Leukemia & Lymphoma, Volume 60, Issue 9 (2019)

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Leukemia & Lymphoma, Volume 60, Issue 9 (2019)

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Commentaries

Article Commentary
The colorful landscape of multiple myeloma
Eli Muchtar & Morie A. Gertz
Pages: 2099-2100
Published online: 27 Feb 2019
CitationforThe colorful landscape of multiple myeloma | Full Text | References | PDF (464.7 KB) | EPUB
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Article Commentary
Tocilizumab, in search for a role in acute GVHD
Usama Gergis & Koen van Besien
Pages: 2101-2103
Published online: 25 Jun 2019
AbstractforTocilizumab, in search for a role in acute GVHD | Full Text | References | PDF (362.2 KB) | EPUB
  • 658 Views
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Reviews

Review
Incidence of infections after therapy completion in children with acute lymphoblastic leukemia or acute myeloid leukemia: a systematic review of the literature
Marie-Claude Pelland-Marcotte, Jeremiah Hwee, Jason D. Pole PhD, Paul C. Nathan & Lillian Sung
Pages: 2104-2114
Published online: 18 Feb 2019
AbstractforIncidence of infections after therapy completion in children with acute lymphoblastic leukemia or acute myeloid leukemia: a systematic review of the literature | Full Text | References | PDF (1,023.3 KB) | EPUB | Supplemental
  • 621 Views
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Review
Importance of early immune recovery after autologous hematopoietic cell transplantation in lymphoma patients
Esa Jantunen, Ville Varmavuo, Jukka Pelkonen & Jaakko Valtola
Pages: 2115-2121
Published online: 07 Mar 2019
AbstractforImportance of early immune recovery after autologous hematopoietic cell transplantation in lymphoma patients | Full Text | References | PDF (555.8 KB) | EPUB
  • 233 Views
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Original Articles

Article
Phase 3 study of subcutaneous bortezomib, thalidomide, and prednisolone consolidation after subcutaneous bortezomib-based induction and autologous stem cell transplantation in patients with previously untreated multiple myeloma: the VCAT study
Noemi Horvath, Andrew Spencer, Melita Kenealy, Douglas Joshua, Philip J Campbell, Je-Jung Lee, Jian Hou, Lugui Qiu, Anna Kalff, Tiffany Khong, Anil Londhe, Sarah Siggins, Maximiliano van Kooten Losio, Michael Eisbacher & H. Miles Prince
Pages: 2122-2133
Published online: 19 Feb 2019
AbstractforPhase 3 study of subcutaneous bortezomib, thalidomide, and prednisolone consolidation after subcutaneous bortezomib-based induction and autologous stem cell transplantation in patients with previously untreated multiple myeloma: the VCAT study | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 545 Views
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Article
Evaluating the role of Tregs in the progression of multiple myeloma
Deepesh Lad, Qing Huang, Romy Hoeppli, Rosa Garcia, Lixin Xu, Megan Levings, Kevin Song & Raewyn Broady
Pages: 2134-2142
Published online: 18 Feb 2019
AbstractforEvaluating the role of Tregs in the progression of multiple myeloma | Full Text | References | PDF (1.7 MB) | EPUB
  • 730 Views
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Article
Oral azacitidine (CC-486) in combination with lenalidomide and dexamethasone in advanced, lenalidomide-refractory multiple myeloma (ROAR study)
Anna Kalff, Tiffany Khong, Sridurga Mithraprabhu, Krystal Bergin, John Reynolds, Kathryn M. Bowen, Anjan Thakurta, Roberto Guzman, Maria Wang, Suzana Couto, Yan Ren & Andrew Spencer
Pages: 2143-2151
Published online: 11 Jun 2019
AbstractforOral azacitidine (CC-486) in combination with lenalidomide and dexamethasone in advanced, lenalidomide-refractory multiple myeloma (ROAR study) | Full Text | References | PDF (842.3 KB) | EPUB
  • 411 Views
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Original Article: Clinical

