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ORIGINAL RESEARCH

Efficacy and Safety of Aclidinium Bromide Compared with Placebo and Tiotropium in Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease: Results from a 6-week, Randomized, Controlled Phase Iiib Study

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Pages 511-522 | Published online: 02 Jul 2013

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Robert A Sandhaus, Charlie Strange, Andrea Zanichelli, Karen Skålvoll, Andreas Rembert Koczulla & Robert A Stockley. (2020) Improving the Lives of Patients with Alpha-1 Antitrypsin Deficiency. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 3313-3322.
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Sanjay Sethi, Edward Kerwin, Henrik Watz, Gary T Ferguson, Robert M Mroz, Rosa Segarra, Eduard Molins, Diana Jarreta & Esther Garcia Gil. (2019) AMPLIFY: a randomized, Phase III study evaluating the efficacy and safety of aclidinium/formoterol vs monocomponents and tiotropium in patients with moderate-to-very severe symptomatic COPD. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 667-682.
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Mario Malerba, Alessandro Radaeli, Giuseppe Santini, Jaymin Morjaria, Nadia Mores, Chiara Mondino, Giuseppe Macis & Paolo Montuschi. (2018) The discovery and development of aclidinium bromide for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Drug Discovery 13:6, pages 563-577.
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Jutta Beier, Robert Mroz, Anne-Marie Kirsten, Ferran Chuecos & Esther Garcia Gil. (2017) Improvement in 24-hour bronchodilation and symptom control with aclidinium bromide versus tiotropium and placebo in symptomatic patients with COPD: post hoc analysis of a Phase IIIb study. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 1731-1740.
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Klaus F. Rabe. (2017) GFF MDI for the improvement of lung function in COPD – A look at the PINNACLE-1 and PINNACLE-2 data and beyond. Expert Review of Clinical Pharmacology 10:7, pages 685-698.
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Amanda R. van Buul, Marise J. Kasteleyn, Niels H. Chavannes & Christian Taube. (2017) Morning symptoms in COPD: a treatable yet often overlooked factor. Expert Review of Respiratory Medicine 11:4, pages 311-322.
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Maria Gabriella Matera, Alessandro Sanduzzi, Roberto Alfano & Mario Cazzola. (2016) Aclidinium bromide inhalation powder for the long-term, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease including chronic bronchitis and emphysema. Expert Review of Clinical Pharmacology 9:6, pages 771-777.
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Marco Contoli, Paolo Solidoro, Fabiano Di Marco, Nicola Scichilone, Angelo Corsico, Fulvio Braido & Pierachille Santus. (2016) Effects of aclidinium on determinants of COPD severity: symptoms and quality of life. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 3043-3050.
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Gregory Feldman, François Maltais, Sanjeev Khindri, Mitra Vahdati-Bolouri, Alison Church, William A Fahy & Roopa Trivedi. (2016) A randomized, blinded study to evaluate the efficacy and safety of umeclidinium 62.5 μg compared with tiotropium 18 μg in patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 719-730.
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Jose Luis Lopez-Campos, Carmen Calero, Cecilia Lopez-Ramirez, Maria Isabel Asensio-Cruz, Eduardo Márquez-Martín & Francisco Ortega-Ruiz. (2015) Patient-reported outcomes and considerations in the management of COPD: focus on aclidinium. Patient Preference and Adherence 9, pages 95-104.
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Subhabrata Moitra, Arvind B Bhome & Bill B Brashier. (2015) Aclidinium bromide/formoterol fixed-dose combination therapy for COPD: the evidence to date. Drug Design, Development and Therapy 9, pages 1989-1999.
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Saiprasad Narsingam, Andrew L. Bozarth & Asem Abdeljalil. (2015) Updates in the management of stable chronic obstructive pulmonary disease. Postgraduate Medicine 127:7, pages 758-770.
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Andrea S Melani. (2015) Long-acting muscarinic antagonists. Expert Review of Clinical Pharmacology 8:4, pages 479-501.
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Afisi Segun Ismaila, Eline L Huisman, Yogesh Suresh Punekar & Andreas Karabis. (2015) Comparative efficacy of long-acting muscarinic antagonist monotherapies in COPD: a systematic review and network meta-analysis. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 2495-2517.
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Basil G Bereza, Anders Troelsgaard Nielsen, Sverrir Valgardsson, Michiel EH Hemels & Thomas R Einarson. (2015) Patient preferences in severe COPD and asthma: a comprehensive literature review. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 739-744.
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Andrea Zanini, Francesca Cherubino, Elisabetta Zampogna, Stefania Croce, Patrizia Pignatti & Antonio Spanevello. (2015) Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 1155-1161.
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Paul W Jones. (2015) Clinical potential of aclidinium bromide in chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 677-687.
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Jun Zhong & Michael Roth. (2014) Clinical potential of aclidinium bromide in chronic obstructive pulmonary disease. Therapeutics and Clinical Risk Management 10, pages 449-453.
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Debra J Reid & Alexa A Carlson. (2014) Clinical use of aclidinium in patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 9, pages 369-379.
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Emily M. Armstrong, Bradley M. Wright, Allison Meyer, Courtney S. Watts & Kristi W. Kelley. (2014) The Role of Aclidinium Bromide in the Treatment of Chronic Obstructive Pulmonary Disease. Hospital Practice 42:4, pages 99-110.
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Maria Gabriella Matera, Paola Rogliani & Mario Cazzola. (2014) Muscarinic receptor antagonists for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 15:7, pages 961-977.
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