1,263
Views
37
CrossRef citations to date
0
Altmetric
Short Communication

Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors

, , & ORCID Icon
Pages 1575-1580 | Received 28 Jul 2018, Accepted 21 Aug 2018, Published online: 09 Oct 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (19)

Tuba Tekeli, Suleyman Akocak, Andrea Petreni, Nebih Lolak, Servet Çete & Claudiu T. Supuran. (2023) Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Jekaterīna Ivanova, Morteza Abdoli, Alessio Nocentini, Raivis Žalubovskis & Claudiu T. Supuran. (2023) Derivatives of 4-methyl-1,2,3-benzoxathiazine 2,2-dioxide as selective inhibitors of human carbonic anhydrases IX and XII over the cytosolic isoforms I and II. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Jekaterina Ivanova, Morteza Abdoli, Alessio Nocentini, Raivis Žalubovskis & Claudiu T. Supuran. (2023) 1,2,3-Benzoxathiazine-2,2-dioxides – effective inhibitors of human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 225-238.
Read now
Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo & Claudiu T. Supuran. (2022) Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2702-2709.
Read now
Morteza Abdoli, Simone Giovannuzzi, Claudiu T. Supuran & Raivis Žalubovskis. (2022) 4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1568-1576.
Read now
Varun Chahal, Sonam Nirwan, Mallika Pathak & Rita Kakkar. (2022) Identification of potent human carbonic anhydrase IX inhibitors: a combination of pharmacophore modeling, 3D-QSAR, virtual screening and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics 40:10, pages 4516-4531.
Read now
Alessio Nocentini, Sonia Del Prete, Margaret D. Mastrolorenzo, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2020) Activation studies of the β-carbonic anhydrases from Escherichia coli with amino acids and amines. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1379-1386.
Read now
Jeremie Brichet, Rodrigo Arancibia, Emanuela Berrino & Claudiu T. Supuran. (2020) Bioorganometallic derivatives of 4-hydrazino-benzenesulphonamide as carbonic anhydrase inhibitors: synthesis, characterisation and biological evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 622-628.
Read now
Aleksandrs Pustenko, Alessio Nocentini, Anastasija Balašova, Mikhail Krasavin, Raivis Žalubovskis & Claudiu T. Supuran. (2020) 7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 650-656.
Read now
Rakia Abd Alhameed, Emanuela Berrino, Zainab Almarhoon, Ayman El-Faham & Claudiu T. Supuran. (2020) A class of carbonic anhydrase IX/XII – selective carboxylate inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 549-554.
Read now
Benedetta Fois, Simona Distinto, Rita Meleddu, Serenella Deplano, Elias Maccioni, Costantino Floris, Antonella Rosa, Mariella Nieddu, Pierluigi Caboni, Claudia Sissi, Andrea Angeli, Claudiu T. Supuran & Filippo Cottiglia. (2020) Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 539-548.
Read now
Hasan Küçükbay, Nesrin Buğday, F. Zehra Küçükbay, Andrea Ageli, Gianluca Bartolucci & Claudiu T. Supuran. (2020) Synthesis and human carbonic anhydrase I, II, VA, and XII inhibition with novel amino acid–sulphonamide conjugates. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 489-497.
Read now
Sinan Bilginer, Baris Gonder, Halise Inci Gul, Ruya Kaya, Ilhami Gulcin, Baris Anil & Claudiu T. Supuran. (2020) Novel sulphonamides incorporating triazene moieties show powerful carbonic anhydrase I and II inhibitory properties. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 325-329.
Read now
Ali Irfan, Fozia Batool, Syeda Andleeb Zahra Naqvi, Amjad Islam, Sameh M. Osman, Alessio Nocentini, Siham A. Alissa & Claudiu T. Supuran. (2020) Benzothiazole derivatives as anticancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 265-279.
Read now
Siham A. Alissa, Hanan A. Alghulikah, Zeid A. Alothman, Sameh M. Osman, Sonia Del Prete, Clemente Capasso, Alessio Nocentini & Claudiu T. Supuran. (2020) Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 59-64.
Read now
Manuel A. Llanos, María L. Sbaraglini, María L. Villalba, María D. Ruiz, Carolina Carrillo, Catalina Alba Soto, Alan Talevi, Andrea Angeli, Seppo Parkkila, Claudiu T. Supuran & Luciana Gavernet. (2020) A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 21-30.
Read now
Mohammad M. Al-Sanea, Ahmed Elkamhawy, Sora Paik, Silvia Bua, So Ha Lee, Mohamed A. Abdelgawad, Eun Joo Roh, Wagdy M. Eldehna & Claudiu T. Supuran. (2019) Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1457-1464.
Read now
Baijayantimala Swain, Andrea Angeli, Srinivas Angapelly, Pavitra S. Thacker, Priti Singh, Claudiu T. Supuran & Mohammed Arifuddin. (2019) Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1199-1209.
Read now
Alessandra Ammazzalorso, Simone Carradori, Andrea Angeli, Atilla Akdemir, Barbara De Filippis, Marialuigia Fantacuzzi, Letizia Giampietro, Cristina Maccallini, Rosa Amoroso & Claudiu T. Supuran. (2019) Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1051-1061.
Read now

Articles from other publishers (18)

