Citations (123)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (58)
Lukasz Skalniak, Ewa Surmiak & Tad A. Holak. (2019) A therapeutic patent overview of MDM2/X-targeted therapies (2014–2018). Expert Opinion on Therapeutic Patents 29:3, pages 151-170.
Read now
Read now
Olga Fedorova, Alexandra Daks, Varvara Petrova, Alexey Petukhov, Larissa Lezina, Oleg Shuvalov, Pavel Davidovich, Darya Kriger, Ekaterina Lomert, Dmitry Tentler, Victor Kartsev, Burhan Uyanik, Vyacheslav Tribulovich, Oleg Demidov, Gerry Melino & Nickolai A. Barlev. (2018) Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis. Cell Cycle 17:15, pages 1917-1930.
Read now
Read now
Ixaura Medina-Medina, Paola García-Beltrán, Ignacio de la Mora-de la Mora, Jesús Oria-Hernández, Guy Millot, Robin Fahraeus, Horacio Reyes-Vivas, José G. Sampedro & Vanesa Olivares-Illana. (2016) Allosteric Interactions by p53 mRNA Govern HDM2 E3 Ubiquitin Ligase Specificity under Different Conditions. Molecular and Cellular Biology 36:16, pages 2195-2205.
Read now
Read now
Krishna M. Chauhan, Gopalakrishnan Ramakrishnan, Madhusudhan Kollareddy & Luis A. Martinez. (2016) Characterization of cancer-associated missense mutations in MDM2. Molecular & Cellular Oncology 3:2.
Read now
Read now
Jeanine L Van Nostrand & Laura D Attardi. (2014) Guilty as CHARGED: p53's expanding role in disease. Cell Cycle 13:24, pages 3798-3807.
Read now
Read now
Matthew T Balmer, Ryan D Katz, Si Liao, James S Goodwine & Susannah Gal. (2014) Doxorubicin and 5-fluorouracil induced accumulation and transcriptional activity of p53 are independent of the phosphorylation at serine 15 in MCF-7 breast cancer cells. Cancer Biology & Therapy 15:8, pages 1000-1012.
Read now
Read now
Qian Cheng, Tanjing Song, Lihong Chen & Jiandong Chen. (2014) Autoactivation of the MDM2 E3 Ligase by Intramolecular Interaction. Molecular and Cellular Biology 34:15, pages 2800-2810.
Read now
Read now
Sara M Reed, Jussara Hagen, Van S Tompkins, Katie Thies, Frederick W Quelle & Dawn E Quelle. (2014) Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53. Cell Cycle 13:8, pages 1288-1298.
Read now
Read now
Shaofang Wu, Lihong Chen, Andreas Becker, Ernst Schonbrunn & Jiandong Chen. (2012) Casein Kinase 1α Regulates an MDMX Intramolecular Interaction To Stimulate p53 Binding. Molecular and Cellular Biology 32:23, pages 4821-4832.
Read now
Read now
YiWei Zhang, Qi Zhang, Shelya X. Zeng, Yu Zhang, Lindsey D. Mayo & Hua Lu. (2012) Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth. Cancer Biology & Therapy 13:10, pages 915-924.
Read now
Read now
Suzanne Camus, Sergio Menéndez, Kenneth Fernandes, Nelly Kua, Geng Liu, Dimitris P. Xirodimas, David P. Lane & Jean-Christophe Bourdon. (2012) The p53 isoforms are differentially modified by Mdm2. Cell Cycle 11:8, pages 1646-1655.
Read now
Read now
Zahid H. Shah, Shafiq U. Ahmed, Jack R. Ford, Simon J. Allison, John R. P. Knight & Jo Milner. (2012) A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes. Molecular and Cellular Biology 32:3, pages 704-716.
Read now
Read now
Qian Cheng, Brittany Cross, Baozong Li, Lihong Chen, Zhenyu Li & Jiandong Chen. (2011) Regulation of MDM2 E3 Ligase Activity by Phosphorylation after DNA Damage. Molecular and Cellular Biology 31:24, pages 4951-4963.
Read now
Read now
Qian Cheng & Jiandong Chen. (2011) The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation. Cell Cycle 10:7, pages 1162-1166.
Read now
Read now
Abhinav K. Jain & Michelle Craig Barton. (2010) Making sense of ubiquitin ligases that regulate p53. Cancer Biology & Therapy 10:7, pages 665-672.
