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Research Article

Article
Synthesis of indole-functionalized isoniazid conjugates with potent antimycobacterial and antioxidant efficacy
Renu Gavadia, Jyoti Rasgania, Neetu Sahu, Mandira Varma-Basil, Varsha Chauhan, Sanjay Kumar, Satbir Mor, Devender Singh & Komal Jakhar
Published online: 23 Jul 2024
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Research Article

Article
New pyridopyrimidine derivatives as dual EGFR and CDK4/cyclin D1 inhibitors: synthesis, biological screening and molecular modeling
Fatma MA Krakisha, Dina IA Othman, Walaa M El Husseiny & Magda NA Nasr
Published online: 18 Jul 2024
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Review

Review Article
Targeted small molecule therapy and inhibitors for lymphoma
Zhong-Hui Wang, Xiang Zheng, Guo-Wu Rao & Quan Zheng
Published online: 17 Jul 2024
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Research Article

Article
Barbiturate–sulfonate hybrids as potent cholinesterase inhibitors: design, synthesis and molecular modeling studies
Asmaa F Kassem, Mohamed A Omar, Ahmed Temirak, Riham A El-Shiekh & Aladdin M Srour
Published online: 16 Jul 2024
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Research Article

Article
Thiourea-functionalized aminoglutethimide derivatives as anti-leishmanial agents
Muhammad Sajid, Hina Siddiqui, Humaira Zafar, Sammer Yousuf, Michael D Threadgill & Muhammad Iqbal Choudhary
Published online: 02 Jul 2024
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Research Article

Article
In vitro anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety
Dalal Nasser Binjawhar, Fawziah A Al-Salmi, Maha Ali Alghamdi, Ola A Abu Ali, Eman Fayad, Youstina William Rizzk, Nourhan M Ali, Ibrahim Mohey El-Deen & Elsayed H Eltamany
Published online: 01 Jul 2024
  • 34 Views
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Review

Review Article
Regulation of post-translational modification of PD-L1 and associated opportunities for novel small-molecule therapeutics
Jinglin Tang, Han Liu, Jinze Li, Yibo Zhang, Suyang Yao, Kan Yang, Zhihao You, Xiaoqiang Qiao & Yali Song
Published online: 01 Jul 2024
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Research Article

Article
A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer
Nur Farisya Shamsudin, Sze-Wei Leong, Andreas Koeberle, Utid Suriya, Thanyada Rungrotmongkol, Suet Lin Chia, Muhammad Taher, Muhammad Salahuddin Haris, Hussah Abdullah Alshwyeh, Areej A Alosaimi, Ahmed Mediani, Muna Abdulsalam Ilowefah, Deri Islami, Siti Munirah Mohd Faudzi, Mohd Fadhlizil Fasihi Mohd Aluwi, Lam Kok Wai & Kamal Rullah
Published online: 01 Jul 2024
  • 71 Views
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Research Article

Article
NMR analysis, cytotoxic activity and theoretical study of a complex between SRPIN340 and p-sulfonic acid calix[6]arene
Lívia Cristina de Souza Viol, Natália Aparecida Liberto Silva, Cristiane Isaac Cerceau, Marcus Vinícius de Andrade Barros, Raoni Pais Siqueira, Victor Hugo Sousa Gonçalves, Gustavo Costa Bressan, Sergio Antonio Fernandes, Elson Santiago Alvarenga & Róbson Ricardo Teixeira
Published online: 01 Jul 2024
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Research Article

Article
Identification of novel benzothiazole–thiadiazole-based thiazolidinone derivative: in vitro and in silico approaches to develop promising anti-Alzheimer’s agents
Shoaib Khan, Rafaqat Hussain, Tayyiaba Iqbal, Yousaf Khan, Urooj Jamal, Hany W Darwish & Muhammad Adnan
Published online: 28 Jun 2024
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Research Article

Article
Synthesis, characterization and biological evaluation of aurones as potential neuroprotective agents
Muhammad Ayaz, Syed Wadood Ali Shah, Mohammad Shoaib, Fawad Ali Shah & Fawad Ahmed
Published online: 28 Jun 2024
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Correction notice

Correction
The emerging field of senotherapeutic drugs
Published online: 27 Jun 2024
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Free Access

Article Commentary

Article Commentary
Expanding potential of quinoline hydrazide/hydrazone derivatives as anticancer agents
Sangeeta Verma, Sukhbir Lal & Rakesh Narang
Published online: 27 Jun 2024
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Research Article