Article
Clinical effects of CD33 and MPC-1 on the prognosis of multiple myeloma treated with bortezomib
Satoko Oka, Kazuo Ono & Masaharu Nohgawa
Pages: 2152-2157
Published online: 19 Mar 2019
AbstractforClinical effects of CD33 and MPC-1 on the prognosis of multiple myeloma treated with bortezomib | Full Text | References | PDF (530 KB) | EPUB
  • 259 Views
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Original Article

Review
The role of adiponectin, LEPTIN, and ghrelin in the progress and prognosis of childhood acute lymphoblastic leukemia
Chrysa Argyrou, Kyriaki Hatziagapiou, Margarita Theodorakidou, Olti Alexandra Nikola, Spiros Vlahopoulos & George I. Lambrou
Pages: 2158-2169
Published online: 30 Jan 2019
AbstractforThe role of adiponectin, LEPTIN, and ghrelin in the progress and prognosis of childhood acute lymphoblastic leukemia | Full Text | References | PDF (961.7 KB) | EPUB
  • 231 Views
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Original Article: Research

Article
MCL-1 or BCL-xL-dependent resistance to the BCL-2 antagonist (ABT-199) can be overcome by specific inhibitor as single agents and in combination with ABT-199 in acute myeloid leukemia cells
Qing Wang, Jiangbo Wan, Wenhao Zhang & Siguo Hao
Pages: 2170-2180
Published online: 10 Jan 2019
AbstractforMCL-1 or BCL-xL-dependent resistance to the BCL-2 antagonist (ABT-199) can be overcome by specific inhibitor as single agents and in combination with ABT-199 in acute myeloid leukemia cells | Full Text | References | PDF (1.1 MB) | EPUB
  • 547 Views
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Original Articles

