3,371
Views
287
CrossRef citations to date
0
Altmetric
Clinical Research Paper

Combined autophagy and proteasome inhibition

A phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma

, , , , , , , , , , , , , , , & show all
Pages 1380-1390 | Received 21 Nov 2013, Accepted 16 May 2014, Published online: 20 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (32)

Lin Chen, Kunzi Zhang, Jian Sun, Jingtong Tang & Jianping Zhou. (2021) Development and Validation of an Autophagy-Stroma-Based Microenvironment Gene Signature for Risk Stratification in Colorectal Cancer. OncoTargets and Therapy 14, pages 3503-3515.
Read now
Eleni Karatza, George Ismailos, Markos Marangos & Vangelis Karalis. (2021) Optimization of hydroxychloroquine dosing scheme based on COVID-19 patients’ characteristics: a review of the literature and simulations. Xenobiotica 51:2, pages 127-138.
Read now
Weichao Li, Shaoping Yao, Hongrong Li, Zengdong Meng & Xianrun Sun. (2021) Curcumin promotes functional recovery and inhibits neuronal apoptosis after spinal cord injury through the modulation of autophagy. The Journal of Spinal Cord Medicine 44:1, pages 37-45.
Read now
Guangzhen Wu, Yingkun Xu, Huayu Zhang, Zihao Ruan, Peizhi Zhang, Zicheng Wang, Han Gao, Xiangyu Che, Qinghua Xia & Feng Chen. (2021) A new prognostic risk model based on autophagy-related genes in kidney renal clear cell carcinoma. Bioengineered 12:1, pages 7805-7819.
Read now
Xian-Bao Li, Nv-Wei Cao, Xiu-Jie Chu, Hao-Yue Zhou, Hua Wang, Si-Jie Yu, Dong-Qing Ye & Bao-Zhu Li. (2021) Antimalarials may reduce cancer risk in patients with systemic lupus erythematosus: a systematic review and meta-analysis of prospective studies. Annals of Medicine 53:1, pages 1688-1696.
Read now
Yu Dong, Yuanjia Hu, Sovan Sarkar, Wei-Xing Zong, Min Li, Du Feng, Ju-Xian Song, Min Li, Diego L. Medina, Jieqiong Tan, Zhuohua Zhang, Zhenyu Yue & Jia-Hong Lu. (2020) Autophagy modulator scoring system: a user-friendly tool for quantitative analysis of methodological integrity of chemical autophagy modulator studies. Autophagy 16:2, pages 195-202.
Read now
Christina G. Towers & Andrew Thorburn. (2019) Circumventing autophagy inhibition. Cell Cycle 18:24, pages 3421-3431.
Read now
Xiao Lu, Dong Zhou, Bing Hou, Quan-Xing Liu, Qian Chen, Xu-Feng Deng, Zu-Bin Yu, Ji-Gang Dai & Hong Zheng. (2018) Dichloroacetate enhances the antitumor efficacy of chemotherapeutic agents via inhibiting autophagy in non-small-cell lung cancer. Cancer Management and Research 10, pages 1231-1241.
Read now
Kautilya Kumar Jena, Srinivasa Prasad Kolapalli, Subhash Mehto, Swati Chauhan & Santosh Chauhan. (2018) TRIM16 controls turnover of protein aggregates by modulating NRF2, ubiquitin system, and autophagy: implication for tumorigenesis. Molecular & Cellular Oncology 5:6.
Read now
Shengfu Piao, Rani Ojha, Vito W. Rebecca, Arabinda Samanta, Xiao-hong Ma, Quentin Mcafee, Michael C. Nicastri, Meghan Buckley, Eric Brown, Jeffrey D. Winkler, Phyllis A. Gimotty & Ravi K. Amaravadi. (2017) ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells. Autophagy 13:12, pages 2056-2071.
Read now
Seung J. Chung, Ganji Purnachandra Nagaraju, Arumugam Nagalingam, Nethaji Muniraj, Panjamurthy Kuppusamy, Alyssa Walker, Juhyung Woo, Balázs Győrffy, Ed Gabrielson, Neeraj K. Saxena & Dipali Sharma. (2017) ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis. Autophagy 13:8, pages 1386-1403.
Read now
Yi-Feng Yu, Peng-Chao Hu, Ying Wang, Xiao-Long Xu, Gerard Martin Rushworth, Zun Zhang, Lei Wei & Jing-Wei Zhang. (2017) Paclitaxel induces autophagy in gastric cancer BGC823 cells. Ultrastructural Pathology 41:4, pages 284-290.
Read now
Xiaoyi Chen, Jason Clark, Mark Wunderlich, Cuiqing Fan, Ashley Davis, Song Chen, Jun-Lin Guan, James C. Mulloy, Ashish Kumar & Yi Zheng. (2017) Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy 13:5, pages 955-966.
Read now
Wolfgang Willenbacher, Shanmugapriya Thangavadivel, Richard Greil, Ella Willenbacher, Roman Weger, Claudia Manzl, Karin Jöhrer & Andrea Brunner. (2016) Low Beclin-1 expression predicts improved overall survival in patients treated with immunomodulatory drugs for multiple myeloma and identifies autophagy inhibition as a promising potentially druggable new therapeutic target: an analysis from The Austrian Myeloma Registry (AMR). Leukemia & Lymphoma 57:10, pages 2330-2341.
Read now
Subhadip Mukhopadhyay, Niharika Sinha, Durgesh Nandini Das, Prashanta Kumar Panda, Prajna Paramita Naik & Sujit Kumar Bhutia. (2016) Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects. Critical Reviews in Clinical Laboratory Sciences 53:4, pages 228-252.
Read now
Yang Wang, Kairong Shi, Li Zhang, Guanlian Hu, Jingyu Wan, Jiajing Tang, Sheng Yin, Jiandong Duan, Ming Qin, Neng Wang, Dandan Xie, Xinle Gao, Huile Gao, Zhirong Zhang & Qin He. (2016) Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin. Autophagy 12:6, pages 949-962.
Read now
Madhuri Chaurasia, Anant Narayan Bhatt, Asmita Das, Bilikere S. Dwarakanath & Kulbhushan Sharma. (2016) Radiation-induced autophagy: mechanisms and consequences. Free Radical Research 50:3, pages 273-290.
Read now
Yulia Haim, Matthias Blüher, Noa Slutsky, Nir Goldstein, Nora Klöting, Ilana Harman-Boehm, Boris Kirshtein, Doron Ginsberg, Martin Gericke, Esther Guiu Jurado, Julia Kovsan, Tanya Tarnovscki, Leonid Kachko, Nava Bashan, Yiftach Gepner, Iris Shai & Assaf Rudich. (2015) Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. Autophagy 11:11, pages 2074-2088.
Read now
Bulent Ozpolat & Doris M Benbrook. (2015) Targeting autophagy in cancer management – strategies and developments. Cancer Management and Research 7, pages 291-299.
Read now
Jing Zhou, Guobing Li, Yi Zheng, Han-Ming Shen, Xiaoye Hu, Qian-Liang Ming, Cheng Huang, Peng Li & Ning Gao. (2015) A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. Autophagy 11:8, pages 1259-1279.
Read now
Enrico Milan, Tommaso Perini, Massimo Resnati, Ugo Orfanelli, Laura Oliva, Andrea Raimondi, Paolo Cascio, Angela Bachi, Magda Marcatti, Fabio Ciceri & Simone Cenci. (2015) A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells. Autophagy 11:7, pages 1161-1178.
Read now
Yuan Zhang, Zhi Liao, Li-juan Zhang & Hong-tao Xiao. (2015) The utility of chloroquine in cancer therapy. Current Medical Research and Opinion 31:5, pages 1009-1013.
Read now
Liangkun You, Zhanggui Wang, Hongsen Li, Jiawei Shou, Zhao Jing, Jiansheng Xie, Xinbing Sui, Hongming Pan & Weidong Han. (2015) The role of STAT3 in autophagy. Autophagy 11:5, pages 729-739.
Read now
Xian Zeng, Hui Zhao, Yubin Li, Jiajun Fan, Yun Sun, Shaofei Wang, Ziyu Wang, Ping Song & Dianwen Ju. (2015) Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia. Autophagy 11:2, pages 355-372.