Read now
Read now
Zhigang Yuan, Alejandro Villagra, Lirong Peng, Domenico Coppola, Michele Glozak, Eduardo M. Sotomayor, Jiandong Chen, William S. Lane & Edward Seto. (2010) The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions. Molecular and Cellular Biology 30:12, pages 3004-3015.
Read now
Read now
Karen A Boehme & Christine Blattner. (2009) Regulation of p53 - insights into a complex process. Critical Reviews in Biochemistry and Molecular Biology 44:6, pages 367-392.
Read now
Read now
Natalia Lukashchuk & Karen H. Vousden. (2007) Ubiquitination and Degradation of Mutant p53. Molecular and Cellular Biology 27:23, pages 8284-8295.
Read now
Read now
Tzu-Hao Cheng & Stanley N. Cohen. (2007) Human MDM2 Isoforms Translated Differentially on Constitutive versus p53-Regulated Transcripts Have Distinct Functions in the p53/MDM2 and TSG101/MDM2 Feedback Control Loops. Molecular and Cellular Biology 27:1, pages 111-119.
Read now
Read now
Li Zhang, Patrick Subarsky & Richard P. Hill. (2007) Hypoxia-regulated p53 and its effect on radiosensitivity in cancer cells. International Journal of Radiation Biology 83:7, pages 443-456.
Read now
Read now
Yaron Pereg, Suzanne Lam, Amina Teunisse, Sharon Biton, Erik Meulmeester, Leonid Mittelman, Giacomo Buscemi, Koji Okamoto, Yoichi Taya, Yosef Shiloh & Aart G. Jochemsen. (2006) Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage. Molecular and Cellular Biology 26:18, pages 6819-6831.
Read now
Read now
Yi Ding, Jin-Fong Lee, Hua Lu, Mong-Hong Lee & Duen-Hwa Yan. (2006) Interferon-Inducible Protein IFIXα1 Functions as a Negative Regulator of HDM2. Molecular and Cellular Biology 26:5, pages 1979-1996.
Read now
Read now
Guilian Niu, Kenneth L. Wright, Yihong Ma, Gabriela M. Wright, Mei Huang, Rosalyn Irby, Jon Briggs, James Karras, W. Douglas Cress, Drew Pardoll, Richard Jove, Jiangdong Chen & Hua Yu. (2005) Role of Stat3 in Regulating p53 Expression and Function. Molecular and Cellular Biology 25:17, pages 7432-7440.
Read now
Read now
Lihong Chen, Changgong Li, Yu Pan & Jiandong Chen. (2005) Regulation of p53-MDMX Interaction by Casein Kinase 1 Alpha. Molecular and Cellular Biology 25:15, pages 6509-6520.
Read now
Read now
Mu-Shui Dai, Shelya X. Zeng, Yetao Jin, Xiao-Xin Sun, Larry David & Hua Lu. (2004) Ribosomal Protein L23 Activates p53 by Inhibiting MDM2 Function in Response to Ribosomal Perturbation but Not to Translation Inhibition. Molecular and Cellular Biology 24:17, pages 7654-7668.
Read now
Read now
Marie Stenmark Askmalm, John Carstensen, Bo Nordenskjöld, Birgit Olsson, Lars Erik Rutqvist, Lambert Skoog & Olle Stål. (2004) Mutation and accumulation of p53 related to results of adjuvant therapy of postmenopausal breast cancer patients. Acta Oncologica 43:3, pages 235-244.
Read now
Read now
Hayla K. Sluss, Heather Armata, Judy Gallant & Stephen N. Jones. (2004) Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice. Molecular and Cellular Biology 24:3, pages 976-984.
Read now
Read now
Sandra Glockzin, Francois-Xavier Ogi, Arnd Hengstermann, Martin Scheffner & Christine Blattner. (2003) Involvement of the DNA Repair Protein hHR23 in p53 Degradation. Molecular and Cellular Biology 23:24, pages 8960-8969.
Read now
Read now
Yu Pan & Jiandong Chen. (2003) MDM2 Promotes Ubiquitination and Degradation of MDMX. Molecular and Cellular Biology 23:15, pages 5113-5121.
Read now
Read now
Hayla K Sluss & Stephen N Jones. (2003) Analysing p53 tumour suppressor functions in mice. Expert Opinion on Therapeutic Targets 7:1, pages 89-99.
