Xenobiotica, Volume 52, Issue 2 (2022)

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Xenobiotica, Volume 52, Issue 2 (2022)

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General Xenobiochemistry

Article
Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes
Joshua L. Johnson, Jiansheng Huang, Michael Rooney & Chungang Gu
Pages: 105-112
Published online: 16 Mar 2022
AbstractforOptimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Article
In silico predictions of the human pharmacokinetics/toxicokinetics of 65 chemicals from various classes using conformal prediction methodology
Urban Fagerholm, Sven Hellberg, Jonathan Alvarsson & Ola Spjuth
Pages: 113-118
Published online: 16 Mar 2022
AbstractforIn silico predictions of the human pharmacokinetics/toxicokinetics of 65 chemicals from various classes using conformal prediction methodology | Full Text | References | PDF (815.5 KB) | EPUB | Supplemental
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Article
Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3 receptor agonist
Motoki Ochi, Kohnosuke Kinoshita, Jun-ichi Yamaguchi & Hiromi Endo
Pages: 119-128
Published online: 29 Mar 2022
AbstractforBottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3 receptor agonist | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Open Access
Article
Species and tissue differences in regorafenib glucuronidation
Ayaka Kojima, Masayuki Nadai & Miki Katoh
Pages: 129-133
Published online: 29 Mar 2022
AbstractforSpecies and tissue differences in regorafenib glucuronidation | Full Text | References | PDF (535.6 KB) | EPUB
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Article
Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13
Tsutomu Shimada, Haruna Nagayoshi, Norie Murayama, Atsuki Sawai, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, F. Peter Guengerich & Shigeo Takenaka
Pages: 134-145
Published online: 13 Apr 2022
AbstractforOxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13 | Full Text | References | PDF (3.2 MB) | EPUB
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Clinical Pharmacokinetics and Metabolism

Article
Bioavailability, safety and tolerability of intravenous brivaracetam in healthy Japanese participants
Junichi Yamamoto, Kaori Ikeda & Armel Stockis
Pages: 146-151
Published online: 28 Mar 2022
AbstractforBioavailability, safety and tolerability of intravenous brivaracetam in healthy Japanese participants | Full Text | References | PDF (642.2 KB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor
Jiyuan Ma, Diksha Kaushik, Shirley Yeh, Valerie Northcutt, John Babiak, Nicole Risher, Marla Weetall, Young-Choon Moon, Ellen M. Welch, Lachlan Molony, Kylie O’Keefe & Ronald Kong
Pages: 152-164
Published online: 25 Mar 2022
AbstractforIn vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor | Full Text | References | PDF (1.5 MB) | EPUB
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Open Access
Article
Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS
Yueying Bian, Mengqi Sun, Huili Chen, Guanghui Ren, Kejia Fu, Nan Yang, Mei Zhang, Nan Zhou, Yang Lu, Ning Li, Yongjie Zhang, Xijing Chen & Di Zhao
Pages: 165-176
Published online: 29 Mar 2022
AbstractforMetabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Article
Herb–drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa
Mohd Aftab Alam, Yousef A. Bin Jardan, Mohammad Raish, Abdullah M. Al-Mohizea, Abdul Ahad & Fahad I. Al-Jenoobi
Pages: 177-185
Published online: 10 Mar 2022
AbstractforHerb–drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor
Yan Tan, Xiandeng Li, Minghai Tang, Huan Wang, Yong Chen, Haoyu Ye, Jiajia Zhao, Rui Wu, Panhong Wei, Leilei Du & Li Wan
Pages: 186-198
Published online: 18 Mar 2022
AbstractforMetabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Article
Spectroscopic observations of β-eudesmol binding to human cytochrome P450 isoforms 3A4 and 1A2, but not to isoforms 2C9, 2C19, and 2D6
Dawid Krenc & Kesara Na-Bangchang
Pages: 199-208
Published online: 08 Apr 2022
AbstractforSpectroscopic observations of β-eudesmol binding to human cytochrome P450 isoforms 3A4 and 1A2, but not to isoforms 2C9, 2C19, and 2D6 | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Xenobiotic transporters

Article
Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats
Fen Chen, Liu Wang, Xuejia Zhai, Nanxi Wang, Yanjie Qin, Chaoran Zhu, Sanlan Wu & Yongning Lu
Pages: 209-217
Published online: 29 Mar 2022
AbstractforEffect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats | Full Text | References | PDF (1 MB) | EPUB
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Correction

Correction
Correction
Page: 218
Published online: 21 Feb 2022
CitationforCorrection | Full Text | PDF (348.8 KB) | EPUB
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