Read now
Adam A. Kraya, Shengfu Piao, Xiaowei Xu, Gao Zhang, Meenhard Herlyn, Phyllis Gimotty, Beth Levine, Ravi K Amaravadi & David W Speicher. (2015) Identification of secreted proteins that reflect autophagy dynamics within tumor cells. Autophagy 11:1, pages 60-74.
Read now
Andrew Poklepovic & David A Gewirtz. (2014) Outcome of early clinical trials of the combination of hydroxychloroquine with chemotherapy in cancer. Autophagy 10:8, pages 1478-1480.
Read now
Devalingam Mahalingam, Monica Mita, John Sarantopoulos, Leslie Wood, Ravi K Amaravadi, Lisa E Davis, Alain C Mita, Tyler J Curiel, Claudia M Espitia, Steffan T Nawrocki, Francis J Giles & Jennifer S Carew. (2014) Combined autophagy and HDAC inhibition. Autophagy 10:8, pages 1403-1414.
Read now
Rebecca A Barnard, Luke A Wittenburg, Ravi K Amaravadi, Daniel L Gustafson, Andrew Thorburn & Douglas H Thamm. (2014) Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma. Autophagy 10:8, pages 1415-1425.
Read now
Reshma Rangwala, Yunyoung C Chang, Janice Hu, Kenneth M Algazy, Tracey L Evans, Leslie A Fecher, Lynn M Schuchter, Drew A Torigian, Jeffrey T Panosian, Andrea B Troxel, Kay-See Tan, Daniel F Heitjan, Angela M DeMichele, David J Vaughn, Maryann Redlinger, Abass Alavi, Jonathon Kaiser, Laura Pontiggia, Lisa E Davis, Peter J O’Dwyer & Ravi K Amaravadi. (2014) Combined MTOR and autophagy inhibition. Autophagy 10:8, pages 1391-1402.
Read now
Reshma Rangwala, Robert Leone, Yunyoung C Chang, Leslie A Fecher, Lynn M Schuchter, Amy Kramer, Kay-See Tan, Daniel F Heitjan, Glenda Rodgers, Maryann Gallagher, Shengfu Piao, Andrea B Troxel, Tracey L Evans, Angela M DeMichele, Katherine L Nathanson, Peter J O’Dwyer, Jonathon Kaiser, Laura Pontiggia, Lisa E Davis & Ravi K Amaravadi. (2014) Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma. Autophagy 10:8, pages 1369-1379.
Read now
Myrna R Rosenfeld, Xiaobu Ye, Jeffrey G Supko, Serena Desideri, Stuart A Grossman, Steven Brem, Tom Mikkelson, Daniel Wang, Yunyoung C Chang, Janice Hu, Quentin McAfee, Joy Fisher, Andrea B Troxel, Shengfu Piao, Daniel F Heitjan, Kay-See Tan, Laura Pontiggia, Peter J O’Dwyer, Lisa E Davis & Ravi K Amaravadi. (2014) A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy 10:8, pages 1359-1368.
Read now

Articles from other publishers (255)

Daniel L. Gustafson, Lindsey O. Viola, Christina G. Towers, Sunetra Das, Dawn L. Duval & Kristen M. Van Eaton. (2023) Sensitivity of osteosarcoma cell lines to autophagy inhibition as determined by pharmacologic and genetic manipulation. Veterinary and Comparative Oncology 21:4, pages 726-738.
Crossref
Longxiyu Meng, Jie Gao, Wenjing Mo, Baojun Wang, Hongwei Shen, Wenmin Cao, Meng Ding, Wenli Diao, Wei Chen, Qing Zhang, Jiaxin Shu, Huiqi Dai & Hongqian Guo. (2023) MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma. Redox Biology 68, pages 102956.
Crossref
Liang Ee Low, Chee Kei Kong, Wei-Hsum Yap, Sangeetaprivya P. Siva, Siew Hua Gan, Wei Sheng Siew, Long Chiau Ming, Ashley Sean Lai-Foenander, Sui Kiat Chang, Wai-Leng Lee, Yongjiang Wu, Kooi-Yeong Khaw, Yong Sze Ong, Beng Ti Tey, Sachin Kumar Singh, Kamal Dua, Dinesh Kumar Chellappan & Bey-Hing Goh. (2023) Hydroxychloroquine: Key therapeutic advances and emerging nanotechnological landscape for cancer mitigation. Chemico-Biological Interactions 386, pages 110750.
Crossref
Meena Pangarkar, Uttara Wagh & Anand Pathak. (2023) Autophagy indicators in oral squamous cell carcinoma. Pathology.
Crossref
Fawzia I. Elshami, Hadeer A. Shereef, Ibrahim M. El-Mehasseb, Shaban Y. Shaban & Rudi van Eldik. (2023) Hydroxychloroquine-Loaded Chitosan Nanoparticles Induce Anticancer Activity in A549 Lung Cancer Cells: Design, BSA Binding, Molecular Docking, Mechanistic, and Biological Evaluation. International Journal of Molecular Sciences 24:18, pages 14103.
Crossref
Zhenyang Ren, Yue Song, Jinhuan Xian, Yuan Liao, Yujuan Zhan, Tingxiu Zhao, Huiqi Wang, Junbo Jiang, Mansi Xu, Yanjun Jiang, Xiaodong Liu, Xianli Wei, Kun Wang & Jianyong Xiao. (2023) Identification of Fangchinoline as a novel autophagy inhibitor with an adjuvant of chemotherapy against lung cancer. Toxicology and Applied Pharmacology, pages 116679.
Crossref
Bonell Patiño-Escobar, Alexis Talbot & Arun P. Wiita. (2023) Overcoming proteasome inhibitor resistance in the immunotherapy era. Trends in Pharmacological Sciences 44:8, pages 507-518.
Crossref
Eloïne Bestion, Eric Raymond, Soraya Mezouar & Philippe Halfon. (2023) Update on Autophagy Inhibitors in Cancer: Opening up to a Therapeutic Combination with Immune Checkpoint Inhibitors. Cells 12:13, pages 1702.
Crossref
Imran H. Yusuf, Peter Charbel Issa & Seong Joon Ahn. (2023) Unmet needs and future perspectives in hydroxychloroquine retinopathy. Frontiers in Medicine 10.
Crossref
Juan Bautista De Sanctis, Jaime Charris, Zuleyma Blanco, Hegira Ramírez, Gricelis Patricia Martínez & Michael Rodney Mijares. (2023) Molecular Mechanisms of Chloroquine and Hydroxychloroquine Used in Cancer Therapy. Anti-Cancer Agents in Medicinal Chemistry 23:10, pages 1122-1144.
Crossref
Amy P. Rossi, Simon Tremblay, Cyd M. Castro-Rojas, Ashley A. Burg, Krishna M. Roskin, Jenna M. Gehman, Adele Rike-Shields, Rita R. Alloway, Paul Brailey, David Allman, David A. Hildeman & E. Steve Woodle. (2023) Effects of in vivo CXCR4 blockade and proteasome inhibition on bone marrow plasma cells in HLA-sensitized kidney transplant candidates. American Journal of Transplantation 23:6, pages 759-775.
Crossref
Yasmeen Dodin. (2023) Integrated Bioinformatics Approach for Disclosing Autophagy Pathway as a Therapeutic Target in Advanced KRAS Mutated/Positive Lung Adenocarcinoma. The Open Bioinformatics Journal 16:1.
