Inhalation Toxicology, Volume 12, Issue sup3 (2000)

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Inhalation Toxicology, Volume 12, Issue sup3 (2000)

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Original Articles

Article
Preface
Paul Borm (Guest Editors) & Ken Donaldson (Guest Editors)
Pages: V-VI
Published online: 14 Sep 2015
CitationforPreface | PDF (791.4 KB)
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Article
Particle Paradigms
Ken Donaldson & Paul Borm
Pages: 1-6
Published online: 14 Sep 2015
First Page PreviewforParticle Paradigms | References | PDF (2.1 MB)
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State of the Art

Article
From Coal Mine Dust To Quartz: Mechanisms of Pulmonary Pathogenicity
Vincent Castranova
Pages: 7-14
Published online: 14 Sep 2015
AbstractforFrom Coal Mine Dust To Quartz: Mechanisms of Pulmonary Pathogenicity | References | PDF (2.8 MB)
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Article
Pathogenesis of Fibrosis Produced by Asbestos and Man-Made Mineral Fibers: What Makes a Fiber Fibrogenic?
A. Churg, J. Wright, B. Gilks & J. Dai
Pages: 15-26
Published online: 14 Sep 2015
AbstractforPathogenesis of Fibrosis Produced by Asbestos and Man-Made Mineral Fibers: What Makes a Fiber Fibrogenic? | References | PDF (4.3 MB)
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Article
Organic Dusts: Beyond Endotoxin
Dick Heederik, Jeroen Douwes, Inge Wouters & Gert Doekes
Pages: 27-33
Published online: 14 Sep 2015
AbstractforOrganic Dusts: Beyond Endotoxin | References | PDF (2.9 MB)
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Article
Particulate Matter and Cardiopulmonary Health: A Perspective
Daniel L. Costa
Pages: 35-44
Published online: 14 Sep 2015
AbstractforParticulate Matter and Cardiopulmonary Health: A Perspective | References | PDF (3.9 MB)
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Article
Particulate Matter Physicochemistry and Toxicology: In Search of Causality—A Critical Perspective
Kevin L. Dreher
Pages: 45-57
Published online: 14 Sep 2015
AbstractforParticulate Matter Physicochemistry and Toxicology: In Search of Causality—A Critical Perspective | References | PDF (4.8 MB)
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Article
Functional Genomics of Particle-Induced Lung Injury
George D. Leikauf, Susan A. McDowell, Kelly Gammon, Scott C. Wesselkamper, Cindy J. Bachurski, Puga Alvaro, Jonathan S. Wiest, John E. Leikauf & Daniel R. Prows
Pages: 59-73
Published online: 14 Sep 2015
AbstractforFunctional Genomics of Particle-Induced Lung Injury | References | PDF (6 MB)
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Physical and Chemical Properties in Relation to Particle Toxicity

Article
Role of Iron in the Cellular Effects of Asbestos
E. Ann Aust, Loren G. Lund, Chien-Chung Chao, Sun-Hee Park & Ruihua Fang
Pages: 75-80
Published online: 14 Sep 2015
AbstractforRole of Iron in the Cellular Effects of Asbestos | References | PDF (2.1 MB)
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Article
Effect of Micromorphology and Surface Reactivity of Several Unusual forms of Crystalline Silica on the toxicity to a Monocyte-Macrophage Tumor Cell Line
I. Fenoglio, B. Fubini, R. Tiozzo & F. Di Renzo
Pages: 81-89
Published online: 14 Sep 2015
AbstractforEffect of Micromorphology and Surface Reactivity of Several Unusual forms of Crystalline Silica on the toxicity to a Monocyte-Macrophage Tumor Cell Line | References | PDF (3.2 MB)
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Article
Lung Biopersistence and in Vitro Dissolution Rate Predict the Pathogenic Potential of Synthetic Vitreous Fibers
T.W. Hesterberg & G.A. Hart
Pages: 91-97
Published online: 14 Sep 2015
AbstractforLung Biopersistence and in Vitro Dissolution Rate Predict the Pathogenic Potential of Synthetic Vitreous Fibers | References | PDF (2.6 MB)
  • 56 Views
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Article
Particle Contamination in Experimental Fiber Preparations
R.C. Brown, P. Sébastien, B. Bellmann & H. Muhle
Pages: 99-107
Published online: 14 Sep 2015
AbstractforParticle Contamination in Experimental Fiber Preparations | References | PDF (2.9 MB)
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Article
The Occurrence of Quartz in Coal Fly Ash Particles
Ruud Meij, Siep Nagengast & Henk te Winkel
Pages: 109-116
Published online: 14 Sep 2015
AbstractforThe Occurrence of Quartz in Coal Fly Ash Particles | References | PDF (2.6 MB)
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Article
Effect of Desferrioxamine on Silica-Induced Pulmonary Reaction
Kyoung-Ah Kim, Eun-Kyung Kim, Hwang-Shin Chang, Ji-Hong Kim, Young Lim, Park Chung-Yill & Kweon-Haeng Lee
Pages: 117-123
Published online: 14 Sep 2015
AbstractforEffect of Desferrioxamine on Silica-Induced Pulmonary Reaction | References | PDF (2 MB)
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Article
Ambient Particulate Matter Induces Oxidative Dna Damage in Lung Epithelial Cells
Ad M. Knaapen, Roel P.F. Schins, Yvonne Steinfartz, Höhr Doris, Lothar Dunemann & Paul J.A. Borm
Pages: 125-132
Published online: 14 Sep 2015
AbstractforAmbient Particulate Matter Induces Oxidative Dna Damage in Lung Epithelial Cells | References | PDF (2.8 MB)
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Original Articles