Article
Minimal residual disease detected by multiparameter flow cytometry is complementary to genetics for risk stratification treatment in acute myeloid leukemia with biallelic CEBPA mutations
Dao-Xing Deng, Hong-Hu Zhu, Yan-Rong Liu, Ying-Jun Chang, Guo-Rui Ruan, Jin-Song Jia, Hao Jiang, Qian Jiang, Xiao-Su Zhao & Xiao-Jun Huang
Pages: 2181-2189
Published online: 18 Feb 2019
AbstractforMinimal residual disease detected by multiparameter flow cytometry is complementary to genetics for risk stratification treatment in acute myeloid leukemia with biallelic CEBPA mutations | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 743 Views
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Article
Disparities in pediatric acute myeloid leukemia (AML) clinical trial enrollment
Lena E. Winestone, Kelly D. Getz, Pooja Rao, Yimei Li, Matt Hall, Yuan-Shung V. Huang, Alix E. Seif, Brian T. Fisher & Richard Aplenc
Pages: 2190-2198
Published online: 07 Feb 2019
AbstractforDisparities in pediatric acute myeloid leukemia (AML) clinical trial enrollment | Full Text | References | PDF (1,015.1 KB) | EPUB | Supplemental
  • 615 Views
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Article
Impact of lenalidomide on collected hematopoietic myeloid and erythroid progenitors: peripheral stem cell collection may not be affected
Talib Dosani, Fahrettin Covut, Raisa Pinto, Byung-Gyu Kim, Naveed Ali, Rose Beck, Robert Maitta, Katharine Downes, Robert Fox, Jane Reese, Marcos de Lima & Ehsan Malek
Pages: 2199-2206
Published online: 07 Mar 2019
AbstractforImpact of lenalidomide on collected hematopoietic myeloid and erythroid progenitors: peripheral stem cell collection may not be affected | Full Text | References | PDF (959.1 KB) | EPUB | Supplemental
  • 368 Views
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Article
A phase 2 clinical trial of eltrombopag for treatment of patients with myelodysplastic syndromes after hypomethylating-agent failure
Mahesh Swaminathan, Gautam Borthakur, Tapan M. Kadia, Alessandra Ferrajoli, Yesid Alvarado, Naveen Pemmaraju, Kristy Bodden, Brittany Yearby, Marina Konopleva, Joseph Khoury, Carlos Bueso-Ramos, Guillermo Garcia-Manero & Courtney D. DiNardo
Pages: 2207-2213
Published online: 18 Feb 2019
AbstractforA phase 2 clinical trial of eltrombopag for treatment of patients with myelodysplastic syndromes after hypomethylating-agent failure | Full Text | References | PDF (716.1 KB) | EPUB
  • 633 Views
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Article
Blinatumomab versus chemotherapy in first salvage or in later salvage for B-cell precursor acute lymphoblastic leukemia
Hervé Dombret, Max S. Topp, Andre C. Schuh, Andrew H. Wei, Simon Durrant, Christopher Larry Bacon, Qui Tran, Zachary Zimmerman & Hagop Kantarjian
Pages: 2214-2222
Published online: 05 Apr 2019
AbstractforBlinatumomab versus chemotherapy in first salvage or in later salvage for B-cell precursor acute lymphoblastic leukemia | Full Text | References | PDF (907.7 KB) | EPUB | Supplemental
  • 7905 Views
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Open Access
Article
Tocilizumab as first-line therapy for steroid-refractory acute graft-versus-host-disease: analysis of a single-center experience
Filiz Yucebay, Christina Matthews, Marcin Puto, Junan Li, Basem William, Samantha M. Jaglowski, Sam L. Penza, Sumithira Vasu, Don M. Benson, Leslie A. Andritsos, Steven M. Devine, Yvonne A. Efebera & Julianna V. F. Roddy
Pages: 2223-2229
Published online: 15 Feb 2019
AbstractforTocilizumab as first-line therapy for steroid-refractory acute graft-versus-host-disease: analysis of a single-center experience | Full Text | References | PDF (716.9 KB) | EPUB
  • 949 Views
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Original Article: Clinical

Article
Human herpes virus 6 reactivation following autologous hematopoietic cell transplantation – a single-center experience
Liat Shargian-Alon, Dafna Yahav, Uri Rozovski, Sara Dovrat, Irina Amitai, Michal Sela-Navon, Oren Pasvolsky, Pia Raanani & Moshe Yeshurun
Pages: 2230-2236
Published online: 18 Feb 2019
AbstractforHuman herpes virus 6 reactivation following autologous hematopoietic cell transplantation – a single-center experience | Full Text | References | PDF (747.3 KB) | EPUB | Supplemental
  • 204 Views
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Original Articles

