Leukemia & Lymphoma, Volume 53, Issue 6 (2012)

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Leukemia & Lymphoma, Volume 53, Issue 6 (2012)

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Commentary on selected articles in this issue

Article Commentary
Therapy for older patients with acute myeloblastic leukemia: a problem in search of a solution
Deepa Sampath & Guillermo Garcia-Manero
Pages: 1013-1014
Published online: 16 Apr 2012
CitationforTherapy for older patients with acute myeloblastic leukemia: a problem in search of a solution | Full Text | References | PDF (129.9 KB)
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Commentaries

Article Commentary
When and how to perform surveillance imaging in patients with lymphoma, and is it worth it?
Martin Hutchings & Aaron Polliack
Pages: 1015-1016
Published online: 30 Apr 2012
CitationforWhen and how to perform surveillance imaging in patients with lymphoma, and is it worth it? | Full Text | References | PDF (130.1 KB)
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Article Commentary
Everything has its place or so we thought: natural killer/T cell lymphoma, nasal type in the testes
John Anastasi
Pages: 1017-1018
Published online: 31 Jan 2012
CitationforEverything has its place or so we thought: natural killer/T cell lymphoma, nasal type in the testes | Full Text | References | PDF (129.3 KB) | Supplemental
  • 545 Views
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Article Commentary
BCNU-associated pneumonitis: portrait of a toxicity
Brian G. Till & David K. Madtes
Pages: 1019-1020
Published online: 31 Jan 2012
CitationforBCNU-associated pneumonitis: portrait of a toxicity | Full Text | References | PDF (130.9 KB) | Supplemental
  • 1959 Views
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Article Commentary
The role of phosphatase and tensin homolog deleted on chromosome 10 and focal adhesion kinase in aggressive multiple myeloma
Yi Lin & Morie A. Gertz
Pages: 1021-1022
Published online: 31 Jan 2012
CitationforThe role of phosphatase and tensin homolog deleted on chromosome 10 and focal adhesion kinase in aggressive multiple myeloma | Full Text | References | PDF (88.6 KB) | Supplemental
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Review

Review Article
Exploiting biological diversity and genomic aberrations in chronic lymphocytic leukemia
Martina Seiffert, Sascha Dietrich, Alexander Jethwa, Hanno Glimm, Peter Lichter & Thorsten Zenz
Pages: 1023-1031
Published online: 06 Dec 2011
AbstractforExploiting biological diversity and genomic aberrations in chronic lymphocytic leukemia | Full Text | References | PDF (283.3 KB) | Supplemental
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Review Articles

Review Article
Molecular pathogenesis and histologic and clinical features of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue type
Marion J. J. Kuper-Hommel & J. Han J. M. van Krieken
Pages: 1032-1045
Published online: 03 Jan 2012
AbstractforMolecular pathogenesis and histologic and clinical features of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue type | Full Text | References | PDF (384.5 KB) | Supplemental
  • 641 Views
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Review Article
Surface profiles for subclassification of chronic lymphocytic leukemia
Pauline Y. Huang, O. Giles Best, Larissa Belov, Stephen P. Mulligan & Richard I. Christopherson
Pages: 1046-1056
Published online: 03 Apr 2012
AbstractforSurface profiles for subclassification of chronic lymphocytic leukemia | Full Text | References | PDF (905.5 KB) | Supplemental
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Review Article
Challenging the current approaches to multiple myeloma- and other cancer-related bone diseases: from bisphosphonates to targeted therapy
Martina Kleber, Josefina Udi, Barbara Metzke, Evangelos Terpos, G. David Roodmann, Gareth Morgan, Angela Dispenzieri, Hermann Einsele, Ralph Wäsch & Monika Engelhardt
Pages: 1057-1061
Published online: 13 Jan 2012
AbstractforChallenging the current approaches to multiple myeloma- and other cancer-related bone diseases: from bisphosphonates to targeted therapy | Full Text | References | PDF (234.4 KB) | Supplemental
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Original Articles Clinical

