Leukemia & Lymphoma, Volume 61, Issue 9 (2020)

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Leukemia & Lymphoma, Volume 61, Issue 9 (2020)

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Commentaries

Pralatrexate and angioimmunoblastic T-cell lymphoma: time for a second look?
Carrie van der Weyden, Sean Harrop & Henry Miles Prince
Pages: 2031-2033
Published online: 30 Jul 2020
First Page PreviewforPralatrexate and angioimmunoblastic T-cell lymphoma: time for a second look? | Full Text | References | PDF (299.3 KB) | EPUB
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Truth or consequences: under-reporting of post-accrual changes in clinical trial design
Mary-Elizabeth M. Percival & Elihu H. Estey
Pages: 2034-2035
Published online: 22 Jun 2020
CitationforTruth or consequences: under-reporting of post-accrual changes in clinical trial design | Full Text | References | PDF (238.8 KB) | EPUB
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Reviews

Review
An update on options of therapy for aggressive mantle cell lymphoma
Jia Ruan, Samuel Yamshon, Koen van Besien & Peter Martin
Pages: 2036-2049
Published online: 26 Apr 2020
AbstractforAn update on options of therapy for aggressive mantle cell lymphoma | Full Text | References | PDF (1,020.5 KB) | EPUB
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Review

Review
Immune dysfunction complexity in chronic lymphocytic leukemia ‒ an issue to consider when designing novel therapeutic strategies
Shimrit Ringelstein-Harlev
Pages: 2050-2058
Published online: 26 Apr 2020
AbstractforImmune dysfunction complexity in chronic lymphocytic leukemia ‒ an issue to consider when designing novel therapeutic strategies | Full Text | References | PDF (902.7 KB) | EPUB
  • 234 Views
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Reviews

Review
Wilms’ tumor 1 gene in hematopoietic malignancies: clinical implications and future directions
Ping Luo, Wei Jing, Kezhen Yi, Sanyun Wu & Fuling Zhou
Pages: 2059-2067
Published online: 13 May 2020
AbstractforWilms’ tumor 1 gene in hematopoietic malignancies: clinical implications and future directions | Full Text | References | PDF (713.2 KB) | EPUB
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Original Articles

Article
SOX11 inhibits tumor proliferation and promotes cell adhesion mediated-drug resistance via a CD43 dependent manner in mantle cell lymphoma
Rumeng Yang, Zitian Huo, Yaqi Duan, Weilin Tong, Yiyun Zheng, Yinxia Su, Liping Lou, Qian Zhang, Sanpeng Xu, Changqing Peng, Dong Kuang & Guoping Wang
Pages: 2068-2081
Published online: 23 May 2020
AbstractforSOX11 inhibits tumor proliferation and promotes cell adhesion mediated-drug resistance via a CD43 dependent manner in mantle cell lymphoma | Full Text | References | PDF (2 MB) | EPUB
  • 248 Views
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Article
Autograft cellular composition and outcome in NHL patients: results of the prospective multicenter GOA study
Antti Turunen, Jaakko Valtola, Anu Partanen, Antti Ropponen, Outi Kuittinen, Hanne Kuitunen, Kaija Vasala, Lasse Ågren, Karri Penttilä, Leena Keskinen, Eeva-Riitta Savolainen, Marja Pyörälä, Taru Kuittinen, Tuomas Selander, Pentti Mäntymaa, Jukka Pelkonen, Esa Jantunen & Ville Varmavuo
Pages: 2082-2092
Published online: 18 May 2020
AbstractforAutograft cellular composition and outcome in NHL patients: results of the prospective multicenter GOA study | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 177 Views
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Article
Clinicopathologic characteristics and survival of patients with primary effusion lymphoma
Cristian Aguilar, Caddie Laberiano, Brady Beltran, Cecilia Diaz, Alvaro Taype-Rondan & Jorge J. Castillo
Pages: 2093-2102
Published online: 25 May 2020
