11,525
Views
109
CrossRef citations to date
0
Altmetric
Original Article

Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations

, , , , &
Pages 1515-1525 | Received 15 Feb 2016, Accepted 14 Sep 2016, Published online: 11 Oct 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (15)

Julien Vignard, Aurelie Pettes-Duler, Eric Gaultier, Christel Cartier, Laurent Weingarten, Antje Biesemeier, Tatjana Taubitz, Philippe Pinton, Cecilia Bebeacua, Laurent Devoille, Jacques Dupuy, Elisa Boutet-Robinet, Nicolas Feltin, Isabelle P. Oswald, Fabrice H. Pierre, Bruno Lamas, Gladys Mirey & Eric Houdeau. (2023) Food-grade titanium dioxide translocates across the buccal mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium. Nanotoxicology 17:4, pages 289-309.
Read now
Wenshu Cheng, Xinyue Xu, Yuanyuan Lang, Zugen Cheng, Mohammad Rizwan, Xiaomin Tang, Lixin Xie, Yanling Liu, Hengyi Xu & Yang Liu. (2021) Anatase and Rutile TiO2 Nanoparticles Lead Effective Bone Damage in Young Rat Model via the IGF-1 Signaling Pathway. International Journal of Nanomedicine 16, pages 7233-7247.
Read now
Juliana Radtke, Raphael Wiedey & Peter Kleinebudde. (2021) Alternatives to titanium dioxide in tablet coating. Pharmaceutical Development and Technology 26:9, pages 989-999.
Read now
Barbara Rothen-Rutishauser, Marika Bogdanovich, Rayna Harter, Ana Milosevic & Alke Petri-Fink. (2021) Use of nanoparticles in food industry: current legislation, health risk discussions and public perception with a focus on Switzerland. Toxicological & Environmental Chemistry 103:4, pages 423-437.
Read now
Vahid Mollabashi, Abbas Farmany, Mohammad Yousef Alikhani, Mohammad Sattari, Ali Reza Soltanian, Parnian Kahvand & Ziba Banisafar. (2020) Effects of TiO2-Coated Stainless Steel Orthodontic Wires on Streptococcus mutans Bacteria: A Clinical Study. International Journal of Nanomedicine 15, pages 8759-8766.
Read now
Walter Brand, Ruud J. B. Peters, Hedwig M. Braakhuis, Lidka Maślankiewicz & Agnes G. Oomen. (2020) Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure. Nanotoxicology 14:7, pages 985-1007.
Read now
Otmar Geiss, Jessica Ponti, Chiara Senaldi, Ivana Bianchi, Dora Mehn, Josefa Barrero, Douglas Gilliland, Reinhard Matissek & Elke Anklam. (2020) Characterisation of food grade titania with respect to nanoparticle content in pristine additives and in their related food products. Food Additives & Contaminants: Part A 37:2, pages 239-253.
Read now
Fakhteh Aliakbari, Sara Haji Hosseinali, Ziba Khalili Sarokhalil, Koorosh Shahpasand, Ali Akbar Saboury, Keivan Akhtari & Mojtaba Falahati. (2019) Reactive oxygen species generated by titanium oxide nanoparticles stimulate the hemoglobin denaturation and cytotoxicity against human lymphocyte cell. Journal of Biomolecular Structure and Dynamics 37:18, pages 4875-4881.
Read now
Laura Talamini, Sara Gimondi, Martina B. Violatto, Fabio Fiordaliso, Federica Pedica, Ngoc Lan Tran, Giovanni Sitia, Federica Aureli, Andrea Raggi, Inge Nelissen, Francesco Cubadda, Paolo Bigini & Luisa Diomede. (2019) Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status. Nanotoxicology 13:8, pages 1087-1101.
Read now
Jia Du, Shaodan Xu, Qinwei Zhou, Huanxuan Li, Li Fu, Jun-Hong Tang & Mei-Qing Jin. (2019) The ecotoxicology of titanium dioxide nanoparticles, an important engineering nanomaterial. Toxicological & Environmental Chemistry 101:3-6, pages 165-189.
Read now
Hailong Hu, Li Li, Qian Guo, He Zong, Yuheng Yan, Yao Yin, Yu Wang, Yuri Oh, Yujie Feng, Qiong Wu & Ning Gu. (2018) RNA sequencing analysis shows that titanium dioxide nanoparticles induce endoplasmic reticulum stress, which has a central role in mediating plasma glucose in mice. Nanotoxicology 12:4, pages 341-356.
Read now
Qian Li, Ti Li, Chengmei Liu, Glen DeLoid, Georgios Pyrgiotakis, Philip Demokritou, Ruojie Zhang, Hang Xiao & David Julian McClements. (2017) Potential impact of inorganic nanoparticles on macronutrient digestion: titanium dioxide nanoparticles slightly reduce lipid digestion under simulated gastrointestinal conditions. Nanotoxicology 11:9-10, pages 1087-1101.
