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Original Article

Beneficial effects of testosterone administration on symptoms of the lower urinary tract in men with late-onset hypogonadism: A pilot study

, , , &
Pages 57-61 | Received 22 Oct 2007, Accepted 17 Jan 2008, Published online: 06 Jul 2009

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Raed M. Al-Zoubi, Mustafa Alwani, Omar M. Aboumarzouk, Mai Elaarag, Ahmad R. Al-Qudimat, Laxmi Ojha & Aksam Yassin. (2022) Updates on androgen replacement therapy and lower urinary tract symptoms: a narrative review. The Aging Male 25:1, pages 234-241.
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Bruno Lunenfeld, George Mskhalaya, Michael Zitzmann, Giovanni Corona, Stefan Arver, Svetlana Kalinchenko, Yuliya Tishova & Abraham Morgentaler. (2021) Recommendations on the diagnosis, treatment and monitoring of testosterone deficiency in men. The Aging Male 24:1, pages 119-138.
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Ozan Efesoy, Duygu Apa, Mesut Tek & Selahittin Çayan. (2016) The effect of testosterone treatment on prostate histology and apoptosis in men with late-onset hypogonadism. The Aging Male 19:2, pages 79-84.
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Kazuyoshi Shigehara, Tohru Miyagi, Takao Nakashima, Koji Izumi, Yasuhide Kitagawa, Atsushi Mizokami, Eitetsu Koh, Masayoshi Shimamura & Mikio Namiki. (2016) Effects of dutasteride on lower urinary tract symptoms: a prospective analysis based on changes in testosterone/dihydrotestosterone levels and total prostatic volume reduction. The Aging Male 19:2, pages 128-133.
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Giorgio Ivan Russo, Tommaso Castelli, Daniele Urzì, Salvatore Privitera, Eugenia Fragalà, Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero, Vincenzo Favilla, Sebastiano Cimino & Giuseppe Morgia. (2015) Connections between lower urinary tract symptoms related to benign prostatic enlargement and metabolic syndrome with its components: a systematic review and meta-analysis. The Aging Male 18:4, pages 207-216.
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Giovanni Corona, Elisa Maseroli & Mario Maggi. (2014) Injectable testosterone undecanoate for the treatment of hypogonadism. Expert Opinion on Pharmacotherapy 15:13, pages 1903-1926.
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Steven A. Kaplan, Edward O’Neill, Robert Lowe, Mary Hanson & Alan G. Meehan. (2013) Prevalence of low testosterone in aging men with benign prostatic hyperplasia: data from the Proscar Long-term Efficacy and Safety Study (PLESS). The Aging Male 16:2, pages 48-51.
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Farid Saad, Aksam A. Yassin, Ahmad Haider & Louis Gooren. (2011) Effects of testosterone on the lower urinary tract go beyond the prostate: New insights, new treatment options. Arab Journal of Urology 9:2, pages 147-152.
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Toshiyasu Amano, Tetsuya Imao, Katsurou Takemae, Teruaki Iwamoto & Mariko Nakanome. (2010) Testosterone replacement therapy by testosterone ointment relieves lower urinary tract symptoms in late onset hypogonadism patients. The Aging Male 13:4, pages 242-246.
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Articles from other publishers (51)

L. Lin, W. Wang, K. Xiao, X. Guo & L. Zhou. (2023) Genetically elevated bioavailable testosterone level was associated with the occurrence of benign prostatic hyperplasia. Journal of Endocrinological Investigation.
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Jason A. Levy, Arthur L. Burnett & Adrian S. Dobs. (2022) Testosterone Treatment and the Risk of Prostate Adverse Events. Endocrinology and Metabolism Clinics of North America 51:1, pages 123-131.
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F. Saad. 2022. Präventionsmedizin und Anti-Aging-Medizin. Präventionsmedizin und Anti-Aging-Medizin 189 207 .
Min Ho Lee, Yu Seob Shin & Sung Chul Kam. (2021) Correlation Between Testosterone Replacement Treatment and Lower Urinary Tract Symptoms. International Neurourology Journal 25:1, pages 12-22.
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Giulia Rastrelli, Linda Vignozzi, Giovanni Corona & Mario Maggi. (2019) Testosterone and Benign Prostatic Hyperplasia. Sexual Medicine Reviews 7:2, pages 259-271.
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Abdulmaged M. Traish & Abraham Morgentaler. 2019. Sex Differences in Cardiovascular Physiology and Pathophysiology. Sex Differences in Cardiovascular Physiology and Pathophysiology 321 354 .