AbstractforClinicopathologic characteristics and survival of patients with primary effusion lymphoma | Full Text | References | PDF (1.5 MB) | EPUB
  • 264 Views
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Article
Open-Label, phase 2 study of blinatumomab as second salvage therapy in adults with relapsed/refractory aggressive B-cell non-Hodgkin lymphoma
Luke Coyle, Nicholas J. Morley, Alessandro Rambaldi, Kylie D. Mason, Gregor Verhoef, Caroline L. Furness, Alicia Zhang, A. Scott Jung, David Cohan & Janet L. Franklin
Pages: 2103-2112
Published online: 16 Jun 2020
AbstractforOpen-Label, phase 2 study of blinatumomab as second salvage therapy in adults with relapsed/refractory aggressive B-cell non-Hodgkin lymphoma | Full Text | References | PDF (1,001.6 KB) | EPUB | Supplemental
  • 4765 Views
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Open Access
Article
Pretreatment serum soluble interleukin-2 receptor level predicts survival in patients with newly diagnosed follicular lymphoma
Kenji Nozaki, Hiroyuki Sugahara, Shuji Ueda, Jun Ishikawa, Shigeo Fuji, Hiroaki Masaie, Yuma Tada, Takahiro Karasuno, Masato Iida, Hideki Mitsui, Tsuyoshi Kamae, Norimitsu Saito, Yasuhiro Moriyama, Manabu Kawakami, Ruri Kato, Yoshiki Nakae, Toru Kida, Satoru Kosugi, Masashi Nakagawa, Yozo Uchida, Yasuhiko Azenishi, Ryoto Sakaniwa, Tetsuhisa Kitamura & Hirohiko Shibayama
Pages: 2113-2121
Published online: 04 May 2020
AbstractforPretreatment serum soluble interleukin-2 receptor level predicts survival in patients with newly diagnosed follicular lymphoma | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 393 Views
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Article
Direct-acting antivirals in relapsed or refractory hepatitis C virus-associated diffuse large B-cell lymphoma
Michele Merli, Irene Defrancesco, Carlo Visco, Caroline Besson, Alice Di Rocco, Annalisa Arcari, Antonello Sica, Emanuele Cencini, Maria Chiara Tisi, Marco Frigeni, Paolo Grossi, Benedetta Bianchi, Barbara Mora, Lorenza Bertù, Raffaele Bruno, Francesco Passamonti & Luca Arcaini
Pages: 2122-2128
Published online: 28 Apr 2020
AbstractforDirect-acting antivirals in relapsed or refractory hepatitis C virus-associated diffuse large B-cell lymphoma | Full Text | References | PDF (1,007.4 KB) | EPUB
  • 290 Views
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Article
Analysis of clinicopathological and cytogenetic differences between B-lymphoblastic lymphoma and B-lymphoblastic leukemia in childhood
Virginia Knez, Liming Bao, Billie Carstens & Xiayuan Liang
Pages: 2129-2135
Published online: 19 May 2020
AbstractforAnalysis of clinicopathological and cytogenetic differences between B-lymphoblastic lymphoma and B-lymphoblastic leukemia in childhood | Full Text | References | PDF (781.8 KB) | EPUB
  • 273 Views
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Article
A real-world study of first-line therapy in 280 consecutive Swedish patients ≥80 years with newly diagnosed diffuse large B-cell lymphoma: very elderly (≥85 years) do well on curative intended therapy
Anna Asklid, Sandra Eketorp Sylvan, Agnes Mattsson, Maria Winqvist, Hemming Johansson, Anders Österborg & Lotta Hansson
Pages: 2136-2144
Published online: 25 May 2020
AbstractforA real-world study of first-line therapy in 280 consecutive Swedish patients ≥80 years with newly diagnosed diffuse large B-cell lymphoma: very elderly (≥85 years) do well on curative intended therapy | Full Text | References | PDF (854.7 KB) | EPUB | Supplemental
  • 291 Views
  • 4 CrossRef citations
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Article
Efficacy and safety of single-agent pralatrexate for treatment of angioimmunoblastic T-cell lymphoma after failure of first line therapy: a pooled analysis
Jun Zhu, Ee Min Yeoh, Yoshinobu Maeda & Kensei Tobinai
Pages: 2145-2152
Published online: 14 Jun 2020
