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Clinical Research Paper

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

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Pages 1359-1368 | Received 21 Nov 2013, Accepted 23 Apr 2014, Published online: 20 May 2014

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Ioannis Ntafoulis, Stijn L. W. Koolen, Sieger Leenstra & Martine L. M. Lamfers. (2022) Drug Repurposing, a Fast-Track Approach to Develop Effective Treatments for Glioblastoma. Cancers 14:15, pages 3705.
Crossref
Edgar Petrosyan, Jawad Fares, Alex Cordero, Aida Rashidi, Víctor A. Arrieta, Deepak Kanojia & Maciej S. Lesniak. (2022) Repurposing autophagy regulators in brain tumors. International Journal of Cancer 151:2, pages 167-180.
Crossref
Ryan C Russell & Kun‐Liang Guan. (2022) The multifaceted role of autophagy in cancer. The EMBO Journal 41:13.
Crossref
Longkai He, Xiaotong Wang, Ya Jin, Weipeng Xu, Jun Lyu, Yi Guan, Jingchao Wu, Shasha Han & Guosheng Liu. (2022) A Prognostic Nomogram for Predicting Overall Survival in Pediatric Wilms Tumor Based on an Autophagy-related Gene Signature. Combinatorial Chemistry & High Throughput Screening 25:8, pages 1385-1397.
Crossref
Suna Zhou, Xuefeng Sun, Zhicheng Jin, Haihua Yang & Wenguang Ye. (2022) The role of autophagy in initiation, progression, TME modification, diagnosis, and treatment of esophageal cancers. Critical Reviews in Oncology/Hematology 175, pages 103702.
Crossref
Juliana B. Vilar, Markus Christmann & Maja T. Tomicic. (2022) Alterations in Molecular Profiles Affecting Glioblastoma Resistance to Radiochemotherapy: Where Does the Good Go?. Cancers 14:10, pages 2416.
Crossref
Huifang Wang, Haoyu Bai, Jiafeng Wang, Xuefei Zhou, Hongda Chen, Liying Wang, Huiming Ren, Zimo Liu, Wei Zhuo, Zhuxian Zhou, Jianbin Tang, Zhijie Li, Jigang Wang, Youqing Shen, Tianhua Zhou & Xiangrui Liu. (2022) Nanoprodrug ratiometrically integrating autophagy inhibitor and genotoxic agent for treatment of triple-negative breast cancer. Biomaterials 283, pages 121458.
Crossref
Hui Liu, Weimin Qiu, Tianyu Sun, Lei Wang, Chenxi Du, Yanyu Hu, Wenyuan Liu, Feng Feng, Yao Chen & Haopeng Sun. (2022) Therapeutic strategies of glioblastoma (GBM): The current advances in the molecular targets and bioactive small molecule compounds. Acta Pharmaceutica Sinica B 12:4, pages 1781-1804.
Crossref
Cho-Hsun Hsieh, Yi-Wei Huang & Tsen-Fang Tsai. (2022) Oral Conventional Synthetic Disease-Modifying Antirheumatic Drugs with Antineoplastic Potential: a Review. Dermatology and Therapy 12:4, pages 835-860.
Crossref
Reui‐Liang Yan & Ruey‐Hwa Chen. (2021) Autophagy and cancer metabolism—The two‐way interplay. IUBMB Life 74:4, pages 281-295.
Crossref
Samiha Mohsen, Philip T. Sobash, Ghada Fahad Algwaiz, Noor Nasef, Safaa Abed Al-Zeidaneen & Nagla Abdel Karim. (2022) Autophagy Agents in Clinical Trials for Cancer Therapy: A Brief Review. Current Oncology 29:3, pages 1695-1708.
Crossref
Giulia Petroni, Lewis C. Cantley, Laura Santambrogio, Silvia C. Formenti & Lorenzo Galluzzi. (2021) Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer. Nature Reviews Clinical Oncology 19:2, pages 114-131.
Crossref
Ligeri Papaioannou & Konstantinos Avgoustakis. (2022) Responsive nanomedicines enhanced by or enhancing physical modalities to treat solid cancer tumors: Preclinical and clinical evidence of safety and efficacy. Advanced Drug Delivery Reviews 181, pages 114075.