Read now
Read now
Christine Blattner, Trevor Hay, David W. Meek & David P. Lane. (2002) Hypophosphorylation of Mdm2 Augments p53 Stability. Molecular and Cellular Biology 22:17, pages 6170-6182.
Read now
Read now
Yaron Daniely, Diana D. Dimitrova & James A. Borowiec. (2002) Stress-Dependent Nucleolin Mobilization Mediated by p53-Nucleolin Complex Formation. Molecular and Cellular Biology 22:16, pages 6014-6022.
Read now
Read now
Dafydd A Dart, Maqsood S Mansoor, Paul M Loadman & Steven M Picksley. (2001) Current advances in the inhibition of the auto-regulatory interaction between the p53 tumour suppressor protein and MDM2 protein. Expert Opinion on Therapeutic Patents 11:12, pages 1825-1835.
Read now
Read now
Marion A. E. Lohrum, Douglas B. Woods, Robert L. Ludwig, Éva Bálint & Karen H. Vousden. (2001) C-Terminal Ubiquitination of p53 Contributes to Nuclear Export. Molecular and Cellular Biology 21:24, pages 8521-8532.
Read now
Read now
Manuel S. Rodriguez, Joana M. P. Desterro, Sonia Lain, David P. Lane & Ronald T. Hay. (2000) Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation. Molecular and Cellular Biology 20:22, pages 8458-8467.
Read now
Read now
Öonagh Loughran & Nicholas B. La Thangue. (2000) Apoptotic and Growth-Promoting Activity of E2F Modulated by MDM2. Molecular and Cellular Biology 20:6, pages 2186-2197.
Read now
Read now
Jijie Gu, Dongli Chen, Jamie Rosenblum, Rachel M. Rubin & Zhi-Min Yuan. (2000) Identification of a Sequence Element from p53 That Signals for Mdm2-Targeted Degradation. Molecular and Cellular Biology 20:4, pages 1243-1253.
Read now
Read now
Christine Blattner, Alison Sparks & David Lane. (1999) Transcription Factor E2F-1 Is Upregulated in Response to DNA Damage in a Manner Analogous to That of p53. Molecular and Cellular Biology 19:5, pages 3704-3713.
Read now
Read now
Xiaoya Zeng, Lihong Chen, Christine A. Jost, Ruth Maya, David Keller, Xinjiang Wang, William G. Kaelin$suffix/text()$suffix/text(), Moshe Oren, Jiandong Chen & Hua Lu. (1999) MDM2 Suppresses p73 Function without Promoting p73 Degradation. Molecular and Cellular Biology 19:5, pages 3257-3266.
Read now
Read now
Jin Xu & Gilbert F. Morris. (1999) p53-Mediated Regulation of Proliferating Cell Nuclear Antigen Expression in Cells Exposed to Ionizing Radiation. Molecular and Cellular Biology 19:1, pages 12-20.
Read now
Read now
Deborah A. Freedman & Arnold J. Levine. (1998) Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6. Molecular and Cellular Biology 18:12, pages 7288-7293.
Read now
Read now
Michael H. G. Kubbutat, Robert L. Ludwig, Margaret Ashcroft & Karen H. Vousden. (1998) Regulation of Mdm2-Directed Degradation by the C Terminus of p53. Molecular and Cellular Biology 18:10, pages 5690-5698.
Read now
Read now
Tamar Juven-Gershon, Ohad Shifman, Tamar Unger, Adi Elkeles, Ygal Haupt & Moshe Oren. (1998) The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb. Molecular and Cellular Biology 18:7, pages 3974-3982.
Read now
Read now
Hua Lu, Robert P. Fisher, Paul Bailey & Arnold J. Levine. (1997) The CDK7-cycH-p36 Complex of Transcription Factor IIH Phosphorylates p53, Enhancing Its Sequence-Specific DNA Binding Activity In Vitro. Molecular and Cellular Biology 17:10, pages 5923-5934.
Read now
Read now
Dale S. Haines. (1997) The mdm2 Proto-Oncogene. Leukemia & Lymphoma 26:3-4, pages 227-238.
Read now
Read now
Troy A. Fiddler, Leslie Smith, Stephen J. Tapscott & Mathew J. Thayer. (1996) Amplification of MDM2 Inhibits MyoD-Mediated Myogenesis. Molecular and Cellular Biology 16:9, pages 5048-5057.
