, HaoDing Yang, Jian Shen, YingHui Liu & JiaHong Zhou. (2022) A Dual Functional Drug Delivery System that Combines Photothermal Therapy and Immunotherapy to Treat Tumors. Molecular Pharmaceutics 19:5, pages 1449-1457.
Crossref
Renren Yu, Bo Zhu & Degao Chen. (2022) Type I interferon-mediated tumor immunity and its role in immunotherapy. Cellular and Molecular Life Sciences 79:3.
Crossref
Baharak Bahmani, Hua Gong, Brian T. Luk, Kristofer J. Haushalter, Ethel DeTeresa, Mark Previti, Jiarong Zhou, Weiwei Gao, Jack D. Bui, Liangfang Zhang, Ronnie H. Fang & Jie Zhang. (2021) Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors. Nature Communications 12:1.
Crossref
Asma Komal, Mamoona Noreen & Attalla F. El-Kott. (2021) TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review. Immunologic Research 69:4, pages 312-322.
Crossref
Karl-Göran Tranberg. (2021) Local Destruction of Tumors and Systemic Immune Effects. Frontiers in Oncology 11.
Crossref
Aradhana Singh, Ranjitsinh Devkar & Anupam Basu. (2020) Myeloid Differentiation Primary Response 88–Cyclin D1 Signaling in Breast Cancer Cells Regulates Toll-Like Receptor 3-Mediated Cell Proliferation. Frontiers in Oncology 10.
Crossref
Nicola E. Annels, Guy R. Simpson & Hardev Pandha. (2020) Modifying the Non-muscle Invasive Bladder Cancer Immune Microenvironment for Optimal Therapeutic Response. Frontiers in Oncology 10.
Crossref
Jenny Sprooten & Abhishek D. Garg. 2020. Biology of the Endoplasmic Reticulum. Biology of the Endoplasmic Reticulum 63 118 .
Yi Wang, Qilu Fang, Yiyi Jin, Zhoudi Liu, Chunpeng Zou, Weihui Yu, Weixin Li, Xiaoou Shan, Ruijie Chen, Zia Khan & Guang Liang. (2019) Blockade of myeloid differentiation 2 attenuates diabetic nephropathy by reducing activation of the renin‐angiotensin system in mouse kidneys. British Journal of Pharmacology 176:14, pages 2642-2657.
Crossref
Peter Düwell, Simon Heidegger & Sebastian Kobold. (2019) Innate Immune Stimulation in Cancer Therapy. Hematology/Oncology Clinics of North America 33:2, pages 215-231.
Crossref
Chan Kyu Sim, Jung Hoon Lee, In-Jeoung Baek, Sang-Wook Lee & Myeong Sup Lee. (2019) Enhanced Antitumor Immune Response in 2 -5 Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy . Journal of Immunology Research 2019, pages 1-14.
Crossref
Emiliano Roselli, Paula Araya, Nicolás Gonzalo Núñez, Gerardo Gatti, Francesca Graziano, Christine Sedlik, Philippe Benaroch, Eliane Piaggio & Mariana Maccioni. (2019) TLR3 Activation of Intratumoral CD103+ Dendritic Cells Modifies the Tumor Infiltrate Conferring Anti-tumor Immunity. Frontiers in Immunology 10.
Crossref
E. Stockfleth, G.F.L. Hofbauer, U. Reinhold, G. Popp, U.R. Hengge, R.M. Szeimies, H. Brüning, M. Anliker, T. Hunger, R. Dummer, C. Ulrich, R. Kenzelmann, C. Surber & L.E. French. (2018) Topical resiquimod dosing regimens in patients with multiple actinic keratoses: a multicentre, partly placebo‐controlled, double‐blind clinical trial. British Journal of Dermatology 180:2, pages 297-305.
Crossref
Jenny Sprooten, Patrizia Agostinis & Abhishek D. Garg. 2019. Immunobiology of Dendritic Cells Part A. Immunobiology of Dendritic Cells Part A 217 262 .
Nikolai N. Khodarev. 2019. Nucleic Acid Sensing and Immunity, Part A. Nucleic Acid Sensing and Immunity, Part A 31 89 .