Read now
Marie Dorier, David Béal, Caroline Marie-Desvergne, Muriel Dubosson, Frédérick Barreau, Eric Houdeau, Nathalie Herlin-Boime & Marie Carriere. (2017) Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress. Nanotoxicology 11:6, pages 751-761.
Read now
Hans J. P. Marvin, Yamine Bouzembrak, Esmée M. Janssen, Meike van der Zande, Finbarr Murphy, Barry Sheehan, Martin Mullins & Hans Bouwmeester. (2017) Application of Bayesian networks for hazard ranking of nanomaterials to support human health risk assessment. Nanotoxicology 11:1, pages 123-133.
Read now

Articles from other publishers (94)

Di Han, Yulan Ji, Saixue Yang, Pei Song, Yihong Shi, Dongyan Shao, Xianqing Chen, Li Shang, Junling Shi & Chunmei Jiang. (2023) Therapeutic effect of iturin A on Candida albicans oral infection and its pathogenic factors . Antimicrobial Agents and Chemotherapy.
Crossref
Bruno Lamas, Laurence Chevalier, Eric Gaultier, Christel Cartier, Laurent Weingarten, Xavier Blanc, Paola Fisicaro, Caroline Oster, Johanna Noireaux, Lauris Evariste, Natalia Martins Breyner & Eric Houdeau. (2023) The food additive titanium dioxide hinders intestinal production of TGF-β and IL-10 in mice, and long-term exposure in adults or from perinatal life blocks oral tolerance to ovalbumin. Food and Chemical Toxicology 179, pages 113974.
Crossref
Filippo Vaccari, Leilei Zhang, Gianluca Giuberti, Alfina Grasso, Francesca Bandini, Pascual García-Pérez, Chiara Copat, Luigi Lucini, Margherita Dall’Asta, Margherita Ferrante & Edoardo Puglisi. (2023) The impact of metallic nanoparticles on gut fermentation processes: An integrated metabolomics and metagenomics approach following an in vitro digestion and fecal fermentation model. Journal of Hazardous Materials 453, pages 131331.
Crossref
Carlos Wells, Marta Pogribna, Beverly Lyn‐Cook & George Hammons. 2023. Impact of Engineered Nanomaterials in Genomics and Epigenomics. Impact of Engineered Nanomaterials in Genomics and Epigenomics 145 186 .
Sabyasachi Ghosh, Swarup Roy, Jishu Naskar & Ramen Kumar Kole. (2023) Plant-Mediated Synthesis of Mono- and Bimetallic (Au–Ag) Nanoparticles: Future Prospects for Food Quality and Safety. Journal of Nanomaterials 2023, pages 1-18.
Crossref
Yangqian Jiang, Yongyue Wei, Wenhui Guo, Jiangbo Du, Tao Jiang, Hongxia Ma, Guangfu Jin, Ting Chen, Rui Qin, Shiyao Tao, Qun Lu, Hong Lv, Xiumei Han, Kun Zhou, Bo Xu, Zhi Li, Mei Li, Yuan Lin, Yankai Xia & Zhibin Hu. (2023) Prenatal titanium exposure and child neurodevelopment at 1 year of age: A longitudinal prospective birth cohort study. Chemosphere 311, pages 137034.
Crossref
Jean-Philippe Klein, Lionel Mery, Delphine Boudard, Célia Ravel, Michèle Cottier & Dimitrios Bitounis. (2022) Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review. International Journal of Molecular Sciences 24:1, pages 576.
Crossref
Mohammad Issa, Gilles Rivière, Eric Houdeau & Karine Adel-Patient. (2022) Perinatal exposure to foodborne inorganic nanoparticles: A role in the susceptibility to food allergy?. Frontiers in Allergy 3.
Crossref
Pégah Jalili, Benjamin-Christoph Krause, Rachelle Lanceleur, Agnès Burel, Harald Jungnickel, Alfonso Lampen, Peter Laux, Andreas Luch, Valérie Fessard & Kevin Hogeveen. (2022) Chronic effects of two rutile TiO2 nanomaterials in human intestinal and hepatic cell lines. Particle and Fibre Toxicology 19:1.
Crossref
Qingying Shi, Chen Yang, Bingjie Zhang, Dongxiao Chen, Fuping Lu & Huabing Zhao. (2022) Bacillus coagulans Alleviates Intestinal Damage Induced by TiO2 Nanoparticles in Mice on a High-Fat Diet. Foods 11:21, pages 3368.
Crossref
Paloma de Almeida Rodrigues, Rafaela Gomes Ferrari, Júlia Vianna da Anunciação de Pinho, Denes Kaic Alves do Rosário, Cristine Couto de Almeida, Tatiana Dillenburg Saint'Pierre, Rachel Ann Hauser-Davis, Luciano Neves dos Santos & Carlos Adam Conte-Junior. (2022) Baseline titanium levels of three highly consumed invertebrates from an eutrophic estuary in southeastern Brazil. Marine Pollution Bulletin 183, pages 114038.