Crossref
Esther Clavero, José Manuel Sanchez-Maldonado, Angelica Macauda, Rob Ter Horst, Belém Sampaio-Marques, Artur Jurczyszyn, Alyssa Clay-Gilmour, Angelika Stein, Michelle A. T. Hildebrandt, Niels Weinhold, Gabriele Buda, Ramón García-Sanz, Waldemar Tomczak, Ulla Vogel, Andrés Jerez, Daria Zawirska, Marzena Wątek, Jonathan N. Hofmann, Stefano Landi, John J. Spinelli, Aleksandra Butrym, Abhishek Kumar, Joaquín Martínez-López, Sara Galimberti, María Eugenia Sarasquete, Edyta Subocz, Elzbieta Iskierka-Jażdżewska, Graham G. Giles, Malwina Rybicka-Ramos, Marcin Kruszewski, Niels Abildgaard, Francisco García Verdejo, Pedro Sánchez Rovira, Miguel Inacio da Silva Filho, Katalin Kadar, Małgorzata Razny, Wendy Cozen, Matteo Pelosini, Manuel Jurado, Parveen Bhatti, Marek Dudzinski, Agnieszka Druzd-Sitek, Enrico Orciuolo, Yang Li, Aaron D. Norman, Jan Maciej Zaucha, Rui Manuel Reis, Miroslaw Markiewicz, Juan José Rodríguez Sevilla, Vibeke Andersen, Krzysztof Jamroziak, Kari Hemminki, Sonja I. Berndt, Vicent Rajkumar, Grzegorz Mazur, Shaji K. Kumar, Paula Ludovico, Arnon Nagler, Stephen J. Chanock, Charles Dumontet, Mitchell J. Machiela, Judit Varkonyi, Nicola J. Camp, Elad Ziv, Annette Juul Vangsted, Elizabeth E. Brown, Daniele Campa, Celine M. Vachon, Mihai G. Netea, Federico Canzian, Asta Försti & Juan Sainz. (2023) Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization. International Journal of Molecular Sciences 24:10, pages 8500.
Crossref
Vaibhav Jain, Mahendra Pal Singh & Ravi K. Amaravadi. (2023) Recent advances in targeting autophagy in cancer. Trends in Pharmacological Sciences 44:5, pages 290-302.
Crossref
Hamed Bashiri & Hossein Tabatabaeian. (2023) Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma. International Journal of Molecular Sciences 24:7, pages 6019.
Crossref
Tania B. López-Méndez, Miguel Sánchez-Álvarez, Flavia Trionfetti, José L. Pedraz, Marco Tripodi, Marco Cordani, Raffaele Strippoli & Juan González-Valdivieso. (2023) Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective. Cell & Bioscience 13:1.
Crossref
Tiantian Yang, Yang Zhang, Junhang Chen & Longhao Sun. (2023) Crosstalk between autophagy and immune cell infiltration in the tumor microenvironment. Frontiers in Medicine 10.
Crossref
Vaibhav Jain, Sandra L. Harper, Amanda M. Versace, Dylan Fingerman, Gregory Schuyler Brown, Monika Bhardwaj, Mary Ann S. Crissey, Aaron R. Goldman, Gordon Ruthel, Qin Liu, Aleksandra Zivkovic, Holgar Stark, Meenhard Herlyn, Phyllis A. Gimotty, David W. Speicher & Ravi K. Amaravadi. (2023) Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition. Cancer Discovery 13:2, pages 454-473.
Crossref
Susan Kilgas & Kristijan Ramadan. (2023) Inhibitors of the ATPase p97/VCP: From basic research to clinical applications. Cell Chemical Biology 30:1, pages 3-21.
Crossref
Houfu Leng, Hanlin Zhang, Linsen Li, Shuhao Zhang, Yanping Wang, Selina J. Chavda, Daria Galas-Filipowicz, Hantao Lou, Adel Ersek, Emma V. Morris, Erdinc Sezgin, Yi-Hsuan Lee, Yunsen Li, Ana Victoria Lechuga-Vieco, Mei Tian, Jian-Qing Mi, Kwee Yong, Qing Zhong, Claire M. Edwards, Anna Katharina Simon & Nicole J. Horwood. (2022) Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease. Nature Communications 13:1.
Crossref
Rubayat Khan, Sudipta Panja, Ling Ding, Siyuan Tang, Weimin Tang, Ekta Kapoor, Robert G. Bennett & David Oupický. (2022) Polymeric Chloroquine as an Effective Antimigration Agent in the Treatment of Pancreatic Cancer. Molecular Pharmaceutics 19:12, pages 4631-4643.
Crossref
Sahib Zada, Jin Seok Hwang, Trang Huyen Lai, Trang Minh Pham, Mahmoud Ahmed, Omar Elashkar, Wanil Kim & Deok Ryong Kim. (2022) Autophagy-mediated degradation of NOTCH1 intracellular domain controls the epithelial to mesenchymal transition and cancer metastasis. Cell & Bioscience 12:1.
Crossref
Kristin Roseth Aass, Tonje Marie Vikene Nedal, Synne Stokke Tryggestad, Einar Haukås, Tobias S. Slørdahl, Anders Waage, Therese Standal & Robin Mjelle. (2022) Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma. Scientific Reports 12:1.
Crossref
Xiaoyan Zang, Jing Wang, Yuan Xia, Jianyong Li, Lijuan Chen, Yan Gu & Xuxing Shen. (2022) LncRNA MEG3 promotes the sensitivity of bortezomib by inhibiting autophagy in multiple myeloma. Leukemia Research 123, pages 106967.
Crossref
Britney Niemann, Amanda Puleo, Conley Stout, Justin Markel & Brian A. Boone. (2022) Biologic Functions of Hydroxychloroquine in Disease: From COVID-19 to Cancer. Pharmaceutics 14:12, pages 2551.
Crossref
Mehdi Sanati, Maryam Moradi Binabaj, Seyed Sajad Ahmadi, Samaneh Aminyavari, Hossein Javid, Hamid Mollazadeh, Bahram Bibak, Elmira Mohtashami, Tannaz Jamialahmadi, Amir R. Afshari & Amirhossein Sahebkar. (2022) Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulation. Biomedicine & Pharmacotherapy 155, pages 113740.
Crossref
Jeffrey Pradeep Raj, Nithya Jaideep Gogtay, Avaneesh Pandey, Ashish Kumar Kakkar, Nusrat Shafiq, Padmaja Mekala, Usharani Pingali, Arun Prasath Raju, Surulivelrajan Mallayasamy & Nilima Arun Kshirsagar. (2022) Population Pharmacokinetics of Hydroxychloroquine Sulfate in Healthcare Workers, Given for Prophylaxis Against Coronavirus Disease 2019 (COVID‐19) in India. The Journal of Clinical Pharmacology 62:11, pages 1403-1411.
Crossref
Guangqi Wang, Fengjuan Fan, Chunyan Sun & Yu Hu. (2022) Looking into Endoplasmic Reticulum Stress: The Key to Drug-Resistance of Multiple Myeloma?. Cancers 14:21, pages 5340.
Crossref
Mei Luo, Lin Ye, Ruimin Chang, Youqiong Ye, Zhao Zhang, Chunjie Liu, Shengli Li, Ying Jing, Hang Ruan, Guanxiong Zhang, Yi He, Yaoming Liu, Yu Xue, Xiang Chen, An-Yuan Guo, Hong Liu & Leng Han. (2022) Multi-omics characterization of autophagy-related molecular features for therapeutic targeting of autophagy. Nature Communications 13:1.
Crossref
Tingting Chen, Chenggong Zeng, Zhuoran Li, Juan Wang, Feifei Sun, Junting Huang, Suying Lu, Jia Zhu, Yizhuo Zhang, Xiaofei Sun & Zijun Zhen. (2022) Investigation of chemoresistance to first-line chemotherapy and its possible association with autophagy in high-risk neuroblastoma. Frontiers in Oncology 12.
Crossref
Amal Kamal Abdel-Aziz, Mona Kamal Saadeldin, Ahmed Hamed Salem, Safaa A. Ibrahim, Samia Shouman, Ashraf B. Abdel-Naim & Roberto Orecchia. (2022) A Critical Review of Chloroquine and Hydroxychloroquine as Potential Adjuvant Agents for Treating People with Cancer. Future Pharmacology 2:4, pages 431-443.
Crossref
Olga García Ruiz, José Manuel Sánchez-Maldonado, Miguel Ángel López-Nevot, Paloma García, Angelica Macauda, Francisca Hernández-Mohedo, Pedro Antonio González-Sierra, Manuel Martínez-Bueno, Eva Pérez, Fernando Jesús Reyes-Zurita, Daniele Campa, Federico Canzian, Manuel Jurado, Juan José Rodríguez-Sevilla & Juan Sainz. (2022) Autophagy in Hematological Malignancies. Cancers 14:20, pages 5072.
Crossref
Babak Jahangiri, Ali Kian Saei, Patience O. Obi, Narjes Asghari, Shahrokh Lorzadeh, Shirin Hekmatirad, Marveh Rahmati, Fatemeh Velayatipour, Mohammad Hosseni Asghari, Ayesha Saleem & Mohammad Amin Moosavi. (2022) Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1868:10, pages 166484.