Article
Oncogenes and Tumor Suppressor Genes in the Carcinogenicity of Fibers and Particles
Agnes B. Kane
Pages: 133-140
Published online: 14 Sep 2015
AbstractforOncogenes and Tumor Suppressor Genes in the Carcinogenicity of Fibers and Particles | References | PDF (3 MB)
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Asbestos

Article
Genotoxicity Versus Carcinogenicity: Implications from Fiber Toxicity Studies
Tom K. Hei, An Xu, Darren Louie & Yong-liang Zhao
Pages: 141-147
Published online: 14 Sep 2015
AbstractforGenotoxicity Versus Carcinogenicity: Implications from Fiber Toxicity Studies | References | PDF (2.3 MB)
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Article
Effects of Crocidolite Fibers on the Peritoneal Mesothelium of Rats
K. Unfried, H. Sandhu, C. Schürkes, C. Albrecht & J. Abel
Pages: 149-155
Published online: 14 Sep 2015
AbstractforEffects of Crocidolite Fibers on the Peritoneal Mesothelium of Rats | References | PDF (2.6 MB)
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Article
Occupational and Environmental Factors Enhancing the Genotoxicity of Asbestos
Qamar Rahman, Elke Dopp, Mohtashim Lohani & Dietmar Schiffmann
Pages: 157-165
Published online: 14 Sep 2015
AbstractforOccupational and Environmental Factors Enhancing the Genotoxicity of Asbestos | References | PDF (3 MB)
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Article
Hyperplastic and Neoplastic Changes in the Lungs of Rats Treated Concurrently with Chrysotile Asbestos and N-Nitrosoheptamethyleneimine
P.T.C. Harrison, J.A. Hoskins, R.C. Brown, G.H. Pigott, P.M. Hext & M.A. Mugglestone
Pages: 167-172
Published online: 14 Sep 2015
AbstractforHyperplastic and Neoplastic Changes in the Lungs of Rats Treated Concurrently with Chrysotile Asbestos and N-Nitrosoheptamethyleneimine | References | PDF (2.2 MB)
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Article
A Comparison of Pleural Mesotheliomas Induced by Asbestos or SV40 Virus in Syrian Golden Hamsters
Ernest E. McConnell & Michele Carbone
Pages: 173-181
Published online: 14 Sep 2015
AbstractforA Comparison of Pleural Mesotheliomas Induced by Asbestos or SV40 Virus in Syrian Golden Hamsters | References | PDF (4.3 MB)
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Article
Investigations of DNA Damage Produced by Asbestos Fibers in Rat Pleural Mesothelial Cells
M.C. Jaurand
Pages: 183-187
Published online: 14 Sep 2015
AbstractforInvestigations of DNA Damage Produced by Asbestos Fibers in Rat Pleural Mesothelial Cells | References | PDF (1.7 MB)
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Silica’s