Suleyman Akocak, Nebih Lolak, Simone Giovannuzzi & Claudiu T. Supuran. (2023) Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides. Bioorganic & Medicinal Chemistry Letters 95, pages 129479.
Crossref
Suleyman Akocak, Nebih Lolak, Hatice Esra Duran, Mesut Işık, Cüneyt Türkeş, Mustafa Durgun & Şükrü Beydemir. (2023) Synthesis and Characterization of Novel 1,3‐Diaryltriazene‐Substituted Sulfaguanidine Derivatives as Selective Carbonic Anhydrase Inhibitors: Biological Evaluation, in Silico ADME/T and Molecular Docking Study . Chemistry & Biodiversity 20:8.
Crossref
Hasan Aydin, Süleyman Akocak, Nebih Lolak, Uğur Uslu, Ahmet Sait, Serol Korkmaz, Ayşe Parmaksiz, Onur Ceylan & Abdulbaki Aksakal. (2023) In vitro multitarget activity of sulfadiazine substituted triazenes as antimicrobial, cytotoxic, and larvicidal agents. Journal of Biochemical and Molecular Toxicology.
Crossref
Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T Supuran & Raivis Žalubovskis. (2023) Investigation of carbonic anhydrase inhibitory potency of ( Z/E )-alkyl N ‘-benzyl- N -(arylsulfonyl)-carbamimidothioates . Future Medicinal Chemistry 15:7, pages 615-627.
Crossref
Abdelrahman I. Zain-Alabdeen, Tarek F. El-Moselhy, Nabaweya Sharafeldin, Andrea Angeli, Claudiu T. Supuran & Mervat H. El-Hamamsy. (2022) Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX. Scientific Reports 12:1.
Crossref
Asif Rasool, Zahra Batool, Majid Khan, Sobia Ahsan Halim, Zahid Shafiq, Ahmed Temirak, Mohamed A. Salem, Tarik E. Ali, Ajmal Khan & Ahmed Al-Harrasi. (2022) Bis-pharmacophore of cinnamaldehyde-clubbed thiosemicarbazones as potent carbonic anhydrase-II inhibitors. Scientific Reports 12:1.
Crossref
Aref A.M. Aly, Amna S.A. Zidan, Ahmed B.M. Ibrahim, Hanan K. Mosbah, Peter Mayer & Saber H. Saber. (2022) Binuclear Cu(II) complex based on N-acetylanthranilic acid induces significant cytotoxic effect on three cancer cell lines. Journal of Molecular Structure 1249, pages 131634.
Crossref
Jacob T. Andring, Mallorie Fouch, Suleyman Akocak, Andrea Angeli, Claudiu T. Supuran, Marc A. Ilies & Robert McKenna. (2020) Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone. Journal of Medicinal Chemistry 63:21, pages 13064-13075.
Crossref
Mesut Işık, Süleyman Akocak, Nabih Lolak, Parham Taslimi, Cüneyt Türkeş, İlhami Gülçin, Mustafa Durgun & Şükrü Beydemir. (2020) Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3‐diaryltriazene‐substituted sulfathiazole derivatives. Archiv der Pharmazie 353:9.
Crossref
Baijayantimala Swain, Andrea Angeli, Priti Singh, Claudiu T. Supuran & Mohammed Arifuddin. (2020) New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorganic & Medicinal Chemistry 28:15, pages 115586.
Crossref
Chaofu Yang, Jing Wang, Yunyun Cheng, Xu Yang, Yan Feng, Xiaomei Zhuang, Zhenwang Li, Wangyu Zhao, Jiwen Zhang, Xianyu Sun & Xinhua He. (2020) N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II. Bioorganic Chemistry 100, pages 103931.
Crossref
Nebih Lolak, Süleyman Akocak, Cüneyt Türkeş, Parham Taslimi, Mesut Işık, Şükrü Beydemir, İlhami Gülçin & Mustafa Durgun. (2020) Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs. Bioorganic Chemistry 100, pages 103897.
Crossref
Süleyman AKOCAK, Mehmet BOGA, Nabih LOLAK, Muhammed TUNEG & Rajesh K K SANKU. (2019) Design, synthesis and biological evaluation of 1,3-diaryltriazenesubstituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. Journal of the Turkish Chemical Society Section A: Chemistry 6:1, pages 63-70.
Crossref
Nabih Lolak, Suleyman Akocak, Silvia Bua, Rajesh K.K. Sanku & Claudiu T. Supuran. (2019) Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors. Bioorganic & Medicinal Chemistry 27:8, pages 1588-1594.
Crossref
Zhensheng Jiang, Qidong You & Xiaojin Zhang. (2019) Medicinal chemistry of metal chelating fragments in metalloenzyme active sites: A perspective. European Journal of Medicinal Chemistry 165, pages 172-197.
Crossref
Suleyman Akocak, Nabih Lolak, Silvia Bua, Alessio Nocentini, Gulcin Karakoc & Claudiu T. Supuran. (2019) α-Carbonic anhydrases are strongly activated by spinaceamine derivatives. Bioorganic & Medicinal Chemistry 27:5, pages 800-804.
Crossref
Nabih Lolak, Suleyman Akocak, Silvia Bua & Claudiu T. Supuran. (2019) Design, synthesis and biological evaluation of novel ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as potent carbonic anhydrase IX inhibitors. Bioorganic Chemistry 82, pages 117-122.
Crossref
Marc A. Ilies & Jean-Yves Winum. 2019. Carbonic Anhydrases. Carbonic Anhydrases 331 365 .