Crossref
Antonio Giovanni Solimando, Eleonora Malerba, Patrizia Leone, Marcella Prete, Carolina Terragna, Michele Cavo & Vito Racanelli. (2022) Drug resistance in multiple myeloma: Soldiers and weapons in the bone marrow niche. Frontiers in Oncology 12.
Crossref
Pavel Spirin, Elena Shyrokova, Valeria Vedernikova, Timofey Lebedev & Vladimir Prassolov. (2022) Emetine in Combination with Chloroquine Induces Oncolytic Potential of HIV-1-Based Lentiviral Particles. Cells 11:18, pages 2829.
Crossref
Yujie Zhang, Yuanru Zhao, Yuanyuan Zhang, Qingguang Liu, Mingzhen Zhang & Kangsheng Tu. (2022) The crosstalk between sonodynamic therapy and autophagy in cancer. Frontiers in Pharmacology 13.
Crossref
Jingxiang Zhao, Zhiqiang Zhao, Wanting Hou, Yue Jiang, Guobin Liu, Xuelian Ren, Kun Liu, Hong Liu, Kaixian Chen & He Huang. (2022) Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine. Molecules 27:16, pages 5175.
Crossref
Xuan Wu, Le Wang, Yan‐Neng Xu, Jian‐Li Chen, Kathy Qian Luo, Ming‐Heng Yuan, Jie Li, Gang Yuan, Ze‐Yun Gu, Xiao‐Hui Jia, Xiuping Chen, Xiao‐Ming Zhu & Ruibin Jiang. (2022) Chemo‐Phototherapy with Carfilzomib‐Encapsulated TiN Nanoshells Suppressing Tumor Growth and Lymphatic Metastasis. Small 18:29.
Crossref
Jessica A. Mills, Feifei Liu, Thomas R. Jarrett, Nicholas L. Fletcher & Kristofer J. Thurecht. (2022) Nanoparticle based medicines: approaches for evading and manipulating the mononuclear phagocyte system and potential for clinical translation. Biomaterials Science 10:12, pages 3029-3053.
Crossref
Victória Tomaz, Karina Griesi-Oliveira, Renato D. Puga, Bruno J. Conti, Fabio P. S. Santos, Nelson Hamerschlak & Paulo V. Campregher. (2022) Molecular Characterization of a First-in-Human Clinical Response to Nimesulide in Acute Myeloid Leukemia. Frontiers in Oncology 12.
Crossref
Nagla Abdel Karim, Asad Ullah, Imran Ahmad, Elmustapha Bahassi, Olugbenga Olowokure, Ahmed Khaled, Harold Davis & John C. Morris. (2022) A Phase I Trial to Determine the Safety and Tolerability of Autophagy Inhibition Using Chloroquine or Hydroxychloroquine in Combination With Carboplatin and Gemcitabine in Patients With Advanced Solid Tumors. Frontiers in Oncology 12.
Crossref
Jiangyan Xu, Jinrong Zhang, Qi-Fen Mao, Jian Wu & Yuan Wang. (2022) The Interaction Between Autophagy and JAK/STAT3 Signaling Pathway in Tumors. Frontiers in Genetics 13.
Crossref
Giada Bianchi, Maria Moscvin & Raymond L. Comenzo. (2022) Laboratory-Based Rationale for Targeting the Protein Homeostasis Network in AL Amyloidosis. Hemato 3:2, pages 298-317.
Crossref
Cho-Hsun Hsieh, Yi-Wei Huang & Tsen-Fang Tsai. (2022) Oral Conventional Synthetic Disease-Modifying Antirheumatic Drugs with Antineoplastic Potential: a Review. Dermatology and Therapy 12:4, pages 835-860.
Crossref
Reui‐Liang Yan & Ruey‐Hwa Chen. (2021) Autophagy and cancer metabolism—The two‐way interplay. IUBMB Life 74:4, pages 281-295.
Crossref
Xi Huang, Wen Cao, Shunnan Yao, Jing Chen, Yang Liu, Jianwei Qu, Yi Li, Xiaoyan Han, Jingsong He, He Huang, Enfan Zhang & Zhen Cai. (2022) NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma. Cell Death & Disease 13:3.
Crossref
Hui Li, Mridul Roy, Long Liang, Wenjie Cao, Bin Hu, Yanan Li, Xiaojuan Xiao, Haiqin Wang, Mao Ye, Shuming Sun, Bin Zhang & Jing Liu. (2022) Deubiquitylase USP12 induces pro-survival autophagy and bortezomib resistance in multiple myeloma by stabilizing HMGB1. Oncogene 41:9, pages 1298-1308.
Crossref
Kim Klapan, Dagmar Simon, Alexander Karaulov, Marina Gomzikova, Albert Rizvanov, Shida Yousefi & Hans-Uwe Simon. (2022) Autophagy and Skin Diseases. Frontiers in Pharmacology 13.
Crossref
Ali Salimi-Jeda, Soad Ghabeshi, Zeinab Gol Mohammad pour, Ehsan Ollah Jazaeri, Mehrdad Araiinejad, Farzaneh Sheikholeslami, Mohsen Abdoli, Mahdi Edalat & Asghar Abdoli. (2022) Autophagy Modulation and Cancer Combination Therapy: A Smart Approach in Cancer Therapy. Cancer Treatment and Research Communications 30, pages 100512.
Crossref
Alok Shiomurti Tripathi, Manish Kumar Tripathi, Pushpendra Singh, Rahul Kumar Maurya, Prashant Shukla, Punit Kaur & Mohammad Yasir. 2022. Autophagy and Metabolism. Autophagy and Metabolism 109 118 .
Prashant Kumar, Yuvraj Anandrao Jagtap, Som Mohanlal Patwa, Sumit Kinger, Ankur Rakesh Dubey, Vijay Kumar Prajapati, Rohan Dhiman, Krishna Mohan Poluri & Amit Mishra. (2021) Autophagy based cellular physiological strategies target oncogenic progression. Journal of Cellular Physiology 237:1, pages 258-277.
Crossref
Elisabetta Iessi, Rosa Vona, Camilla Cittadini & Paola Matarrese. (2021) Targeting the Interplay between Cancer Metabolic Reprogramming and Cell Death Pathways as a Viable Therapeutic Path. Biomedicines 9:12, pages 1942.
Crossref
Yomna S. Abd El-Aziz, Lionel Y. W. Leck, Patric J. Jansson & Sumit Sahni. (2021) Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma. Cancers 13:24, pages 6152.
Crossref
Liqiang Zhou, Minfeng Huo, Xiaoqin Qian, Li Ding, Luodan Yu, Wei Feng, Xinwu Cui & Yu Chen. (2021) Autophagy blockade synergistically enhances nanosonosensitizer-enabled sonodynamic cancer nanotherapeutics. Journal of Nanobiotechnology 19:1.
Crossref
Simone Patergnani, Sonia Missiroli, Giampaolo Morciano, Mariasole Perrone, Cristina M. Mantovani, Gabriele Anania, Francesco Fiorica, Paolo Pinton & Carlotta Giorgi. (2021) Understanding the Role of Autophagy in Cancer Formation and Progression Is a Real Opportunity to Treat and Cure Human Cancers. Cancers 13:22, pages 5622.
Crossref
Yuchen Lei & Daniel J. Klionsky. (2021) The Emerging Roles of Autophagy in Human Diseases. Biomedicines 9:11, pages 1651.
Crossref
Ingo Ganzleben, Markus F. Neurath & Christoph Becker. (2021) Autophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances. Cancers 13:21, pages 5575.
Crossref
Paulo Michel Pinheiro Ferreira, José Roberto de Oliveira Ferreira, Rayran Walter Ramos de Sousa, Daniel Pereira Bezerra & Gardenia Carmen Gadelha Militão. (2021) Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features. Journal of Oncology 2021, pages 1-18.
Crossref
Alyssa Gabrielle Apilan & Carmel Mothersill. (2021) Targeted and Non-Targeted Mechanisms for Killing Hypoxic Tumour Cells—Are There New Avenues for Treatment?. International Journal of Molecular Sciences 22:16, pages 8651.