Article
Study of Cell Division Aberrations Induced by Some Silica Dusts in Mammalian Cells in Vitro
F. Béna, M.C. Danière, F. Terzetti, O. Poirot & Z. Elias
Pages: 189-198
Published online: 14 Sep 2015
AbstractforStudy of Cell Division Aberrations Induced by Some Silica Dusts in Mammalian Cells in Vitro | References | PDF (3.1 MB)
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Article
In Vivo Genotoxicity of Crystalline Silica as Evidenced by Micronuclei in Pulmonary Alveolar Macrophages: Low-Dose Study
James Leigh, Antonio Bonin & He Wang
Pages: 199-204
Published online: 14 Sep 2015
AbstractforIn Vivo Genotoxicity of Crystalline Silica as Evidenced by Micronuclei in Pulmonary Alveolar Macrophages: Low-Dose Study | References | PDF (2.3 MB)
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Article
DNA Damage and Inflammation in the Rat Quartz Model: Differences in Inflammatory Response and Formation of Oxidative DNA Adducts to High and Low Dose of DQ12 Quartz
J. Bruch, F. Seiler & B. Rehn
Pages: 205-213
Published online: 14 Sep 2015
AbstractforDNA Damage and Inflammation in the Rat Quartz Model: Differences in Inflammatory Response and Formation of Oxidative DNA Adducts to High and Low Dose of DQ12 Quartz | References | PDF (3 MB)
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Article
Lung Carcinogenesis by Diesel Exhaust Particles and the Carcinogenic Mechanism Via Active Oxygens
Masaru Sagai, Heung-Bin Lim & Takamichi Ichinose
Pages: 215-223
Published online: 14 Sep 2015
AbstractforLung Carcinogenesis by Diesel Exhaust Particles and the Carcinogenic Mechanism Via Active Oxygens | References | PDF (3 MB)
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Article
Chronic Inflammation and Tumor Formation in Rats After Intratracheal Instillation of High Doses of Coal Dusts, Titanium Dioxides, and Quartz
Paul J.A. Borm, Doris Höhr, Yvonne Steinfartz, Isabel Zeitträger & Catrin Albrecht
Pages: 225-231
Published online: 14 Sep 2015
AbstractforChronic Inflammation and Tumor Formation in Rats After Intratracheal Instillation of High Doses of Coal Dusts, Titanium Dioxides, and Quartz | References | PDF (2.6 MB)
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Non-Neoplastic Effects of Particles

Article
Systemic Effect of Particulate Air Pollution
W. MacNee, X.Y. Li, P. Gilmour & K. Donaldson
Pages: 233-244
Published online: 14 Sep 2015
AbstractforSystemic Effect of Particulate Air Pollution | References | PDF (4.2 MB)
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Article
Inhalation of Asbestos Fibers and Consequent Expression of Peptide Growth Factors
Arnold R. Brody
Pages: 245-250
Published online: 14 Sep 2015
AbstractforInhalation of Asbestos Fibers and Consequent Expression of Peptide Growth Factors | References | PDF (2.5 MB)
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Article
Asbestos-Related Pleural Thickening is Independently Associated With Lower Levels of Lung Function and with Shortness of Breath
E. Algranti, J.B.P. Freitas, E.M.C. Mendonça, E.M. DeCapitani, H.C. Silva & M.A. Bussacos
Pages: 251-260
Published online: 14 Sep 2015
AbstractforAsbestos-Related Pleural Thickening is Independently Associated With Lower Levels of Lung Function and with Shortness of Breath | References | PDF (3.4 MB)
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Article
Short-Term Inhalation Exposure of Healthy and Compromised Rats and Mice to Fine and Ultrafine Carbon Particles
J.H.E. Arts, S.M. Spoor, H. Muijser, M.T. Kleinman, L. van Bree & F.R. Cassee
Pages: 261-266
Published online: 14 Sep 2015
AbstractforShort-Term Inhalation Exposure of Healthy and Compromised Rats and Mice to Fine and Ultrafine Carbon Particles | References | PDF (2.3 MB)
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Article
Comparative Injurious and Proinflammatory Effects of Three Ultrafine Metals in Macrophages from Young and Old Rats
Qunwei Zhang, Yukinori Kusaka & Kenneth Donaldson
Pages: 267-273
Published online: 14 Sep 2015
AbstractforComparative Injurious and Proinflammatory Effects of Three Ultrafine Metals in Macrophages from Young and Old Rats | References | PDF (2.3 MB)
  • 27 Views
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Article
Comparison of Selected Pulmonary Responses of Rats, Mice, and Syrian Golden Hamsters to Inhaled Pigmentary Titanium Dioxide
J.I. Everitt, J.B. Mangum, E. Bermudez, B.A. Wong, B. Asgharian, E.E. Reverdy, P.M. Hext & D.B. Warheit
Pages: 275-282
Published online: 14 Sep 2015
AbstractforComparison of Selected Pulmonary Responses of Rats, Mice, and Syrian Golden Hamsters to Inhaled Pigmentary Titanium Dioxide | References | PDF (2.4 MB)
  • 47 Views
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Article
Protein Carbonyls in Bronchoalveolar Lavage Fluid in Mice, Rats and Hamsters Following Inhalation of Pigmentary Titanium Dioxide Particles
E.E. Reverdy, E. Bermudez, J.B. Mangum, B. Asgharian, B. Wong & J.I. Everitt
Pages: 283-289
Published online: 14 Sep 2015
AbstractforProtein Carbonyls in Bronchoalveolar Lavage Fluid in Mice, Rats and Hamsters Following Inhalation of Pigmentary Titanium Dioxide Particles | References | PDF (2.2 MB)
  • 28 Views
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Article
A Morphologic Study on the Fate of Ultrafine Silver Particles: Distribution Pattern of Phagocytized Metallic Silver in Vitro and in Vivo
S. Takenaka, E. Karg, W. Möller, C. Roth, A. Ziesenis, U. Heinzmann, P. Schramel & J. Heyder
Pages: 291-299
Published online: 14 Sep 2015
AbstractforA Morphologic Study on the Fate of Ultrafine Silver Particles: Distribution Pattern of Phagocytized Metallic Silver in Vitro and in Vivo | References | PDF (2.9 MB)
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Article
Gene Expression of Matrix Metalloproteinases in Clara-Cell Secretory Protein-Deficient Mice Exposed to Cigarette Smoke
Yasuo Morimoto, Tohru Tsuda & Isamu Tanaka
Pages: 301-305
Published online: 14 Sep 2015
AbstractforGene Expression of Matrix Metalloproteinases in Clara-Cell Secretory Protein-Deficient Mice Exposed to Cigarette Smoke | References | PDF (1.7 MB)
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Signaling Pathways, Inflammation, and Immune Response