AbstractforEfficacy and safety of single-agent pralatrexate for treatment of angioimmunoblastic T-cell lymphoma after failure of first line therapy: a pooled analysis | Full Text | References | PDF (926 KB) | EPUB
  • 2747 Views
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Open Access
Article
Efficacy and safety of stem cell mobilization following gemcitabine, dexamethasone, cisplatin (GDP) salvage chemotherapy in patients with relapsed or refractory lymphoma
Catherine Tang, Osvaldo Espin-Garcia, Anca Prica, Vishal Kurkreti, Robert Kridel, Armand Keating, Christopher J. Patriquin, John Kuruvilla & Michael Crump
Pages: 2153-2160
Published online: 01 Jun 2020
AbstractforEfficacy and safety of stem cell mobilization following gemcitabine, dexamethasone, cisplatin (GDP) salvage chemotherapy in patients with relapsed or refractory lymphoma | Full Text | References | PDF (973.6 KB) | EPUB | Supplemental
  • 207 Views
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Article
Ponatinib-based therapy in adults with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the real-life OPAL study
Suzanne Tavitian, Madalina Uzunov, Emilie Bérard, Didier Bouscary, Xavier Thomas, Emmanuel Raffoux, Thibaut Leguay, Maria Pilar Gallego Hernanz, Ana Berceanu, Stéphane Leprêtre, Yosr Hicheri, Patrice Chevallier, Sarah Bertoli, Véronique Lhéritier, Hervé Dombret & Françoise Huguet
Pages: 2161-2167
Published online: 08 Jun 2020
AbstractforPonatinib-based therapy in adults with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the real-life OPAL study | Full Text | References | PDF (583.6 KB) | EPUB
  • 402 Views
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Article
Subclonal patterns in follow-up of acute myeloid leukemia combining whole exome sequencing and ultrasensitive IBSAFE digital droplet analysis
Louise Pettersson, Yilun Chen, Anthony M. George, Robert Rigo, Vladimir Lazarevic, Gunnar Juliusson, Lao H. Saal & Mats Ehinger
Pages: 2168-2179
Published online: 19 May 2020
AbstractforSubclonal patterns in follow-up of acute myeloid leukemia combining whole exome sequencing and ultrasensitive IBSAFE digital droplet analysis | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 2253 Views
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Open Access
Article
Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience*
Jan Philipp Bewersdorf, Rory M. Shallis, Lohith Gowda, Wei Wei, Karl Hager, Iris Isufi, Tae Kon Kim, Manoj M. Pillai, Stuart Seropian, Nikolai A. Podoltsev, Steven D. Gore, Alexa J. Siddon & Amer M. Zeidan
Pages: 2180-2190
Published online: 02 May 2020
AbstractforClinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience* | Full Text | References | PDF (1.2 MB) | EPUB
  • 463 Views
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Article
A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia
Stephen A. Strickland, Xin Victoria Wang, Jan Cerny, Jacob M. Rowe, Witold Rybka, Martin S. Tallman, Mark Litzow & Hillard M. Lazarus
Pages: 2191-2199
Published online: 30 May 2020
AbstractforA novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 309 Views
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Article
Venous thromboembolism following pegaspargase in adults receiving antithrombin supplementation
Craig W. Freyer, Alison Carulli, Alex Ganetsky, Mitchell E. Hughes, Tracy M. Krause, Colleen Timlin, Noelle V. Frey, Saar I. Gill, Elizabeth O. Hexner, Alison W. Loren, James K. Mangan, Mary Ellen Martin, Shannon R. McCurdy, Alexander E. Perl, Keith Pratz, David L. Porter & Selina M. Luger
Pages: 2200-2207
Published online: 01 Jun 2020
AbstractforVenous thromboembolism following pegaspargase in adults receiving antithrombin supplementation | Full Text | References | PDF (728.9 KB) | EPUB
  • 403 Views
  • 6 CrossRef citations
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Article
