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Clinical Trials in Progress

Clinical Trial Design Considerations in Assessing Long‐Term Functional Impacts of Tiotropium in COPD: The Uplift Trial

, M.D., , , , , & show all
Pages 303-312 | Published online: 18 Aug 2004

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A-B Tonnel, T Perez, J-M Grosbois, C Verkindre, M-L Bravo & M Brun. (2008) Effect of tiotropium on health-related quality of life as a primary efficacy endpoint in COPD. International Journal of Chronic Obstructive Pulmonary Disease 3:2, pages 301-310.
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Andrea S. Gershon, Li Wang, Teresa To, Jin Luo & Ross E.G. Upshur. (2008) Survival with Tiotropium Compared to Long-Acting Beta-2-Agonists in Chronic Obstructive Pulmonary Disease. COPD: Journal of Chronic Obstructive Pulmonary Disease 5:4, pages 229-234.
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Kayleigh M Kew, Sofia Dias & Christopher J Cates. (2014) Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis. Cochrane Database of Systematic Reviews.
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Vito Brusasco & Fernando Martinez. 2011. Comprehensive Physiology. Comprehensive Physiology 1 31 .
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Crossref
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Crossref
Roozbeh Sharif, Christel R. Cuevas, Yue Wang, Mohit Arora & Gulshan Sharma. (2013) Guideline adherence in management of stable chronic obstructive pulmonary disease. Respiratory Medicine 107:7, pages 1046-1052.
Crossref
Loes E.M. Kistemaker, Tjitske A. Oenema, Herman Meurs & Reinoud Gosens. (2012) Regulation of airway inflammation and remodeling by muscarinic receptors: Perspectives on anticholinergic therapy in asthma and COPD. Life Sciences 91:21-22, pages 1126-1133.
Crossref
Heather Parsons, Rachel Damico & Venkataramana Sidhaye. 2012. Pulmonary Nanomedicine. Pulmonary Nanomedicine 235 257 .
Charlotta Karner, Jimmy Chong & Phillippa Poole. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Lorcan P. McGarvey, Sheldon Magder, Deborah Burkhart, Steven Kesten, Dacheng Liu, Raymond C. Manuel & Denis E. Niewoehner. (2012) Cause-specific mortality adjudication in the UPLIFT? COPD trial: Findings and recommendations. Respiratory Medicine 106:4, pages 515-521.
Crossref
Bartolome R Celli, Marc Decramer, Theodore Lystig, Steven Kesten & Donald P Tashkin. (2012) Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease. Respiratory Research 13:1, pages 66.
Crossref
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Crossref
Steven Kesten, Bartolome Celli, Marc Decramer, Dacheng Liu & Donald Tashkin. (2011) Adverse health consequences in COPD patients with rapid decline in FEV1 - evidence from the UPLIFT trial. Respiratory Research 12:1.
Crossref
Marc Decramer, Geert Molenberghs, Dacheng Liu, Bartolome Celli, Steven Kesten, Theodore Lystig & Donald P. Tashkin. (2011) Premature discontinuation during the UPLIFT study. Respiratory Medicine 105:10, pages 1523-1530.
Crossref
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Crossref
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Crossref
Bartolome R. Celli. 2011. COPD. COPD 81 98 .
Donald Tashkin, Bartolome Celli, Steven Kesten, Ted Lystig & Marc Decramer. (2010) Effect of tiotropium in men and women with COPD: Results of the 4-year UPLIFT? trial. Respiratory Medicine 104:10, pages 1495-1504.
Crossref
Mark T Dransfield, William Bailey, Glenn Crater, Amanda Emmett, Dianne M O'Dell & Barbara Yawn. (2010) Disease severity and symptoms among patients receiving monotherapy for COPD. Primary Care Respiratory Journal 20:1, pages 46-53.