Article
Role of Mitogen-Activated Protein Kinases, Early Response Protooncogenes, and Activator Protein-1 in Cell Signaling by Asbestos
Brooke Mossman, Andrea Hubbard, Arti Shukla & Cynthia R. Timblin
Pages: 307-316
Published online: 14 Sep 2015
AbstractforRole of Mitogen-Activated Protein Kinases, Early Response Protooncogenes, and Activator Protein-1 in Cell Signaling by Asbestos | References | PDF (3.6 MB)
  • 14 Views
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Article
Nuclear Factor Kappa-B Activation by Particles and Fibers
Roel P.F. Schins & Ken Donaldson
Pages: 317-326
Published online: 14 Sep 2015
AbstractforNuclear Factor Kappa-B Activation by Particles and Fibers | References | PDF (3.7 MB)
  • 49 Views
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Article
Cell Signaling in Mesothelial Cells by Asbestos: Evidence for the Involvement of Oxidative Stress in the Regulation of the Epidermal Growth Factor Receptor
Stephen P. Faux & Catherine E. Houghton
Pages: 327-336
Published online: 14 Sep 2015
AbstractforCell Signaling in Mesothelial Cells by Asbestos: Evidence for the Involvement of Oxidative Stress in the Regulation of the Epidermal Growth Factor Receptor | References | PDF (3.2 MB)
  • 29 Views
  • 4 CrossRef citations
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Article
Differential Display Analysis of Fiber-Induced Carcinogenesis in Rat: Clue for Involvement of Integrin-Mediated Signal Transduction
H. Sandhu, H. Olbrück, J. Abel & K. Unfried
Pages: 337-343
Published online: 14 Sep 2015
AbstractforDifferential Display Analysis of Fiber-Induced Carcinogenesis in Rat: Clue for Involvement of Integrin-Mediated Signal Transduction | References | PDF (2.2 MB)
  • 18 Views
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Article
Ultrafine Particle-Mediated Activation of Macrophages: Intracellular Calcium Signaling and Oxidative Stress
V. Stone, D.M. Brown, N. Watt, M. Wilson, K. Donaldson, H. Ritchie & W. MacNee
Pages: 345-351
Published online: 14 Sep 2015
AbstractforUltrafine Particle-Mediated Activation of Macrophages: Intracellular Calcium Signaling and Oxidative Stress | References | PDF (2.1 MB)
  • 86 Views
  • 25 CrossRef citations
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Article
Molecular Activation of Activator Protein-1 In Silica and Asbestos-Induced Carcinogenesis
Val Vallyathan, Min Ding, Xianglin Shi & Vincent Castranova
Pages: 353-357
Published online: 14 Sep 2015
AbstractforMolecular Activation of Activator Protein-1 In Silica and Asbestos-Induced Carcinogenesis | References | PDF (1.7 MB)
  • 23 Views
  • 2 CrossRef citations
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Article
Activation of Transcription Factors by Diesel Exhaust Particles in Human Bronchial Epithelial Cells in Vitro
Véronique Bonvallot, Armelle Baeza-Squiban, Sonja Boland & Francelyne Marano
Pages: 359-364
Published online: 14 Sep 2015
AbstractforActivation of Transcription Factors by Diesel Exhaust Particles in Human Bronchial Epithelial Cells in Vitro | References | PDF (2.1 MB)
  • 45 Views
  • 14 CrossRef citations
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Article
IgE Adjuvant Activity of Particles—What Physical Characteristics are Important?
Berit Granum, Per Ivar Gaarder & Martinus Løvik
Pages: 365-372
Published online: 14 Sep 2015
AbstractforIgE Adjuvant Activity of Particles—What Physical Characteristics are Important? | References | PDF (2.8 MB)
  • 12 Views
  • 6 CrossRef citations
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Article
Enhanced Allergic Sensitization in Animals Exposed to Particulate Air Pollution
M.I. Gilmour, M.J.K. Selgrade & A.L. Lambert
Pages: 373-380
Published online: 14 Sep 2015
AbstractforEnhanced Allergic Sensitization in Animals Exposed to Particulate Air Pollution | References | PDF (3 MB)
  • 29 Views
  • 6 CrossRef citations
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Article
Time Course of Eosinophilic Recruitment and Pulmonary Toxicity Biomarkers in an Allergic Asthma Model in Brown Norway Rats
D.B. Warheit, T.R. Webb & K.L. Reed
Pages: 381-388
Published online: 14 Sep 2015
AbstractforTime Course of Eosinophilic Recruitment and Pulmonary Toxicity Biomarkers in an Allergic Asthma Model in Brown Norway Rats | References | PDF (2.5 MB)
  • 27 Views
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Methods, Models, and Risk Assessment

