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Review

Review of the pharmaceutical properties and clinical effects of the topical NSAID formulation, diclofenac epolamine

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Pages 2967-2992 | Accepted 25 Jul 2008, Published online: 02 Oct 2008

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Gabriella Onila do Nascimento Soares, Flávia Alves Lima, Gisele Assis Castro Goulart & Rodrigo Lambert Oréfice. (2022) Physicochemical characterization of the gelatin/polycaprolactone nanofibers loaded with diclofenac potassium for topical use aiming potential anti-inflammatory action. International Journal of Polymeric Materials and Polymeric Biomaterials 71:17, pages 1303-1318.
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Graham Pennick, Adam Robinson-Miller & Imogen Cush. (2021) Topical NSAIDs for acute local pain relief: in vitro characterization of drug delivery profiles into and through human skin. Drug Development and Industrial Pharmacy 47:6, pages 908-918.
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K. D. Rainsford, Michael S. Roberts, Alessandro Nencioni & Clarence Jones. (2019) Rationale and evidence for the incorporation of heparin into the diclofenac epolamine medicated plaster. Current Medical Research and Opinion 35:6, pages 989-1002.
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Martina Hagen & Mark Baker. (2017) Skin penetration and tissue permeation after topical administration of diclofenac. Current Medical Research and Opinion 33:9, pages 1623-1634.
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L. Tyler Wadsworth, Jeffrey D. Kent & Robert J. Holt. (2016) Efficacy and safety of diclofenac sodium 2% topical solution for osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled, 4 week study. Current Medical Research and Opinion 32:2, pages 241-250.
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Tarun Garg, Goutam Rath & Amit K. Goyal. (2015) Comprehensive review on additives of topical dosage forms for drug delivery. Drug Delivery 22:8, pages 969-987.
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Zora Palac, Julia Hurler, Nataša Škalko-Basnet, Jelena Filipović-Grčić & Željka Vanić. (2015) Elastic liposomes-in-vehicle formulations destined for skin therapy: the synergy between type of liposomes and vehicle. Drug Development and Industrial Pharmacy 41:8, pages 1247-1253.
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Allan Gibofsky, Roy Altman, Stephen Daniels, Olaolu Imasogie & Clarence Young. (2015) Low-dose SoluMatrix diclofenac: a review of safety across two Phase III studies in patients with acute and osteoarthritis pain. Expert Opinion on Drug Safety 14:8, pages 1327-1339.
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Chunde Li, Valeria Frangione, Stefano Rovati & Qingshan Zheng. (2013) Diclofenac epolamine medicated plaster in the treatment of minor soft tissue injuries: a multicenter randomized controlled trial. Current Medical Research and Opinion 29:9, pages 1137-1146.
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Susanna Tse, Kendall D Powell, Stephen J MacLennan, Allan R Moorman, Craig Paterson & Rosonald R Bell. (2012) Skin permeability and pharmacokinetics of diclofenac epolamine administered by dermal patch in Yorkshire-Landrace pigs. Journal of Pain Research 5, pages 401-408.
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Peter Hoffmann, Pavel Kopačka, Barbara Gugliotta & Stefano Rovati. (2012) Efficacy and tolerability of DHEP-heparin plaster in reducing pain in mild-to-moderate muscle contusions: a double-blind, randomized trial. Current Medical Research and Opinion 28:8, pages 1313-1321.
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Harleen Grewal, Sanjay R. Dhakate, Amit K. Goyal, Tanmay S. Markandeywar, Basant Malik & Goutam Rath. (2012) Development of Transmucosal Patch Using Nanofibers. Artificial Cells, Blood Substitutes, and Biotechnology 40:1-2, pages 146-150.
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David R Lionberger, Eric Joussellin, Jillmarie Yanchick, Merrell Magelli & Arturo Lanzarotti. (2011) Pooled analysis of clinical trial data evaluating the safety and effectiveness of diclofenac epolamine topical patch 1.3% for the treatment of acute ankle sprain. Open Access Journal of Sports Medicine 2, pages 75-84.
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Liliana L Jorge, Caroline C Feres & Vitor EP Teles. (2011) Topical preparations for pain relief: efficacy and patient adherence. Journal of Pain Research 4, pages 11-24.
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Charles E. Argoff. (2011) Recent developments in the treatment of osteoarthritis with NSAIDs. Current Medical Research and Opinion 27:7, pages 1315-1327.
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A. Klainguti, A. Forgacs, I. Berkes & E. Castellacci. (2010) A plaster containing DHEP and heparin for mild to moderate contusions and sprains with haematoma: a double-blind randomized study. Current Medical Research and Opinion 26:9, pages 2243-2251.
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Tong J. Gan. (2010) Diclofenac: an update on its mechanism of action and safety profile. Current Medical Research and Opinion 26:7, pages 1715-1731.
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