Crossref
Qiang Dong, Degui Wang, Lanlan Li, Jie Wang, Qiao Li, Lei Duan, Hang Yin, Xiaoqing Wang, Yang Liu, Guoqiang Yuan & Yawen Pan. (2022) Biochanin A Sensitizes Glioblastoma to Temozolomide by Inhibiting Autophagy. Molecular Neurobiology 59:2, pages 1262-1272.
Crossref
XIAOXU LI, YUN WANG, JUAN FANG, ZHI WANG, XIAOAN TAO, JUAN XIA & BIN CHENG. (2022) KRT4 suppresses oral squamous cell carcinoma development by reducing ATG4B-mediated autophagy. BIOCELL 46:2, pages 441-451.
Crossref
Z. C. Shao, B. H. Zhu, A. F. Huang, M. Q. Su, L. J. An, Z. P. Wu, Y. J. Jiang, H. Guo, X.-Q. Han & Chi-Ming Liu. (2022) Docosahexaenoic Acid Reverses Epithelial-Mesenchymal Transition and Drug Resistance by Impairing the PI3K/AKT/Nrf2/GPX4 Signalling Pathway in Docetaxel-Resistant PC3 Prostate Cancer Cells. Folia Biologica 68:2, pages 59-71.
Crossref
Qi Xu, Hao Zhang, Hanghang Liu, Yaobao Han, Weibao Qiu & Zhen Li. (2022) Inhibiting autophagy flux and DNA repair of tumor cells to boost radiotherapy of orthotopic glioblastoma. Biomaterials 280, pages 121287.
Crossref
Safwan Alomari, Irma Zhang, Adrian Hernandez, Caitlin Y. Kraft, Divyaansh Raj, Jayanidhi Kedda & Betty Tyler. (2021) Drug Repurposing for Glioblastoma and Current Advances in Drug Delivery—A Comprehensive Review of the Literature. Biomolecules 11:12, pages 1870.
Crossref
Kristen M. Van Eaton & Daniel L. Gustafson. (2021) Pharmacokinetic and Pharmacodynamic Assessment of Hydroxychloroquine in Breast Cancer. Journal of Pharmacology and Experimental Therapeutics 379:3, pages 331-342.
Crossref
Aileen R. Ariosa, Vikramjit Lahiri, Yuchen Lei, Ying Yang, Zhangyuan Yin, Zhihai Zhang & Daniel J. Klionsky. (2021) A perspective on the role of autophagy in cancer. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867:12, pages 166262.
Crossref
Amanda J. Manea & Swapan K. Ray. (2021) Regulation of autophagy as a therapeutic option in glioblastoma. Apoptosis 26:11-12, pages 574-599.
Crossref
Evangelos Koustas, Eleni-Myrto Trifylli, Panagiotis Sarantis, Nikolaos I. Kontolatis, Christos Damaskos, Nikolaos Garmpis, Christos Vallilas, Anna Garmpi, Athanasios G. Papavassiliou & Michalis V. Karamouzis. (2021) The Implication of Autophagy in Gastric Cancer Progression. Life 11:12, pages 1304.
Crossref
Farnaz Sedigheh Takhsha, Christel Vangestel, Muhammet Tanc, Sven De Bruycker, Maya Berg, Isabel Pintelon, Sigrid Stroobants, Guido R. Y. De Meyer, Pieter Van Der Veken & Wim Martinet. (2021) ATG4B Inhibitor UAMC-2526 Potentiates the Chemotherapeutic Effect of Gemcitabine in a Panc02 Mouse Model of Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology 11.
Crossref
Simone Patergnani, Sonia Missiroli, Giampaolo Morciano, Mariasole Perrone, Cristina M. Mantovani, Gabriele Anania, Francesco Fiorica, Paolo Pinton & Carlotta Giorgi. (2021) Understanding the Role of Autophagy in Cancer Formation and Progression Is a Real Opportunity to Treat and Cure Human Cancers. Cancers 13:22, pages 5622.
