Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 24, Issue 3 (2009)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 24, Issue 3 (2009)

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Research Article

Article
Synthesis of a novel class of some 1,3,4-oxadiazole derivatives as antimicrobial agents
Kishor H. Chikhalia, Dhaval B. Vashi & Mayank J. Patel
Pages: 617-622
Published online: 20 Oct 2008
AbstractforSynthesis of a novel class of some 1,3,4-oxadiazole derivatives as antimicrobial agents | Full Text | References | PDF (113.6 KB)
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Article
Novel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 cells
Shu-Yan Zhang, Xiao-Feng Ma, Chao-Gu Zheng, Yan Wang, Xue-Li Cao & Wei-Xi Tian
Pages: 623-631
Published online: 20 Oct 2008
AbstractforNovel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 cells | Full Text | References | PDF (225.9 KB)
  • 614 Views
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Article
Anti-inflammatory, analgesic and antipyretic activities of Physalis minima Linn
Murad Ali Khan, Haroon Khan, Sarwar Khan, Tahira Mahmood, Pir Mohammad Khan & Abdul Jabar
Pages: 632-637
Published online: 01 Jun 2009
AbstractforAnti-inflammatory, analgesic and antipyretic activities of Physalis minima Linn | Full Text | References | PDF (241 KB)
  • 4893 Views
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Article
Effectiveness of commercial inhibitors against subtype F HIV-1 protease
Sandra Krauchenco, Nadia H. Martins, Mario Sanches & Igor Polikarpov
Pages: 638-645
Published online: 01 Jun 2009
AbstractforEffectiveness of commercial inhibitors against subtype F HIV-1 protease | Full Text | References | PDF (400.7 KB)
  • 791 Views
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Article
Biochemical and structural characterization of TLXI, the Triticum aestivum L. thaumatin-like xylanase inhibitor
Ellen Fierens, Kurt Gebruers, Arnout R.D. Voet, Marc De Maeyer, Christophe M. Courtin & Jan A. Delcour
Pages: 646-654
Published online: 01 Jun 2009
AbstractforBiochemical and structural characterization of TLXI, the Triticum aestivum L. thaumatin-like xylanase inhibitor | Full Text | References | PDF (830 KB)
  • 1068 Views
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Article
Aromatic esters of progesterone as 5α-reductase and prostate growth inhibitors
Eugene Bratoeff, Tania Segura, Sergio Recillas, Eric Carrizales, Anay Palacios, Ivonne Heuze & Marisa Cabeza
Pages: 655-662
Published online: 01 Jun 2009
AbstractforAromatic esters of progesterone as 5α-reductase and prostate growth inhibitors | Full Text | References | PDF (150.5 KB)
  • 751 Views
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Article
Superoxide radicals scavenging and xanthine oxidase inhibitory activity of magnesium lithospermate B from Salvia miltiorrhiza
Xiaoyu Liu, Ruohua Chen, Yanjun Shang, Binghua Jiao & Caiguo Huang
Pages: 663-668
Published online: 20 Oct 2008
AbstractforSuperoxide radicals scavenging and xanthine oxidase inhibitory activity of magnesium lithospermate B from Salvia miltiorrhiza | Full Text | References | PDF (194 KB)
  • 1893 Views
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Article
A facile solid-state synthesis and in vitro antimicrobial activities of some 2,6-diarylpiperidin/tetrahydrothiopyran and tetrahydropyran-4-one oximes
M. Gopalakrishnan, J. Thanusu & V. Kanagarajan
Pages: 669-675
Published online: 01 Jun 2009
AbstractforA facile solid-state synthesis and in vitro antimicrobial activities of some 2,6-diarylpiperidin/tetrahydrothiopyran and tetrahydropyran-4-one oximes | Full Text | References | PDF (110.8 KB)
  • 629 Views
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Article
Calpain inhibitory flavonoids isolated from Orostachys japonicus
Choong Je Ma, Won Joo Jung, Ki Yong Lee, Young Choong Kim & Sang Hyun Sung
Pages: 676-679
Published online: 01 Jun 2009
AbstractforCalpain inhibitory flavonoids isolated from Orostachys japonicus | Full Text | References | PDF (120.4 KB)
  • 1275 Views
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Article
In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048
Miroslav Pohanka, Daniel Jun & Kamil Kuca
Pages: 680-683
Published online: 01 Jun 2009
AbstractforIn vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048 | Full Text | References | PDF (101.2 KB)
  • 481 Views
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Article
Hypoglycemic activity of the antioxidant saponarin, characterized as α-glucosidase inhibitor present in Tinospora cordifolia