Crossref
Kazutoshi Toriyama, Naoharu Takano, Hiroko Kokuba, Hiromi Kazama, Shota Moriya, Masaki Hiramoto, Shinji Abe & Keisuke Miyazawa. (2021) Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells. Cancer Science 112:8, pages 3324-3337.
Crossref
Heyang Cui, Yongjia Weng, Ning Ding, Chen Cheng, Longlong Wang, Yong Zhou, Ling Zhang, Yongping Cui & Weimin Zhang. (2021) Autophagy-Related Three-Gene Prognostic Signature for Predicting Survival in Esophageal Squamous Cell Carcinoma. Frontiers in Oncology 11.
Crossref
Mona Foth & Martin McMahon. (2021) Autophagy Inhibition in BRAF-Driven Cancers. Cancers 13:14, pages 3498.
Crossref
Pollyanna Stephanie Gomes, Patrícia de Almeida Machado, Andre M.O. Gomes, Andrea C. Oliveira, Jerson L. Silva & Herbert Leonel de Matos Guedes. (2021) COVID-19 and the Challenges of Chemotherapy: The Failure Case of Hydroxychloroquine in the Clinical Treatment of SARS-CoV-2 Infection. Coronaviruses 2:7.
Crossref
Shuting Sun, Jianguo Tao, Parish P. Sedghizadeh, Philip Cherian, Adam F. Junka, Esmat Sodagar, Lianping Xing, Robert K. BoeckmanJrJr, Venkatesan Srinivasan, Zhenqiang Yao, Brendan F. Boyce, Brea Lipe, Jeffrey D. Neighbors, R. Graham G. Russell, Charles E. McKenna & Frank H. Ebetino. (2021) Bisphosphonates for delivering drugs to bone. British Journal of Pharmacology 178:9, pages 2008-2025.
Crossref
Houjun Xia, Douglas R. Green & Weiping Zou. (2021) Autophagy in tumour immunity and therapy. Nature Reviews Cancer 21:5, pages 281-297.
Crossref
Romina Cabrera-Rodríguez, Silvia Pérez-Yanes, Judith Estévez-Herrera, Daniel Márquez-Arce, Cecilia Cabrera, Lucile Espert, Julià Blanco & Agustín Valenzuela-Fernández. (2021) The Interplay of HIV and Autophagy in Early Infection. Frontiers in Microbiology 12.
Crossref
Kaitlyn M. Dykstra, Hannah R. S. Fay, Ashish C. Massey, Neng Yang, Matthew Johnson, Scott Portwood, Monica L. Guzman & Eunice S. Wang. (2021) Inhibiting autophagy targets human leukemic stem cells and hypoxic AML blasts by disrupting mitochondrial homeostasis. Blood Advances 5:8, pages 2087-2100.
Crossref
Sinan Xiong, Wee-Joo Chng & Jianbiao Zhou. (2021) Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma. Cellular and Molecular Life Sciences 78:8, pages 3883-3906.
Crossref
Tina Paradzik, Cecilia Bandini, Elisabetta Mereu, Maria Labrador, Elisa Taiana, Nicola Amodio, Antonino Neri & Roberto Piva. (2021) The Landscape of Signaling Pathways and Proteasome Inhibitors Combinations in Multiple Myeloma. Cancers 13:6, pages 1235.
Crossref
Nienke Visser, Harm Jan Lourens, Gerwin Huls, Edwin Bremer & Valerie R. Wiersma. (2021) Inhibition of Autophagy Does Not Re-Sensitize Acute Myeloid Leukemia Cells Resistant to Cytarabine. International Journal of Molecular Sciences 22:5, pages 2337.
Crossref
Timothy Marsh, Bhairavi Tolani & Jayanta Debnath. (2021) The pleiotropic functions of autophagy in metastasis. Journal of Cell Science 134:2.
Crossref
PA Shantanu, NP Syamprasad, Bishal Rajdev, Basveshwar Gawali, AvdheshKumar Rai, Tashnin Rahman & VG M. Naidu. (2021) Delineating the role of autophagy in driving the resistance to cancer chemotherapy. Annals of Oncology Research and Therapy 1:2, pages 78.
Crossref
晗 许. (2021) Autophagy in Hematological Malignancies. World Journal of Cancer Research 11:04, pages 126-130.
Crossref
Waleska Kerllen Martins, Maryana do Nascimento da Silva, Kiran Pandey, Ikuko Maejima, Ercília Ramalho, Vania Claudia Olivon, Susana Nogueira Diniz & Daniel Grasso. (2021) Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions. Current Research in Pharmacology and Drug Discovery 2, pages 100033.
Crossref
Nipa H. Patel, Sarah Bloukh, Enas Alwohosh, Ahmad Alhesa, Tareq Saleh & David A. Gewirtz. 2021. Autophagy and Senescence in Cancer Therapy. Autophagy and Senescence in Cancer Therapy 1 74 .
Melissa K. Bennett, Stuart M. Pitson & Craig T. Wallington-Beddoe. 2021. Resistance to Targeted Therapies in Multiple Myeloma. Resistance to Targeted Therapies in Multiple Myeloma 39 59 .
Doh Yu Hwang, Ju-In Eom, Ji Eun Jang, Hoi-Kyung Jeung, Haerim Chung, Jin Seok Kim, June-Won Cheong & Yoo Hong Min. (2020) ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia. Journal of Experimental & Clinical Cancer Research 39:1.
Crossref
Chaeuk Chung, Wonhyoung Seo, Prashanta Silwal & Eun-Kyeong Jo. (2020) Crosstalks between inflammasome and autophagy in cancer. Journal of Hematology & Oncology 13:1.
Crossref
Immacolata Faraone, Fabiana Labanca, Maria Ponticelli, Nunziatina De Tommasi & Luigi Milella. (2020) Recent Clinical and Preclinical Studies of Hydroxychloroquine on RNA Viruses and Chronic Diseases: A Systematic Review. Molecules 25:22, pages 5318.
Crossref
Pengping Li, Guodong Cao, Yuqing Huang, Wei Wu, Bo Chen, Zhenyu Wang & Maoming Xiong. (2020) siMTA1-Loaded Exosomes Enhanced Chemotherapeutic Effect of Gemcitabine in Luminal-b Type Breast Cancer by Inhibition of EMT/HIF-α and Autophagy Pathways. Frontiers in Oncology 10.
Crossref
Dong Wook Shin. (2020) Dual Roles of Autophagy and Their Potential Drugs for Improving Cancer Therapeutics. Biomolecules & Therapeutics 28:6, pages 503-511.
Crossref
Mohd Ishaq, Rani Ojha, Aditya P. Sharma & Shrawan K. Singh. (2020) Autophagy in cancer: Recent advances and future directions. Seminars in Cancer Biology 66, pages 171-181.
Crossref
Srimanta Patra, Chandra Sekhar Bhol, Debasna Pritimanjari Panigrahi, Prakash Priyadarshi Praharaj, Biswajita Pradhan, Mrutyunjay Jena & Sujit Kumar Bhutia. (2020) Gamma irradiation promotes chemo-sensitization potential of gallic acid through attenuation of autophagic flux to trigger apoptosis in an NRF2 inactivation signalling pathway. Free Radical Biology and Medicine 160, pages 111-124.
Crossref
Marveh Rahmati, Shiva Ebrahim, Saadeh Hashemi, Masoumeh Motamedi & Mohammad Amin Moosavi. (2020) New insights on the role of autophagy in the pathogenesis and treatment of melanoma. Molecular Biology Reports 47:11, pages 9021-9032.
Crossref
Gricelis P. Martinez, Mercedes E. Zabaleta, Camilo Di Giulio, Jaime E. Charris & Michael R. Mijares. (2020) The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases. Current Pharmaceutical Design 26:35, pages 4467-4485.
Crossref
Namrita Kaur, Rida Raja, Andrea Ruiz-Velasco & Wei Liu. (2020) Cellular Protein Quality Control in Diabetic Cardiomyopathy: From Bench to Bedside. Frontiers in Cardiovascular Medicine 7.
Crossref
Sibi Raj, Vaishali Chandel, Arun Kumar, Kavindra Kumar Kesari, Shailendra Asthana, Janne Ruokolainen, Mohammad Amjad Kamal & Dhruv Kumar. (2020) Molecular mechanisms of interplay between autophagy and metabolism in cancer. Life Sciences 259, pages 118184.