Crossref
Langzhi He, Hongbo Wang, Shumin Duan, Yanjun Gao, Lizhi Lyu, Xiaxian Ou, Nairui Yu, Yaoyun Zhang, Lingna Zheng & Yun Wang. (2022) Characterization of titanium dioxide nanoparticles in confectionary products and estimation of dietary exposure level among the Chinese population. NanoImpact 28, pages 100435.
Crossref
Aida Kanouté, Serigne Ndame Dieng, Mbathio Diop, Amadou Dieng, Ayotollah Khoumeyni Sene, Massamba Diouf, Cheikh Mbacké Lo, Daouda Faye & Florence Carrouel. (2022) Chemical vs. natural toothpaste: which formulas for which properties? A scoping review. Journal of Public Health in Africa 13:3.
Crossref
Dora Rolo, Ricardo Assunção, Célia Ventura, Paula Alvito, Lídia Gonçalves, Carla Martins, Ana Bettencourt, Peter Jordan, Nádia Vital, Joana Pereira, Fátima Pinto, Paulo Matos, Maria João Silva & Henriqueta Louro. (2022) Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles—A Systematic Review. Nanomaterials 12:19, pages 3275.
Crossref
Jing Wang, Le Yue, Jian Zhao, Xuesong Cao, Chuanxi Wang, Feiran Chen, Zhenggao Xiao, Yan Feng & Zhenyu Wang. (2022) Uptake and bioaccumulation of nanoparticles by five higher plants using single-particle-inductively coupled plasma-mass spectrometry. Environmental Science: Nano 9:8, pages 3066-3080.
Crossref
Carolina Rodríguez-Ibarra, Estefany I. Medina-Reyes, Alejandro Déciga-Alcaraz, Norma Laura Delgado-Buenrostro, Ericka Marel Quezada-Maldonado, Octavio Ispanixtlahuatl-Meráz, Adriana Ganem-Rondero, José Ocotlán Flores-Flores, Gustavo J. Vázquez-Zapién, Mónica M. Mata-Miranda, Rebeca López-Marure, José Pedraza-Chaverri, Claudia M. García-Cuéllar, Yesennia Sánchez-Pérez & Yolanda I. Chirino. (2022) Food grade titanium dioxide accumulation leads to cellular alterations in colon cells after removal of a 24-hour exposure. Toxicology 478, pages 153280.
Crossref
Zaira Colin-Val, Carlos Daniel Vera-Márquez, Manuel Alejandro Herrera-Rodríguez, María del Pilar Ramos-Godinez, Alejandro López-Saavedra, Agustina Cano-Martínez, Diana Xochiquetzal Robledo-Cadena, Sara Rodríguez-Enríquez, Francisco Correa, Norma Laura Delgado‐Buenrostro, Yolanda I. Chirino & Rebeca López-Marure. (2022) Titanium Dioxide (E171) Induces Toxicity in H9c2 Rat Cardiomyoblasts and Ex Vivo Rat Hearts. Cardiovascular Toxicology 22:8, pages 713-726.
Crossref
Ewa Baranowska-Wójcik, Dominik Szwajgier & Anna Winiarska-Mieczan. (2022) A review of research on the impact of E171/TiO2 NPs on the digestive tract. Journal of Trace Elements in Medicine and Biology 72, pages 126988.
Crossref
R. R. Remya & Angeline Julius. (2022) Titanium dioxide nanomaterials coated films in food packaging: a mini review. Vegetos 35:3, pages 565-570.
Crossref
Giovanni Sitia, Fabio Fiordaliso, Martina B. Violatto, Jennifer Fernandez Alarcon, Laura Talamini, Alessandro Corbelli, Lorena Maria Ferreira, Ngoc Lan Tran, Indranath Chakraborty, Mario Salmona, Wolfgang J. Parak, Luisa Diomede & Paolo Bigini. (2022) Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice. Nanomaterials 12:10, pages 1669.
Crossref
Robert Garnier, Joël Poupon, Nouzha Djebrani-Oussedik & Jérôme Langrand. (2022) Titanium cutaneous metallosis after reverse total shoulder arthroplasty. JSES Reviews, Reports, and Techniques 2:2, pages 190-193.
Crossref
Jun Yan, Qi Chen, Lei Tian, Kang Li, Wenqing Lai, Liping Bian, Jie Han, Rui Jia, Xiaohua Liu & Zhuge Xi. (2022) Intestinal toxicity of micro- and nano-particles of foodborne titanium dioxide in juvenile mice: Disorders of gut microbiota–host co-metabolites and intestinal barrier damage. Science of The Total Environment 821, pages 153279.
Crossref
Fabio Fiordaliso, Paolo Bigini, Mario Salmona & Luisa Diomede. (2022) Toxicological impact of titanium dioxide nanoparticles and food-grade titanium dioxide (E171) on human and environmental health. Environmental Science: Nano 9:4, pages 1199-1211.