Article
Survey and analysis of the efficacy and prescription pattern of sorafenib in patients with acute myeloid leukemia
Christoph Röllig, Christian Brandts, Shabnam Shaid, Marcus Hentrich, Alwin Krämer, Christian Junghanß, Eberhard Schleyer, Carsten Müller-Tidow, Wolfgang E. Berdel, Barbara Ritter, Karl-Heinz Pflüger, Michael Kramer, Martina Haibach, Gerhard Ehninger, Hubert Serve & Stefan W. Krause
Pages: 1062-1067
Published online: 07 Dec 2011
AbstractforSurvey and analysis of the efficacy and prescription pattern of sorafenib in patients with acute myeloid leukemia | Full Text | References | PDF (198.6 KB) | Supplemental
  • 491 Views
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Research Articles

Article
Infectious complications in adult acute myeloid leukemia: analysis of the Acute Leukemia French Association-9802 prospective multicenter clinical trial
Giovanna Cannas, Cécile Pautas, Emmanuel Raffoux, Bruno Quesnel, Stéphane de Botton, Thierry de Revel, Oumedaly Reman, Claude Gardin, Mohamed Elhamri, Nicolas Boissel, Pierre Fenaux, Mauricette Michallet, Sylvie Castaigne, Hervé Dombret & Xavier Thomas
Pages: 1068-1076
Published online: 31 Jan 2012
AbstractforInfectious complications in adult acute myeloid leukemia: analysis of the Acute Leukemia French Association-9802 prospective multicenter clinical trial | Full Text | References | PDF (278.7 KB) | Supplemental
  • 742 Views
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Article
Valproic acid combined with cytosine arabinoside in elderly patients with acute myeloid leukemia has in vitro but limited clinical activity
Steven Lane, Devinder Gill, Nigel A. J. McMillan, Nicholas Saunders, Rachel Murphy, Terrence Spurr, Colm Keane, Helen Mar Fan & Peter Mollee
Pages: 1077-1083
Published online: 11 Jan 2012
AbstractforValproic acid combined with cytosine arabinoside in elderly patients with acute myeloid leukemia has in vitro but limited clinical activity | Full Text | References | PDF (391.8 KB) | Supplemental
  • 232 Views
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Article
Different immunoprofiles in patients with chronic myeloid leukemia treated with imatinib, nilotinib or dasatinib
Yoshiki Hayashi, Hirohisa Nakamae, Takako Katayama, Takahiko Nakane, Hideo Koh, Mika Nakamae, Asao Hirose, Kiyoyuki Hagihara, Yoshiki Terada, Yoshitaka Nakao & Masayuki Hino
Pages: 1084-1089
Published online: 20 Jan 2012
AbstractforDifferent immunoprofiles in patients with chronic myeloid leukemia treated with imatinib, nilotinib or dasatinib | Full Text | References | PDF (306 KB) | Supplemental
  • 955 Views
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Article
Vascular access devices in leukemia: a retrospective review amongst patients treated at The Ottawa Hospital with induction chemotherapy for acute leukemia
Elie R. Skaff, Steve Doucette, Sheryl McDiarmid, Lothar Huebsch & Mitchell Sabloff
Pages: 1090-1095
Published online: 13 Dec 2011
AbstractforVascular access devices in leukemia: a retrospective review amongst patients treated at The Ottawa Hospital with induction chemotherapy for acute leukemia | Full Text | References | PDF (245.8 KB) | Supplemental
  • 394 Views
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Article
Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia
Nina Erčulj, Barbara Faganel Kotnik, Maruša Debeljak, Janez Jazbec & Vita Dolžan
Pages: 1096-1104
Published online: 03 Feb 2012
AbstractforInfluence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia | Full Text | References | PDF (205.7 KB) | Supplemental
  • 667 Views
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Article
LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era
James R. Cerhan, Yasodha Natkunam, Lindsay M. Morton, Matthew J. Maurer, Yan Asmann, Thomas M. Habermann, Mohammad A. Vasef, Wendy Cozen, Charles F. Lynch, Cristine Allmer, Susan L. Slager, Izidore S. Lossos, Stephen J. Chanock, Nathaniel Rothman, Patricia Hartge, Ahmet Dogan & Sophia S. Wang