Article
Analysis of circulating tumor DNA by targeted ultra-deep sequencing across various non-Hodgkin lymphoma subtypes
Seung-Ho Shin, Yeon Jeong Kim, Danbi Lee, Duck Cho, Young Hyeh Ko, Junhun Cho, Woong-Yang Park, Donghyun Park, Seok Jin Kim & Won Seog Kim
Pages: 2237-2246
Published online: 18 Feb 2019
AbstractforAnalysis of circulating tumor DNA by targeted ultra-deep sequencing across various non-Hodgkin lymphoma subtypes | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 702 Views
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Article
Histological findings in patients with suspected mediastinal lymphoma relapse according to positive positron emission tomography scan during follow-up: a large retrospective analysis in 96 patients
Alessandro Broccoli, Sergio Nicola Forti Parri, Cinzia Pellegrini, Beatrice Casadei, Barbara Bonfanti, Luca Bertolaccini, Claudio Agostinelli, Maurizio Boaron, Stefano Fanti, Cristina Nanni, Lisa Argnani & Pier Luigi Zinzani
Pages: 2247-2254
Published online: 01 Mar 2019
AbstractforHistological findings in patients with suspected mediastinal lymphoma relapse according to positive positron emission tomography scan during follow-up: a large retrospective analysis in 96 patients | Full Text | References | PDF (1 MB) | EPUB
  • 100 Views
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Article
Clinical impact of Internet-based tools to guide therapeutic decisions for mantle cell lymphoma
Srinivasa N. Gopalsamy, Kristen M. Rosenthal, Amy A. Ayers, Andre Goy, John P. Leonard, Julie M. Vose, Kevin L. Obholz, James O. Armitage & Christopher R. Flowers
Pages: 2255-2263
Published online: 08 Mar 2019
AbstractforClinical impact of Internet-based tools to guide therapeutic decisions for mantle cell lymphoma | Full Text | References | PDF (759.6 KB) | EPUB
  • 194 Views
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Article
Impaired lymphocyte reconstitution after autologous transplant is associated with apoptosis of CD8+ T cells and adverse clinical outcome
Uri Rozovski, Ella Naparstek, Shani Frank, Alexey Fourman, Eti Zigman-Hoffman, Margalit Bleiberg, Moshe Yeshurun, Svetlana Trestman & Boris Tartakovsky
Pages: 2264-2270
Published online: 18 Jan 2019
AbstractforImpaired lymphocyte reconstitution after autologous transplant is associated with apoptosis of CD8+ T cells and adverse clinical outcome | Full Text | References | PDF (1.1 MB) | EPUB
  • 115 Views
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Article
Impact of early rasburicase on incidence of clinical tumor lysis syndrome in lymphoma
Heather A. Personett, Erin F. Barreto, Kristen B. McCullough, Ross Dierkhising, Nelson Leung & Thomas M. Habermann
Pages: 2271-2277
Published online: 21 Jun 2019
AbstractforImpact of early rasburicase on incidence of clinical tumor lysis syndrome in lymphoma | Full Text | References | PDF (989 KB) | EPUB
  • 433 Views
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Original Article: Clinical

Article
Staging identifies non-CNS malignancies in a large cohort with newly diagnosed lymphomatous brain lesions
Rachna Malani, Ankush Bhatia, Julia Wolfe & Christian Grommes
Pages: 2278-2282
Published online: 10 Jan 2019
AbstractforStaging identifies non-CNS malignancies in a large cohort with newly diagnosed lymphomatous brain lesions | Full Text | References | PDF (789.7 KB) | EPUB
  • 144 Views
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Original Article

Article
Acute liver injury leading to death in the setting of brentuximab vedotin monotherapy
Jeremy Neeman, Anthony Friedman & Joseph McKendrick
Pages: 2283-2286
Published online: 01 Mar 2019
AbstractforAcute liver injury leading to death in the setting of brentuximab vedotin monotherapy | Full Text | References | PDF (674.1 KB) | EPUB
  • 295 Views
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Letters to the Editor