Read now
Read now
. (1996) Patent Evaluation Oncologic, Endocrine & Metabolic: Interruption of binding of MDM-2 and p53 protein; potential for the treatment of cancer. Expert Opinion on Therapeutic Patents 6:8, pages 805-809.
Read now
Read now
Jiandong Chen, Xiangwei Wu, Jiayuh Lin & Arnold J. Levine. (1996) mdm-2 Inhibits the G1 Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein. Molecular and Cellular Biology 16:5, pages 2445-2452.
Read now
Read now
Takashi Watanabe, Atsushi Ichikawa, Hidehiko Saito & Tomomitsu Hotta. (1996) Overexpression of the MDM2 Oncogene in Leukemia and Lymphoma. Leukemia & Lymphoma 21:5-6, pages 391-397.
Read now
Read now
Steven M. Picksley, James F. Spicer, Diana M. Barnes & David P. Lane. (1996) The P53-MDM2 Interaction in a Cancer-Prone Family, and the Identification of a Novel Therapeutic Target. Acta Oncologica 35:4, pages 429-434.
Read now
Read now
Chittari V. Shivakumar, Doris R. Brown, Sumitra Deb & Swati Palit Deb. (1995) Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter. Molecular and Cellular Biology 15:12, pages 6785-6793.
Read now
Read now
Huey-Jen L. Lin, Valerie Eviner, George C. Prendergast & Eileen White. (1995) Activated H-ras Rescues E1A-Induced Apoptosis and Cooperates with E1A To Overcome p53-Dependent Growth Arrest. Molecular and Cellular Biology 15:8, pages 4536-4544.
Read now
Read now
Antonio Gualberto, Mary L. Hixon, Timothy S. Finco, Neil D. Perkins, Gary J. Nabel & Albert S. Baldwin$suffix/text()$suffix/text(). (1995) A Proliferative p53-Responsive Element Mediates Tumor Necrosis Factor Alpha Induction of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat. Molecular and Cellular Biology 15:6, pages 3450-3459.
Read now
Read now
Horng-Chin Yan, Joseph M. Pilewski, Qian Zhang, Horace M. Delisser, Lewis Romer & Steven M. Albelda. (1995) Localization of Multiple Functional Domains on Human PECAM-1 (CD31) by Monoclonal Antibody Epitope Mapping. Cell Adhesion and Communication 3:1, pages 45-66.
Read now
Read now
Carlos E. Bueso-Ramos, Taghi Manshouri, Mohammad A. Haidar, Yang O. Huh, Michael J. Keating & Maher Albitar. (1995) Multiple Patterns of MDM-2 Deregulation in Human Leukemias: Implications in Leukemogenesis and Prognosis. Leukemia & Lymphoma 17:1-2, pages 13-18.
Read now
Read now
Vincent Marechal, Brian Elenbaas, Jacques Piette, Jean-Claude Nicolas & Arnold J. Levine. (1994) The Ribosomal L5 Protein Is Associated with mdm-2 and mdm-2-p53 Complexes. Molecular and Cellular Biology 14:11, pages 7414-7420.
Read now
Read now
Dale S. Haines, John E. Landers, Linda J. Engle & Donna L. George. (1994) Physical and Functional Interaction between Wild-Type p53 and mdm2 Proteins. Molecular and Cellular Biology 14:2, pages 1171-1178.
Read now
Read now
Doris R. Brown, Sumitra Deb, Rubén M. Muñoz, Mark A. Subler & Swati Palit Deb. (1993) The Tumor Suppressor p53 and the Oncoprotein Simian Virus 40 T Antigen Bind to Overlapping Domains on the MDM2 Protein. Molecular and Cellular Biology 13:11, pages 6849-6857.
Read now
Read now
Articles from other publishers (65)
Zeenat Farooq, Shahnawaz Wani, Vijay Avin Balaji Ragunathrao, Rakesh Kochhar & Mumtaz Anwar. 2022. p53 - A Guardian of the Genome and Beyond. p53 - A Guardian of the Genome and Beyond.
Alexsandra N. Corrigan & Justin A. Lemkul. (2022) Electronic Polarization at the Interface between the p53 Transactivation Domain and Two Binding Partners. The Journal of Physical Chemistry B 126:26, pages 4814-4827.