Crossref
Sophie Boutillier, Sophie Fourmentin & Blandine Laperche. (2021) History of titanium dioxide regulation as a food additive: a review. Environmental Chemistry Letters 20:2, pages 1017-1033.
Crossref
Marlene Schwarzfischer & Gerhard Rogler. (2022) The Intestinal Barrier—Shielding the Body from Nano- and Microparticles in Our Diet. Metabolites 12:3, pages 223.
Crossref
Qian Li, Lu Liu, Mengran Duan, Xiaoqiang Chen, Jing Li, Tiantian Zhao, Yinxin Fu, David Julian McClements, Jialu Huang, Hongyi Lin & Jinglan Shi. (2022) TiO2 nanoparticles negatively impact the bioavailability and antioxidant activity of tea polyphenols. Food Chemistry 371, pages 131045.
Crossref
Adriana Vieira, Nádia Vital, Dora Rolo, Rossana Roque, Lídia M. Gonçalves, Ana Bettencourt, Maria João Silva & Henriqueta Louro. (2022) Investigation of the genotoxicity of digested titanium dioxide nanomaterials in human intestinal cells. Food and Chemical Toxicology 161, pages 112841.
Crossref
Qian Li, Jing Li, Mengran Duan, Lu Liu, Yinxin Fu, David Julian McClements, Tiantian Zhao, Hongyi Lin, Jinglan Shi & Xiaoqiang Chen. (2022) Impact of food additive titanium dioxide on the polyphenol content and antioxidant activity of the apple juice. LWT 154, pages 112574.
Crossref
Taiyi Jin, Max Costa & Xiao Chen. 2022. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 857 868 .
Frédérick Barreau, Céline Tisseyre, Sandrine Ménard, Audrey Ferrand & Marie Carriere. (2021) Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer. Particle and Fibre Toxicology 18:1.
Crossref
Atif Mossad Ali, Mahmoud Ahmed Sayed, Hamed Algarni, Vanga Ganesh, Muhd Aslam, Adel Ali Ismail & Haitham Mohamed El-Bery. (2021) Synthesis, Characterization and Photoelectric Properties of Fe2O3 Incorporated TiO2 Photocatalyst Nanocomposites. Catalysts 11:9, pages 1062.
Crossref
Shanji Liu, Yizhou Tang, Bolu Chen, Yu Zhao, Zoraida P Aguilar, Xueying Tao & Hengyi Xu. (2021) Inhibition of testosterone synthesis induced by oral TiO2 NPs is associated with ROS-MAPK(ERK1/2)-StAR signaling pathway in SD rat. Toxicology Research 10:4, pages 937-946.
Crossref
Justyna Modrzynska, Alicja Mortensen, Trine Berthing, Gitte Ravn-Haren, Józef Szarek, Anne Thoustrup Saber & Ulla Vogel. (2021) Effect on Mouse Liver Morphology of CeO2, TiO2 and Carbon Black Nanoparticles Translocated from Lungs or Deposited Intravenously. Applied Nano 2:3, pages 222-241.
Crossref
Urška Blaznik, Sanja Krušič, Maša Hribar, Anita Kušar, Katja Žmitek & Igor Pravst. (2021) Use of Food Additive Titanium Dioxide (E171) before the Introduction of Regulatory Restrictions Due to Concern for Genotoxicity. Foods 10:8, pages 1910.
Crossref
Ja Kyung Seol, Myeongkyu Park, Jae Min Im, Heung Sik Seo, Hee Ju Park & Sung Soon Nah. (2021) Acute toxicity assessment for TiO2 photocatalyst (GST) made from wastewater using TiCl4 in rat. Environmental Analysis Health and Toxicology 36:3, pages e2021019.
Crossref
Tanushree Parsai & Arun Kumar. (2021) Setting guidelines for co-occurring nanoparticles in water medium. Science of The Total Environment 776, pages 145175.
Crossref
Sheeana Gangadoo, Huu Nguyen, Piumie Rajapaksha, Hala Zreiqat, Kay Latham, Daniel Cozzolino, James Chapman & Vi Khanh Truong. (2021) Inorganic nanoparticles as food additives and their influence on the human gut microbiota. Environmental Science: Nano 8:6, pages 1500-1518.
Crossref
Encarnación Fuster, Héctor Candela, Jorge Estévez, Eugenio Vilanova & Miguel A. Sogorb. (2021) Titanium Dioxide, but Not Zinc Oxide, Nanoparticles Cause Severe Transcriptomic Alterations in T98G Human Glioblastoma Cells. International Journal of Molecular Sciences 22:4, pages 2084.
Crossref
Emanuele Rinninella, Marco Cintoni, Pauline Raoul, Vincenzina Mora, Antonio Gasbarrini & Maria Cristina Mele. (2021) Impact of Food Additive Titanium Dioxide on Gut Microbiota Composition, Microbiota-Associated Functions, and Gut Barrier: A Systematic Review of In Vivo Animal Studies. International Journal of Environmental Research and Public Health 18:4, pages 2008.