A phase II study of pomalidomide, daily oral cyclophosphamide, and dexamethasone in relapsed/refractory multiple myeloma
Oliver Van Oekelen, Samir Parekh, Hearn J. Cho, Nivetha Vishnuvardhan, Deepu Madduri, Joshua Richter, Chun Ip, Kenneth Lau, Erika Florendo, Ines S. Mancia, Joanne Thomas, Daniel Verina, Elaine Chan, Katarzyna Zarychta, Lisa La, Gina Strumolo, David T. Melnekoff, Violetta V. Leshchenko, Seunghee Kim-Schulze, Suzana Couto, Maria Wang, William E. Pierceall, Anjan Thakurta, Alessandro Laganà, Sundar Jagannath & Ajai Chari
Pages: 2208-2215
Published online: 19 Aug 2020
AbstractforA phase II study of pomalidomide, daily oral cyclophosphamide, and dexamethasone in relapsed/refractory multiple myeloma | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 3679 Views
  • 7 CrossRef citations
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Open Access
Article
Changes in primary outcome and sample size measures after initiation of accrual among trials supporting approval of drugs for hematological malignancies by the US food and drug administration
Irina Amitai, Pia Raanani & Daniel Shepshelovich
Pages: 2216-2220
Published online: 23 May 2020
AbstractforChanges in primary outcome and sample size measures after initiation of accrual among trials supporting approval of drugs for hematological malignancies by the US food and drug administration | Full Text | References | PDF (492.6 KB) | EPUB | Supplemental
  • 101 Views
  • 2 CrossRef citations
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Article
Venetoclax is safe and efficacious in relapsed/refractory AML
Chezi Ganzel, Ron Ram, Alexander Gural, Ofir Wolach, Sharon Gino-Moor, Vladimir Vainstein, Boaz Nachmias, Arie Apel, Maya Koren-Michowitz, Oren Pasvolsky, Ronit Yerushalmi, Ivetta Danylesko, Yosef Cohen, Galit Peretz, Yakir Moshe, Miri Zektser, Shay Yeganeh, Jacob M. Rowe & Yishai Ofran
Pages: 2221-2225
Published online: 18 May 2020
AbstractforVenetoclax is safe and efficacious in relapsed/refractory AML | Full Text | References | PDF (852 KB) | EPUB
  • 820 Views
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Letters to the Editor

Letter
Progressive multifocal leukoencephalopathy responsive to withdrawal of imatinib in a patient with FIP1L1-PDGFRA positive myeloid neoplasm
Sabine Blum, Vincent Dunet, Patrizia Comoli, Yordanka Tirefort, Yves Chalandon, Onya Opota, Denis Comte, Olivier Spertini, Françoise Livio, Jean Philippe Brouland & Renaud Du Pasquier
Pages: 2226-2229
Published online: 04 May 2020
First Page PreviewforProgressive multifocal leukoencephalopathy responsive to withdrawal of imatinib in a patient with FIP1L1-PDGFRA positive myeloid neoplasm | Full Text | References | PDF (1.7 MB) | EPUB
  • 307 Views
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Letter
Calcineurin-inhibitor induced pain syndrome after stem cell transplant
Ankur Varma, Jacob Loya, Mohammad Junaid Hussain, Hyun Don Yun, Elizabeth K. Gobbi, Ashley Reimer, Sunita Nathan, Celalettin Ustun & Lori Muffly
Pages: 2230-2233
Published online: 20 May 2020
First Page PreviewforCalcineurin-inhibitor induced pain syndrome after stem cell transplant | Full Text | References | PDF (470.3 KB) | EPUB
  • 289 Views
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Letter
Progressive multifocal leukoencephalopathy during treatment with lenalidomide and elotuzumab for multiple myeloma
Yuta Usui, Hiroto Nakano, Junji Komatsu, Kazuo Nakamichi, Masayuki Saijo, Seiichiro Takano, Ken-ichi Kamiya, Tsuyoshi Hamaguchi & Masahito Yamada
Pages: 2234-2237
Published online: 18 May 2020
First Page PreviewforProgressive multifocal leukoencephalopathy during treatment with lenalidomide and elotuzumab for multiple myeloma | Full Text | References | PDF (505.6 KB) | EPUB
  • 306 Views
  • 5 CrossRef citations
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Letter