Crossref
Crossref
Mariana Bonjiorno Martins, Fernando de Assis Batista, Marjory Alana Marcello, Natassia Elena Bufalo, Karina Colombera Peres, Elaine Cristina Morari, Fernando Augusto Soares, José Vassallo & Laura Sterian Ward. (2021) Clinical utility of the imunohistochemical co-expression of p53 and MDM2 in thyroid follicular lesions. Annals of Diagnostic Pathology 53, pages 151766.
Crossref
Crossref
Zhi He, Faqiang Deng, Zhijun Ma, Qian Zhang, Jiayang He, Lijuan Ye, Hongjun Chen, Deying Yang, Liang He, Jie Luo, Sen Xiong & Taiming Yan. (2021) Molecular characterization, expression, and H2O2 induction of p53 and mdm2 in the ricefield eel, Monopterus albus. Aquaculture Reports 20, pages 100675.
Crossref
Crossref
Lihong Chen, Wade Borcherds, Shaofang Wu, Andreas Becker, Ernst SchonbrunnGary W. Daughdrill & Jiandong Chen. (2015) Autoinhibition of MDMX by intramolecular p53 mimicry. Proceedings of the National Academy of Sciences 112:15, pages 4624-4629.
Crossref
Crossref
Xin-Zi Chi, Jiyeon Kim, Yong-Hee Lee, Jung-Won Lee, Kyeong-Sook Lee, Heejun Wee, Wun-Jae Kim, Woo-Yoon Park, Byung-Chul Oh, Gary S. Stein, Yoshiaki Ito, Andre J. van Wijnen & Suk-Chul Bae. (2009) Runt-Related Transcription Factor RUNX3 Is a Target of MDM2-Mediated Ubiquitination. Cancer Research 69:20, pages 8111-8119.
Crossref
Crossref
Abhik Saha, Masanao Murakami, Pankaj Kumar, Bharat Bajaj, Karen Sims & Erle S. Robertson. (2009) Epstein-Barr Virus Nuclear Antigen 3C Augments Mdm2-Mediated p53 Ubiquitination and Degradation by Deubiquitinating Mdm2. Journal of Virology 83:9, pages 4652-4669.
Crossref
Crossref
Holger Hannemann, Kyle Rosenke, John M. O'Dowd & Elizabeth A. Fortunato. (2009) The Presence of p53 Influences the Expression of Multiple Human Cytomegalovirus Genes at Early Times Postinfection. Journal of Virology 83:9, pages 4316-4325.
Crossref
Crossref
Sanjeev Shangary, Ke Ding, Su Qiu, Zaneta Nikolovska-Coleska, Joshua A. Bauer, Meilan Liu, Guoping Wang, Yipin Lu, Donna McEachern, Denzil Bernard, Carol R. Bradford, Thomas E. Carey & Shaomeng Wang. (2008) Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer. Molecular Cancer Therapeutics 7:6, pages 1533-1542.
Crossref
Crossref
Dawn S. Chandler, Ravi K. Singh, Lisa C. Caldwell, Jaquelyn L. Bitler & Guillermina Lozano. (2006) Genotoxic Stress Induces Coordinately Regulated Alternative Splicing of the p53 Modulators MDM2 and MDM4. Cancer Research 66:19, pages 9502-9508.
Crossref
Crossref
Jianhong Ma, John D. Martin, Hong Zhang, Kurt R. Auger, Thau F. Ho, Robert B. Kirkpatrick, Michael H. Grooms, Kyung O. Johanson, Peter J. Tummino, Robert A. Copeland, and & Zhihong Lai. (2006) A Second p53 Binding Site in the Central Domain of Mdm2 Is Essential for p53 Ubiquitination. Biochemistry 45:30, pages 9238-9245.
Crossref
Crossref
Hans-Guido WendelElisa de StanchinaEnriqué CeperoSagarika RayMichael EmigJordan S. FridmanDarren R. VeachWilliam G. BornmannBayard ClarksonW. Richard McCombieScott C. Kogan, Andreas HochhausScott W. Lowe. (2006)
Loss of
p53
impedes the antileukemic response to BCR-ABL inhibition
. Proceedings of the National Academy of Sciences 103:19, pages 7444-7449.
Crossref
Crossref
Sarah Francoz, Pascal Froment, Sven Bogaerts, Sarah De Clercq, Marion Maetens, Gilles Doumont, Eric Bellefroid & Jean-Christophe Marine. (2006)
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells
in vivo
. Proceedings of the National Academy of Sciences 103:9, pages 3232-3237.