Crossref
Ingo Ganzleben, Markus F. Neurath & Christoph Becker. (2021) Autophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances. Cancers 13:21, pages 5575.
Crossref
Mengdie Cao, Xiangyuan Luo, Kongming Wu & Xingxing He. (2021) Targeting lysosomes in human disease: from basic research to clinical applications. Signal Transduction and Targeted Therapy 6:1.
Crossref
Evangelos Koustas, Eleni-Myrto Trifylli, Panagiotis Sarantis, Athanasios G Papavassiliou & Michalis V Karamouzis. (2021) Role of autophagy in cholangiocarcinoma: An autophagy-based treatment strategy. World Journal of Gastrointestinal Oncology 13:10, pages 1229-1243.
Crossref
Pei-Ru Jin, Yen-Nhi Ngoc Ta, I-Ting Chen, Yan-Ning Yu, Hsin Tzu Hsieh, Van-Anh Thi Nguyen, Shang-Ying Hsieh, Tiffaney Hsia, Hao Liu, Chan-Wei Hsu, Jeng-Liang Han & Yunching Chen. (2021) Cinchona Alkaloid-Inspired Urea-Containing Autophagy Inhibitor Shows Single-Agent Anticancer Efficacy. Journal of Medicinal Chemistry 64:19, pages 14513-14525.
Crossref
Yuxiang Fan, Yubo Wang, Jian Zhang, Xuechao Dong, Pu Gao, Kai Liu, Chengyuan Ma & Gang Zhao. (2021) Breaking Bad: Autophagy Tweaks the Interplay Between Glioma and the Tumor Immune Microenvironment. Frontiers in Immunology 12.
Crossref
José A. Campos-Sandoval, María C. Gómez-García, Juan de los Santos-Jiménez, José M. Matés, Francisco J. Alonso & Javier Márquez. (2021) Antioxidant responses related to temozolomide resistance in glioblastoma. Neurochemistry International 149, pages 105136.
Crossref
Paulo Michel Pinheiro Ferreira, José Roberto de Oliveira Ferreira, Rayran Walter Ramos de Sousa, Daniel Pereira Bezerra & Gardenia Carmen Gadelha Militão. (2021) Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features. Journal of Oncology 2021, pages 1-18.
Crossref
Xiaoran Zhang, Christopher P. Deibert, Wi-Jin Kim, Emade Jaman, Aparna V. Rao, Michael T. Lotze & Nduka M. Amankulor. (2020) Autophagy inhibition is the next step in the treatment of glioblastoma patients following the Stupp era. Cancer Gene Therapy 28:9, pages 971-983.
Crossref
Sara G. Pelaz, Claudia Ollauri-Ibáñez, Concepción Lillo & Arantxa Tabernero. (2021) Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43266-283 in Glioblastoma Stem Cells. Cancers 13:17, pages 4262.
Crossref
Amin Mahoutforoush, Atefeh Solouk, Hamed Hamishehkar, Masoumeh Haghbin Nazarpak & Soheil Abbaspour-Ravasjani. (2021) Novel decorated nanostructured lipid carrier for simultaneous active targeting of three anti-cancer agents. Life Sciences 279, pages 119576.
Crossref
Sahib Zada, Jin Seok Hwang, Mahmoud Ahmed, Trang Huyen Lai, Trang Minh Pham, Omar Elashkar & Deok Ryong Kim. (2021) Cross talk between autophagy and oncogenic signaling pathways and implications for cancer therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1876:1, pages 188565.
Crossref
Hailun Wu, Weibin Li, Tingting Wang, Yan Rong, Ziying He, Siting Huang, Lifan Zhang, Zuoxing Wu & Chanzhen Liu. (2021) α-Tomatine, a novel early-stage autophagy inhibitor, inhibits autophagy to enhance apoptosis via Beclin-1 in Skov3 cells. Fitoterapia 152, pages 104911.
Crossref
Elisa Helena Farias Jandrey, Marcelle Bezerra, Lilian Tiemi Inoue, Frank B. Furnari, Anamaria Aranha Camargo & Érico Tosoni Costa. (2021) A Key Pathway to Cancer Resilience: The Role of Autophagy in Glioblastomas. Frontiers in Oncology 11.