Crossref
Adam Lubojanski, Maciej Dobrzynski, Nicole Nowak, Justyna Rewak-Soroczynska, Klaudia Sztyler, Wojciech Zakrzewski, Wojciech Dobrzynski, Maria Szymonowicz, Zbigniew Rybak, Katarzyna Wiglusz & Rafal J. Wiglusz. (2021) Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry. Nanomaterials 11:2, pages 259.
Crossref
Gabriele Sauthier Romano de Melo, Renato Polimeni Constantin, Josielle Abrahão, Marcela de Paiva Foletto-Felipe, Rodrigo Polimeni Constantin, Wanderley Dantas dos Santos, Osvaldo Ferrarese-Filho & Rogério Marchiosi. (2021) Titanium Dioxide Nanoparticles Induce Root Growth Inhibition in Soybean Due to Physical Damages. Water, Air, & Soil Pollution 232:1.
Crossref
Nicolaj S. Bischoff, Theo M. de Kok, Dick T.H.M. Sijm, Simone G. van Breda, Jacco J. Briedé, Jacqueline J.M. Castenmiller, Antoon Opperhuizen, Yolanda I. Chirino, Hubert Dirven, David Gott, Eric Houdeau, Agnes G. Oomen, Morten Poulsen, Gerhard Rogler & Henk van Loveren. (2020) Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System. International Journal of Molecular Sciences 22:1, pages 207.
Crossref
Alfina Grasso, Margherita Ferrante, Pietro Zuccarello, Tommaso Filippini, Giovanni Arena, Maria Fiore, Antonio Cristaldi, Gea Oliveri Conti & Chiara Copat. (2020) Chemical Characterization and Quantification of Titanium Dioxide Nanoparticles (TiO2-NPs) in Seafood by Single-Particle ICP-MS: Assessment of Dietary Exposure. International Journal of Environmental Research and Public Health 17:24, pages 9547.
Crossref
A. Guillard, E. Gaultier, C. Cartier, L. Devoille, J. Noireaux, L. Chevalier, M. Morin, F. Grandin, M. Z. Lacroix, C. Coméra, A. Cazanave, A. de Place, V. Gayrard, V. Bach, K. Chardon, N. Bekhti, K. Adel-Patient, C. Vayssière, P. Fisicaro, N. Feltin, F. de la Farge, N. Picard-Hagen, B. Lamas & E. Houdeau. (2020) Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiO2 nanoparticles in an ex vivo placental perfusion model. Particle and Fibre Toxicology 17:1.
Crossref
Tommaso Filippini, Stefano Tancredi, Carlotta Malagoli, Marcella Malavolti, Annalisa Bargellini, Luciano Vescovi, Fausto Nicolini & Marco Vinceti. (2019) Dietary Estimated Intake of Trace Elements: Risk Assessment in an Italian Population. Exposure and Health 12:4, pages 641-655.
Crossref
Zhen Luo, Zhuoqing Li, Zhe Xie, Inna M. Sokolova, Lan Song, Willie J. G. M. Peijnenburg, Menghong Hu & Youji Wang. (2020) Rethinking Nano‐TiO 2 Safety: Overview of Toxic Effects in Humans and Aquatic Animals . Small 16:36, pages 2002019.
Crossref
Zhangjian Chen, Shuo Han, Pai Zheng, Shupei Zhou & Guang Jia. (2020) Combined effect of titanium dioxide nanoparticles and glucose on the blood glucose homeostasis in young rats after oral administration. Journal of Applied Toxicology 40:9, pages 1284-1296.
Crossref
S. Ramoju, M.E. Andersen, A. Nong, N. Karyakina, N. Shilnikova, K. Krishnan & D. Krewski. (2020) Derivation of whole blood biomonitoring equivalents for titanium for the interpretation of biomonitoring data. Regulatory Toxicology and Pharmacology 114, pages 104671.
Crossref
Zhangjian Chen, Shuo Han, Di Zhou, Pai Zheng, Shupei Zhou & Guang Jia. (2020) Serum metabolomic signatures of Sprague-Dawley rats after oral administration of titanium dioxide nanoparticles. NanoImpact 19, pages 100236.
Crossref
Wen Li, Ming Xi Jia, Jing Deng, Jian Hui Wang, Zavuga Zuberi, Sheng Yang, Jie Ba & Zhu Chen. (2020) MicroRNA Response and Toxicity of Potential Pathways in Human Colon Cancer Cells Exposed to Titanium Dioxide Nanoparticles. Cancers 12:5, pages 1236.
Crossref
Zhangjian Chen, Shuo Han, Shupei Zhou, Huimin Feng, Ying Liu & Guang Jia. (2020) Review of health safety aspects of titanium dioxide nanoparticles in food application. NanoImpact 18, pages 100224.