Crossref
Crossref
Zhuo Zhang, Hui Wang, Mao Li, Elizabeth R Rayburn, Sudhir Agrawal & Ruiwen Zhang. (2005) Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene 24:48, pages 7238-7247.
Crossref
Crossref
Lihong Chen, Hang Yin, Bilal Farooqi, Said Sebti, Andrew D. Hamilton & Jiandong Chen. (2005) p53 α-Helix mimetics antagonize p53/MDM2 interaction and activate p53. Molecular Cancer Therapeutics 4:6, pages 1019-1025.
Crossref
Crossref
Yaron Pereg, Dganit Shkedy, Petra de Graaf, Erik Meulmeester, Marina Edelson-Averbukh, Mogjiborahman Salek, Sharon Biton, Amina F. A. S. Teunisse, Wolf D. Lehmann, Aart G. Jochemsen & Yosef Shiloh. (2005) Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage. Proceedings of the National Academy of Sciences 102:14, pages 5056-5061.
Crossref
Crossref
Tomoo Iwakuma, John M Parant, Mark FasuloJrJr, Edwin Zwart, Tyler Jacks, Annemieke de Vries & Guillermina Lozano. (2004) Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice. Oncogene 23:46, pages 7644-7650.
Crossref
Crossref
Li Zhang & Richard P. Hill. (2004) Hypoxia Enhances Metastatic Efficiency by Up-Regulating Mdm2 in KHT Cells and Increasing Resistance to Apoptosis. Cancer Research 64:12, pages 4180-4189.
Crossref
Crossref
Patrick Chène. (2004) Inhibition of the p53-MDM2 Interaction: Targeting a Protein-Protein Interface. Molecular Cancer Research 2:1, pages 20-28.
Crossref
Crossref
Jonas A Nilsson & John L Cleveland. (2003) Myc pathways provoking cell suicide and cancer. Oncogene 22:56, pages 9007-9021.
Crossref
Crossref
Deepa Sampath, V Ashutosh Rao & William Plunkett. (2003) Mechanisms of apoptosis induction by nucleoside analogs. Oncogene 22:56, pages 9063-9074.
Crossref
Crossref
Carolyn J Foster & Guillermina Lozano. (2002) Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland. Oncogene 21:22, pages 3525-3531.
Crossref
Crossref
Béatrice Eymin, Sylvie Gazzeri, Christian Brambilla & Elisabeth Brambilla. (2002) Mdm2 overexpression and p14ARF inactivation are two mutually exclusive events in primary human lung tumors. Oncogene 21:17, pages 2750-2761.
Crossref
Crossref
Adriana Folberg-Blum, Amir Sapir, Ben-Zion Shilo & Moshe Oren. (2002) Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila. Oncogene 21:15, pages 2413-2417.
Crossref
Crossref
Margaret Ashcroft, Robert L Ludwig, Douglas B Woods, Terry D Copeland, H Oliver Weber, Elizabeth J MacRae & Karen H Vousden. (2002) Phosphorylation of HDM2 by Akt. Oncogene 21:13, pages 1955-1962.
Crossref
Crossref
Alison L. Greenway, Dale A. McPhee, Kelly Allen, Ricky Johnstone, Gavan Holloway, John Mills, Ahmed Azad, Sonia Sankovich & Paul Lambert. (2002) Human Immunodeficiency Virus Type 1 Nef Binds to Tumor Suppressor p53 and Protects Cells against p53-Mediated Apoptosis. Journal of Virology 76:6, pages 2692-2702.
Crossref
Crossref
Francesca Gentiletti, Francesca Mancini, Marco D'Angelo, Ada Sacchi, Alfredo Pontecorvi, Aart G Jochemsen & Fabiola Moretti. (2002) MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts. Oncogene 21:6, pages 867-877.
Crossref
Crossref
Leena Latonen, Yoichi Taya & Marikki Laiho. (2001) UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts. Oncogene 20:46, pages 6784-6793.
Crossref
Crossref
Lindsey D. Mayo & David B. Donner. (2001) A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proceedings of the National Academy of Sciences 98:20, pages 11598-11603.
Crossref
Crossref
Jennifer Michalowski, Scott E Seavey, Susan M Mendrysa & Mary Ellen Perry. (2001) Defects in transcription coupled repair interfere with expression of p90MDM2 in response to ultraviolet light. Oncogene 20:41, pages 5856-5864.
