Expert Opinion on Drug Discovery, Volume 19, Issue 6 (2024)

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Expert Opinion on Drug Discovery, Volume 19, Issue 6 (2024)

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Editorial

Editorial
Lessons learnt from machine learning in early stages of drug discovery
Claudio N. Cavasotto, Juan I. Di Filippo & Valeria Scardino
Pages: 631-633
Published online: 10 May 2024
First Page PreviewforLessons learnt from machine learning in early stages of drug discovery | Full Text | References | PDF (165.2 KB) | EPUB
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Editorial
Challenges with drug efficacy prediction of in vitro models of biofilms infecting cystic fibrosis airway
Ana Margarida Sousa & Maria Olívia Pereira
Pages: 635-638
Published online: 07 May 2024
First Page PreviewforChallenges with drug efficacy prediction of in vitro models of biofilms infecting cystic fibrosis airway | Full Text | References | PDF (170.5 KB) | EPUB
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Drug Discovery Case History

Article
Lessons learned from the failure of solanezumab as a prospective treatment strategy for Alzheimer’s disease
Madia Lozupone, Vittorio Dibello, Rodolfo Sardone, Fabio Castellana, Roberta Zupo, Luisa Lampignano, Ilaria Bortone, Roberta Stallone, Mario Altamura, Antonello Bellomo, Antonio Daniele, Vincenzo Solfrizzi & Francesco Panza
Pages: 639-647
Published online: 29 Apr 2024
AbstractforLessons learned from the failure of solanezumab as a prospective treatment strategy for Alzheimer’s disease | Full Text | References | PDF (1.9 MB) | EPUB
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Review

Review Article
Recent advances in computational and experimental protein-ligand affinity determination techniques
Visvaldas Kairys, Lina Baranauskiene, Migle Kazlauskiene, Asta Zubrienė, Vytautas Petrauskas, Daumantas Matulis & Egidijus Kazlauskas
Pages: 649-670
Published online: 07 May 2024
AbstractforRecent advances in computational and experimental protein-ligand affinity determination techniques | Full Text | References | PDF (1.9 MB) | EPUB
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Review Article
Understanding the impact of binding free energy and kinetics calculations in modern drug discovery
Victor A. Adediwura, Kushal Koirala, Hung N. Do, Jinan Wang & Yinglong Miao
Pages: 671-682
Published online: 09 May 2024
AbstractforUnderstanding the impact of binding free energy and kinetics calculations in modern drug discovery | Full Text | References | PDF (847.8 KB) | EPUB
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Review Article
Another string to your bow: machine learning prediction of the pharmacokinetic properties of small molecules
Davide Bassani, Neil John Parrott, Nenad Manevski & Jitao David Zhang
Pages: 683-698
Published online: 10 May 2024
AbstractforAnother string to your bow: machine learning prediction of the pharmacokinetic properties of small molecules | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
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Open Access
Review Article
Innovative peptide architectures: advancements in foldamers and stapled peptides for drug discovery
Zhou Dongrui, Maho Miyamoto, Hidetomo Yokoo & Yosuke Demizu
Pages: 699-723
Published online: 16 May 2024
AbstractforInnovative peptide architectures: advancements in foldamers and stapled peptides for drug discovery | Full Text | References | PDF (1.7 MB) | EPUB
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Review Article
Using DNA-encoded libraries of fragments for hit discovery of challenging therapeutic targets
Guixian Zhao, Mengping Zhu, Yangfeng Li, Gong Zhang & Yizhou Li
Pages: 725-740
Published online: 16 May 2024
AbstractforUsing DNA-encoded libraries of fragments for hit discovery of challenging therapeutic targets | Full Text | References | PDF (2.3 MB) | EPUB
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Review Article
New drug discovery strategies for the treatment of benznidazole-resistance in Trypanosoma cruzi, the causative agent of Chagas disease
Silvane Maria Fonseca Murta, Pedro Augusto Lemos Santana, Thibault Joseph William Jacques Dit Lapierre, André Berndt Penteado, Marissa El Hajje, Thabata Corazza Navarro Vinha, Daniel Barbosa Liarte, Mariana Laureano de Souza, Gustavo Henrique Goulart Trossini, Celso de Oliveira Rezende Júnior, Renata Barbosa de Oliveira & Rafaela Salgado Ferreira
Pages: 741-753
Published online: 07 May 2024
AbstractforNew drug discovery strategies for the treatment of benznidazole-resistance in Trypanosoma cruzi, the causative agent of Chagas disease | Full Text | References | PDF (1.4 MB) | EPUB
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Review Article
Hits and misses with animal models of narcolepsy and the implications for drug discovery
Ramakrishna Nirogi, Pradeep Jayarajan, Vijay Benade, Renny Abraham & Vinod Kumar Goyal
Pages: 755-768
Published online: 15 May 2024
AbstractforHits and misses with animal models of narcolepsy and the implications for drug discovery | Full Text | References | PDF (592.7 KB) | EPUB
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