Xenobiotica, Volume 53, Issue 4 (2023)

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Xenobiotica, Volume 53, Issue 4 (2023)

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General Xenobiochemistry

Article
Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences
Michael J. Doerksen, Denny Seo, Alexander D. Smith, Robert S. Jones, Michael W.H Coughtrie & Abby C. Collier
Pages: 223-230
Published online: 16 Jul 2023
AbstractforComparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
Investigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes
Fengping Chen, Haizhu Zou, Ping Zhang & Yuqi Yan
Pages: 231-240
Published online: 19 Jun 2023
AbstractforInvestigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver
Shun Hayashi, Hiroko Kawaguchi, Takao Watanabe, Izuru Miyawaki, Tatsuki Fukami & Miki Nakajima
Pages: 241-247
Published online: 15 Jun 2023
AbstractforEstimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver | Full Text | References | PDF (793.7 KB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MSE
Li Zhang, Ruijuan Li, Ting Zheng, Huan Wu & Yanyan Yin
Pages: 248-259
Published online: 30 Jun 2023
AbstractforAn integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MSE | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions
Rajkumar Boddu, Sivacharan Kollipara, Gautam Vijaywargi & Tausif Ahmed
Pages: 260-278
Published online: 25 Jul 2023
AbstractforPower of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
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Article
Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans
Gopinath Nallani, Appavu Chandrasekaran, Kelem Kassahun, Li Shen, Rick Reiss & Paul Whatling
Pages: 279-287
Published online: 03 Jul 2023
AbstractforDetermination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
ADME properties of CHF6366, a novel bi-functional M3 muscarinic receptor antagonist and ß2 adrenoceptor agonist (MABA) radiolabelled at both functional moieties
Alberto Ghiglieri, Monica Messina, Valentina Cenacchi, Claudia Piutti, Flavio Cinato, Giandomenico Brogin & Paola Puccini
Pages: 288-308
Published online: 14 Jul 2023
AbstractforADME properties of CHF6366, a novel bi-functional M3 muscarinic receptor antagonist and ß2 adrenoceptor agonist (MABA) radiolabelled at both functional moieties | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Molecular Toxicology

Article
Biochemical responses of the mussel Perna perna after exposure to environmental concentrations of the UV filter Benzophenone-3
Gabriel S. Cruz, Juliana R. Moser, Miguel Saldaña-Serrano, Camila L. V. Bastolla, Daína Lima, Carlos H. A. M. Gomes, Micheli R. de Castro, Uclédia R. A. dos Santos, Gabriel S. Coutinho, Jacó J. Mattos & Maria R. F. Marques
Pages: 309-319
Published online: 21 Jul 2023
AbstractforBiochemical responses of the mussel Perna perna after exposure to environmental concentrations of the UV filter Benzophenone-3 | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Cell cycle dysregulation on prenatal and postnatal arsenic exposure in skin of Wistar rat neonates
Navneet Kumar, Astha Mathur, Suresh Kumar Bunker & Placheril J. John
Pages: 320-331
Published online: 20 Jul 2023
AbstractforCell cycle dysregulation on prenatal and postnatal arsenic exposure in skin of Wistar rat neonates | Full Text | References | PDF (2.3 MB) | EPUB
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Minutes of Meeting

Review Article
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2022
Jesper Kammersgaard Christensen, Inga Bjørnsdottir, Anders Sonesson & Steve Hood
Pages: 332-337
Published online: 19 Jun 2023
AbstractforMeeting report: DMDG peptide and oligonucleotide ADME workshop 2022 | Full Text | References | PDF (654.9 KB) | EPUB
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