Subhabrata Sengupta, Abhishek Mukherjee, Riddhi Goswami & Srabanti Basu
Pages: 684-690
Published online: 01 Jun 2009
AbstractforHypoglycemic activity of the antioxidant saponarin, characterized as α-glucosidase inhibitor present in Tinospora cordifolia | Full Text | References | PDF (343.2 KB)
  • 2566 Views
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Article
Aggregation and inhibition of rat intestinal alkaline phosphatase by high concentrations of calcium. Reversibility of the processes
Lucas R. Brun, Aneley Traverso & Alfredo Rigalli
Pages: 691-696
Published online: 01 Jun 2009
AbstractforAggregation and inhibition of rat intestinal alkaline phosphatase by high concentrations of calcium. Reversibility of the processes | Full Text | References | PDF (151.4 KB)
  • 617 Views
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Article
Antimicrobial and cytotoxicity activities of the medicinal plant Primula macrophylla
Qazi Najmus-Saqib, Fiaz Alam & Mansoor Ahmad
Pages: 697-701
Published online: 20 Oct 2008
AbstractforAntimicrobial and cytotoxicity activities of the medicinal plant Primula macrophylla | Full Text | References | PDF (64.2 KB)
  • 1089 Views
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Article
Cholinesterase inhibitory effects of Rhizophora lamarckii, Avicennia officinalis, Sesuvium portulacastrum and Suaeda monica: Mangroves inhabiting an Indian coastal area (Vellar Estuary)
Natarajan Suganthy, Shanmugiahthevar Karutha Pandian & Kasi Pandima Devi
Pages: 702-707
Published online: 20 Oct 2008
AbstractforCholinesterase inhibitory effects of Rhizophora lamarckii, Avicennia officinalis, Sesuvium portulacastrum and Suaeda monica: Mangroves inhabiting an Indian coastal area (Vellar Estuary) | Full Text | References | PDF (93.2 KB)
  • 1586 Views
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Article
CD26/DPPIV cell membrane expression and DPPIV activity in plasma of patients with acute leukemia
Camilla F. C. G. de Andrade, Ricardo Bigni, Maria S. Pombo-de-Oliveira, Gilda Alves & Denise A. Pereira
Pages: 708-714
Published online: 01 Jun 2009
AbstractforCD26/DPPIV cell membrane expression and DPPIV activity in plasma of patients with acute leukemia | Full Text | References | PDF (116.5 KB)
  • 1014 Views
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Article
DNA cleavage, binding and intercalation studies of drug-based oxovanadium(IV) complexes
M. N. Patel, M. R. Chhasatia, S. H. Patel, H. S. Bariya & V. R. Thakkar
Pages: 715-721
Published online: 01 Jun 2009
AbstractforDNA cleavage, binding and intercalation studies of drug-based oxovanadium(IV) complexes | Full Text | References | PDF (163.1 KB)
  • 1254 Views
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Article
Quantitative structure–activity relationship (QSAR) studies on a series of 1,3,4-thiadiazole-2-thione derivatives as tumor-associated carbonic anhydrase IX inhibitors
Mohammed K. Abdel-Hamid, Atef A. Abdel-Hafez, Nawal A. El-Koussi & Nadia M. Mahfouz
Pages: 722-729
Published online: 20 Oct 2008
AbstractforQuantitative structure–activity relationship (QSAR) studies on a series of 1,3,4-thiadiazole-2-thione derivatives as tumor-associated carbonic anhydrase IX inhibitors | Full Text | References | PDF (149.9 KB)
  • 754 Views
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Article
Synthesis, spectral characterization, in vitro microbial and cytotoxic studies of lanthanum(III) and thorium(IV) complexes with 1,2,4-triazole Schiff bases
Gangadhar B. Bagihalli, Sangamesh A. Patil & Prema S. Badami
Pages: 730-741
Published online: 01 Jun 2009
AbstractforSynthesis, spectral characterization, in vitro microbial and cytotoxic studies of lanthanum(III) and thorium(IV) complexes with 1,2,4-triazole Schiff bases | Full Text | References | PDF (460.3 KB) | Supplemental
  • 877 Views
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Article
Anti-oxidant, in vitro, in vivo anti-inflammatory activity and antiproliferative activity of mefenamic acid and its metal complexes with manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II)
Dimitra Kovala-Demertzi, Dimitra Hadjipavlou-Litina, Malgorzata Staninska, Alexandra Primikiri, Chronis Kotoglou & Mavroudis A. Demertzis
Pages: 742-752
Published online: 20 Oct 2008
AbstractforAnti-oxidant, in vitro, in vivo anti-inflammatory activity and antiproliferative activity of mefenamic acid and its metal complexes with manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) | Full Text | References | PDF (229.9 KB)
  • 3663 Views