Abdulmaged M. Traish & Vanessa Johansen. (2018) Impact of Testosterone Deficiency and Testosterone Therapy on Lower Urinary Tract Symptoms in Men with Metabolic Syndrome. The World Journal of Men's Health 36:3, pages 199.
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Farid Saad, Gheorghe DorosKarim Sultan HaiderAhmad Haider. (2018) Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms. Investigative and Clinical Urology 59:6, pages 399.
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Abdulmaged M. Traish. (2018) Benefits and Health Implications of Testosterone Therapy in Men With Testosterone Deficiency. Sexual Medicine Reviews 6:1, pages 86-105.
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Karim Sultan Haider, Ahmad Haider, Gheorghe Doros & Abdulmaged Traish. (2018) Long-Term Testosterone Therapy Improves Urinary and Sexual Function, and Quality of Life in Men with Hypogonadism: Results from a Propensity Matched Subgroup of a Controlled Registry Study. Journal of Urology 199:1, pages 257-265.
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Mauro Gacci, Arcangelo Sebastianelli & Matteo Salvi. 2018. Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia. Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia 89 111 .
Giselle Bravo, Helen Massa, Roselyn Rose’Meyer, Russ Chess-Williams, Catherine McDermott & Donna J. Sellers. (2017) Effect of short-term androgen deficiency on bladder contractility and urothelial mediator release. Naunyn-Schmiedeberg's Archives of Pharmacology 390:5, pages 547-556.
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Jasmin Katrin Badawi, Ruud Bosch, Jens Christian Djurhuus & Ann T. Hanna-Mitchell. (2017) Is testosterone important in LUT function in men and women? ICI-RS 2015. Neurourology and Urodynamics 36:4, pages 859-862.
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Kazuyoshi ShigeharaKoji IzumiAtsushi MizokamiMikio Namiki. (2017) Testosterone Deficiency and Nocturia: A Review. The World Journal of Men's Health 35:1, pages 14.
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Ti Lu, Ya-Han Hu, Chih-Fong Tsai, Shih-Ping Liu & Pei-Ling Chen. (2016) Applying machine learning techniques to the identification of late-onset hypogonadism in elderly men. SpringerPlus 5:1.
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N. Enatsu, H. Miyake, T. Haraguchi, K. Chiba & M. Fujisawa. (2016) Effects of dutasteride on serum free-testosterone and clinical significance of testosterone changes. Andrologia 48:10, pages 1195-1201.
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Chen-Li Cheng & William C. de Groat. (2016) Effect of orchiectomy and testosterone replacement on lower urinary tract function in anesthetized rats. American Journal of Physiology-Renal Physiology 311:5, pages F864-F870.
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Mohit Khera, Gregory A. Broderick, Culley C. CarsonIIIIII, Adrian S. Dobs, Martha M. Faraday, Irwin Goldstein, Lawrence S. Hakim, Wayne J.G. Hellstrom, Ravi Kacker, Tobias S. Köhler, Jesse N. Mills, Martin Miner, Hossein Sadeghi-Nejad, Allen D. Seftel, Ira D. Sharlip, Stephen J. Winters & Arthur L. Burnett. (2016) Adult-Onset Hypogonadism. Mayo Clinic Proceedings 91:7, pages 908-926.
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T.G. Adedeji, A.A. Fasanmade & E.O. Olapade-Olaopa. (2016) An association between diet, metabolic syndrome and lower urinary tract symptoms. African Journal of Urology 22:2, pages 61-66.
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Mohit Khera. (2016) Male hormones and men's quality of life. Current Opinion in Urology 26:2, pages 152-157.
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Linda Vignozzi, Mauro Gacci & Mario Maggi. (2016) Lower urinary tract symptoms, benign prostatic hyperplasia and metabolic syndrome. Nature Reviews Urology 13:2, pages 108-119.
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Martin Kathrins, Karen Doersch, Tony Nimeh, Arturo Canto, Craig Niederberger & Allen Seftel. (2016) The Relationship Between Testosterone-Replacement Therapy and Lower Urinary Tract Symptoms: A Systematic Review. Urology 88, pages 22-32.
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Aaron Moore, Michael J. Butcher & Tobias S. Köhler. (2015) Testosterone Replacement Therapy on the Natural History of Prostate Disease. Current Urology Reports 16:8.
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Ahmed A. M. Abdel-Hamid & Eyad M. T. Ali. (2015) Effect of testosterone therapy on the urinary bladder in experimental hypogonadism of rats. Journal of Molecular Histology 46:3, pages 263-272.
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Jun Ho Lee, Yooseok Kim, Yeon Won Park & Dong-Gi Lee. (2014) Relationship Between Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms and Total Serum Testosterone Level in Healthy Middle-Aged Eugonadal Men. The Journal of Sexual Medicine 11:5, pages 1309-1315.