Crossref
Paulo Michel Pinheiro Ferreira, Rayran Walter Ramos de Sousa, José Roberto de Oliveira Ferreira, Gardenia Carmen Gadelha Militão & Daniel Pereira Bezerra. (2021) Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms. Pharmacological Research 168, pages 105582.
Crossref
Ziqi Zhang, Pengfei Yue, Tianqi Lu, Yang Wang, Yuquan Wei & Xiawei Wei. (2021) Role of lysosomes in physiological activities, diseases, and therapy. Journal of Hematology & Oncology 14:1.
Crossref
Houjun Xia, Douglas R. Green & Weiping Zou. (2021) Autophagy in tumour immunity and therapy. Nature Reviews Cancer 21:5, pages 281-297.
Crossref
Fei Wang, Aftab Ullah, Xuelian Fan, Zhou Xu, Rongling Zong, Xuewen Wang & Gang Chen. (2021) Delivery of nanoparticle antigens to antigen-presenting cells: from extracellular specific targeting to intracellular responsive presentation. Journal of Controlled Release 333, pages 107-128.
Crossref
Balawant Kumar, Rizwan Ahmad, Swagat Sharma, Saiprasad Gowrikumar, Mark Primeaux, Sandeep Rana, Amarnath Natarajan, David Oupicky, Corey R. Hopkins, Punita Dhawan & Amar B. Singh. (2021) PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells. Cancers 13:9, pages 2168.
Crossref
Kaitlyn M. Dykstra, Hannah R. S. Fay, Ashish C. Massey, Neng Yang, Matthew Johnson, Scott Portwood, Monica L. Guzman & Eunice S. Wang. (2021) Inhibiting autophagy targets human leukemic stem cells and hypoxic AML blasts by disrupting mitochondrial homeostasis. Blood Advances 5:8, pages 2087-2100.
Crossref
Elisabete Cruz Da Silva, Marie-Cécile Mercier, Nelly Etienne-Selloum, Monique Dontenwill & Laurence Choulier. (2021) A Systematic Review of Glioblastoma-Targeted Therapies in Phases II, III, IV Clinical Trials. Cancers 13:8, pages 1795.
Crossref
Zhenzhan Zhang, Jianguang Ji & Hao Liu. (2021) Drug Repurposing in Oncology: Current Evidence and Future Direction. Current Medicinal Chemistry 28:11, pages 2175-2194.
Crossref
Anna Chmurska, Karolina Matczak & Agnieszka Marczak. (2021) Two Faces of Autophagy in the Struggle against Cancer. International Journal of Molecular Sciences 22:6, pages 2981.
Crossref
Xin Chien Lee, Evelyn Werner & Marco Falasca. (2021) Molecular Mechanism of Autophagy and Its Regulation by Cannabinoids in Cancer. Cancers 13:6, pages 1211.
Crossref
Nienke Visser, Harm Jan Lourens, Gerwin Huls, Edwin Bremer & Valerie R. Wiersma. (2021) Inhibition of Autophagy Does Not Re-Sensitize Acute Myeloid Leukemia Cells Resistant to Cytarabine. International Journal of Molecular Sciences 22:5, pages 2337.
Crossref
Evangelos Koustas, Panagiotis Sarantis, Michalis V. Karamouzis, Philippe Vielh & Stamatios Theocharis. (2021) The Controversial Role of Autophagy in Ewing Sarcoma Pathogenesis—Current Treatment Options. Biomolecules 11:3, pages 355.
Crossref
Shalini Sundramurthi Chelliah, Ervin Ashley Lourdes Paul, Muhamad Noor Alfarizal Kamarudin & Ishwar Parhar. (2021) Challenges and Perspectives of Standard Therapy and Drug Development in High-Grade Gliomas. Molecules 26:4, pages 1169.
Crossref
Imran Khan, Mohammad Hassan Baig, Sadaf Mahfooz, Moniba Rahim, Busra Karacam, Elif Burce Elbasan, Ilya Ulasov, Jae-June Dong & Mustafa Aziz Hatiboglu. (2021) Deciphering the Role of Autophagy in Treatment of Resistance Mechanisms in Glioblastoma. International Journal of Molecular Sciences 22:3, pages 1318.