Pages: 1105-1112
Published online: 03 Jan 2012
AbstractforLIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era | Full Text | References | PDF (282 KB) | Supplemental
  • 224 Views
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Article
High rates of surveillance imaging for treated diffuse large B-cell lymphoma: findings from a large national database
Gregory A. Abel, Ann Vanderplas, Maria A. Rodriguez, Allison L. Crosby, Myron S. Czuczman, Joyce C. Niland, Leo I. Gordon, Michael Millenson, Andrew D. Zelenetz, Jonathan W. Friedberg & Ann S. LaCasce
Pages: 1113-1116
Published online: 03 Feb 2012
AbstractforHigh rates of surveillance imaging for treated diffuse large B-cell lymphoma: findings from a large national database | Full Text | References | PDF (171.5 KB) | Supplemental
  • 323 Views
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Article
Extranodal nasal type natural killer/T-cell lymphoma of testis: report of seven cases with review of literature
Dong-Ni Liang, Zhi-Rong Yang, Wei-Ya Wang, Sha Zhao, Qun-Pei Yang, Yuan Tang, Cheng-Feng Bi & Wei-Ping Liu
Pages: 1117-1123
Published online: 03 Jan 2012
AbstractforExtranodal nasal type natural killer/T-cell lymphoma of testis: report of seven cases with review of literature | Full Text | References | PDF (485.7 KB) | Supplemental
  • 449 Views
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Article
Long-term survival in patients with peripheral T-cell non-Hodgkin lymphomas after allogeneic hematopoietic stem cell transplant
Jenna D. Goldberg, Joanne F. Chou, Steven Horwitz, Julie Teruya-Feldstein, Juliet N Barker, Farid Boulad, Hugo Castro-Malaspina, Sergio Giralt, Ann A. Jakubowski, Guenther Koehne, Marcel R. M. van den Brink, James W. Young, Zhigang Zhang, Esperanza B. Papadopoulos & Miguel-Angel Perales
Pages: 1124-1129
Published online: 31 Jan 2012
AbstractforLong-term survival in patients with peripheral T-cell non-Hodgkin lymphomas after allogeneic hematopoietic stem cell transplant | Full Text | References | PDF (240.6 KB) | Supplemental
  • 539 Views
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Article
Risk factors for development of pneumonitis after high-dose chemotherapy with cyclophosphamide, BCNU and etoposide followed by autologous stem cell transplant
Andrew A. Lane, Philippe Armand, Yang Feng, Donna S. Neuberg, Jeremy S. Abramson, Jennifer R. Brown, David C. Fisher, Ann S. LaCasce, Eric D. Jacobsen, Steven L. McAfee, Thomas R. Spitzer, Arnold S. Freedman & Yi-Bin Chen
Pages: 1130-1136
Published online: 03 Jan 2012
AbstractforRisk factors for development of pneumonitis after high-dose chemotherapy with cyclophosphamide, BCNU and etoposide followed by autologous stem cell transplant | Full Text | References | PDF (242.7 KB) | Supplemental
  • 344 Views
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Article
Activity of topotecan 21-day infusion in patients with previously treated large cell lymphoma: long-term follow-up of an Eastern Cooperative Oncology Group study (E5493)
Peter H. Wiernik, Hailun Li, Edie Weller, Howard S. Hochster, Sandra J. Horning, Tipu Nazeer, Leo I. Gordon, Thomas M. Habermann, Carl J. Minniti Jr, Gary R. Shapiro & Peter A. Cassileth
Pages: 1137-1142
Published online: 11 Jan 2012
AbstractforActivity of topotecan 21-day infusion in patients with previously treated large cell lymphoma: long-term follow-up of an Eastern Cooperative Oncology Group study (E5493) | Full Text | References | PDF (217.5 KB) | Supplemental
  • 81 Views
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Article
Indoleamine 2,3-dioxygenase expression and serum kynurenine concentrations in patients with diffuse large B-cell lymphoma