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Article
An inhibition study of beauvericin on human and rat cytochrome P450 enzymes and its pharmacokinetics in rats
Li Mei, Lixin Zhang & Renke Dai
Pages: 753-762
Published online: 01 Jun 2009
AbstractforAn inhibition study of beauvericin on human and rat cytochrome P450 enzymes and its pharmacokinetics in rats | Full Text | References | PDF (416.1 KB)
  • 1068 Views
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Article
Synthesis of functionalized amino acid derivatives as new pharmacophores for designing anticancer agents
Vivek Kumar, Mukesh M. Mudgal, Nidhi Rani, Amrita Jha, Manu Jaggi, Anu T. Singh, Vinod K. Sanna, Pratibha Singh, Pramod K. Sharma, Raghuveer Irchhaiya & Anand C. Burman
Pages: 763-770
Published online: 20 Oct 2008
AbstractforSynthesis of functionalized amino acid derivatives as new pharmacophores for designing anticancer agents | Full Text | References | PDF (124.5 KB)
  • 787 Views
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Article
Inhibition of glycogen synthase kinase by curcumin: Investigation by simulated molecular docking and subsequent in vitro/in vivo evaluation
Yasser Bustanji, Mutasem O. Taha, Ihab M. Almasri, Mohamed A.S. Al-Ghussein, Mohammad K. Mohammad & Hatim S. Alkhatib
Pages: 771-778
Published online: 20 Oct 2008
AbstractforInhibition of glycogen synthase kinase by curcumin: Investigation by simulated molecular docking and subsequent in vitro/in vivo evaluation | Full Text | References | PDF (264 KB)
  • 3042 Views
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Article
Macrocyclic inhibitors for the serine protease plasmin
Fengtian Xue & Christopher T. Seto
Pages: 779-794
Published online: 01 Jun 2009
AbstractforMacrocyclic inhibitors for the serine protease plasmin | Full Text | References | PDF (322.8 KB)
  • 606 Views
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Article
Biologically active macrocyclic complexes derived from diaminonaphthalene and glyoxal: Template synthesis and spectroscopic approach
D. P. Singh, Krishan Kumar, Saurabh Sudha Dhiman & Jitender Sharma
Pages: 795-803
Published online: 01 Jun 2009
AbstractforBiologically active macrocyclic complexes derived from diaminonaphthalene and glyoxal: Template synthesis and spectroscopic approach | Full Text | References | PDF (364.5 KB)
  • 1404 Views
  • 19 CrossRef citations
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Article
Cytotoxic activity of 4′-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I
Halise Inci Gul, Murat Cizmecioglu, Sevil Zencir, Mustafa Gul, Pakize Canturk, Mustafa Atalay & Zeki Topcu
Pages: 804-807
Published online: 01 Jun 2009
AbstractforCytotoxic activity of 4′-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I | Full Text | References | PDF (113.8 KB)
  • 767 Views
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Article
Neuroprotective effect of naphtha[1,2-d]thiazol-2-amine in an animal model of Parkinson's disease
Faizul Azam, Sandeep Kumar Barodia, Tarique Anwer & M. M. Alam
Pages: 808-817
Published online: 01 Jun 2009
AbstractforNeuroprotective effect of naphtha[1,2-d]thiazol-2-amine in an animal model of Parkinson's disease | Full Text | References | PDF (337.3 KB)
  • 705 Views
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Article
A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease
Rosa Tundis, Federica Menichini, Filomena Conforti, Monica R. Loizzo, Marco Bonesi, Giancarlo Statti & Francesco Menichini
Pages: 818-824
Published online: 01 Jun 2009
AbstractforA potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease | Full Text | References | PDF (174.7 KB)
  • 2356 Views
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Article
Synthesis and biological activities of new hydrazide derivatives
Ahmet Özdemir, Gulhan Turan-Zitouni, Zafer Asim Kaplancikli & Yağmur Tunali
Pages: 825-831
Published online: 01 Jun 2009
AbstractforSynthesis and biological activities of new hydrazide derivatives | Full Text | References | PDF (105.4 KB)
  • 3690 Views
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Article
Improved synthesis of EM-1745, preparation of its C17-ketone analogue and comparison of their inhibitory potency on 17β-hydroxysteroid dehydrogenase type 1
Marie Bérubé & Donald Poirier
Pages: 832-843
Published online: 01 Jun 2009
AbstractforImproved synthesis of EM-1745, preparation of its C17-ketone analogue and comparison of their inhibitory potency on 17β-hydroxysteroid dehydrogenase type 1 | Full Text | References | PDF (213.8 KB)
  • 544 Views