Crossref
Crossref
Dimitris Xirodimas, Mark K Saville, Charlotte Edling, David P Lane & Sonia Laín. (2001) Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene 20:36, pages 4972-4983.
Crossref
Crossref
Natalie A Little & Aart G Jochemsen. (2001) Hdmx and Mdm2 can repress transcription activation by p53 but not by p63. Oncogene 20:33, pages 4576-4580.
Crossref
Crossref
Susan C Evans, Meena Viswanathan, Jason D Grier, Meera Narayana, Adel K El-Naggar & Guillermina Lozano. (2001) An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2. Oncogene 20:30, pages 4041-4049.
Crossref
Crossref
Wenge Lu, Lihong Chen, Yanhua Peng & Jiandong Chen. (2001) Activation of p53 by roscovitine-mediated suppression of MDM2 expression. Oncogene 20:25, pages 3206-3216.
Crossref
Crossref
Patrick Chène. (2001) The role of tetramerization in p53 function. Oncogene 20:21, pages 2611-2617.
Crossref
Crossref
Manuela Argentini, Nadia Barboule & Bohdan Wasylyk. (2001) The contribution of the acidic domain of MDM2 to p53 and MDM2 stability. Oncogene 20:11, pages 1267-1275.
Crossref
Crossref
Teresa Johnson-Pais, Catherine Degnin & Mathew J. Thayer. (2001) pRB induces Sp1 activity by relieving inhibition mediated by MDM2. Proceedings of the National Academy of Sciences 98:5, pages 2211-2216.
Crossref
Crossref
Limin Li, Jian Liao, Jürgen Ruland, Tak W. Mak & Stanley N. Cohen. (2001) A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control. Proceedings of the National Academy of Sciences 98:4, pages 1619-1624.
Crossref
Crossref
Ricky W Johnstone, Wu Wei, Alison Greenway & Joseph A Trapani. (2000) Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16. Oncogene 19:52, pages 6033-6042.
Crossref
Crossref
Eric Kobet, Xiaoya Zeng, Yong Zhu, David Keller & Hua Lu. (2000) MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins. Proceedings of the National Academy of Sciences 97:23, pages 12547-12552.
Crossref
Crossref
Supriya V Gaitonde, Jayme R Riley, Dianhua Qiao & Jesse D Martinez. (2000) Conformational phenotype of p53 is linked to nuclear translocation. Oncogene 19:35, pages 4042-4049.
Crossref
Crossref
Manuela Argentini, Nadia Barboule & Bohdan Wasylyk. (2000) The contribution of the RING finger domain of MDM2 to cell cycle progression. Oncogene 19:34, pages 3849-3857.
Crossref
Crossref
Sakari Hietanen, Sonia Lain, Eberhard Krausz, Christine Blattner & David P. Lane. (2000) Activation of p53 in cervical carcinoma cells by small molecules. Proceedings of the National Academy of Sciences 97:15, pages 8501-8506.
Crossref
Crossref
Ruth Maya & Moshe Oren. (2000) Unmasking of phosphorylation-sensitive epitopes on p53 and Mdm2 by a simple Western-phosphatase procedure. Oncogene 19:28, pages 3213-3215.
Crossref
Crossref
Carol A Midgley, Joana MP Desterro, Mark K Saville, Stephanie Howard, Alison Sparks, Ronald T Hay & David P Lane. (2000) An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo. Oncogene 19:19, pages 2312-2323.
Crossref
Crossref
R Honda & H Yasuda. (2000) Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene 19:11, pages 1473-1476.
Crossref
Crossref
Sagar Sengupta, Ranju Ralhan & Bohdan Wasylyk. (2000) Tumour regression in a ligand inducible manner mediated by a chimeric tumour suppressor derived from p53. Oncogene 19:3, pages 337-350.
Crossref
Crossref
Wenge Lu, Radhika Pochampally, Lihong Chen, Mullika Traidej, Yiliang Wang & Jiandong Chen. (2000) Nuclear exclusion of p53 in a subset of tumors requires MDM2 function. Oncogene 19:2, pages 232-240.
Crossref
Crossref
Rami Khosravi, Ruth Maya, Tanya Gottlieb, Moshe Oren, Yosef Shiloh & Dganit Shkedy. (1999) Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proceedings of the National Academy of Sciences 96:26, pages 14973-14977.