Crossref
Nicola A. Hanania, David M. Mannino, Barbara P. Yawn, Douglas W. Mapel, Fernando J. Martinez, James F. Donohue, Mark Kosinski, Regina Rendas-Baum, Matthew Mintz, Steven Samuels, Priti Jhingran & Anand A. Dalal. (2010) Predicting risk of airflow obstruction in primary care: Validation of the lung function questionnaire (LFQ). Respiratory Medicine 104:8, pages 1160-1170.
Crossref
E.D. Bateman, S. Rennard, P.J. Barnes, P.V. Dicpinigaitis, R. Gosens, N.J. Gross, J.A. Nadel, M. Pfeifer, K. Racké, K.F. Rabe, B.K. Rubin, T. Welte & I. Wessler. (2009) Alternative mechanisms for tiotropium. Pulmonary Pharmacology & Therapeutics 22:6, pages 533-542.
Crossref
Bartolome Celli, Marc Decramer, Steven Kesten, Dacheng Liu, Sunil Mehra & Donald P. Tashkin. (2009) Mortality in the 4-Year Trial of Tiotropium (UPLIFT) in Patients with Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine 180:10, pages 948-955.
Crossref
Marc Decramer, Bartolome Celli, Steven Kesten, Theodore Lystig, Sunil Mehra & Donald P Tashkin. (2009) Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial. The Lancet 374:9696, pages 1171-1178.
Crossref
С.И. ОвчаренкоВ.А. Капустина. (2009) Хроническая обструктивная болезнь легких: особенности у женщин. PULMONOLOGIYA:2, pages 102-112.
Crossref
Gaetano Caramori, Ian M. Adcock & Alberto Papi. (2009) Clinical Definition of COPD Exacerbations and Classification of Their Severity. Southern Medical Journal 102:3, pages 277-282.
Crossref
A. Gillissen. (2009) Tiotropium in der Langzeittherapie bei COPDTiotropium in long-term treatment of COPD. Der Pneumologe 6:2, pages 111-112.
Crossref
. (2009) Tiotropium in Chronic Obstructive Pulmonary Disease. New England Journal of Medicine 360:2, pages 185-187.
Crossref
Didier Saey, Nad?ge Gosselin, Marc Decramer & Thierry Troosters. 2009. Kin?sith?rapie respiratoire. Kin?sith?rapie respiratoire 159 171 .
Stephen I. Rennard. 2009. Asthma and COPD. Asthma and COPD 823 836 .
Trevor T. Hansel, Andrew J. Tan, Peter J. Barnes & Onn Min Kon. 2009. Asthma and COPD. Asthma and COPD 615 626 .
Fabrizio Luppi, Bianca Beghè, Lorenzo Corbetta & Leonardo M. Fabbri. 2009. Asthma and COPD. Asthma and COPD 523 541 .
I. E. Stepanyan. (2008) Effect of long-term treatment with tiotropium bromide on lung function in patients with chronic obstructive pulmonary disease (the UPLIFT trial). PULMONOLOGIYA:6, pages 90-94.
Crossref
Andrea M Chen, Suzanne G Bollmeier & Patrick M Finnegan. (2008) Long-Acting Bronchodilator Therapy for the Treatment of Chronic Obstructive Pulmonary Disease. Annals of Pharmacotherapy 42:12, pages 1832-1842.
Crossref
Jan B. Oostenbrink, Maiwenn J. Al, Mark Oppe & Maureen P.M.H. Rutten-van M?lken. (2008) Expected Value of Perfect Information: An Empirical Example of Reducing Decision Uncertainty by Conducting Additional Research. Value in Health 11:7, pages 1070-1080.
Crossref
M. Decramer. (2008) Éclairage apporté par les essais cliniques avec le tiotropium. Revue des Maladies Respiratoires 25:10, pages 21-24.
Crossref
Nicholas J. Gross. (2008) Chronic Obstructive Pulmonary Disease: An Evidence-Based Approach to Treatment With a Focus on Anticholinergic Bronchodilation. Mayo Clinic Proceedings 83:11, pages 1241-1250.
Crossref
Donald P. Tashkin, Bartolome Celli, Stephen Senn, Deborah Burkhart, Steven Kesten, Shailendra Menjoge & Marc Decramer. (2008) A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease. New England Journal of Medicine 359:15, pages 1543-1554.