Crossref
Jaione Auzmendi-Iriarte & Ander Matheu. (2021) Impact of Chaperone-Mediated Autophagy in Brain Aging: Neurodegenerative Diseases and Glioblastoma. Frontiers in Aging Neuroscience 12.
Crossref
PA Shantanu, NP Syamprasad, Bishal Rajdev, Basveshwar Gawali, AvdheshKumar Rai, Tashnin Rahman & VG M. Naidu. (2021) Delineating the role of autophagy in driving the resistance to cancer chemotherapy. Annals of Oncology Research and Therapy 1:2, pages 78.
Crossref
Xiang-ling Chen, Peng Liu, Wei-liang Zhu & Li-guang Lou. (2020) DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer. Acta Pharmacologica Sinica 42:1, pages 132-141.
Crossref
Jofer Andree Zamame Ramirez, Graziela Gorete Romagnoli & Ramon Kaneno. (2021) Inhibiting autophagy to prevent drug resistance and improve anti-tumor therapy. Life Sciences 265, pages 118745.
Crossref
Waleska Kerllen Martins, Maryana do Nascimento da Silva, Kiran Pandey, Ikuko Maejima, Ercília Ramalho, Vania Claudia Olivon, Susana Nogueira Diniz & Daniel Grasso. (2021) Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions. Current Research in Pharmacology and Drug Discovery 2, pages 100033.
Crossref
Nipa H. Patel, Sarah Bloukh, Enas Alwohosh, Ahmad Alhesa, Tareq Saleh & David A. Gewirtz. 2021. Autophagy and Senescence in Cancer Therapy. Autophagy and Senescence in Cancer Therapy 1 74 .
Marina Gergues, Vibha Harindra Savanur, David Prado, Adam Eljarrah, James K. Liu, Mohammed Jaloudi & Pranela Rameshwar. 2021. Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies. Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies 507 545 .
Vadivel Siva, Chunchana Kuppe Renuka Prasad Ravikumar, Ponnusamy Thillai Arasu, Nagendra Nath Yadav, Arumugam Murugan, Hardeo Singh Yadav, Sultan Asath Bahadur & Saminathan Balamurali. 2021. Cancer Nanotheranostics. Cancer Nanotheranostics 53 91 .
Yang Yang, Qi Wang, Dongjian Song, Ruirui Zen, Lei Zhang, Yingjun Wang, Heying Yang, Da Zhang, Jia Jia, Jiao Zhang & Jiaxiang Wang. (2020) Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway. Journal of Experimental & Clinical Cancer Research 39:1.
Crossref
Meng Luo, Jin-Fan Li, Qi Yang, Kun Zhang, Zhan-Wei Wang, Shu Zheng & Jiao-Jiao Zhou. (2020) Stem cell quiescence and its clinical relevance. World Journal of Stem Cells 12:11, pages 1307-1326.
Crossref
Jingwen Xu, Nipa H. Patel & David A. Gewirtz. (2020) Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance. International Journal of Molecular Sciences 21:23, pages 8991.
Crossref
Valdenizia R. Silva, Sara P. Neves, Luciano de S. Santos, Rosane B. Dias & Daniel P. Bezerra. (2020) Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy. Cancers 12:11, pages 3461.
Crossref
Bárbara Paranhos Coelho, Camila Felix de Lima Fernandes, Jacqueline Marcia Boccacino, Maria Clara da Silva Souza, Maria Isabel Melo-Escobar, Rodrigo Nunes Alves, Mariana Brandão Prado, Rebeca Piatniczka Iglesia, Giovanni Cangiano, Giulia La Rocca Mazzaro & Marilene Hohmuth Lopes. (2020) Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma. Frontiers in Oncology 10.
Crossref
Emily Crowley, Euphemia Leung, Jóhannes Reynisson & Alan Richardson. (2020) Rapid changes in the ATG5‐ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT). The FEBS Journal 287:22, pages 4917-4932.
Crossref
Mohd Ishaq, Rani Ojha, Aditya P. Sharma & Shrawan K. Singh. (2020) Autophagy in cancer: Recent advances and future directions. Seminars in Cancer Biology 66, pages 171-181.