Letter
CCGG deletion (rs201074739) in CD33 results in premature termination codon and complete loss of CD33 expression: another key variant with potential impact on response to CD33-directed agents
Ioannis Papageorgiou, Michael R. Loken, Lisa Eidenschink Brodersen, Mohammed Gbadamosi, Geoffrey L. Uy, Soheil Meshinchi & Jatinder K. Lamba
Pages: 2287-2290
Published online: 05 Feb 2019
First Page PreviewforCCGG deletion (rs201074739) in CD33 results in premature termination codon and complete loss of CD33 expression: another key variant with potential impact on response to CD33-directed agents | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 386 Views
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Letter
Toxicity and efficacy of alemtuzumab combined with CHOP for aggressive T-cell lymphoma: a phase 1 dose-escalation trial
Elizabeth H. Phillips, Stephen Devereux, John Radford, Naheed Mir, Toyin Adedayo, Laura Clifton-Hadley & Rod Johnson
Pages: 2291-2294
Published online: 18 Feb 2019
First Page PreviewforToxicity and efficacy of alemtuzumab combined with CHOP for aggressive T-cell lymphoma: a phase 1 dose-escalation trial | Full Text | References | PDF (489.3 KB) | EPUB | Supplemental
  • 198 Views
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Letter
Enhancing the feasibility of outpatient daratumumab administration via a split-dosing strategy with initial doses
Justin R. Arnall, Donald C. Moore, Hailey L. Hill, Sarah Griffin, Maxine K. Mueller, Lesli A. Lavery, Peter M. Voorhees & Saad Z. Usmani
Pages: 2295-2298
Published online: 08 Mar 2019
First Page PreviewforEnhancing the feasibility of outpatient daratumumab administration via a split-dosing strategy with initial doses | Full Text | References | PDF (360.9 KB) | EPUB
  • 346 Views
  • 6 CrossRef citations
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Letter
Myeloid neoplasm with eosinophilia and PCM1-JAK2 associated with acute promyelocytic leukemia with PML-RARA
Sajad Salehi, John M. Astle, Sam Sadigh, Jonathan Lake, Vania Aikawa, Guilin Tang, Sa A. Wang & Adam Bagg
Pages: 2299-2303
Published online: 26 Feb 2019
First Page PreviewforMyeloid neoplasm with eosinophilia and PCM1-JAK2 associated with acute promyelocytic leukemia with PML-RARA | Full Text | References | PDF (1.7 MB) | EPUB
  • 210 Views
  • 2 CrossRef citations
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Letter
Diagnostic utility of bronchoscopy in adults with acute myeloid leukemia and other high-grade myeloid neoplasms
Sarah A. Buckley, Nicholas M. Mark, Megan Othus, Elihu H. Estey, Kevin Patel & Roland B. Walter
Pages: 2304-2307
Published online: 11 Mar 2019
First Page PreviewforDiagnostic utility of bronchoscopy in adults with acute myeloid leukemia and other high-grade myeloid neoplasms | Full Text | References | PDF (451.9 KB) | EPUB | Supplemental
  • 231 Views
  • 2 CrossRef citations
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Letter
HSP90 inhibition depletes DNA repair proteins to sensitize acute myelogenous leukemia to nucleoside analog chemotherapeutics
Tzung-Huei Lai, Shaneice Mitchell, Pei-Jung Wu, Shelley Orwick, Chaomei Liu, Janani Ravikrishnan, Jennifer Woyach, Alice Mims, William Plunkett, Vinay K. Puduvalli, John C. Byrd, Rosa Lapalombella & Deepa Sampath
Pages: 2308-2311
Published online: 18 Feb 2019
First Page PreviewforHSP90 inhibition depletes DNA repair proteins to sensitize acute myelogenous leukemia to nucleoside analog chemotherapeutics | Full Text | References | PDF (811.9 KB) | EPUB | Supplemental
  • 320 Views
  • 4 CrossRef citations
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Letter
Asparaginase activity monitoring experience from the Maritimes, Canada
Meghan Pike, Ketan Kulkarni & Tamara MacDonald
Pages: 2312-2315
Published online: 05 Feb 2019
First Page PreviewforAsparaginase activity monitoring experience from the Maritimes, Canada | Full Text | References | PDF (360.8 KB) | EPUB
  • 160 Views
  • 3 CrossRef citations
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Letter
Nivolumab for the treatment of relapsed and refractory classical Hodgkin lymphoma after ASCT and in ASCT-naïve patients