Crossref
Crossref
Gretchen S Jimenez, Shireen H Khan, Jayne M Stommel & Geoffrey M Wahl. (1999) p53 regulation by post-translational modification and nuclear retention in response to diverse stresses. Oncogene 18:53, pages 7656-7665.
Crossref
Crossref
Philip Smart, E Birgitte Lane, David P Lane, Carol Midgley, Borek Vojtesek & Sonia Laín. (1999) Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B. Oncogene 18:51, pages 7378-7386.
Crossref
Crossref
Nik Veldhoen, Su Metcalfe & Jo Milner. (1999) A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein. Oncogene 18:50, pages 7026-7033.
Crossref
Crossref
Scott E. Seavey, Marisa Holubar, Leslie J. Saucedo & Mary Ellen Perry. (1999)
The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19
ARF
. Journal of Virology 73:9, pages 7590-7598.
Crossref
Crossref
Mark J. O’Connor, Holger Zimmermann, Søren Nielsen, Hans-Ulrich Bernard & Tony Kouzarides. (1999) Characterization of an E1A-CBP Interaction Defines a Novel Transcriptional Adapter Motif (TRAM) in CBP/p300. Journal of Virology 73:5, pages 3574-3581.
Crossref
Crossref
Matthias Dobbelstein, Sandra Wienzek, Claudia König & Judith Roth. (1999) Inactivation of the p53-homologue p73 by the mdm2-oncoprotein. Oncogene 18:12, pages 2101-2106.
Crossref
Crossref
Patrick E Carroll, Masaru Okuda, Henning F Horn, Paul Biddinger, Peter J Stambrook, Lyon L Gleich, Ya-Qin Li, Pheruza Tarapore & Kenji Fukasawa. (1999) Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene 18:11, pages 1935-1944.
Crossref
Crossref
Weikang Tao & Arnold J. Levine. (1999) Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. Proceedings of the National Academy of Sciences 96:6, pages 3077-3080.
Crossref
Crossref
Jay S Wunder, Kolja Eppert, Sarah R Burrow, Nalan Gogkoz, Robert S Bell & Irene L Andrulis. (1999) Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. Oncogene 18:3, pages 783-788.
Crossref
Crossref
Volker Böttger, Angelika Böttger, Carlos Garcia-Echeverria, Yolande FM Ramos, Alex J van der Eb, Aart G Jochemsen & David P Lane. (1999) Comparative study of the p53-mdm2 and p53-MDMX interfaces. Oncogene 18:1, pages 189-199.
Crossref
Crossref
Juan Cárcamo, Mark W. Ravera, Renée Brissette, Olga Dedova, James R. Beasley, Ameena Alam-Moghé, Changhong Wan, Arthur Blume & Wlodek Mandecki. (1998) Unexpected frameshifts from gene to expressed protein in a phage-displayed peptide library. Proceedings of the National Academy of Sciences 95:19, pages 11146-11151.
Crossref
Crossref
Takehiko Kamijo, Jason D. Weber, Gerard Zambetti, Frederique Zindy, Martine F. Roussel & Charles J. Sherr. (1998) Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proceedings of the National Academy of Sciences 95:14, pages 8292-8297.
Crossref
Crossref
Xiaoya Zeng, Arnold J. Levine & Hua Lu. (1998) Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53. Proceedings of the National Academy of Sciences 95:12, pages 6681-6686.
Crossref
Crossref
Cynthia A. Pise-Masison, Kyeong-Sook Choi, Michael Radonovich, Jürgen Dittmer, Seong-Jin Kim & John N. Brady. (1998) Inhibition of p53 Transactivation Function by the Human T-Cell Lymphotropic Virus Type 1 Tax Protein. Journal of Virology 72:2, pages 1165-1170.
Crossref
Crossref
Lihong Chen, Sudhir Agrawal, Wenqiang Zhou, Ruiwen Zhang & Jiandong Chen. (1998)
Synergistic activation of p53 by inhibition of
MDM2
expression and DNA damage
. Proceedings of the National Academy of Sciences 95:1, pages 195-200.
Crossref
Crossref
Paul H. KussieSvetlana GorinaVincent MarechalBrian ElenbaasJacque MoreauArnold J. LevineNikola P. Pavletich. (1996) Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain. Science 274:5289, pages 948-953.
Crossref
Crossref