Article
Dosimetry of Particles: Critical Factors Having Risk Assessment Implications
Frederick J. Miller
Pages: 389-395
Published online: 14 Sep 2015
AbstractforDosimetry of Particles: Critical Factors Having Risk Assessment Implications | References | PDF (2.5 MB)
  • 54 Views
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Article
Evaluation of Particle Clearance and Retention Kinetics in the Lungs of U.S. Coal Miners
Eileen D. Kuempel, Chi-Lang Tran, Ellen J. O’Flaherty, Leslie T. Stayner, Randall J. Smith, David A. Dankovic & John A. Bailer
Pages: 397-402
Published online: 14 Sep 2015
AbstractforEvaluation of Particle Clearance and Retention Kinetics in the Lungs of U.S. Coal Miners | References | PDF (2 MB)
  • 21 Views
  • 5 CrossRef citations
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Article
Mathematical Modeling to Predict the Responses to Poorly Soluble Particles in Rat Lungs
C.L. Tran, D. Buchanan, B.G. Miller, A.D. Jones & K. Donaldson
Pages: 403-409
Published online: 14 Sep 2015
AbstractforMathematical Modeling to Predict the Responses to Poorly Soluble Particles in Rat Lungs | References | PDF (2.1 MB)
  • 34 Views
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Article
Asbestos Fiber Type and Length in Lungs of Chrysotile Textile and Production Workers: Fibers Longer than 18 μm
Bruce W. Case, André Dufresne, A.D. McDonald, J.C. McDonald & Patrick Sébastien
Pages: 411-418
Published online: 14 Sep 2015
AbstractforAsbestos Fiber Type and Length in Lungs of Chrysotile Textile and Production Workers: Fibers Longer than 18 μm | References | PDF (2.8 MB)
  • 160 Views
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Article
The Necessity of Developing New Criteria for Carcinogen Classification of Fibers by the Mak Commission
Helmut Greim, Britta Brinkmann, Christina Pohlenz-Michel & Kyriakoula Ziegler-Skylakakis
Pages: 419-425
Published online: 14 Sep 2015
AbstractforThe Necessity of Developing New Criteria for Carcinogen Classification of Fibers by the Mak Commission | References | PDF (2.4 MB)
  • 23 Views
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