Soranobu Ninomiya, Takeshi Hara, Hisashi Tsurumi, Naoe Goto, Kuniaki Saito, Mitsuru Seishima, Tsuyoshi Takami & Hisataka Moriwaki
Pages: 1143-1145
Published online: 11 Jan 2012
First Page PreviewforIndoleamine 2,3-dioxygenase expression and serum kynurenine concentrations in patients with diffuse large B-cell lymphoma | Full Text | References | PDF (198.7 KB) | Supplemental
  • 260 Views
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Article
Lifetime costs to Medicare of providing care to patients with chronic lymphocytic leukemia
Marie-Hélène Lafeuille, Francis Vekeman, Si-Tien Wang, Matthew Kerrigan, Laura Menditto & Mei Sheng Duh
Pages: 1146-1154
Published online: 03 Feb 2012
AbstractforLifetime costs to Medicare of providing care to patients with chronic lymphocytic leukemia | Full Text | References | PDF (239 KB) | Supplemental
  • 473 Views
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Article
MicroRNA-223 expression is uniformly down-regulated in B cell lymphoproliferative disorders and is associated with poor survival in patients with chronic lymphocytic leukemia
Keshu Zhou, Shuhua Yi, Zhen Yu, Zengjun Li, Yanying Wang, Dehui Zou, Junyuan Qi, Yaozhong Zhao & Lugui Qiu
Pages: 1155-1161
Published online: 31 Jan 2012
AbstractforMicroRNA-223 expression is uniformly down-regulated in B cell lymphoproliferative disorders and is associated with poor survival in patients with chronic lymphocytic leukemia | Full Text | References | PDF (279.1 KB) | Supplemental
  • 360 Views
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Article
Expression levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and focal adhesion kinase in patients with multiple myeloma and their relationship to clinical stage and extramedullary infiltration
Su-Yun Wang, Hong-Ling Hao, Kai Deng, Yan Li, Zhi-Yong Cheng, Chao Lv, Zhi-Miao Liu, Jie Yang & Ling Pan
Pages: 1162-1168
Published online: 31 Jan 2012
AbstractforExpression levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and focal adhesion kinase in patients with multiple myeloma and their relationship to clinical stage and extramedullary infiltration | Full Text | References | PDF (221.3 KB) | Supplemental
  • 222 Views
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Article
High incidence of skin rash in patients with hairy cell leukemia treated with cladribine
Chezi Ganzel, Moshe E. Gatt, Alexander Maly, Dina Ben-Yehuda & Neta Goldschmidt
Pages: 1169-1173
Published online: 07 Dec 2011
AbstractforHigh incidence of skin rash in patients with hairy cell leukemia treated with cladribine | Full Text | References | PDF (164.3 KB) | Supplemental
  • 667 Views
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Article
Bortezomib mitigates adverse prognosis conferred by Bcl-2 overexpression in patients with relapsed/refractory multiple myeloma
Sikander Ailawadhi, Jeff Miecznikowski, Dan P. Gaile, Dongliang Wang, Taimur Sher, George Mulligan, Barb Bryant, Gregory E. Wilding, Terry Mashtare, Leighton Stein, Aisha Masood, Rachel Neuwirth, Kelvin P. Lee & Asher Chanan-Khan
Pages: 1174-1182
Published online: 06 Dec 2011
AbstractforBortezomib mitigates adverse prognosis conferred by Bcl-2 overexpression in patients with relapsed/refractory multiple myeloma | Full Text | References | PDF (392 KB) | Supplemental
  • 361 Views
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Article
Variant genotypes of MDR1 C3435T increase the risk of leukemia: evidence from 10 case–control studies
Xifeng Qian, Songyu Cao, Guohua Yang, Jing Dong, Guangfu Jin, Yunfeng Shen & Zhibin Hu
Pages: 1183-1187
Published online: 03 Jan 2012
AbstractforVariant genotypes of MDR1 C3435T increase the risk of leukemia: evidence from 10 case–control studies | Full Text | References | PDF (235.2 KB) | Supplemental
  • 161 Views
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Original Articles Research

