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Cancer Biology & Therapy Volume 12, 2011 - Issue 10
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Research Paper

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

Ubaldo E. Martinez-Outschoorn Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Department of Medical Oncology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; These authors contributed equally on this paper
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Allison F. Goldberg Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Department of Medical Oncology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; These authors contributed equally on this paper
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Zhao Lin Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
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Ying-Hui Ko Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
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Neal Flomenberg The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Department of Surgery; Thomas Jefferson University; Philadelphia, PA USA
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Chenguang Wang Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
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Stephanos Pavlides Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
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Richard G. Pestell Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
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Anthony Howell Manchester Breast Center and Breakthrough Breast Cancer Research Unit; Paterson Institute for Cancer Research; School of Cancer, Enabling Sciences and Technology; Manchester Academic Health Science Center; University of Manchester, UK
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Federica Sotgia Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Manchester Breast Center and Breakthrough Breast Cancer Research Unit; Paterson Institute for Cancer Research; School of Cancer, Enabling Sciences and Technology; Manchester Academic Health Science Center; University of Manchester, UKCorrespondence[email protected] [email protected]
&
Michael P. Lisanti Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Manchester Breast Center and Breakthrough Breast Cancer Research Unit; Paterson Institute for Cancer Research; School of Cancer, Enabling Sciences and Technology; Manchester Academic Health Science Center; University of Manchester, UK; Department of Surgery; Thomas Jefferson University; Philadelphia, PA USACorrespondence[email protected] [email protected]
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Pages 924-938 | Received 20 Jul 2011, Accepted 16 Aug 2011, Published online: 15 Nov 2011

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Aria Dianati-Nasab, Hamid Nasrollahi, Zahra Khoshdel, Mahboobeh Ghorbani & Sayed Mohammad Shafiee. (2022) Overexpression of TIGAR and HO-1 in peripheral blood mononuclear cells (PBMCs) of breast cancer patients treated with radiotherapy. International Journal of Radiation Biology 98:10, pages 1551-1558.
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Michael P. Lisanti, Ubaldo E. Martinez-Outschoorn & Federica Sotgia. (2013) Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery. Cell Cycle 12:17, pages 2723-2732.
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Ubaldo E Martinez-Outschoorn, Joseph M Curry, Ying-Hui Ko, Zhao Lin, Madalina Tuluc, David Cognetti, Ruth C Birbe, Edmund Pribitkin, Alessandro Bombonati, Richard G Pestell, Anthony Howell, Federica Sotgia & Michael P Lisanti. (2013) Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment. Cell Cycle 12:16, pages 2580-2597.
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Heath D. Skinner, Matthew R. McCurdy, Alfredo E. Echeverria, Steven H. Lin, James W. Welsh, Michael S. O'Reilly, Wayne L. Hofstetter, Jaffer A. Ajani, Ritsuko Komaki, James D. Cox, Vlad C. Sandulache, Jeffrey N. Myers & Thomas M. Guerrero. (2013) Metformin use and improved response to therapy in esophageal adenocarcinoma. Acta Oncologica 52:5, pages 1002-1009.
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Paola Avena, Wanda Anselmo, Chenguang Wang, Richard G. Pestell, Rebecca S. Lamb, Ivan Casaburi, Sebastiano Andò, Ubaldo E. Martinez-Outschoorn & Michael P. Lisanti. (2013) Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle 12:9, pages 1360-1370.
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Joseph M. Curry, Madalina Tuluc, Diana Whitaker-Menezes, Julie A. Ames, Archana Anantharaman, Aileen Butera, Benjamin Leiby, David Cognetti, Federica Sotgia, Michael P. Lisanti & Ubaldo E. Martinez-Outschoorn. (2013) Cancer metabolism, stemness and tumor recurrence. Cell Cycle 12:9, pages 1371-1384.
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Ahmed F. Salem, Mazhar Salim Al-Zoubi, Diana Whitaker-Menezes, Ubaldo E. Martinez-Outschoorn, Rebecca Lamb, James Hulit, Anthony Howell, Ricardo Gandara, Marina Sartini, Ferruccio Galbiati, Generoso Bevilacqua, Federica Sotgia & Michael P. Lisanti. (2013) Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment. Cell Cycle 12:5, pages 818-825.
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Rosa Sanchez-Alvarez, Ubaldo E. Martinez-Outschoorn, Zhao Lin, Rebecca Lamb, James Hulit, Anthony Howell, Federica Sotgia, Emanuel Rubin & Michael P. Lisanti. (2013) Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism. Cell Cycle 12:2, pages 289-301.
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Rosa Sanchez-Alvarez, Ubaldo E. Martinez-Outschoorn, Rebecca Lamb, James Hulit, Anthony Howell, Ricardo Gandara, Marina Sartini, Emanuel Rubin, Michael P. Lisanti & Federica Sotgia. (2013) Mitochondrial dysfunction in breast cancer cells prevents tumor growth. Cell Cycle 12:1, pages 172-182.
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Ubaldo E. Martinez-Outschoorn, Renee Balliet, Zhao Lin, Diana Whitaker-Menezes, Ruth C. Birbe, Alessandro Bombonati, Stephanos Pavlides, Rebecca Lamb, Sharon Sneddon, Anthony Howell, Federica Sotgia & Michael P. Lisanti. (2012) BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment. Cell Cycle 11:23, pages 4402-4413.
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Ubaldo E. Martinez-Outschoorn, Renee M. Balliet, Zhao Lin, Diana Whitaker-Menezes, Anthony Howell, Federica Sotgia & Michael P. Lisanti. (2012) Hereditary ovarian cancer and two-compartment tumor metabolism. Cell Cycle 11:22, pages 4152-4166.
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Claudia Capparelli, Barbara Chiavarina, Diana Whitaker-Menezes, Timothy G. Pestell, Richard G. Pestell, James Hulit, Sebastiano Andò, Anthony Howell, Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle 11:19, pages 3599-3610.
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Agnieszka K. Witkiewicz, Diana Whitaker-Menezes, Abhijit Dasgupta, Nancy J. Philp, Zhao Lin, Ricardo Gandara, Sharon Sneddon, Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) Using the “reverse Warburg effect” to identify high-risk breast cancer patients. Cell Cycle 11:6, pages 1108-1117.
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Adam Ertel, Aristotelis Tsirigos, Diana Whitaker-Menezes, Ruth Birbe, Stephanos Pavlides, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Federica Sotgia & Michael P. Lisanti. (2012) Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism. Cell Cycle 11:2, pages 253-263.
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Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Mark L. Tykocinski, Fnu Nagajyothi, Fabiana S. Machado, Herbert B. Tanowitz, Federica Sotgia & Michael P. Lisanti. (2011) Energy transfer in "parasitic" cancer metabolism. Cell Cycle 10:24, pages 4208-4216.
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Diana Whitaker-Menezes, Ubaldo E. Martinez-Outschoorn, Neal Flomenberg, Ruth Birbe, Agnieszka K. Witkiewicz, Anthony Howell, Stephanos Pavlides, Aristotelis Tsirigos, Adam Ertel, Richard G. Pestell, Paolo Broda, Carlo Minetti, Michael P. Lisanti & Federica Sotgia. (2011) Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ. Cell Cycle 10:23, pages 4047-4064.
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