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Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting

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Pages 957-972 | Published online: 16 Apr 2013

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Laura Deruyver, Clément Rigaut, Alejandro Gomez-Perez, Pierre Lambert, Benoit Haut & Jonathan Goole. (2023) In vitro Evaluation of Paliperidone Palmitate Loaded Cubosomes Effective for Nasal-to-Brain Delivery. International Journal of Nanomedicine 18, pages 1085-1106.
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Nitish Kumar, Bharat Khurana & Daisy Arora. (2023) Nose-to-brain drug delivery for the treatment of glioblastoma multiforme: nanotechnological interventions. Pharmaceutical Development and Technology 0:0, pages 1-16.
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Kawthar K. Abla & Mohammed M. Mehanna. (2023) The battle of lipid-based nanocarriers against blood-brain barrier: a critical review. Journal of Drug Targeting 31:8, pages 832-857.
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Prabakaran A, Mukta Agrawal, Mithun Rajendra Dethe, Hafiz Ahmed, Awesh Yadav, Umesh Gupta & Amit Alexander. (2022) Nose-to-brain drug delivery for the treatment of Alzheimer’s disease: current advancements and challenges. Expert Opinion on Drug Delivery 19:1, pages 87-102.
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Yang Liu, Shuyuan Shuai, Guiting Huang, Yingchong Chen, Baode Shen & Pengfei Yue. (2021) Nanocrystals based mucosal delivery system: research advances. Drug Development and Industrial Pharmacy 47:11, pages 1700-1712.
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Chandrakantsing V. Pardeshi, Rahul N. Dhangar, Vilas R. Jagatap & Raju O. Sonawane. (2021) New cationic neuronanoemulsion-laden Eulophia herbacea mucilage based mucoadhesive hydrogel for intranasal delivery of chlorpromazine. Materials Technology 36:4, pages 189-202.
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Mihika Shringarpure, Sankalp Gharat, Munira Momin & Abdelwahab Omri. (2021) Management of epileptic disorders using nanotechnology-based strategies for nose-to-brain drug delivery. Expert Opinion on Drug Delivery 18:2, pages 169-185.
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Nanci S. Guest, Trisha A. VanDusseldorp, Michael T. Nelson, Jozo Grgic, Brad J. Schoenfeld, Nathaniel D. M. Jenkins, Shawn M. Arent, Jose Antonio, Jeffrey R. Stout, Eric T. Trexler, Abbie E. Smith-Ryan, Erica R. Goldstein, Douglas S. Kalman & Bill I. Campbell. (2021) International society of sports nutrition position stand: caffeine and exercise performance. Journal of the International Society of Sports Nutrition 18:1.
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Usama A Fahmy, Osama A A Ahmed, Shaimaa M Badr-Eldin, Hibah M Aldawsari, Solomon Z Okbazghi, Zuhier A Awan, Muhammed A Bakhrebah, Mohammad N Alomary, Wesam H Abdulaal, Carlos Medina & Nabil A Alhakamy. (2020) Optimized Nanostructured Lipid Carriers Integrated into In Situ Nasal Gel for Enhancing Brain Delivery of Flibanserin. International Journal of Nanomedicine 15, pages 5253-5264.
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Akhil Suresh, Reema Narayan & Usha Y Nayak. (2020) Recent advances in the development of asenapine formulations. Expert Opinion on Drug Delivery 17:10, pages 1377-1393.
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Siyabonga Melamane, Roderick B. Walker & Sandile M. M. Khamanga. (2020) Formulation optimization of smart thermosetting lamotrigine loaded hydrogels using response surface methodology, box benhken design and artificial neural networks. Drug Development and Industrial Pharmacy 46:9, pages 1402-1415.
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Ajinkya N. Nikam, Mahesh P. More, Abhijeet P. Pandey, Pravin O. Patil, Ashwini G. Patil & Prashant K. Deshmukh. (2020) Design and development of thiolated graphene oxide nanosheets for brain tumor targeting. International Journal of Polymeric Materials and Polymeric Biomaterials 69:10, pages 611-621.
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Madeleine S. A. Tan, Harendra S Parekh, Preeti Pandey, Dan J. Siskind & James R. Falconer. (2020) Nose-to-brain delivery of antipsychotics using nanotechnology: a review. Expert Opinion on Drug Delivery 17:6, pages 839-853.