Article
Triptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs
Xin Huang, Min Yang & Jie Jin
Pages: 1188-1195
Published online: 13 Feb 2012
AbstractforTriptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs | Full Text | References | PDF (495.8 KB) | Supplemental
  • 336 Views
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Research Articles

Article
Inhibition of Hedgehog signaling induces monocytic differentiation of HL-60 cells
Li-Yuan Bai, Jing-Ru Weng, Wen-Jyi Lo, Su-Peng Yeh, Chia-Yung Wu, Ching-Ying Wang, Chang-Fang Chiu & Cheng-Wen Lin
Pages: 1196-1202
Published online: 05 Jan 2012
AbstractforInhibition of Hedgehog signaling induces monocytic differentiation of HL-60 cells | Full Text | References | PDF (425.9 KB) | Supplemental
  • 298 Views
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Article
Antioxidant α-tocopherol checks lymphoma promotion via regulation of expression of protein kinase C-α and c-Myc genes and glycolytic metabolism
Renu Sharma & Manjula Vinayak
Pages: 1203-1210
Published online: 11 Jan 2012
AbstractforAntioxidant α-tocopherol checks lymphoma promotion via regulation of expression of protein kinase C-α and c-Myc genes and glycolytic metabolism | Full Text | References | PDF (437.8 KB) | Supplemental
  • 158 Views
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Article
Expression of ABCB5 gene in hematological malignances and its significance
Ming Yang, Wei Li, Dongmei Fan, Yan Yan, Xiuli Zhang, Yizhi Zhang & Dongsheng Xiong
Pages: 1211-1215
Published online: 07 Dec 2011
AbstractforExpression of ABCB5 gene in hematological malignances and its significance | Full Text | References | PDF (307.3 KB) | Supplemental
  • 289 Views
  • 15 CrossRef citations
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Article
Investigation and analysis of single nucleotide polymorphisms in Janus kinase/signal transducer and activator of transcription genes with leukemia
Yuejiao Zhong, Jianzhong Wu, Baoan Chen, Rong Ma, Haixia Cao, Zhuo Wang, Lu Cheng, Jiahua Ding & Jifeng Feng
Pages: 1216-1221
Published online: 11 Jan 2012
AbstractforInvestigation and analysis of single nucleotide polymorphisms in Janus kinase/signal transducer and activator of transcription genes with leukemia | Full Text | References | PDF (213.8 KB) | Supplemental
  • 240 Views
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Letters to the Editor

Letter
MLL–ELL fusion gene in two infants with acute monoblastic leukemia and myeloid sarcoma
Etienne de Braekeleer, Nathalie Douet-Guilbert, Claus Meyer, Frédéric Morel, Rolf Marschalek & Marc de Braekeleer
Pages: 1222-1224
Published online: 31 Jan 2012
First Page PreviewforMLL–ELL fusion gene in two infants with acute monoblastic leukemia and myeloid sarcoma | Full Text | References | PDF (160 KB) | Supplemental
  • 176 Views
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Letters