Wieslaw Kozak, Tomasz Jedrzejewski, Malgorzata Pawlikowska, Jakub Piotrowski & Sylwia Wrotek. (2018) Toward Antitumor Immunity and Febrile Infections: Gamma/Delta (γδ) T Cells Hypothesis. The Quarterly Review of Biology 93:3, pages 187-205.
Crossref
Cong Ding, Li Li, Yi Zhang, Zhenyu Ji, Chenglong Zhang, Taotao Liang, Xun Guo, Xin Liu & Qiaozhen Kang. (2018) Toll‑like receptor agonist rMBP‑NAP enhances antitumor cytokines production and CTL activity of peripheral blood mononuclear cells from patients with lung cancer. Oncology Letters.
Crossref
Naoto Nishii, Hidetake Tachinami, Yuta Kondo, Yulong Xia, Yoshihisa Kashima, Tatsukuni Ohno, Shigenori Nagai, Lixin Li, Walter Lau, Hiroyuki Harada & Miyuki Azuma. (2018) Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy. Oncotarget 9:17, pages 13301-13312.
Crossref
Fangxuan Li, Rupeng Zhang, Shixia Li & Juntian Liu. (2017) IDO1: An important immunotherapy target in cancer treatment. International Immunopharmacology 47, pages 70-77.
Crossref
Wai Hoe Lau, Xiphias Ge Zhu, Shamaine Wei Ting Ho, Shu Chun Chang & Jeak Ling Ding. (2017) Combinatorial treatment with polyI:C and anti-IL6 enhances apoptosis and suppresses metastasis of lung cancer cells. Oncotarget 8:20, pages 32884-32904.
Crossref
Thomas C.B. Klauber, Janne M. Laursen, Daniel Zucker, Susanne Brix, Simon S. Jensen & Thomas L. Andresen. (2017) Delivery of TLR7 agonist to monocytes and dendritic cells by DCIR targeted liposomes induces robust production of anti-cancer cytokines. Acta Biomaterialia 53, pages 367-377.
Crossref
Praveen K. Bommareddy, Ann W. Silk & Howard L. Kaufman. (2017) Intratumoral Approaches for the Treatment of Melanoma. The Cancer Journal 23:1, pages 40-47.
Crossref
Jason Maggi & George Miller. 2017. Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 2-Volume Set. Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 2-Volume Set 188 200.e3 .
Maurice Orange, Uwe Reuter & Uwe Hobohm. (2016) Coley’s Lessons Remembered. Integrative Cancer Therapies 15:4, pages 502-511.
Crossref
Martine Cordeau, Assila Belounis, Martin Lelaidier, Paulo Cordeiro, Hervé Sartelet, Sabine Herblot & Michel Duval. (2016) Efficient Killing of High Risk Neuroblastoma Using Natural Killer Cells Activated by Plasmacytoid Dendritic Cells. PLOS ONE 11:10, pages e0164401.
Crossref
James I. Andorko, Joshua M. Gammon, Lisa H. Tostanoski, Qin Zeng & Christopher M. Jewell. (2016) Targeted Programming of the Lymph Node Environment Causes Evolution of Local and Systemic Immunity. Cellular and Molecular Bioengineering 9:3, pages 418-432.
Crossref
E. Fehri, E. Ennaifer, R. Bel Haj Rhouma, L. Guizani-Tabbane, I. Guizani & S. Boubaker. (2016) The role of Toll-like receptor 9 in gynecologic cancer. Current Research in Translational Medicine 64:3, pages 155-159.
Crossref
Chan Kyu Sim, Yeon Sook Cho, Byung Soo Kim, In-Jeoung Baek, Young-Joon Kim & Myeong Sup Lee. (2016) 2??5? Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons. Cancer Immunology, Immunotherapy 65:6, pages 663-675.
Crossref
Megumi Tatematsu, Ryuji Yoshida, Yuka Morioka, Noriko Ishii, Kenji Funami, Ayako Watanabe, Kazuko Saeki, Tsukasa Seya & Misako Matsumoto. (2016) Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type–Specific Manner. The Journal of Immunology 196:9, pages 3865-3876.