Crossref
N. Roche. (2008) Histoire naturelle de la BPCO?: des grandes ?tudes ? la pratique. Revue des Maladies Respiratoires 25:8, pages 16-19.
Crossref
Todd A. LeeA. Simon PickardDavid H. AuBrian BartleKevin B. Weiss. (2008) Risk for Death Associated with Medications for Recently Diagnosed Chronic Obstructive Pulmonary Disease. Annals of Internal Medicine 149:6, pages 380.
Crossref
Stephen I. Rennard & Jørgen Vestbo. (2008) The Many “Small COPDs”. Chest 134:3, pages 623-627.
Crossref
Patricia Macedo & Omar S. Usmani. (2008) Inhaled Drug Therapy in Chronic Obstructive Pulmonary Disease. Clinical Pulmonary Medicine 15:5, pages 239-247.
Crossref
Bartolomé R. Celli, Nicola E. Thomas, Julie A. Anderson, Gary T. Ferguson, Christine R. Jenkins, Paul W. Jones, Jørgen Vestbo, Katharine Knobil, Julie C. Yates & Peter M. A. Calverley. (2008) Effect of Pharmacotherapy on Rate of Decline of Lung Function in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine 178:4, pages 332-338.
Crossref
Christopher B. Cooper & Mark Dransfield. (2008) Primary Care of the Patient with Chronic Obstructive Pulmonary Disease?Part 4: Understanding the Clinical Manifestations of a Progressive Disease. The American Journal of Medicine 121:7, pages S33-S45.
Crossref
Nicholas Gross & David Levin. (2008) Primary Care of the Patient with Chronic Obstructive Pulmonary Disease?Part 2: Pharmacologic Treatment Across All Stages of Disease. The American Journal of Medicine 121:7, pages S13-S24.
Crossref
Bartolome R. Celli. (2008) Update on the Management of COPD. Chest 133:6, pages 1451-1462.
Crossref
Bartolome R. Celli, Claudia G. Cote, Suzanne C. Lareau & Paula M. Meek. (2008) Predictors of Survival in COPD: More than Just the FEV1. Respiratory Medicine 102, pages S27-S35.
Crossref
J. Moita, C. Bárbara, J. Cardoso, R. Costa, M. Sousa, J. Ruiz & M.L. Santos. (2008) Tiotropium improves FEV1 in patients with COPD irrespective of smoking status. Pulmonary Pharmacology & Therapeutics 21:1, pages 146-151.
Crossref
Juan Jos? Soler Catalu?a & Miguel ?ngel Mart?nez Garc?a. (2007) Factores pron?sticos en la EPOC. Archivos de Bronconeumolog?a 43:12, pages 680-691.
Crossref
S. Nitschmann & G. Schultze-Werninghaus. (2007) Auswirkungen der COPD-Therapie auf das PatientenüberlebenImpact of COPD therapy on patient survival: the TORCH study (TOwards a Revolution in COPD Health). Der Internist 48:12, pages 1450-1452.
Crossref
Nicola A. Hanania. (2007) Optimizing Maintenance Therapy for Chronic Obstructive Pulmonary Disease: Strategies for Improving Patient-Centered Outcomes. Clinical Therapeutics 29:10, pages 2121-2133.
Crossref
Nicola A. Hanania & Amir Sharafkhaneh. (2007) Update on the Pharmacologic Therapy for Chronic Obstructive Pulmonary Disease. Clinics in Chest Medicine 28:3, pages 589-607.
Crossref
Antonio Anzueto. (2007) Disease Modification in Chronic Obstructive Pulmonary Disease. Clinics in Chest Medicine 28:3, pages 609-616.
Crossref
Peter MA Calverley & Stephen I Rennard. (2007) What have we learned from large drug treatment trials in COPD?. The Lancet 370:9589, pages 774-785.
Crossref
Robert A. Wise & Donald P. Tashkin. (2007) Optimizing Treatment of Chronic Obstructive Pulmonary Disease: An Assessment of Current Therapies. The American Journal of Medicine 120:8, pages S4-S13.