Crossref
Hailong Hu, Boya Zhang, Li Li, Qian Guo, Daqian Yang, Xiangjuan Wei, Xingpei Fan, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Changlin Wang, Liping Hou & Ning Gu. (2019) The toxic effects of titanium dioxide nanoparticles on plasma glucose metabolism are more severe in developing mice than in adult mice. Environmental Toxicology 35:4, pages 443-456.
Crossref
Eveline Verleysen, Nadia Waegeneers, Frédéric Brassinne, Sandra De Vos, Isaac Ojea Jimenez, Stella Mathioudaki & Jan Mast. (2020) Physicochemical Characterization of the Pristine E171 Food Additive by Standardized and Validated Methods. Nanomaterials 10:3, pages 592.
Crossref
Mohammad Hossein Ahmadi, Alireza Baghban, Milad Sadeghzadeh, Masoud Hadipoor & Mahyar Ghazvini. (2020) Evolving connectionist approaches to compute thermal conductivity of TiO /water nanofluid . Physica A: Statistical Mechanics and its Applications 540, pages 122489.
Crossref
A.M. Curtin, C.A. Vail & H.L. Buckley. (2020) CdTe in thin film photovoltaic cells: Interventions to protect drinking water in production and end-of-life. Water-Energy Nexus 3, pages 15-28.
Crossref
Shunbang Yu, Feng Wang, Yujie Bi, Pu Wang, Rui Zhang, Joanna Bohatko-Naismith, Xudong Zhang & He Wang. (2020) Autophagy regulates the Wnt/GSK3β/β-catenin/cyclin D1 pathway in mesenchymal stem cells (MSCs) exposed to titanium dioxide nanoparticles (TiO2NPs). Toxicology Reports 7, pages 1216-1222.
Crossref
L. Reijnders. 2020. Nanotoxicity. Nanotoxicity 215 237 .
Ewa Baranowska-Wójcik, Dominik Szwajgier, Patryk Oleszczuk & Anna Winiarska-Mieczan. (2019) Effects of Titanium Dioxide Nanoparticles Exposure on Human Health—a Review. Biological Trace Element Research 193:1, pages 118-129.
Crossref
Luca Di Giampaolo, Claudia Petrarca, Rocco Mangifesta, Cosima Schiavone, Cinzia Pini, Alice Malandra, Francesca Bramante, Alessio Pollutri, Michele Di Frischia & Mario Di Gioacchino. 2020. Allergy and Immunotoxicology in Occupational Health - The Next Step. Allergy and Immunotoxicology in Occupational Health - The Next Step 17 35 .
Flávia Suelen de Oliveira Pereira, Danielle Araújo Agarrayua, Caroline Brandão Quines & Daiana Ávila. 2020. Nanopesticides. Nanopesticides 299 316 .
Juan BuenoJuan Bueno. 2020. Preclinical Evaluation of Antimicrobial Nanodrugs. Preclinical Evaluation of Antimicrobial Nanodrugs 61 74 .
Fan Wu & Andrea L Hicks. (2019) Estimating human exposure to titanium dioxide from personal care products through a social survey approach. Integrated Environmental Assessment and Management 16:1, pages 10-16.
Crossref
Hailong Hu, Xingpei Fan, Yao Yin, Qian Guo, Daqian Yang, Xiangjuan Wei, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Kun Chen, Yujie Feng, Liping Hou, Li Li & Ning Gu. (2019) Mechanisms of titanium dioxide nanoparticle‐induced oxidative stress and modulation of plasma glucose in mice. Environmental Toxicology 34:11, pages 1221-1235.
Crossref
Ji-Soo Hwang, Jin Yu, Hyoung-Mi Kim, Jae-Min Oh & Soo-Jin Choi. (2019) Food Additive Titanium Dioxide and Its Fate in Commercial Foods. Nanomaterials 9:8, pages 1175.
Crossref
Maged Younes, Gabriele Aquilina, Laurence Castle, Karl‐Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Rainer Gürtler, Ursula Gundert‐Remy, Trine Husøy, Wim Mennes, Peter Moldeus Agneta Oskarsson, Sandra Rainieri, Romina Shah, Ine Waalkens‐Berendsen, Detlef Wölfle, Eric Gaffet, Jan Mast, Ruud Peters, Ana Maria Rincon & Peter Fürst. (2019) Scientific opinion on the proposed amendment of the EU specifications for titanium dioxide (E 171) with respect to the inclusion of additional parameters related to its particle size distribution. EFSA Journal 17:7.
Crossref
Tejal Barkhade, Sarthak Mishra, Harish Chander, Santosh Kumar Mahapatra & Indrani Banerjee. (2019) Effect of TiO 2 and Fe doped TiO 2 nanoparticles on mitochondrial membrane potential in HBL-100 cells . Biointerphases 14:4, pages 041003.
Crossref
Frankjen Y. de Boer, Arnout Imhof & Krassimir P. Velikov. (2019) Encapsulation of colorants by natural polymers for food applications. Coloration Technology 135:3, pages 183-194.