Crossref
Michael Ost, Anurag Singh, Andreas Peschel, Roman Mehling, Nikolaus Rieber & Dominik Hartl. (2016) Myeloid-Derived Suppressor Cells in Bacterial Infections. Frontiers in Cellular and Infection Microbiology 6.
Crossref
David Andrés Nocera, Emiliano Roselli, Paula Araya, Nicolás Gonzalo Nuñez, Stefan Lienenklaus, Jadwiga Jablonska, Siegfried Weiss, Gerardo Gatti, Melanie M. Brinkmann, Andrea Kröger, Gabriel Morón & Mariana Maccioni. (2016) In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration. The Journal of Immunology 196:6, pages 2860-2869.
Crossref
Belinda S. Parker, Jai Rautela & Paul J. Hertzog. (2016) Antitumour actions of interferons: implications for cancer therapy. Nature Reviews Cancer 16:3, pages 131-144.
Crossref
YUWEN DIAO, XIAODONG WANG, YANYAN WAN, JINGJING ZHONG, DONG GAO, YU LIU, NINGNING GAO, WANG LI, BING LIU, XINPING HUANG, ZHENCHAO JIN, BOYA PENG, ZHULIN WANG, LI FU, SIPING CHEN & GUANGYI JIN. (2016) Antitumor activity of a novel small molecule TLR7 agonist via immune response induction and tumor microenvironment modulation. Oncology Reports 35:2, pages 793-800.
Crossref
Junjie Xu & Wenwei Mao. (2016) Overview of Research and Development for Anticancer Drugs. Journal of Cancer Therapy 07:10, pages 762-772.
Crossref
Simon Gebremeskel & Brent Johnston. (2015) Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies. Oncotarget 6:39, pages 41600-41619.
Crossref
Sabine Kuhn, Jianping Yang & Franca Ronchese. (2015) Monocyte-Derived Dendritic Cells Are Essential for CD8+ T Cell Activation and Antitumor Responses After Local Immunotherapy. Frontiers in Immunology 6.
Crossref
Marjolein van Egmond, Gestur Vidarsson & Jantine E. Bakema. (2015) Cross-talk between pathogen recognizing Toll-like receptors and immunoglobulin Fc receptors in immunity. Immunological Reviews 268:1, pages 311-327.
Crossref
L. Apetoh, S. Ladoire, G. Coukos & F. Ghiringhelli. (2015) Combining immunotherapy and anticancer agents: the right path to achieve cancer cure?. Annals of Oncology 26:9, pages 1813-1823.
Crossref
J. Michels, T. Yamasaki & L. Apetoh. (2015) Immunogénicité de la chimiothérapieImmunogenicity of Chemotherapy. Oncologie 17:9, pages 345-353.
Crossref
Jitka Fucikova, Irena Moserova, Linda Urbanova, Lucillia Bezu, Oliver Kepp, Isabelle Cremer, Cyril Salek, Pavel Strnad, Guido Kroemer, Lorenzo Galluzzi & Radek Spisek. (2015) Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer. Frontiers in Immunology 6.
Crossref
Oliver Kepp, Michaela Semeraro, José Manuel Bravo-San Pedro, Norma Bloy, Aitziber Buqué, Xing Huang, Heng Zhou, Laura Senovilla, Guido Kroemer & Lorenzo Galluzzi. (2015) eIF2α phosphorylation as a biomarker of immunogenic cell death. Seminars in Cancer Biology 33, pages 86-92.
Crossref
Laurence Zitvogel, Lorenzo Galluzzi, Oliver Kepp, Mark J. Smyth & Guido Kroemer. (2015) Type I interferons in anticancer immunity. Nature Reviews Immunology 15:7, pages 405-414.
Crossref
Leonardo Rivadeneyra, Roberto Gabriel Pozner, Roberto Meiss, Carlos Fondevila, Ricardo Martin Gómez & Mirta Schattner. (2017) Poly (I:C) downregulates platelet production and function through type I interferon. Thrombosis and Haemostasis 114:11, pages 982-993.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.