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Cholesterol lowering with bile salt hydrolase-active probiotic bacteria, mechanism of action, clinical evidence, and future direction for heart health applications

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Pages 631-642 | Published online: 28 Jan 2013

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Yin Liu, Shujuan Zheng, Jiale Cui, Tingting Guo & Jingtao Zhang. (2021) Effect of bile salt hydrolase-active Lactobacillus plantarum Y15 on high cholesterol diet induced hypercholesterolemic mice. CyTA - Journal of Food 19:1, pages 408-417.
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Baolei Jia, Dongbin Park, Yoonsoo Hahn & Che Ok Jeon. (2020) Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health. Gut Microbes 11:5, pages 1300-1313.
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Nidhi Gupta, Nikita Sharma, Sandeep K. Mathur, Ramesh Chandra & Surendra Nimesh. (2018) Advancement in nanotechnology-based approaches for the treatment and diagnosis of hypercholesterolemia. Artificial Cells, Nanomedicine, and Biotechnology 46:sup1, pages 188-197.
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Jason M. Ridlon, Spencer C. Harris, Shiva Bhowmik, Dae-Joong Kang & Phillip B. Hylemon. (2016) Consequences of bile salt biotransformations by intestinal bacteria. Gut Microbes 7:1, pages 22-39.
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Sy-Bing Choi, Lee-Ching Lew, Siok-Koon Yeo, Seema Nair Parvathy & Min-Tze Liong. (2015) Probiotics and the BSH-related cholesterol lowering mechanism: a Jekyll and Hyde scenario. Critical Reviews in Biotechnology 35:3, pages 392-401.
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Malkanthi Evans, John A Rumberger, Isao Azumano, Joseph J Napolitano, Danielle Citrolo & Toshikazu Kamiya. (2014) Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vascular Health and Risk Management 10, pages 89-100.
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Susan A Joyce, Fergus Shanahan, Colin Hill & Cormac GM Gahan. (2014) Bacterial bile salt hydrolase in host metabolism: Potential for influencing gastrointestinal microbe-host crosstalk. Gut Microbes 5:5, pages 669-674.
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Eamonn P Culligan, Roy D Sleator, Julian R Marchesi & Colin Hill. (2014) Metagenomics and novel gene discovery. Virulence 5:3, pages 399-412.
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