BEAM conditioning regimen ensures better progression-free survival compared with TEAM but not with FEAM in lymphoma patients undergoing autologous stem cell transplant
Francesco Marchesi, Saveria Capria, Mariangela Pedata, Irene Terrenato, Laura Ballotta, Cira Riccardi, Elena Papa, Costantino Riemma, Silvia Trisolini, Maria Celentano, Giulia Regazzo, Felicetto Ferrara, Andrea Mengarelli & Alessandra Picardi
Pages: 2238-2241
Published online: 18 May 2020
First Page PreviewforBEAM conditioning regimen ensures better progression-free survival compared with TEAM but not with FEAM in lymphoma patients undergoing autologous stem cell transplant | Full Text | References | PDF (541.4 KB) | EPUB
  • 223 Views
  • 5 CrossRef citations
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Letter
A higher frequency of monoclonal B cell lymphocytosis among Egyptian relatives of CLL patients
Sara Kassem, Manal Fouda, Ahmed Akef, Khalid Elnaghi, Maryan Fahmi, Noha Eisa & Mohamad Rashwan
Pages: 2242-2245
Published online: 12 May 2020
First Page PreviewforA higher frequency of monoclonal B cell lymphocytosis among Egyptian relatives of CLL patients | Full Text | References | PDF (617.6 KB) | EPUB
  • 49 Views
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Letter
Primary plasma cell leukemia presenting as secondary pulmonary alveolar proteinosis
Aristea-Maria Papanota, Ioannis Ntanasis-Stathopoulos, Aliki Liakea, Efstathios Kastritis, Evangelos Terpos, Meletios-Athanasios Dimopoulos & Maria Gavriatopoulou
Pages: 2246-2249
Published online: 13 May 2020
First Page PreviewforPrimary plasma cell leukemia presenting as secondary pulmonary alveolar proteinosis | Full Text | References | PDF (1.1 MB) | EPUB
  • 138 Views
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Letter
Stage IV natural killer/T-cell lymphoma with chronic active Epstein–Barr virus, treated with pembrolizumab and TCRαβ-depleted haploidentical hematopoietic stem cell transplantation
Yeong Eun Kim, Hyery Kim, Juhee Shin, So Yoon Min, Sung Han Kang, Jin Kyung Suh, Kyung-Nam Koh & Ho Joon Im
Pages: 2250-2253
Published online: 30 Apr 2020
First Page PreviewforStage IV natural killer/T-cell lymphoma with chronic active Epstein–Barr virus, treated with pembrolizumab and TCRαβ-depleted haploidentical hematopoietic stem cell transplantation | Full Text | References | PDF (1.8 MB) | EPUB
  • 241 Views
  • 2 CrossRef citations
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Letter
Isolated trisomy 11 in patients with acute myeloid leukemia – is the prognosis not as grim as previously thought?*
Jan Philipp Bewersdorf, Rory M. Shallis, Autumn Diadamo, Lohith Gowda, Nikolai A. Podoltsev, Alexa Siddon & Amer M. Zeidan
Pages: 2254-2257
Published online: 26 Apr 2020
First Page PreviewforIsolated trisomy 11 in patients with acute myeloid leukemia – is the prognosis not as grim as previously thought?* | Full Text | References | PDF (747.5 KB) | EPUB | Supplemental
  • 227 Views
  • 1 CrossRef citations
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Letter
Evidence for separate transformation to acute myeloid leukemia and blastic plasmacytoid dendritic cell neoplasm from a shared ancestral hematopoietic clone
Marlise R. Luskin, Annette S. Kim, Sanjay S. Patel, Kyle Wright, Nicole R. LeBoeuf & Andrew A. Lane
Pages: 2258-2261
Published online: 04 May 2020
First Page PreviewforEvidence for separate transformation to acute myeloid leukemia and blastic plasmacytoid dendritic cell neoplasm from a shared ancestral hematopoietic clone | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 321 Views
  • 6 CrossRef citations
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Letter
Prevalence and clinical characteristics of EBV-positive diffuse large B-cell lymphoma in adult patients: a single center study in Thailand
Theerin Lanamtieng, Nattiya Teawtrakul & Piti Ungarreevittaya
Pages: 2262-2264
Published online: 14 May 2020