Crossref
Maeve Long & Thomas G. McWilliams. (2020) Monitoring autophagy in cancer: From bench to bedside. Seminars in Cancer Biology 66, pages 12-21.
Crossref
Christopher Farrell, Wenyin Shi, Alexa Bodman & Jeffrey J. Olson. (2020) Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of emerging developments in the management of newly diagnosed glioblastoma. Journal of Neuro-Oncology 150:2, pages 269-359.
Crossref
Jose G. Alvarez-Meythaler, Yoelsis Garcia-Mayea, Cristina Mir, Hiroshi Kondoh & Matilde E. LLeonart. (2020) Autophagy Takes Center Stage as a Possible Cancer Hallmark. Frontiers in Oncology 10.
Crossref
Gricelis P. Martinez, Mercedes E. Zabaleta, Camilo Di Giulio, Jaime E. Charris & Michael R. Mijares. (2020) The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases. Current Pharmaceutical Design 26:35, pages 4467-4485.
Crossref
Huilin Zhang & Bingjian Lu. (2020) The Roles of ceRNAs-Mediated Autophagy in Cancer Chemoresistance and Metastasis. Cancers 12:10, pages 2926.
Crossref
Lisa Derosa, Cléa Melenotte, Franck Griscelli, Bertrand Gachot, Aurélien Marabelle, Guido Kroemer & Laurence Zitvogel. (2020) The immuno-oncological challenge of COVID-19. Nature Cancer 1:10, pages 946-964.
Crossref
Md. Abdul Alim Al‐Bari. (2020) Co‐targeting of lysosome and mitophagy in cancer stem cells with chloroquine analogues and antibiotics. Journal of Cellular and Molecular Medicine 24:20, pages 11667-11679.
Crossref
Shuhui Cheng, Eleanor J. Cheadle & Timothy M. Illidge. (2020) Understanding the Effects of Radiotherapy on the Tumour Immune Microenvironment to Identify Potential Prognostic and Predictive Biomarkers of Radiotherapy Response. Cancers 12:10, pages 2835.
Crossref
Yang Song & Elise Fields. (2020) Pharmacological Advances of Chloroquine and Hydroxychloroquine: From Antimalarials to Investigative Therapies in COVID-19. Natural Product Communications 15:9, pages 1934578X2095364.
Crossref
Joanne E. Simpson & Noor Gammoh. (2020) The impact of autophagy during the development and survival of glioblastoma. Open Biology 10:9.
Crossref
Jingjing Fan, Ziyuan Feng & Ning Chen. (2020) Spermidine as a target for cancer therapy. Pharmacological Research 159, pages 104943.
Crossref
Yan Li, Mi Hyeon Cho, Seon Sook Lee, Dong-Eun Lee, Heesun Cheong & Yongdoo Choi. (2020) Hydroxychloroquine-loaded hollow mesoporous silica nanoparticles for enhanced autophagy inhibition and radiation therapy. Journal of Controlled Release 325, pages 100-110.
Crossref
Lydie M.O. Barbeau, Tom G.H. Keulers & Kasper M.A. Rouschop. (2020) Tumors Responsive to Autophagy-Inhibition: Identification and Biomarkers. Cancers 12:9, pages 2463.
Crossref
Laurel Chandler, Imran Yusuf, Michelle McClements, Alun Barnard, Robert MacLaren & Kanmin Xue. (2020) Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy. International Journal of Molecular Sciences 21:14, pages 4972.
Crossref
Susanna Ambrosio & Barbara Majello. (2020) Autophagy Roles in Genome Maintenance. Cancers 12:7, pages 1793.
Crossref
Congting Guo & Ying Zhao. (2020) Autophagy and DNA damage repair. Genome Instability & Disease 1:4, pages 172-183.
Crossref
Nipa H. Patel, Sahib S. Sohal, Masoud H Manjili, J. Chuck Harrell & David A. Gewirtz. (2020) The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation. Radiation Research 194:2, pages 103.