Crossref
Thomas Meyer, Tom Venus, Holger Sieg, Linda Böhmert, Birgitta M. Kunz, Benjamin Krause, Pegah Jalili, Kevin Hogeveen, Soizic Chevance, Fabienne Gauffre, Agnes Burel, Harald Jungnickel, Jutta Tentschert, Peter Laux, Andreas Luch, Albert Braeuning, Alfonso Lampen, Valerie Fessard, Jan Meijer & Irina Estrela‐Lopis. (2019) Simultaneous Quantification and Visualization of Titanium Dioxide Nanomaterial Uptake at the Single Cell Level in an In Vitro Model of the Human Small Intestine. Small Methods 3:5, pages 1800540.
Crossref
Zhangjian Chen, Di Zhou, Yun Wang, Lin Zhao, Guiping Hu, Jiaxing Liu, Huimin Feng, Changmao Long, Tenglong Yan, Shupei Zhou & Guang Jia. (2018) Combined effect of titanium dioxide nanoparticles and glucose on the cardiovascular system in young rats after oral administration. Journal of Applied Toxicology 39:4, pages 590-602.
Crossref
Klaus Abraham, Davide Arcella, Katrin Blume, Polly E. Boon, Gianfranco Brambilla, Francesco Cubadda, Birgit Dusemund, Stefan Fabiansson, Rainer Gürtler, Gerhard Heinemeyer, Sven Knüppel, Oliver Lindtner, Birgit Niemann, Christian Sieke & Andrea Straßburg. 2019. The Practice of Consumer Exposure Assessment. The Practice of Consumer Exposure Assessment 167 359 .
M. B. Heringa, R. J. B. Peters, R. L. A. W. Bleys, M. K. van der Lee, P. C. Tromp, P. C. E. van Kesteren, J. C. H. van Eijkeren, A. K. Undas, A. G. Oomen & H. Bouwmeester. (2018) Detection of titanium particles in human liver and spleen and possible health implications. Particle and Fibre Toxicology 15:1.
Crossref
Hans Christian Winkler, Tina Notter, Urs Meyer & Hanspeter Naegeli. (2018) Critical review of the safety assessment of titanium dioxide additives in food. Journal of Nanobiotechnology 16:1.
Crossref
Ina Saliasi, Juan Llodra, Manuel Bravo, Paul Tramini, Claude Dussart, Stéphane Viennot & Florence Carrouel. (2018) Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial. International Journal of Environmental Research and Public Health 15:12, pages 2660.
Crossref
D. Koller, P. Bramhall, J. Devoy, H. Goenaga-Infante, C. F. Harrington, E. Leese, J. Morton, S. Nuñez, J. Rogers, B. Sampson & J. J. Powell. (2018) Analysis of soluble or titanium dioxide derived titanium levels in human whole blood: consensus from an inter-laboratory comparison. The Analyst 143:22, pages 5520-5529.
Crossref
Tina Notter, Leonie Aengenheister, Ulrike Weber-Stadlbauer, Hanspeter Naegeli, Peter Wick, Urs Meyer & Tina Buerki-Thurnherr. (2018) Prenatal exposure to TiO2 nanoparticles in mice causes behavioral deficits with relevance to autism spectrum disorder and beyond. Translational Psychiatry 8:1.
Crossref
Qian Li, Yinxin Fu, Chengmei Liu, Ruojie Zhang, Zipei Zhang & David Julian McClements. (2018) Impact of Titanium Dioxide on the Bioaccessibility of β-Carotene in Emulsions with Different Particle Sizes. Journal of Agricultural and Food Chemistry 66:35, pages 9318-9325.
Crossref
Fabio Fiordaliso, Claudia Foray, Monica Salio, Mario Salmona & Luisa Diomede. (2018) Realistic Evaluation of Titanium Dioxide Nanoparticle Exposure in Chewing Gum. Journal of Agricultural and Food Chemistry 66:26, pages 6860-6868.
Crossref
Maged Younes, Peter Aggett, Fernando Aguilar, Riccardo Crebelli, Birgit Dusemund, Metka Filipič, Maria Jose Frutos, Pierre Galtier, David Gott, Ursula Gundert‐Remy, Gunter Georg Kuhnle, Claude Lambré, Jean‐Charles Leblanc, Inger Therese Lillegaard, Peter Moldeus, Alicja Mortensen, Agneta Oskarsson, Ivan Stankovic, Ine Waalkens‐Berendsen, Matthew Wright, Federica Lodi, Ana Maria Rincon, Camilla Smeraldi & Rudolf Antonius Woutersen. (2018) Evaluation of four new studies on the potential toxicity of titanium dioxide used as a food additive (E 171). EFSA Journal 16:7.
Crossref
Anthony Hardy, Diane Benford, Thorhallur Halldorsson, Michael John Jeger, Helle Katrine Knutsen, Simon More, Hanspeter Naegeli, Hubert Noteborn, Colin Ockleford, Antonia Ricci, Guido Rychen, Josef R. Schlatter, Vittorio Silano, Roland Solecki, Dominique Turck, Maged Younes, Qasim Chaudhry, Francesco Cubadda, David Gott, Agnes Oomen, Stefan Weigel, Melpo Karamitrou, Reinhilde Schoonjans & Alicja Mortensen. (2018) Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health. EFSA Journal 16:7.