Kirill V. Lepik, Natalia B. Mikhailova, Ivan S. Moiseev, Elena V. Kondakova, Luibov A. Tsvetkova, Yuri R. Zalyalov, Evgeniya S. Borzenkova, Elena V. Babenko, Vadim V. Baykov, Inna V. Markova & Boris V. Afanasyev
Pages: 2316-2319
Published online: 04 Feb 2019
First Page PreviewforNivolumab for the treatment of relapsed and refractory classical Hodgkin lymphoma after ASCT and in ASCT-naïve patients | Full Text | References | PDF (874.5 KB) | EPUB | Supplemental
  • 329 Views
  • 17 CrossRef citations
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Letter
Myeloablative single-unit cord blood transplantation overcomes the negative prognostic impact of FLT3-ITD in adult acute myeloid leukemia
Takaaki Konuma, Seiko Kato, Maki Oiwa-Monna, Mai Mizusawa, Masamichi Isobe, Kazuaki Yokoyama, Satoshi Takahashi & Arinobu Tojo
Pages: 2320-2323
Published online: 18 Feb 2019
First Page PreviewforMyeloablative single-unit cord blood transplantation overcomes the negative prognostic impact of FLT3-ITD in adult acute myeloid leukemia | Full Text | References | PDF (700.6 KB) | EPUB | Supplemental
  • 205 Views
  • 1 CrossRef citations
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Letter
High-dose chemotherapy without transfusion for Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in two Jehovah’s Witnesses patients: a feasible option in the age of hematopoietic growth factors
Louis Perol, Eric Grignano, Adrien Contejean, Lauris Gastaud, Marielle Legoff, Patricia Franchi, Bénédicte Deau-Fischer, Lise Willems, Didier Bouscary & Jerome Tamburini
Pages: 2324-2327
Published online: 18 Feb 2019
First Page PreviewforHigh-dose chemotherapy without transfusion for Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in two Jehovah’s Witnesses patients: a feasible option in the age of hematopoietic growth factors | Full Text | References | PDF (644.3 KB) | EPUB | Supplemental
  • 222 Views
  • 2 CrossRef citations
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Letter
A complex mutational profile and a distinct clonal evolution during NPM1 myeloid sarcoma
Ludovic Fouillet, Elisabeth Daguenet, Denis Guyotat, Lydia Campos-Guyotat, Rémi Grange, Jérôme Cornillon, Elie Jalaber, Caroline Lejeune, Emmanuelle Tavernier & Pascale Flandrin-Gresta
Pages: 2328-2330
Published online: 01 Feb 2019
First Page PreviewforA complex mutational profile and a distinct clonal evolution during NPM1 myeloid sarcoma | Full Text | References | PDF (655.4 KB) | EPUB
  • 182 Views
  • 1 CrossRef citations
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Letter
Detection of hemophagocytic extremely multinucleated giant plasma cells after rituximab/low-dose lenalidomide treatment in CD20+ multiple myeloma
Roland Christian Schelker, Matthias Grube, Albrecht Reichle, Beate Wagner, Wolfgang Herr, Matthias Evert & Martin Vogelhuber
Pages: 2331-2333
Published online: 05 Feb 2019
First Page PreviewforDetection of hemophagocytic extremely multinucleated giant plasma cells after rituximab/low-dose lenalidomide treatment in CD20+ multiple myeloma | Full Text | References | PDF (787.3 KB) | EPUB
  • 219 Views
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Letter
Comparison of low-dose and standard-dose total skin electron beam therapy in mycosis fungoides
Joshua B. Dault, Alexander N. Slade, Sherry Zhao & Shiyu Song
Pages: 2334-2336
Published online: 14 Feb 2019
First Page PreviewforComparison of low-dose and standard-dose total skin electron beam therapy in mycosis fungoides | Full Text | References | PDF (438.1 KB) | EPUB | Supplemental
  • 158 Views
  • 6 CrossRef citations
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Letter
Acquired red cell aplasia associated with monoclonal gammopathy of undetermined significance
Akaolisa S. Eziokwu, Bernard Silver & Christy Samaras
Pages: 2337-2339
Published online: 03 Feb 2019
First Page PreviewforAcquired red cell aplasia associated with monoclonal gammopathy of undetermined significance | Full Text | References | PDF (303.6 KB) | EPUB
  • 167 Views
  • 3 CrossRef citations
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