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Review

The benefits and risks of testosterone replacement therapy: a review

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Pages 427-448 | Published online: 11 Jun 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (22)

Orlanda Harvey, Margarete Parrish, Edwin van Teijlingen & Steven Trenoweth. (2022) Libido as a motivator for starting and restarting non-prescribed anabolic androgenic steroid use among men: a mixed-methods study. Drugs: Education, Prevention and Policy 29:3, pages 276-288.
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Julius Fink, Brad J. Schoenfeld, Anthony C. Hackney, Takahiro Maekawa & Shigeo Horie. (2021) Human chorionic gonadotropin treatment: a viable option for management of secondary hypogonadism and male infertility. Expert Review of Endocrinology & Metabolism 16:1, pages 1-8.
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Yuki Kato, Kazuyoshi Shigehara, Kazufumi Nakashima, Masashi Iijima, Shohei Kawagushi, Takahiro Nohara, Kouji Izumi, Yoshifumi Kadono, Hiroyuki Konaka, Mikio Namiki & Atsushi Mizokami. (2020) The five-year effects of testosterone replacement therapy on lipid profile and glucose tolerance among hypogonadal men in Japan: a case control study. The Aging Male 23:1, pages 23-28.
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Ningyin Li, Ruixin Ma, Shixiong Wang, Yang Zhao, Ping Wang, Zhitao Yang, Lingling Jin, Panpan Zhang, Hong Ding, Feng Bai & Jing Yu. (2019) The potential role of testosterone in hypertension and target organ damage in hypertensive postmenopausal women. Clinical Interventions in Aging 14, pages 743-752.
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Tom E. Nightingale, Pamela Moore, Joshua Harman, Refka Khalil, Ranjodh S. Gill, Teodoro Castillo, Robert A. Adler & Ashraf S. Gorgey. (2018) Body composition changes with testosterone replacement therapy following spinal cord injury and aging: A mini review. The Journal of Spinal Cord Medicine 41:6, pages 624-636.
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Kazuyoshi Shigehara, Hiroyuki Konaka, Kazuhiro Sugimoto, Takahiro Nohara, Koji Izumi, Yoshifumi Kadono, Mikio Namiki & Atsushi Mizokami. (2018) Sleep disturbance as a clinical sign for severe hypogonadism: efficacy of testosterone replacement therapy on sleep disturbance among hypogonadal men without obstructive sleep apnea. The Aging Male 21:2, pages 99-105.
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Kazuyoshi Shigehara, Hiroyuki Konaka, Eitetsu Koh, Kazufumi Nakashima, Masashi Iijima, Takahiro Nohara, Koji Izumi, Yasuhide Kitagawa, Yoshifumi Kadono, Kazuhiro Sugimoto, Teruaki Iwamoto, Atsushi Mizokami & Mikio Namiki. (2017) Effects of testosterone replacement therapy on hypogonadal men with osteopenia or osteoporosis: a subanalysis of a prospective randomized controlled study in Japan (EARTH study). The Aging Male 20:3, pages 139-145.
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Onder Canguven, Raidh A. Talib, Walid El Ansari, Dany-Jan Yassin & Abdullah Al Naimi. (2017) Vitamin D treatment improves levels of sexual hormones, metabolic parameters and erectile function in middle-aged vitamin D deficient men. The Aging Male 20:1, pages 9-16.
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Kazuyoshi Shigehara, Hiroyuki Konaka, Masashi Ijima, Takahiro Nohara, Kazutaka Narimoto, Koji Izumi, Yoshifumi Kadono, Yasuhide Kitagawa, Atsushi Mizokami & Mikio Namiki. (2016) The correlation between highly sensitive C-reactive protein levels and erectile function among men with late-onset hypogonadism. The Aging Male 19:4, pages 239-243.
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Aydogan Aydogdu & Ronald S. Swerdloff. (2016) Emerging medication for the treatment of male hypogonadism. Expert Opinion on Emerging Drugs 21:3, pages 255-266.