Letter
Rapid detection of FLT3 exon 20 tyrosine kinase domain mutations in patients with acute myeloid leukemia by high-resolution melting analysis
Angela Y.-C. Tan, Stephen Q. Wong, Charlotte Guldborg Nyvold, Dennis A. Carney, Andrew Wei, John F. Seymour, Peter Hokland, Westerman & Alexander Dobrovic
Pages: 1225-1229
Published online: 13 Jan 2012
First Page PreviewforRapid detection of FLT3 exon 20 tyrosine kinase domain mutations in patients with acute myeloid leukemia by high-resolution melting analysis | Full Text | References | PDF (234.5 KB) | Supplemental
  • 222 Views
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Letter
A meta-analysis of TET2 mutations shows a distinct distribution pattern in de novo acute myeloid leukemia and chronic myelomonocytic leukemia
Begoña Euba, José L. Vizmanos, Marta García-Granero, Paula Aranaz, Cristina Hurtado, Itziar Migueliz, Francisco J. Novo & Marina García-Delgado
Pages: 1230-1233
Published online: 02 Apr 2012
First Page PreviewforA meta-analysis of TET2 mutations shows a distinct distribution pattern in de novo acute myeloid leukemia and chronic myelomonocytic leukemia | Full Text | References | PDF (289.4 KB) | Supplemental
  • 463 Views
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Letter
Somatic mutation of STAG2, an aneuploidy-related gene, is rare in acute leukemias
Nak Gyun Chung, Min Sung Kim, Nam Jin Yoo & Sug Hyung Lee
Pages: 1234-1235
Published online: 03 Jan 2012
CitationforSomatic mutation of STAG2, an aneuploidy-related gene, is rare in acute leukemias | Full Text | References | PDF (153.4 KB) | Supplemental
  • 308 Views
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Letter
Very poor outcome of leukemic transformation in myelofibrosis: a single center experience with 13 patients
Grzegorz Helbig, Agata Wieczorkiewicz-Kabut, Jacek Pajak, Agnieszka Wieclawek, Małgorzata Stachowicz, Anna Soja, Anna Rusek, Agnieszka Karolczyk, Aleksandra Bartkowska-Chrobok & Sławomira Kyrcz-Krzemien
Pages: 1236-1238
Published online: 03 Jan 2012
First Page PreviewforVery poor outcome of leukemic transformation in myelofibrosis: a single center experience with 13 patients | Full Text | References | PDF (167.4 KB) | Supplemental
  • 74 Views
  • 2 CrossRef citations
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Letter
Donor leukocyte infusions in recurrent Hodgkin lymphoma following allogeneic stem cell transplant: 10-year experience at the M. D. Anderson Cancer Center
Paolo Anderlini, Rima Saliba, Sandra Acholonu, Grace-Julia Okoroji, Celina Ledesma, Borje S. Andersson, Roy Jones, Uday R. Popat, Chitra M. Hosing, Yago Nieto, Muzaffar H. Qazilbash, Naoto T. Ueno, Sergio A. Giralt, Marcos J. de Lima & Richard E. Champlin
Pages: 1239-1241
Published online: 05 Jan 2012
First Page PreviewforDonor leukocyte infusions in recurrent Hodgkin lymphoma following allogeneic stem cell transplant: 10-year experience at the M. D. Anderson Cancer Center | Full Text | References | PDF (164.9 KB) | Supplemental
  • 261 Views
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Letter
Rapidly progressive B-cell dominated inflammatory neuropathy and littoral cell angioma of the spleen associated with plasmablastic B-cell lymphoma
Nico Melzer, Peter Josef Barth, Klaus-Michael Müller, Hans-Dieter Foss, Utz Krug, Matthias Schilling, Martin Marziniak, Oliver Martin Grauer & Heinz Wiendl
Pages: 1242-1244
Published online: 03 Jan 2012
First Page PreviewforRapidly progressive B-cell dominated inflammatory neuropathy and littoral cell angioma of the spleen associated with plasmablastic B-cell lymphoma | Full Text | References | PDF (273.4 KB) | Supplemental
  • 114 Views
  • 4 CrossRef citations
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Letter
Acarbose is an effective treatment for severe hypertriglyceridemia secondary to l-asparaginase and dexamethasone
Matthew Tan, Daniel Wai, Chiaw Ling Chng & William Hwang
Pages: 1245-1246
Published online: 31 Jan 2012
CitationforAcarbose is an effective treatment for severe hypertriglyceridemia secondary to l-asparaginase and dexamethasone | Full Text | References | PDF (132.1 KB) | Supplemental
  • 229 Views
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