Crossref
Jan Hraběta, Marie Belhajová, Hana Šubrtová, Miguel Angel Merlos Rodrigo, Zbyněk Heger & Tomáš Eckschlager. (2020) Drug Sequestration in Lysosomes as One of the Mechanisms of Chemoresistance of Cancer Cells and the Possibilities of Its Inhibition. International Journal of Molecular Sciences 21:12, pages 4392.
Crossref
Thomas G. Biel, Baikuntha Aryal, Michael H. Gerber, Josè G. Trevino, Naoko Mizuno & V. Ashutosh Rao. (2020) Mitochondrial dysfunction generates aggregates that resist lysosomal degradation in human breast cancer cells. Cell Death & Disease 11:6.
Crossref
Stephane Picot, Aileen Marty, Anne-Lise Bienvenu, Lucille H. Blumberg, Jean Dupouy-Camet, Pierre Carnevale, Shigeyuki Kano, Malcolm K. Jones, Cláudio Tadeu Daniel-Ribeiro & Santiago Mas-Coma. (2020) Coalition: Advocacy for prospective clinical trials to test the post-exposure potential of hydroxychloroquine against COVID-19. One Health 9, pages 100131.
Crossref
Wang Zheng, Qianping Chen, Chen Wang, Dan Yao, Lin Zhu, Yan Pan, Jianghong Zhang, Yang Bai & Chunlin Shao. (2020) Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy. Molecular Carcinogenesis 59:6, pages 651-660.
Crossref
Maria Condello, Giovanna Mancini & Stefania Meschini. (2020) The Exploitation of Liposomes in the Inhibition of Autophagy to Defeat Drug Resistance. Frontiers in Pharmacology 11.
Crossref
Tuhina Khan, Nicola Relitti, Margherita Brindisi, Stefania Magnano, Daniela Zisterer, Sandra Gemma, Stefania Butini & Giuseppe Campiani. (2019) Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas. Medicinal Research Reviews 40:3, pages 1002-1060.
Crossref
Maria Krchniakova, Jan Skoda, Jakub Neradil, Petr Chlapek & Renata Veselska. (2020) Repurposing Tyrosine Kinase Inhibitors to Overcome Multidrug Resistance in Cancer: A Focus on Transporters and Lysosomal Sequestration. International Journal of Molecular Sciences 21:9, pages 3157.
Crossref
Ferda Kaleağasıoğlu, Doaa M. Ali & Martin R. Berger. (2020) Multiple Facets of Autophagy and the Emerging Role of Alkylphosphocholines as Autophagy Modulators. Frontiers in Pharmacology 11.
Crossref
Ting Liu, Jing Zhang, Kangdi Li, Lingnan Deng & Hongxiang Wang. (2020) Combination of an Autophagy Inducer and an Autophagy Inhibitor: A Smarter Strategy Emerging in Cancer Therapy. Frontiers in Pharmacology 11.
Crossref
Nestor Ishimwe, Wenbin Zhang, Jieying Qian, Yunjiao Zhang & Longping Wen. (2020) Autophagy regulation as a promising approach for improving cancer immunotherapy. Cancer Letters 475, pages 34-42.
Crossref
Ling Ma, Zhangding Wang, Mengyan Xie, Yunlin Quan, Weiyou Zhu, Fengming Yang, Chenhui Zhao, Yu Fan, Na Fang, Huning Jiang, Qiang Wang, Shouyu Wang, Jianwei Zhou, Xiaofeng Chen & Yongqian Shu. (2020) Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7. Cell Death & Disease 11:3.
Crossref
Lokman Varisli, Osman Cen & Spiros Vlahopoulos. (2019) Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways. Immunology 159:3, pages 257-278.
Crossref
Eva Schrezenmeier & Thomas Dörner. (2020) Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nature Reviews Rheumatology 16:3, pages 155-166.
Crossref
Jean M. Mulcahy Levy & Andrew Thorburn. (2019) Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients. Cell Death & Differentiation 27:3, pages 843-857.