Crossref
C.P. van Schayck, P.J.E. Bindels, M. Decramer, P.N.R. Dekhuijzen, H.A.M. Kerstjens, J.W.M. Muris, G.M. Asijee & C. Spreeuwenberg. (2007) Making COPD a treatable disease?An integrated care perspective. Respiratory Medicine: COPD Update 3:2, pages 49-56.
Crossref
Maureen P. M. H. Rutten-van Mölken, Jan B. Oostenbrink, Marc Miravitlles & Brigitta U. Monz. (2007) Modelling the 5-year cost effectiveness of tiotropium, salmeterol and ipratropium for the treatment of chronic obstructive pulmonary disease in Spain. The European Journal of Health Economics 8:2, pages 123-135.
Crossref
V. A. Ignatiev, O. N. Titova, M. A. Kameneva & O. A. Sukhovskaya. (2007) Experience of long-term treatment with tiotropium bromide of patients with chronic obstructive pulmonary disease. PULMONOLOGIYA:2, pages 74-78.
Crossref
Klaus F. Rabe. (2007) Treating COPD ? The TORCH Trial, P Values, and the Dodo. New England Journal of Medicine 356:8, pages 851-854.
Crossref
Juan Jos? Soler Catalu?a & Miguel ?ngel Mart?nez Garc?a. (2007) Prognostic Factors in Chronic Obstructive Pulmonary Disease. Archivos de Bronconeumolog?a ((English Edition)) 43:12, pages 680-691.
Crossref
Didier Saey, Nad?ge Gosselin, Marc Decramer & Thierry Troosters. 2007. Kin?sith?rapie respiratoire. Kin?sith?rapie respiratoire 135 147 .
Robert A. Stockley, Stephen I. Rennard, Klaus Rabe & Bartolome CelliJoan B. Soriano. 2007. Chronic Obstructive Pulmonary Disease. Chronic Obstructive Pulmonary Disease 792 804 .
Maureen P.M.H. Rutten-van M?lken, Jan B. Oostenbrink, Donald P. Tashkin, Deborah Burkhart & Brigitta U. Monz. (2006) Does Quality of Life of COPD Patients as Measured by the Generic EuroQol Five-Dimension Questionnaire Differentiate Between COPD Severity Stages?. Chest 130:4, pages 1117-1128.
Crossref
Donald P. Tashkin. (2006) The Role of Patient-Centered Outcomes in the Course of Chronic Obstructive Pulmonary Disease: How Long-Term Studies Contribute to Our Understanding. The American Journal of Medicine 119:10, pages 63-72.
Crossref
Claudia G. Cote. (2006) Surrogates of Mortality in Chronic Obstructive Pulmonary Disease. The American Journal of Medicine 119:10, pages 54-62.
Crossref
Antonio Anzueto. (2006) Clinical Course of Chronic Obstructive Pulmonary Disease: Review of Therapeutic Interventions. The American Journal of Medicine 119:10, pages 46-53.
Crossref
Graeme P. Currie, Catherine Rossiter, Sean A. Miles, Daniel K.C. Lee & Owen J. Dempsey. (2006) Effects of tiotropium and other long acting bronchodilators in chronic obstructive pulmonary disease. Pulmonary Pharmacology & Therapeutics 19:2, pages 112-119.
Crossref
Bartolome Celli, Roger Goldstein, Jos? Jardim & Katharine Knobil. (2005) Future perspectives in COPD. Respiratory Medicine 99, pages S41-S48.
Crossref
R Graham Barr, Jean Bourbeau & Carlos A Camargo Jr. (2005) Tiotropium for stable chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2013:1.
Crossref
James F Donohue. (2005) Still looking for answers in COPD. The Lancet 365:9470, pages 1518-1520.
Crossref
Tsuyoshi Ohmura & Hidekazu Nishikawa. (2005) . Folia Pharmacologica Japonica 125:5, pages 307-313.
Crossref

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