First Page PreviewforPrevalence and clinical characteristics of EBV-positive diffuse large B-cell lymphoma in adult patients: a single center study in Thailand | Full Text | References | PDF (490.2 KB) | EPUB
  • 188 Views
  • 1 CrossRef citations
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Letter
Peripherally inserted central catheter in patients with acute myeloid leukemia: incidence and risk factors for premature removal
Antonella Bruzzese, Antonio Chistolini, Salvatore Giacomo Morano, Danilo Alunni Fegatelli & Alessandra Micozzi
Pages: 2265-2267
Published online: 21 May 2020
First Page PreviewforPeripherally inserted central catheter in patients with acute myeloid leukemia: incidence and risk factors for premature removal | Full Text | References | PDF (370.7 KB) | EPUB
  • 133 Views
  • 3 CrossRef citations
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Letter
Primary cutaneous anaplastic large cell lymphoma and evolving clinical practice: 26 years of skin lesions with locoregional progression to systemic disease
Crystal Gao, Sean Harrop, Carrie Van Der Weyden, Chris McCormack & H. Miles Prince
Pages: 2268-2270
Published online: 12 May 2020
First Page PreviewforPrimary cutaneous anaplastic large cell lymphoma and evolving clinical practice: 26 years of skin lesions with locoregional progression to systemic disease | Full Text | References | PDF (626.2 KB) | EPUB
  • 137 Views
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Letter
Selecting the optimal targeted therapy for relapsed B-acute lymphoblastic leukemia
Jill Fulcher, Eugene Leung, Grace Christou, Christopher Bredeson & Mitchell Sabloff
Pages: 2271-2273
Published online: 19 May 2020
First Page PreviewforSelecting the optimal targeted therapy for relapsed B-acute lymphoblastic leukemia | Full Text | References | PDF (604.6 KB) | EPUB
  • 107 Views
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Letter
Hypomagnesemia is associated with an increased risk of early clinical failure in patients with Burkitt lymphoma
Jennifer Gile, Gordon Ruan, Jithma Abeykoon, M. Molly McMahon, William R. Macon & Thomas E. Witzig
Pages: 2274-2276
Published online: 02 May 2020
First Page PreviewforHypomagnesemia is associated with an increased risk of early clinical failure in patients with Burkitt lymphoma | Full Text | References | PDF (520.2 KB) | EPUB
  • 160 Views
  • 2 CrossRef citations
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Letter
Efficacy of venetoclax based salvage chemotherapy followed by “Minimal Residual Disease driven”-venetoclax maintenance therapy post-allotransplant in a young patient with high risk primary refractory acute myeloid leukemia
Elisabetta Todisco, Federica Gigli, Simona Sammassimo, Chiara Camisaschi, Patrizia Mancuso, Chiara Ronchini, Safaa Ramadan, Francesco Bertolini, Rocco Pastano & Corrado Tarella
Pages: 2277-2279
Published online: 02 May 2020
First Page PreviewforEfficacy of venetoclax based salvage chemotherapy followed by “Minimal Residual Disease driven”-venetoclax maintenance therapy post-allotransplant in a young patient with high risk primary refractory acute myeloid leukemia | Full Text | References | PDF (621.2 KB) | EPUB
  • 264 Views
  • 4 CrossRef citations
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Letter
C-reactive protein: not always a reliable marker of ongoing cytokine release syndrome in CAR-T therapy following IL-6 blockade
Jonathan Siglin, Ali Bukhari, Forat Lutfi, Noa G. Holtzman, Carl Shanholtz, Jean A. Yared, Nancy M. Hardy, Aaron P. Rapoport & Saurabh Dahiya
Pages: 2280-2282
Published online: 28 Apr 2020
First Page PreviewforC-reactive protein: not always a reliable marker of ongoing cytokine release syndrome in CAR-T therapy following IL-6 blockade | Full Text | References | PDF (419.3 KB) | EPUB
  • 245 Views
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