Expert Opinion on Drug Discovery, Volume 16, Issue 12 (2021)

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Expert Opinion on Drug Discovery, Volume 16, Issue 12 (2021)

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Editorial

Editorial
How necessary are animal models for modern drug discovery?
Vijay K Singh & Thomas M Seed
Pages: 1391-1397
Published online: 03 Sep 2021
First Page PreviewforHow necessary are animal models for modern drug discovery? | Full Text | References | PDF (812.1 KB) | EPUB
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Editorial
How can we improve peptide drug discovery? Learning from the past
David J. Craik & Meng-Wei Kan
Pages: 1399-1402
Published online: 04 Aug 2021
First Page PreviewforHow can we improve peptide drug discovery? Learning from the past | Full Text | References | PDF (171.1 KB) | EPUB
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Drug Discovery Case History

Article
An overview of the preclinical discovery and development of bamlanivimab for the treatment of novel coronavirus infection (COVID-19): reasons for limited clinical use and lessons for the future
Marco Tuccori, Irma Convertino, Sara Ferraro, Giulia Valdiserra, Emiliano Cappello, Elisabetta Fini & Daniele Focosi
Pages: 1403-1414
Published online: 30 Jul 2021
AbstractforAn overview of the preclinical discovery and development of bamlanivimab for the treatment of novel coronavirus infection (COVID-19): reasons for limited clinical use and lessons for the future | Full Text | References | PDF (354 KB) | EPUB
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Perspective

Article
What is the gold standard model for Alzheimer’s disease drug discovery and development?
Ramón Cacabelos, Iván Carrera, Olaia Martínez-Iglesias, Natalia Cacabelos & Vinogran Naidoo
Pages: 1415-1440
Published online: 25 Aug 2021
AbstractforWhat is the gold standard model for Alzheimer’s disease drug discovery and development? | Full Text | References | PDF (2 MB) | EPUB
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Review

Article
Evolution of the drug-target residence time model
Robert A. Copeland
Pages: 1441-1451
Published online: 01 Jul 2021
AbstractforEvolution of the drug-target residence time model | Full Text | References | PDF (737.3 KB) | EPUB
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An update on the importance of plasma protein binding in drug discovery and development
Li Di
Pages: 1453-1465
Published online: 17 Aug 2021
AbstractforAn update on the importance of plasma protein binding in drug discovery and development | Full Text | References | PDF (1 MB) | EPUB
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Recent advances in proteolytic stability for peptide, protein, and antibody drug discovery
Xianyin Lai, Jason Tang & Mohamed E.H. ElSayed
Pages: 1467-1482
Published online: 30 Jun 2021
AbstractforRecent advances in proteolytic stability for peptide, protein, and antibody drug discovery | Full Text | References | PDF (2 MB) | EPUB
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Article
Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors
Till A Röhn, Shin Numao, Heike Otto, Christian Loesche & Gebhard Thoma
Pages: 1483-1495
Published online: 16 Jul 2021
AbstractforDrug discovery strategies for novel leukotriene A4 hydrolase inhibitors | Full Text | References | PDF (2 MB) | EPUB
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Glycyrrhetinic acid: a promising scaffold for the discovery of anticancer agents
Hidayat Hussain, Iftikhar Ali, Daijie Wang, Faruck L. Hakkim, Bernhard Westermann, Ishtiaq Ahmed, Ahmed M. Ashour, Amjad Khan, Amjad Hussain, Ivan R. Green & Syed Tasadaque Ali Shah
Pages: 1497-1516
Published online: 30 Jul 2021
AbstractforGlycyrrhetinic acid: a promising scaffold for the discovery of anticancer agents | Full Text | References | PDF (3.2 MB) | EPUB
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Open Access
Retinoic acid-related orphan receptor gamma t (RORγt) inverse agonists/antagonists for the treatment of inflammatory diseases – where are we presently?
Christian Gege
Pages: 1517-1535
Published online: 07 Jul 2021
AbstractforRetinoic acid-related orphan receptor gamma t (RORγt) inverse agonists/antagonists for the treatment of inflammatory diseases – where are we presently? | Full Text | References | PDF (2 MB) | EPUB
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