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Chandrakantsing V. Pardeshi & Veena S Belgamwar. (2020) Improved brain pharmacokinetics following intranasal administration of N,N,N-trimethyl chitosan tailored mucoadhesive NLCs. Materials Technology 35:5, pages 249-266.
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Qiong Wu, Rong Yan & Jingjing Sun. (2020) Probing the drug delivery strategies in ischemic stroke therapy. Drug Delivery 27:1, pages 1644-1655.
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Rubin Hao, Bixi Sun, Lihua Yang, Chun Ma & Shuling Li. (2020) RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery. Drug Delivery 27:1, pages 772-781.
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M.D. Cayero-Otero, Maria João Gomes, Cláudia Martins, J. Álvarez-Fuentes, M. Fernández-Arévalo, B. Sarmento & L. Martín-Banderas. (2019) In vivo biodistribution of venlafaxine-PLGA nanoparticles for brain delivery: plain vs. functionalized nanoparticles. Expert Opinion on Drug Delivery 16:12, pages 1413-1427.
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Heba F. Salem, Rasha M. Kharshoum, Heba A. Abou-Taleb & Demiana M. Naguib. (2019) Nanosized nasal emulgel of resveratrol: preparation, optimization, in vitro evaluation and in vivo pharmacokinetic study. Drug Development and Industrial Pharmacy 45:10, pages 1624-1634.
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Dnyandev G. Gadhave & Chandrakant R. Kokare. (2019) Nanostructured lipid carriers engineered for intranasal delivery of teriflunomide in multiple sclerosis: optimization and in vivo studies. Drug Development and Industrial Pharmacy 45:5, pages 839-851.
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Lari K. Dkhar, Jim Bartley, David White & Ali Seyfoddin. (2018) Intranasal drug delivery devices and interventions associated with post-operative endoscopic sinus surgery. Pharmaceutical Development and Technology 23:3, pages 282-294.
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Qian Yang, Chuang Zhao, Jun Zhao & Yong Ye. (2017) Photoresponsive nanocapsulation of cobra neurotoxin and enhancement of its central analgesic effects under red light. International Journal of Nanomedicine 12, pages 3463-3470.
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Chandrakantsing Vijaysing Pardeshi & Veena Shailendra Belgamwar. (2017) Ropinirole-dextran sulfate nanoplex for nasal administration against Parkinson’s disease: in silico molecular modeling and in vitro–ex vivo evaluation. Artificial Cells, Nanomedicine, and Biotechnology 45:3, pages 635-648.
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Abdullah Kumral, Burcin Iscan, Defne Engur, Funda Tuzun, Seda Ozbal, Bekir Ugur Ergur, Munevver Kaynak Turkmen, Nuray Duman & Hasan Ozkan. (2017) Intranasal surfactant protein D as neuroprotective rescue in a neonatal rat model of periventricular leukomalacia. The Journal of Maternal-Fetal & Neonatal Medicine 30:4, pages 446-451.
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Juilee A. Kulkarni & Amelia M. Avachat. (2017) Pharmacodynamic and pharmacokinetic investigation of cyclodextrin-mediated asenapine maleate in situ nasal gel for improved bioavailability. Drug Development and Industrial Pharmacy 43:2, pages 234-245.
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Abhijeet D Kulkarni, Harun M Patel, Sanjay J Surana, Veena S Belgamwar & Chandrakantsing V Pardeshi. (2016) Brain–blood ratio: implications in brain drug delivery. Expert Opinion on Drug Delivery 13:1, pages 85-92.
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Yongjun Jiang, Yun Li & Xinfeng Liu. (2015) Intranasal delivery: circumventing the iron curtain to treat neurological disorders. Expert Opinion on Drug Delivery 12:11, pages 1717-1725.
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Abhijeet D. Kulkarni, Yogesh H. Vanjari, Karan H. Sancheti, Veena S. Belgamwar, Sanjay J. Surana & Chandrakantsing V. Pardeshi. (2015) Nanotechnology-mediated nose to brain drug delivery for Parkinson's disease: a mini review. Journal of Drug Targeting 23:9, pages 775-788.
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P. R. Ravi, N. Aditya, S. Patil & L. Cherian. (2015) Nasal in-situ gels for delivery of rasagiline mesylate: improvement in bioavailability and brain localization. Drug Delivery 22:7, pages 903-910.
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Eliana B Souto. (2013) Expert Opinion. Expert Opinion on Drug Delivery 10:7, pages i-ii.
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