Crossref
Nethaji Muniraj, Sumit Siddharth, Marey Shriver, Arumugam Nagalingam, Sheetal Parida, Juhyung Woo, Justin Elsey, Kathleen Gabrielson, Edward Gabrielson, Jack L. Arbiser, Neeraj K. Saxena & Dipali Sharma. (2020) Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon honokiol treatment. Cell Death Discovery 6:1.
Crossref
Yan Li, Mi Hyeon Cho, Seon Sook Lee, Dong-Eun Lee, Heesun Cheong & Yongdoo Choi. (2020) Hydroxychloroquine-loaded hollow mesoporous silica nanoparticles for enhanced autophagy inhibition and radiation therapy. Journal of Controlled Release 325, pages 100-110.
Crossref
Chiara Fucci, Massimo Resnati, Elena Riva, Tommaso Perini, Elena Ruggieri, Ugo Orfanelli, Francesca Paradiso, Floriana Cremasco, Andrea Raimondi, Elena Pasqualetto, Mario Nuvolone, Luca Rampoldi, Simone Cenci & Enrico Milan. (2020) The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis. Cell Reports 32:12, pages 108162.
Crossref
Guiqin Hou, Ang Jia, Li Yang, Yu Zhao, Yi Hu, Wuduo Zhao, Wen Zhao, Hong-Min Liu & Zhaoming Lu. (2020) OP16 induces deadly autophagy and apoptosis of cells by inhibiting Akt in esophageal squamous cell carcinoma. Molecular and Cellular Biochemistry 472:1-2, pages 219-230.
Crossref
Michael F. Marmor. (2020) COVID-19 and Chloroquine/Hydroxychloroquine: Is There Ophthalmological Concern?. American Journal of Ophthalmology 216, pages A1-A2.
Crossref
Susanna Ambrosio & Barbara Majello. (2020) Autophagy Roles in Genome Maintenance. Cancers 12:7, pages 1793.
Crossref
Zhe Zhang, Li Zhou, Na Xie, Edouard C. Nice, Tao Zhang, Yongping Cui & Canhua Huang. (2020) Overcoming cancer therapeutic bottleneck by drug repurposing. Signal Transduction and Targeted Therapy 5:1.
Crossref
G. A. Horne, J. Stobo, C. Kelly, A. Mukhopadhyay, A. L. Latif, J. Dixon-Hughes, L. McMahon, P. Cony-Makhoul, J. Byrne, G. Smith, S. Koschmieder, T. H. BrÜmmendorf, P. Schafhausen, P. Gallipoli, F. Thomson, W. Cong, R. E. Clark, D. Milojkovic, G. V. Helgason, L. Foroni, F. E. Nicolini, T. L. Holyoake & M. Copland. (2020) A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease. Leukemia 34:7, pages 1775-1786.
Crossref
Chong Zhao, ShaoZhuang Qiu, Jie He, Yao Peng, Haoming Xu, Zhiqiang Feng, Hongli Huang, Yanlei Du, Yongjian Zhou & Yuqiang Nie. (2020) Prodigiosin impairs autophagosome-lysosome fusion that sensitizes colorectal cancer cells to 5-fluorouracil-induced cell death. Cancer Letters 481, pages 15-23.
Crossref
Congting Guo & Ying Zhao. (2020) Autophagy and DNA damage repair. Genome Instability & Disease 1:4, pages 172-183.
Crossref
Nipa H. Patel, Sahib S. Sohal, Masoud H Manjili, J. Chuck Harrell & David A. Gewirtz. (2020) The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation. Radiation Research 194:2, pages 103.
Crossref
Thomas G. Biel, Baikuntha Aryal, Michael H. Gerber, Josè G. Trevino, Naoko Mizuno & V. Ashutosh Rao. (2020) Mitochondrial dysfunction generates aggregates that resist lysosomal degradation in human breast cancer cells. Cell Death & Disease 11:6.
Crossref
Changyu Shan, Wenqi Hui, Hongwei Li, Zheng Wang, Chunling Guo, Ruikun Peng, Jing Gu, Yingchun Chen & Qin Ouyang. (2020) Discovery of Novel Autophagy Inhibitors and Their Sensitization Abilities for Vincristine‐Resistant Esophageal Cancer Cell Line Eca109/VCR. ChemMedChem 15:11, pages 970-981.
Crossref
Sabrina Manni, Anna Fregnani, Gregorio Barilà, Renato Zambello, Gianpietro Semenzato & Francesco Piazza. (2020) Actionable Strategies to Target Multiple Myeloma Plasma Cell Resistance/Resilience to Stress: Insights From “Omics” Research. Frontiers in Oncology 10.
Crossref
Haruka Chino & Noboru Mizushima. (2020) ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum. Trends in Cell Biology 30:5, pages 384-398.
Crossref
Michael F. Marmor. (2020) COVID-19 and Chloroquine/Hydroxychloroquine: is there Ophthalmological Concern?. American Journal of Ophthalmology 213, pages A3-A4.
Crossref
Tuhina Khan, Nicola Relitti, Margherita Brindisi, Stefania Magnano, Daniela Zisterer, Sandra Gemma, Stefania Butini & Giuseppe Campiani. (2019) Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas. Medicinal Research Reviews 40:3, pages 1002-1060.
Crossref
Ferda Kaleağasıoğlu, Doaa M. Ali & Martin R. Berger. (2020) Multiple Facets of Autophagy and the Emerging Role of Alkylphosphocholines as Autophagy Modulators. Frontiers in Pharmacology 11.
Crossref
Ting Liu, Jing Zhang, Kangdi Li, Lingnan Deng & Hongxiang Wang. (2020) Combination of an Autophagy Inducer and an Autophagy Inhibitor: A Smarter Strategy Emerging in Cancer Therapy. Frontiers in Pharmacology 11.
Crossref
Jiliang Xia, Yanjuan He, Bin Meng, Shilian Chen, Jingyu Zhang, Xuan Wu, Yinghong Zhu, Yi Shen, Xiangling Feng, Yongjun Guan, Chunmei Kuang, Jiaojiao Guo, Qian Lei, Yangbowen Wu, Gang An, Guancheng Li, Lugui Qiu, Fenghuang Zhan & Wen Zhou. (2020) NEK2 induces autophagy‐mediated bortezomib resistance by stabilizing Beclin‐1 in multiple myeloma. Molecular Oncology 14:4, pages 763-778.
Crossref
Paula Saavedra-García, Francesca Martini & Holger W. Auner. (2020) Proteasome inhibition in multiple myeloma: lessons for other cancers. American Journal of Physiology-Cell Physiology 318:3, pages C451-C462.
Crossref
Jean M. Mulcahy Levy & Andrew Thorburn. (2019) Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients. Cell Death & Differentiation 27:3, pages 843-857.
Crossref
Giuseppe Di Lernia, Patrizia Leone, Antonio Giovanni Solimando, Alessio Buonavoglia, Ilaria Saltarella, Roberto Ria, Paolo Ditonno, Nicola Silvestris, Lucilla Crudele, Angelo Vacca & Vito Racanelli. (2020) Bortezomib Treatment Modulates Autophagy in Multiple Myeloma. Journal of Clinical Medicine 9:2, pages 552.
Crossref
Hang Gao, Siyue Lou, Huanwu Hong, Qiufu Ge & Huajun Zhao. (2020) Autophagy Inhibition Potentiates the Anticancer Effects of a Bendamustine Derivative NL-101 in Acute T Lymphocytic Leukemia. BioMed Research International 2020, pages 1-12.
Crossref
Vanessa Pinto, Rui Bergantim, Hugo R. Caires, Hugo Seca, José E. Guimarães & M. Helena Vasconcelos. (2020) Multiple Myeloma: Available Therapies and Causes of Drug Resistance. Cancers 12:2, pages 407.
Crossref
Young Hyun Cho, Seung-Hwan Lee, Sook-Jeong Lee, Ha Na Kim & Jae-Young Koh. (2020) A role of metallothionein-3 in radiation-induced autophagy in glioma cells. Scientific Reports 10:1.
Crossref
Alejandro Losada, Juan José Berlanga, José Manuel Molina-Guijarro, Antonio Jiménez-Ruiz, Federico Gago, Pablo Avilés, César de Haro & Juan Fernando Martínez-Leal. (2020) Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells. Biochemical Pharmacology 172, pages 113744.