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Article
Biological activity of bis-benzimidazole derivatives on DNA topoisomerase I and HeLa, MCF7 and A431 cells
A. Selcen Alpan, Sevil Zencir, István Zupkó, Gunes Coban, Borbála Réthy, H. Semih Gunes & Zeki Topcu
Pages: 844-849
Published online: 01 Jun 2009
AbstractforBiological activity of bis-benzimidazole derivatives on DNA topoisomerase I and HeLa, MCF7 and A431 cells | Full Text | References | PDF (118.4 KB)
  • 1720 Views
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Article
Insights through AM1 calculations into the structural requirement of N-hydroxythiosemicarbazone analogs as anti-tubercular agents
Revathi A. Gupta, Arun Kumar Gupta, Love Kumar Soni & S. G. Kaskhedikar
Pages: 850-858
Published online: 01 Jun 2009
AbstractforInsights through AM1 calculations into the structural requirement of N-hydroxythiosemicarbazone analogs as anti-tubercular agents | Full Text | References | PDF (144 KB)
  • 314 Views
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Article
Metal based isatin-derived sulfonamides: Their synthesis, characterization, coordination behavior and biological activity
Zahid H. Chohan, Claudiu T. Supuran, Taibi Ben Hadda, Faiz-Ul-Hassan Nasim & Khalid M. Khan
Pages: 859-870
Published online: 01 Jun 2009
AbstractforMetal based isatin-derived sulfonamides: Their synthesis, characterization, coordination behavior and biological activity | Full Text | References | PDF (1.4 MB)
  • 1002 Views
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Article
Synthesis and preliminary screening of novel N-{2-[4-(substituted)piperazin-1-yl]-2-oxoethyl}acetamides as potential atypical antipsychotic agents
Kondapalli Venkata Gowri Chandra Sekhar, Vajja Samabasiva Rao & Mutyala Murali Krishna
Pages: 871-875
Published online: 01 Jun 2009
AbstractforSynthesis and preliminary screening of novel N-{2-[4-(substituted)piperazin-1-yl]-2-oxoethyl}acetamides as potential atypical antipsychotic agents | Full Text | References | PDF (103.6 KB)
  • 379 Views
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Article
Synthesis and evaluation of in vitro antiviral activity of novel phenoxy acetic acid derivatives
M. Shahar Yar, M. Afroz Bakht, A. A. Siddiqui, M. M. Abdullah & Erik De Clercq
Pages: 876-882
Published online: 01 Jun 2009
AbstractforSynthesis and evaluation of in vitro antiviral activity of novel phenoxy acetic acid derivatives | Full Text | References | PDF (102.4 KB)
  • 1081 Views
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Article
Antibacterial activity and spectral studies of trivalent chromium, manganese, iron macrocyclic complexes derived from oxalyldihydrazide and glyoxal
D. P. Singh, Ramesh Kumar & Jitender Singh
Pages: 883-889
Published online: 01 Jun 2009
AbstractforAntibacterial activity and spectral studies of trivalent chromium, manganese, iron macrocyclic complexes derived from oxalyldihydrazide and glyoxal | Full Text | References | PDF (246.4 KB)
  • 885 Views
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Article
Synthesis of 4-benzyl-1,3-thiazole derivatives as potential anti-inflammatory agents: An analogue-based drug design approach
Ritesh N. Sharma, Franklin P. Xavier, Kamala K. Vasu, Subhash C. Chaturvedi & Shyam S. Pancholi
Pages: 890-897
Published online: 01 Jun 2009
AbstractforSynthesis of 4-benzyl-1,3-thiazole derivatives as potential anti-inflammatory agents: An analogue-based drug design approach | Full Text | References | PDF (201.6 KB)
  • 3232 Views
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Article
Investigation of antioxidant properties of some 6-(α-aminobenzyl)thiazolo[3,2-b]-1,2,4-triazole-5-ol compounds
Goknur Aktay, Birsen Tozkoparan & Mevlut Ertan
Pages: 898-902
Published online: 01 Jun 2009
AbstractforInvestigation of antioxidant properties of some 6-(α-aminobenzyl)thiazolo[3,2-b]-1,2,4-triazole-5-ol compounds | Full Text | References | PDF (87 KB)
  • 551 Views
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Article
2,4,5-trimethoxycinnamic acid: the major metabolite of α-asarone, retains most of the pharmacological properties of α-asarone
Javier Antunez-Solis, Fernando Hernández-Derramadero, Mayda Aquino-Vega, Selene Ibarra-Ramírez, Lorena Rodríguez-Páez, Isabel Baeza & Carlos Wong
Pages: 903-909
Published online: 20 Oct 2008
Abstractfor2,4,5-trimethoxycinnamic acid: the major metabolite of α-asarone, retains most of the pharmacological properties of α-asarone | Full Text | References | PDF (124.1 KB)
  • 620 Views
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