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Kazuyoshi Shigehara, Hiroyuki Konaka, Eitetsu Koh, Koji Izumi, Yasuhide Kitagawa, Atsushi Mizokami, Takao Nakashima, Masayoshi Shimamura, Teruaki Iwamoto & Mikio Namiki. (2015) Effects of testosterone replacement therapy on nocturia and quality of life in men with hypogonadism: a subanalysis of a previous prospective randomized controlled study in Japan. The Aging Male 18:3, pages 169-174.
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Jason Kovac, Alexander W. Pastuszak, Dolores J. Lamb & Larry I. Lipshultz. (2014) Testosterone Supplementation Therapy in the Treatment of Patients with Metabolic Syndrome. Postgraduate Medicine 126:7, pages 149-156.
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Mark L Anderson. (2014) Evaluation of Resettin® on serum hormone levels in sedentary males. Journal of the International Society of Sports Nutrition 11:1.
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Keisuke Okada, Kohei Yamaguchi, Koji Chiba, Hideaki Miyake & Masato Fujisawa. (2014) Comprehensive evaluation of androgen replacement therapy in aging Japanese men with late-onset hypogonadism. The Aging Male 17:2, pages 72-75.
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Hai-Tang Zhang, Jin-Qing Jiang, Zi-Liang Wang, Jun-Jie Chen, Shu-Yun Wang, Han Ding, Xin-peng Li & Yi Li. (2014) Preparation and validation of monoclonal antibody-based indirect competitive ELISA for detecting testosterone levels. Food and Agricultural Immunology 25:2, pages 256-266.
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Kazuyoshi Shigehara, Eitetsu Koh, Jiro Sakamoto, Hiroshi Yaegashi, Koji Izumi, Satoru Ueno, Yasuhide Kitagawa, Yuji Maeda, Yoshifumi Kadono, Hiroyuki Konaka, Atsushi Mizokami, Takao Nakashima & Mikio Namiki. (2014) Effects of dutasteride on lower urinary tract symptoms and general health in men with benign prostatic hypertroplasia and hypogonadism: a prospective study. The Aging Male 17:1, pages 51-56.
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David E. Vance, Joan E. Dodson, Carrie Ann Gakumo, David Morris, Beth Kitchin & Kerstin E. E. Schroder. (2012) Successful Cognitive Aging in HIV: Potential Strategies for Treatment and Research. Physical & Occupational Therapy In Geriatrics 30:3, pages 229-244.
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Hisanori Taniguchi, Gen Kawa, Hidefumi Kinoshita & Tadashi Matsuda. (2011) Symptomatic change in Japanese hypogonadal patients several years after androgen replacement therapy. The Aging Male 14:3, pages 190-194.
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Kazuyoshi Shigehara, Kazuhiro Sugimoto, Hiroyuki Konaka, Masashi Iijima, Masato Fukushima, Yuji Maeda, Atsushi Mizokami, Eitetsu Koh, Hideki Origasa, Teruaki Iwamoto & Mikio Namiki. (2011) Androgen replacement therapy contributes to improving lower urinary tract symptoms in patients with hypogonadism and benign prostate hypertrophy: a randomised controlled study. The Aging Male 14:1, pages 53-58.
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Megha Agarwal, Jesse Naghi, Kiran Philip, Anita Phan, Robert D Willix Jr & Ernst R Schwarz. (2010) Growth hormone and testosterone in heart failure therapy. Expert Opinion on Pharmacotherapy 11:11, pages 1835-1844.
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Eric Holt, Muyuan Wang, Stefan Andrew Harry, Chengkun He, Yuang Wang, Nicolas Henriquez, Michael Richard Xiang, Andrea Zhu, Fereshte Ghorbani & Thomas Lectka. (2023) An Electrochemical Approach to Directed Fluorination. The Journal of Organic Chemistry 88:4, pages 2557-2560.