Crossref
Kun Wang, Qing Gong, Yujuan Zhan, Bonan Chen, Ting Yin, Yuhua Lu, Yilin Zhang, Huiqi Wang, Junzi Ke, Biaoyan Du, Xiaodong Liu & Jianyong Xiao. (2020) Blockage of Autophagic Flux and Induction of Mitochondria Fragmentation by Paroxetine Hydrochloride in Lung Cancer Cells Promotes Apoptosis via the ROS-MAPK Pathway. Frontiers in Cell and Developmental Biology 7.
Crossref
Lucy Brazil, Angela L Swampillai, Ka Man Mak, Darren Edwards, Pavlina Mesiri, Laura Clifton-Hadley, Richard Shaffer, Joanne Lewis, Colin Watts, Sarah Jeffries, Pinelopi Gkogkou, Anthony J Chalmers, Naomi L Fersht, Allan Hackshaw & Susan C Short. (2020) Hydroxychloroquine and short-course radiotherapy in elderly patients with newly diagnosed high-grade glioma: a randomized phase II trial. Neuro-Oncology Advances 2:1.
Crossref
Kelie Chen, Dexin Yang, Fan Zhao, Shengchao Wang, Yao Ye, Wenjie Sun, Haohua Lu, Zhi Ruan, Jinming Xu, Tianru Wang, Guang Lu, Liming Wang, Yu Shi, Honghe Zhang, Han Wu, Weiguo Lu, Han-Ming Shen, Dajing Xia & Yihua Wu. (2020) Autophagy and Tumor Database: ATdb, a novel database connecting autophagy and tumor. Database 2020.
Crossref
Benjamin Bonavida. 2020. Autophagy in Immune Response: Impact on Cancer Immunotherapy. Autophagy in Immune Response: Impact on Cancer Immunotherapy 9 27 .
Dipanwita Das Mukherjee, Satabdi Datta Choudhury & Gopal Chakrabarti. 2020. Autophagy in tumor and tumor microenvironment. Autophagy in tumor and tumor microenvironment 249 264 .
Mei Lan Tan, Heng Kean Tan & Tengku Sifzizul Tengku Muhammad. 2020. Cancer Immunology. Cancer Immunology 355 402 .
Agrotis & Ketteler. (2019) On ATG4B as Drug Target for Treatment of Solid Tumours—The Knowns and the Unknowns. Cells 9:1, pages 53.
Crossref
Christina G. Towers, Darya Wodetzki & Andrew Thorburn. (2019) Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations. The Journal of Cell Biology, pages jcb.201909033.
Crossref
Nam & Jeon. (2019) Proteostasis In The Endoplasmic Reticulum: Road to Cure. Cancers 11:11, pages 1793.
Crossref
Marta Pérez-Hernández, Alain Arias, David Martínez-García, Ricardo Pérez-Tomás, Roberto Quesada & Vanessa Soto-Cerrato. (2019) Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization. Cancers 11:10, pages 1599.
Crossref
Francesca Cuomo, Lucia Altucci & Gilda Cobellis. (2019) Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy. Cancers 11:10, pages 1465.
Crossref
Tavakol, Ashrafizadeh, Deng, Azarian, Abdoli, Motavaf, Poormoghadam, Khanbabaei, Afshar, Mandegary, Pardakhty, Yap, Mohammadinejad & Kumar. (2019) Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems. Biomolecules 9:10, pages 530.
Crossref
Ravi K. Amaravadi, Alec C. Kimmelman & Jayanta Debnath. (2019) Targeting Autophagy in Cancer: Recent Advances and Future Directions. Cancer Discovery 9:9, pages 1167-1181.
Crossref
Shouping Xu, Shiyao Sui, Xianyu Zhang, Boran Pang, Lin Wan & Da Pang. (2019) Modulation of autophagy in human diseases strategies to foster strengths and circumvent weaknesses. Medicinal Research Reviews 39:5, pages 1953-1999.
Crossref
Nicholas Howard, Marco Clementino, Donghern Kim, Lei Wang, Angela Verma, Xianglin Shi, Zhuo Zhang & Robert S. DiPaola. (2019) New developments in mechanisms of prostate cancer progression. Seminars in Cancer Biology 57, pages 111-116.
Crossref
Fabio Penna, Riccardo Ballarò, Paula Martinez-Cristobal, David Sala, David Sebastian, Silvia Busquets, Maurizio Muscaritoli, Josep M. Argilés, Paola Costelli & Antonio Zorzano. (2019) Autophagy Exacerbates Muscle Wasting in Cancer Cachexia and Impairs Mitochondrial Function. Journal of Molecular Biology 431:15, pages 2674-2686.
Crossref
Wenyi Yang, Chunlan Jiang, Weiya Xia, Houyu Ju, Shufang Jin, Shuli Liu, Liming Zhang, Guoxin Ren, Hailong Ma, Min Ruan & Jingzhou Hu. (2019) Blocking autophagy flux promotes interferon-alpha-mediated apoptosis in head and neck squamous cell carcinoma. Cancer Letters 451, pages 34-47.
Crossref
Liliana Torres-López, Paola Maycotte, Andrómeda Liñán-Rico, Liliana Liñán-Rico, Luis Donis-Maturano, Iván Delgado-Enciso, Carmen Meza-Robles, Clemente Vásquez-Jiménez, Arturo Hernández-Cruz & Oxana Dobrovinskaya. (2019) Tamoxifen induces toxicity, causes autophagy, and partially reverses dexamethasone resistance in Jurkat T cells. Journal of Leukocyte Biology 105:5, pages 983-998.
Crossref
Jenna Wahbeh & Sarah Milkowski. (2019) The Use of Hydrazones for Biomedical Applications. SLAS Technology 24:2, pages 161-168.
Crossref
Naomi B. Haas, Leonard J. Appleman, Mark Stein, Maryann Redlinger, Melissa Wilks, Xiaowei Xu, Angelique Onorati, Anusha Kalavacharla, Taehyong Kim, Chao Jie Zhen, Sabah Kadri, Jeremy P. Segal, Phyllis A. Gimotty, Lisa E. Davis & Ravi K. Amaravadi. (2019) Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma. Clinical Cancer Research 25:7, pages 2080-2087.
Crossref
Pablo Baquero, Amy Dawson, Arunima Mukhopadhyay, Elodie M. Kuntz, Rebecca Mitchell, Orianne Olivares, Angela Ianniciello, Mary T. Scott, Karen Dunn, Michael C. Nicastri, Jeffrey D. Winkler, Alison M. Michie, Kevin M. Ryan, Christina Halsey, Eyal Gottlieb, Erin P. Keaney, Leon O. Murphy, Ravi K. Amaravadi, Tessa L. Holyoake & G. Vignir Helgason. (2018) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia 33:4, pages 981-994.
Crossref
Rushika M. PereraChiara Di Malta & Andrea Ballabio. (2019) MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer. Annual Review of Cancer Biology 3:1, pages 203-222.
Crossref
Hendrik Folkerts, Susan Hilgendorf, Edo Vellenga, Edwin Bremer & Valerie R. Wiersma. (2018) The multifaceted role of autophagy in cancer and the microenvironment. Medicinal Research Reviews 39:2, pages 517-560.
Crossref
Yassine El HianiEmmanuel Eroume-A EgomXian-Ping Dong. (2019) mTOR signalling: jack-of-all-trades. Biochemistry and Cell Biology 97:1, pages 58-67.
Crossref
Matthew Ho Zhi Guang, Emma Kavanagh, Luke Dunne, Paul Dowling, Li Zhang, Sinéad Lindsay, Despina Bazou, Chia Goh, Cathal Hanley, Giada Bianchi, Kenneth Anderson, Peter O’Gorman & Amanda McCann. (2019) Targeting Proteotoxic Stress in Cancer: A Review of the Role that Protein Quality Control Pathways Play in Oncogenesis. Cancers 11:1, pages 66.
Crossref
Giada Bianchi & Kenneth C. Anderson. (2019) Contribution of Inhibition of Protein Catabolism in Myeloma. The Cancer Journal 25:1, pages 11-18.
Crossref
Jyoti Malhotra, Salma Jabbour, Michelle Orlick, Gregory Riedlinger, Yanxiang Guo, Eileen White & Joseph Aisner. (2019) Phase Ib/II study of hydroxychloroquine in combination with chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC). Cancer Treatment and Research Communications 21, pages 100158.
