mAbs, Volume 10, Issue 5 (2018)

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mAbs, Volume 10, Issue 5 (2018)

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Review

Review
The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity
Natasha A. Pereira, Kah Fai Chan, Pao Chun Lin & Zhiwei Song
Pages: 693-711
Published online: 07 May 2018
AbstractforThe “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity | Full Text | References | PDF (554.4 KB)
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Brief Report

Brief Report
N-terminal α-amino group modification of antibodies using a site-selective click chemistry method
De-zhi Li, Bing-nan Han, Rui Wei, Gui-yang Yao, Zhizhen Chen, Jie Liu, Terence C.W. Poon, Wu Su, Zhongyu Zhu, Dimiter S. Dimitrov & Qi Zhao
Pages: 712-719
Published online: 13 Apr 2018
AbstractforN-terminal α-amino group modification of antibodies using a site-selective click chemistry method | Full Text | References | PDF (881.2 KB) | Supplemental
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Reports

Report
Fab is the most efficient format to express functional antibodies by yeast surface display
Coline Sivelle, Raphaël Sierocki, Kelly Ferreira-Pinto, Stéphanie Simon, Bernard Maillere & Hervé Nozach
Pages: 720-729
Published online: 24 May 2018
AbstractforFab is the most efficient format to express functional antibodies by yeast surface display | Full Text | References | PDF (1,008.1 KB) | Supplemental
  • 6011 Views
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Report
A long non-coding SINEUP RNA boosts semi-stable production of fully human monoclonal antibodies in HEK293E cells
Emanuele Sasso, Debora Latino, Guendalina Froechlich, Mariangela Succoio, Margherita Passariello, Claudia De Lorenzo, Alfredo Nicosia & Nicola Zambrano PhD
Pages: 730-737
Published online: 10 May 2018
AbstractforA long non-coding SINEUP RNA boosts semi-stable production of fully human monoclonal antibodies in HEK293E cells | Full Text | References | PDF (731.5 KB) | Supplemental
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Open Access
Report
Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC
Isabel Figueroa, Doug Leipold, Steve Leong, Bing Zheng, Montserrat Triguero-Carrasco, Aimee Fourie-O'Donohue, Katherine R. Kozak, Keyang Xu, Melissa Schutten, Hong Wang, Andrew G. Polson & Amrita V. Kamath
Pages: 738-750
Published online: 18 May 2018
AbstractforPrediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC | Full Text | References | PDF (1.1 MB) | Supplemental
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Report
Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach
Alison Betts, Anne Keunecke, Tamara J. van Steeg, Piet H. van der Graaf, Lindsay B. Avery, Hannah Jones & Jan Berkhout
Pages: 751-764
Published online: 14 May 2018
AbstractforLinear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach | Full Text | References | PDF (1.3 MB) | Supplemental
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Report
Brain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration
Denise Karaoglu Hanzatian, Annette Schwartz, Farid Gizatullin, Jamie Erickson, Kangwen Deng, Ruth Villanueva, Christopher Stedman, Cristina Harris, Tariq Ghayur & Andrew Goodearl
Pages: 765-777
Published online: 05 Jun 2018
AbstractforBrain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration | Full Text | References | PDF (1 MB)
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Report
Delivery of ALX-0171 by inhalation greatly reduces respiratory syncytial virus disease in newborn lambs
Alejandro Larios Mora, Laurent Detalle, Jack M. Gallup, Albert Van Geelen, Thomas Stohr, Linde Duprez & Mark R. Ackermann
Pages: 778-795
Published online: 07 May 2018
AbstractforDelivery of ALX-0171 by inhalation greatly reduces respiratory syncytial virus disease in newborn lambs | Full Text | References | PDF (1.7 MB) | Supplemental
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Report
A unique allosteric insulin receptor monoclonal antibody that prevents hypoglycemia in the SUR-1−/− mouse model of KATP hyperinsulinism
Puja Patel, Lawrenshey Charles, John Corbin, Ira D. Goldfine, Kirk Johnson, Paul Rubin & Diva D. De León
Pages: 796-802
Published online: 01 Jun 2018
AbstractforA unique allosteric insulin receptor monoclonal antibody that prevents hypoglycemia in the SUR-1−/− mouse model of KATP hyperinsulinism | Full Text | References | PDF (703 KB)
  • 895 Views
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Report
Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice
Wolfgang F. Richter, Gregory J. Christianson, Nicolas Frances, Hans Peter Grimm, Gabriele Proetzel & Derry C. Roopenian
Pages: 803-813
Published online: 09 May 2018
AbstractforHematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice | Full Text | References | PDF (845.2 KB)
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