Crossref
Riccardo Vanzo, Jirina Bartkova, Joanna Maria Merchut-Maya, Arnaldur Hall, Jan Bouchal, Lars Dyrskjøt, Lisa B. Frankel, Vassilis Gorgoulis, Apolinar Maya-Mendoza, Marja Jäättelä & Jiri Bartek. (2019) Autophagy role(s) in response to oncogenes and DNA replication stress. Cell Death & Differentiation 27:3, pages 1134-1153.
Crossref
Ilya Ulasov, Jawad Fares, Petr Timashev & Maciej S. Lesniak. (2020) Editing Cytoprotective Autophagy in Glioma: An Unfulfilled Potential for Therapy. Trends in Molecular Medicine 26:3, pages 252-262.
Crossref
Ana Laura Vieira Alves, Angela Margarida Costa, Olga Martinho, Vinicius Duval da Silva, Peter Jordan, Viviane Aline Oliveira Silva & Rui Manuel Reis. (2020) WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line. Cells 9:2, pages 485.
Crossref
Young Hyun Cho, Seung-Hwan Lee, Sook-Jeong Lee, Ha Na Kim & Jae-Young Koh. (2020) A role of metallothionein-3 in radiation-induced autophagy in glioma cells. Scientific Reports 10:1.
Crossref
Wei Zhou, Yulian Guo, Xin Zhang & Zheng Jiang. (2019) Lys05 induces lysosomal membrane permeabilization and increases radiosensitivity in glioblastoma. Journal of Cellular Biochemistry 121:2, pages 2027-2037.
Crossref
Lucy Brazil, Angela L Swampillai, Ka Man Mak, Darren Edwards, Pavlina Mesiri, Laura Clifton-Hadley, Richard Shaffer, Joanne Lewis, Colin Watts, Sarah Jeffries, Pinelopi Gkogkou, Anthony J Chalmers, Naomi L Fersht, Allan Hackshaw & Susan C Short. (2020) Hydroxychloroquine and short-course radiotherapy in elderly patients with newly diagnosed high-grade glioma: a randomized phase II trial. Neuro-Oncology Advances 2:1.
Crossref
Kelie Chen, Dexin Yang, Fan Zhao, Shengchao Wang, Yao Ye, Wenjie Sun, Haohua Lu, Zhi Ruan, Jinming Xu, Tianru Wang, Guang Lu, Liming Wang, Yu Shi, Honghe Zhang, Han Wu, Weiguo Lu, Han-Ming Shen, Dajing Xia & Yihua Wu. (2020) Autophagy and Tumor Database: ATdb, a novel database connecting autophagy and tumor. Database 2020.
Crossref
Yuhao Wang & Benjamin Bonavida. 2020. Prognostic and Therapeutic Applications of RKIP in Cancer. Prognostic and Therapeutic Applications of RKIP in Cancer 47 75 .
Benjamin Bonavida. 2020. Autophagy in Immune Response: Impact on Cancer Immunotherapy. Autophagy in Immune Response: Impact on Cancer Immunotherapy 9 27 .
Niharika Sinha. 2020. Autophagy in tumor and tumor microenvironment. Autophagy in tumor and tumor microenvironment 203 222 .
Grace Nehme & Nancy Gordon. 2020. Current Advances in the Science of Osteosarcoma. Current Advances in the Science of Osteosarcoma 167 175 .
Mei Lan Tan, Heng Kean Tan & Tengku Sifzizul Tengku Muhammad. 2020. Cancer Immunology. Cancer Immunology 355 402 .
Maria L. Molina, David García-Bernal, Salvador Martinez & Rut Valdor. (2019) Autophagy in the Immunosuppressive Perivascular Microenvironment of Glioblastoma. Cancers 12:1, pages 102.
Crossref
Zhi-peng Wen, Wen-jing Zeng, Yan-hong Chen, He Li, Jie-ya Wang, Quan Cheng, Jing Yu, Hong-hao Zhou, Zheng-zheng Liu, Jian Xiao & Xiao-ping Chen. (2019) Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux. Journal of Experimental & Clinical Cancer Research 38:1.
Crossref
Nan Zhou, Zi Xuan Wei & Zeng Xin Qi. (2019) Inhibition of autophagy triggers melatonin-induced apoptosis in glioblastoma cells. BMC Neuroscience 20:1.
Crossref

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