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L. Vignozzi, G. Rastrelli, G. Corona, M. Gacci, G. Forti & M. Maggi. (2014) Benign prostatic hyperplasia: a new metabolic disease?. Journal of Endocrinological Investigation 37:4, pages 313-322.
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Giovanni Corona, Linda Vignozzi, Giulia Rastrelli, Francesco Lotti, Sarah Cipriani & Mario Maggi. (2014) Benign Prostatic Hyperplasia: A New Metabolic Disease of the Aging Male and Its Correlation with Sexual Dysfunctions. International Journal of Endocrinology 2014, pages 1-14.
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Mohit Khera, David Crawford, Alvaro Morales, Andrea Salonia & Abraham Morgentaler. (2014) A New Era of Testosterone and Prostate Cancer: From Physiology to Clinical Implications. European Urology 65:1, pages 115-123.
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P. Comeglio, A. Morelli, I. Cellai, L. Vignozzi, E. Sarchielli, S. Filippi, E. Maneschi, F. Corcetto, C. Corno, M. Gacci, G.B. Vannelli & M. Maggi. (2014) Opposite effects of tamoxifen on metabolic syndrome-induced bladder and prostate alterations: A role for GPR30/GPER?. The Prostate 74:1, pages 10-28.
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I. A. Tyuzikov, А. G. Martov & S. Yu. Kalinchenko. (2012) New system mechanisms of pathogenesis of low urinary tract symptoms at men (literary review). Bulletin of Siberian Medicine 11:2, pages 93-100.
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I. A. Tyuzikov, А. G. Martov & Yu. S. Kalinchenko. (2012) Influence of obesity and androgen deficiency on prostatic blood circulation. Bulletin of Siberian Medicine 11:2, pages 80-83.
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Chun-Hou Liao, Han-Sun Chiang & Po-Jen Hsiao. (2011) Lower urinary tract symptoms and erectile dysfunction. Urological Science 22:4, pages 135-140.
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Stephanie T. Page, Lianne Hirano, Janet Gilchriest, Manjiri Dighe, John K. Amory, Brett T. Marck & Alvin M. Matsumoto. (2011) Dutasteride Reduces Prostate Size and Prostate Specific Antigen in Older Hypogonadal Men With Benign Prostatic Hyperplasia Undergoing Testosterone Replacement Therapy. Journal of Urology 186:1, pages 191-197.
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Jing Meng, Elahe A. Mostaghel, Funda Vakar-Lopez, Bruce Montgomery, Larry True & Peter S. Nelson. (2011) Testosterone Regulates Tight Junction Proteins and Influences Prostatic Autoimmune Responses. Hormones and Cancer 2:3, pages 145-156.
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Farid SaadLouis J Gooren. (2011) Late Onset Hypogonadism and Lower Urinary Tract Symptoms: New Insights. Korean Journal of Andrology 29:1, pages 1.
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Firas AbdollahAlberto BrigantiNazareno SuardiFabio CastiglioneAndrea GallinaUmberto CapitanioFrancesco Montorsi. (2011) Metabolic Syndrome and Benign Prostatic Hyperplasia: Evidence of a Potential Relationship, Hypothesized Etiology, and Prevention. Korean Journal of Urology 52:8, pages 507.
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Kazuyoshi ShigeharaMikio Namiki. (2011) Late-Onset Hypogonadism Syndrome and Lower Urinary Tract Symptoms. Korean Journal of Urology 52:10, pages 657.
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Michael D. Trifiro, J. Kellogg Parsons, Kerrin Palazzi-Churas, Jaclyn Bergstrom, Charles Lakin & Elizabeth Barrett-Connor. (2010) Serum sex hormones and the 20-year risk of lower urinary tract symptoms in community-dwelling older men. BJU International 105:11, pages 1554-1559.
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Julie K. Gammack. (2010) Lower Urinary Tract Symptoms. Clinics in Geriatric Medicine 26:2, pages 249-260.
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In Ho Chang, Seung Young Oh & Sae Chul Kim. (2009) A Possible Relationship Between Testosterone and Lower Urinary Tract Symptoms in Men. Journal of Urology 182:1, pages 215-220.
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Bruno LunenfeldMichael Oettel. (2009) Therapeutic potential of testosterone gels. Aging Health 5:2, pages 227-245.
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Akira Tsujimura & Akihiko Okuyama. (2008) Treatment for late-onset hypogonadism: the current situation in Japan. Journal of Men's Health 5:4, pages 342-349.
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