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Ashokkumar Jain, Danielle Haussner, Tjasa Hranjec, Fauzia Butt, Jonathan G. Stine, Anita Ankola, Hussain Al Yousif, Russell Dicristina, Karen L. Krok & Juan Arenas. (2022) Review of Sarcopenia and Testosterone Deficiency With Chronic Liver Disease and Postoperative Liver Transplant Utility of Short-Term Testosterone Replacement Therapy. Experimental and Clinical Transplantation 20:11, pages 1000-1008.
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Alexandru Turza, Violeta Popescu, Liviu Mare & Gheorghe Borodi. (2022) Structural Aspects and Intermolecular Energy for Some Short Testosterone Esters. Materials 15:20, pages 7245.
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Linlin Xu, Yuan Yuan, Zhaodi Che, Xiaozhi Tan, Bin Wu, Cunchuan Wang, Chengfang Xu & Jia Xiao. (2022) The Hepatoprotective and Hepatotoxic Roles of Sex and Sex-Related Hormones. Frontiers in Immunology 13.
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Savi Shishkov & Mila Boyadzhieva. (2022) Testosterone and cardiovascular disease - a literature review. Scripta Scientifica Medica 54:1, pages 9.
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Paul N. Bryman, Leonard A. Powell & Terrie B. Ginsberg. 2020. Geriatric Medicine. Geriatric Medicine 1 19 .
Hina Usmani & Ravi Kant. (2021) Testosterone: An Insight into Its Clinical and Biochemical Assessments. Indian Journal of Medical Biochemistry 25:1, pages 24-30.
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Vittoria Russo, Rui Chen & Reina Armamento-Villareal. (2021) Hypogonadism, Type-2 Diabetes Mellitus, and Bone Health: A Narrative Review. Frontiers in Endocrinology 11.
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Juliano Vilela Alves, Rafael Menezes da Costa, Camila André Pereira, Aline Garcia Fedoce, Carlos Alberto Aguiar Silva, Fernando Silva Carneiro, Núbia Souza Lobato & Rita C. Tostes. (2020) Supraphysiological Levels of Testosterone Induce Vascular Dysfunction via Activation of the NLRP3 Inflammasome. Frontiers in Immunology 11.
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Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Ha-Na Lee & Young-Joon Surh. (2020) 17β-Estradiol supplementation changes gut microbiota diversity in intact and colorectal cancer-induced ICR male mice. Scientific Reports 10:1.
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Rahim Ahmadi, Seyedeh Nasim Mirbahari & Masoumeh Ghornani vahed. (2020) The Effects of Gasoline Vapor Inhalation on Serum Level of Testosterone and Testes Tissue in Male Rats. Caspian Journal of Health Research 5:2, pages 34-38.
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M. R. Gofur. (2020) Effect of testosterone on penile and urethral development in Black Bengal goat. Bangladesh Journal of Veterinary Medicine 17:2.
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Emile CH Woo & Belinda Rodis. (2019) Sarcopenia in Elderly Surgery. Annals of the Academy of Medicine, Singapore 48:11, pages 363-369.
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M. L. Sizonenko, G. V. Bryukhin & M. A. Sheremeteva. (2019) The problem of men's infertility: possible ways of solution (literature review). Problemy reproduktsii 25:2, pages 90.
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Yu. L. Skorodok, I. Yu. Ioffe, I. I. Nagornaya & I. L. Nikitina. (2018) The use of recombinant FSH in combination therapy in a young male with idiopathic hypogonadotropic hypogonadism. Medical Council:17, pages 260-264.
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Arinto Y. P. Wardoyo, Unggul P. Juswono & Johan A. E. Noor. An observation of histological evidence on internal organ damages in mice caused by repeated exposures to motorcycle emissions. An observation of histological evidence on internal organ damages in mice caused by repeated exposures to motorcycle emissions.
Lina E Aguirre, Georgia Colleluori, Kenneth E Fowler, Irum Zeb Jan, Kenneth Villareal, Clifford Qualls, David Robbins, Dennis T Villareal & Reina Armamento-Villareal. (2015) High aromatase activity in hypogonadal men is associated with higher spine bone mineral density, increased truncal fat and reduced lean mass. European Journal of Endocrinology 173:2, pages 167-174.
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