Crossref
Pégah Jalili, Nelly Gueniche, Rachelle Lanceleur, Agnès Burel, Marie-Thérèse Lavault, Holger Sieg, Linda Böhmert, Thomas Meyer, Benjamin-Christoph Krause, Alfonso Lampen, Irina Estrela-Lopis, Peter Laux, Andreas Luch, Kevin Hogeveen & Valérie Fessard. (2018) Investigation of the in vitro genotoxicity of two rutile TiO2 nanomaterials in human intestinal and hepatic cells and evaluation of their interference with toxicity assays. NanoImpact 11, pages 69-81.
Crossref
Joris T.K. Quik, Martine Bakker, Dik van de Meent, Mikko Poikkimäki, Miikka Dal Maso & Willie Peijnenburg. (2018) Directions in QPPR development to complement the predictive models used in risk assessment of nanomaterials. NanoImpact 11, pages 58-66.
Crossref
Mahsan Karimi, Rohollah Sadeghi & Jozef Kokini. (2018) Human exposure to nanoparticles through trophic transfer and the biosafety concerns that nanoparticle-contaminated foods pose to consumers. Trends in Food Science & Technology 75, pages 129-145.
Crossref
Andrey Yasinskiy, Javier Navas, Teresa Aguilar, Rodrigo Alcántara, Juan Jesús Gallardo, Antonio Sánchez-Coronilla, Elisa I. Martín, Desireé De Los Santos & Concha Fernández-Lorenzo. (2018) Dramatically enhanced thermal properties for TiO2-based nanofluids for being used as heat transfer fluids in concentrating solar power plants. Renewable Energy 119, pages 809-819.
Crossref
Babak Abbaszadeh Asl, Leila Mogharizadeh, Niloofar Khomjani, Behnam Rasti, Seyed Pouyan Pishva, Keivan Akhtari, Farnoosh Attar & Mojtaba Falahati. (2018) Probing the interaction of zero valent iron nanoparticles with blood system by biophysical, docking, cellular, and molecular studies. International Journal of Biological Macromolecules 109, pages 639-650.
Crossref
Agnes G. Oomen, Klaus Günter Steinhäuser, Eric A.J. Bleeker, Fleur van Broekhuizen, Adriënne Sips, Susan Dekkers, Susan W.P. Wijnhoven & Philip G. Sayre. (2018) Risk assessment frameworks for nanomaterials: Scope, link to regulations, applicability, and outline for future directions in view of needed increase in efficiency. NanoImpact 9, pages 1-13.
Crossref
Valeria De Matteis & Rosaria Rinaldi. 2018. Cellular and Molecular Toxicology of Nanoparticles. Cellular and Molecular Toxicology of Nanoparticles 1 19 .
Hans Bouwmeester, Meike van der Zande & Mark A. Jepson. (2017) Effects of food‐borne nanomaterials on gastrointestinal tissues and microbiota. WIREs Nanomedicine and Nanobiotechnology 10:1.
Crossref
Chunyang Yin, Weilu Zhao, Rui Liu, Rong Liu, Zhe Wang, Lingyan Zhu, Wei Chen & Sijin Liu. (2017) TiO2 particles in seafood and surimi products: Attention should be paid to their exposure and uptake through foods. Chemosphere 188, pages 541-547.
Crossref
Bhanuramya Mangalampalli, Naresh Dumala & Paramjit Grover. (2017) Acute oral toxicity study of magnesium oxide nanoparticles and microparticles in female albino Wistar rats. Regulatory Toxicology and Pharmacology 90, pages 170-184.
Crossref
Linpeng Niu, Mengjiao Shao, Yuan Liu, Jinfeng Hu, Ruofan Li, Heran Xie, Lixiao Zhou, Lei Shi, Rong Zhang & Yujie Niu. (2017) Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice. Chemico-Biological Interactions 275, pages 133-144.
Crossref
Thomas P. Farrell & Berna Magnuson. (2017) Absorption, Distribution and Excretion of Four Forms of Titanium Dioxide Pigment in the Rat. Journal of Food Science 82:8, pages 1985-1993.
Crossref
Cassiana Ganem Achtschin & Aytan Miranda Sipahi. (2017) The role of titanium dioxide in the gut. Nutrition & Food Science 47:3, pages 432-442.
Crossref
Robert Landsiedel, Ursula G. Sauer & Wim H. de Jong. 2017. Adverse Effects of Engineered Nanomaterials. Adverse Effects of Engineered Nanomaterials 189 222 .
Reinhilde Schoonjans. (2016) Annual report of the EFSA Scientific Network of Risk Assessment of Nanotechnologies in Food and Feed for 2016. EFSA Supporting Publications 13:12.
Crossref