Crossref
Emmanuel K. CudjoeJr.Jr., S. Lauren Kyte, Tareq Saleh, Joseph W. Landry & David A. Gewirtz. 2019. Targeting Cell Survival Pathways to Enhance Response to Chemotherapy. Targeting Cell Survival Pathways to Enhance Response to Chemotherapy 259 273 .
Simon Heine, Markus Kleih, Neus Giménez, Kathrin Böpple, German Ott, Dolors Colomer, Walter E. Aulitzky, Heiko van der Kuip & Elisabeth Silkenstedt. (2018) Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA. Journal of Hematology & Oncology 11:1.
Crossref
Lei Zhan, Jun Li & Bing Wei. (2018) Autophagy therapeutics: preclinical basis and initial clinical studies. Cancer Chemotherapy and Pharmacology 82:6, pages 923-934.
Crossref
Yujuan Zhan, Kun Wang, Qiao Li, Yidan Zou, Bonan Chen, Qing Gong, Hiuting HO, Ting Yin, Fangyuan Zhang, Yuhua Lu, Weijie Wu, Yilin Zhang, Yuhui Tan, Biaoyan Du, Xiaodong Liu & Jianyong Xiao. (2018) The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells. International Journal of Molecular Sciences 19:10, pages 3221.
Crossref
Nur Mehpare Kocaturk & Devrim Gozuacik. (2018) Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System. Frontiers in Cell and Developmental Biology 6.
Crossref
Brendan F. Boyce, Jinbo Li, Lianping Xing & Zhenqiang Yao. (2018) Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption. Frontiers in Immunology 9.
Crossref
Michael J. MorganBrent E. FitzwalterCharles R. OwensRani K. Powers, Joseph L. SottnikGraciela GamezJames C. Costello, Dan TheodorescuAndrew Thorburn. (2018) Metastatic cells are preferentially vulnerable to lysosomal inhibition. Proceedings of the National Academy of Sciences 115:36.
Crossref
Angelique V. Onorati, Matheus Dyczynski, Rani Ojha & Ravi K. Amaravadi. (2018) Targeting autophagy in cancer. Cancer 124:16, pages 3307-3318.
Crossref
Timothy M Hall, Marie-Pier Tétreault, Kathryn E Hamilton & Kelly A Whelan. (2018) Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma. Current Opinion in Pharmacology 41, pages 12-19.
Crossref
Fabrizio Marcucci & Cristiano Rumio. (2018) How Tumor Cells Choose Between Epithelial-Mesenchymal Transition and Autophagy to Resist Stress—Therapeutic Implications. Frontiers in Pharmacology 9.
Crossref
Elizabeth A. Hall, Jon E. Ramsey, Zhihua Peng, Davit Hayrapetyan, Viacheslav Shkepu, Bruce O'Rourke, William Geiger, Kevin Lam & Claire F. Verschraegen. (2018) Novel organometallic chloroquine derivative inhibits tumor growth. Journal of Cellular Biochemistry 119:7, pages 5921-5933.
Crossref
Keagan P. Collins, Kristen M. Jackson & Daniel L. Gustafson. (2018) Hydroxychloroquine: A Physiologically-Based Pharmacokinetic Model in the Context of Cancer-Related Autophagy Modulation. Journal of Pharmacology and Experimental Therapeutics 365:3, pages 447-459.
Crossref
Marion Orsini, Franck Morceau, Mario Dicato & Marc Diederich. (2018) Autophagy as a pharmacological target in hematopoiesis and hematological disorders. Biochemical Pharmacology 152, pages 347-361.
Crossref
Xilong Wu, Yundi Wu, Zhiyong Wang, Lixin Liu, Chengxin Sun, Yongming Chen & Chun Wang. (2018) A Cascade-Targeting Nanocapsule for Enhanced Photothermal Tumor Therapy with Aid of Autophagy Inhibition. Advanced Healthcare Materials 7:11, pages 1800121.
Crossref
Yu Cao, Min Chen, Dehua Tang, Hongli Yan, Xiwei Ding, Fan Zhou, Mingming Zhang, Guifang Xu, Weijie Zhang, Shu Zhang, Yuzheng Zhuge, Lei Wang & Xiaoping Zou. (2018) The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses. Cell Death & Disease 9:6.
Crossref
Zizhuo Zhao, Jiayi Wu, Xiaodi Liu, Ming Liang, Xinchuan Zhou, Shi Ouyang, Jiyi Yao, Jinquan Wang & Baoming Luo. (2018) Insufficient radiofrequency ablation promotes proliferation of residual hepatocellular carcinoma via autophagy. Cancer Letters 421, pages 73-81.
Crossref
Han Zhang. (2018) Targeting autophagy in lymphomas: a double-edged sword?. International Journal of Hematology 107:5, pages 502-512.
Crossref
Ana Serrano-Puebla & Patricia Boya. (2018) Lysosomal membrane permeabilization as a cell death mechanism in cancer cells. Biochemical Society Transactions 46:2, pages 207-215.
Crossref
Andrew Thorburn. (2018) Autophagy and disease. Journal of Biological Chemistry 293:15, pages 5425-5430.
Crossref
Yuan Qing Qu, Flora Gordillo-Martinez, Betty Yuen Kwan Law, Yu Han, Anguo Wu, Wu Zeng, Wai Kei Lam, Charles Ho, Simon Wing Fai Mok, Hu Qiang He, Vincent Kam Wai Wong & Renxiao Wang. (2018) 2-Aminoethoxydiphenylborane sensitizes anti-tumor effect of bortezomib via suppression of calcium-mediated autophagy. Cell Death & Disease 9:3.
Crossref
Annan Yang, Grit Herter-Sprie, Haikuo Zhang, Elaine Y. Lin, Douglas Biancur, Xiaoxu Wang, Jiehui Deng, Josephine Hai, Shenghong Yang, Kwok-Kin Wong & Alec C. Kimmelman. (2018) Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms. Cancer Discovery 8:3, pages 276-287.
Crossref
Hong‐Ye Wan, Jian‐Li Chen, Xingzhong Zhu, Liang Liu, Jianfang Wang & Xiao‐Ming Zhu. (2017) Titania‐Coated Gold Nano‐Bipyramids for Blocking Autophagy Flux and Sensitizing Cancer Cells to Proteasome Inhibitor‐Induced Death. Advanced Science 5:3.
Crossref
Janice M. Santiago-O’Farrill, Eugenie S. Kleinerman, Mario G. Hollomon, Andrew Livingston, Wei-Lien Wang, Jen-Wei Tsai & Nancy B. Gordon. (2017) Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy. Oncotarget 9:2, pages 1602-1616.
Crossref
Xuhui Wang, Yue Qiu, Qianwen Yu, Hui Li, Xiaoxiao Chen, Man Li, Yang Long, Yayuan Liu, Libao Lu, Jiajing Tang, Zhirong Zhang & Qin He. (2018) Enhanced glioma therapy by synergistic inhibition of autophagy and tyrosine kinase activity. International Journal of Pharmaceutics 536:1, pages 1-10.
Crossref
Pan Zhang, Ze-Lin Lai, Hui-Fen Chen, Min Zhang, An Wang, Tao Jia, Wen-Qin Sun, Xi-Min Zhu, Xiao-Feng Chen, Zheng Zhao & Jun Zhang. (2017) RETRACTED ARTICLE: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. Journal of Experimental & Clinical Cancer Research 36:1.
Crossref
Tabea Wiedmer, Annika Blank, Sophia Pantasis, Lea Normand, Ruben Bill, Philippe Krebs, Mario P. Tschan, Ilaria Marinoni & Aurel Perren. (2017) Autophagy Inhibition Improves Sunitinib Efficacy in Pancreatic Neuroendocrine Tumors via a Lysosome-dependent Mechanism. Molecular Cancer Therapeutics 16:11, pages 2502-2515.
Crossref
Richard L. Sleightholm, Beth K. Neilsen, Jing Li, Maria M. Steele, Rakesh K. Singh, Michael A. Hollingsworth & David Oupicky. (2017) Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy. Pharmacology & Therapeutics 179, pages 158-170.
Crossref

Displaying 200 of 287 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.