Article
Structural investigations and antibacterial, antifungal and anticancer studies on zinc salicylaldimine complexes
Ahmed BM Ibrahim, Ereny S Williem, S Abd Elkhalik, Alexander Villinger & SM Abbas
Published online: 20 Jun 2024
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Research Article

Article
Synthesis of novel hybrids of 1,2,3-triazoles-hydrazone: targeting cholinesterases and Alzheimer's related genes
Diba Shareghi-Boroujeni, Aida Iraji, Mahintaj Dara, Mohammad Hashem Hashempur, Shahrokh Zare, Roshanak Hariri, Tahmineh Akbarzadeh & Mina Saeedi
Published online: 12 Jun 2024
  • 52 Views
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Review

Review Article
Aminopyridines in the development of drug candidates against protozoan neglected tropical diseases
Romain Mustière, Alexandra Dassonville-Klimpt & Pascal Sonnet
Published online: 10 Jun 2024
  • 10 Views
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Research Article

Article
Novel candidates synthesis of indenopyrazole, indenoazine and indenothiophene, with anticancer and in silico studies
Magda H Abdellattif, Mohammed Gomma Assy, Ahmed Elfarargy, Fawzy Ramadan, Marwa S Elgendy, Abdul-Hamid M Emwas, Mariusz Jaremko & Wesam S Shehab
Published online: 05 Jun 2024
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Research Article

Article
Thiazolidinone-linked-1,2,3-triazoles with (R)-Carvone as new potential anticancer agents
Ali Oubella, Manal A Alossaimi, Yassine Riadi, Mashooq Ahmad Bhat, Ahmed Hassan Bakheit, Mohamed Labd Taha, Aziz Auhmani, Hamid Morjani, Mohammed H Geesi & Moulay Youssef Ait Itto
Published online: 30 May 2024
  • 39 Views
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Research Article

Article
Exploring the therapeutic potential of cinnamoyl derivatives in attenuating inflammation in lipopolysaccharide-induced Caco-2 cells
Marcella Reale, Erica Costantini, Lisa Aielli, Annalisa Di Rienzo, Giuseppe Di Biase, Antonio Di Stefano & Ivana Cacciatore
Published online: 29 May 2024
  • 11 Views
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Research Article

Article
Design, semi-synthesis and bioevaluation of koumine-like derivatives as potential antitumor agents in vitro and in vivo
Xingjun Xu, Yan Yu, Zhiwei Wang, Han Zhou, Ling Zhang, Hao Wang, Dian Liu, Yanfang Liu, Jixia Wang, Yaopeng Zhao & Xinmiao Liang
Published online: 29 May 2024
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Editorial

Editorial
Epigenetics: rethinking of drug research and development
Kenneth Lundstrom
Published online: 29 May 2024
  • 90 Views
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Research Article

Article
Isocoumarins incorporating chalcone moieties act as isoform selective tumor-associated carbonic anhydrase inhibitors
Mehmet Onyilmaz, Murat Koca, Andrea Ammara, Mustafa Degirmenci & Claudiu T Supuran
Published online: 28 May 2024
  • 23 Views
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Research Article

Article
In vitro cytotoxicity screening of some 3-substituted-4-oxo-imidazolidin-2-(1H)-thione derivatives as anticancer drug
Ibrahim Mohey El-Deen, Elsayed H Eltamany & Nourhan M Ali
Published online: 24 May 2024
  • 17 Views
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Research Article

Article
Palbociclib-derived multifunctional molecules for lysosomal targeting and diagnostic-therapeutic integration
Haili Yang, Xiaoyang Zhang, Letian Xu, Yuting Zhou, Rui Ma, Hao Chen, Siqin Zhao, Munkhtsetseg Baatar, Lvyi Chen, Xukun Deng, Hongwei Gu & Xiaoming Wang
Published online: 22 May 2024
  • 20 Views
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Research Article

Article
Design, synthesis and inhibition evaluation of novel chalcone amide α-glucosidase inhibitors
Song Yao Lv & Li Ping Cheng
Published online: 22 May 2024
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Research Article

Article
Design, synthesis and biological evaluation of novel pyrazole-based compounds as potential chemotherapeutic agents
Maiy Y Jaballah, Nooran S Elleboudy, Marwa Sharaky, Khaled A M Abouzid & Mai I Shahin
Published online: 20 May 2024
  • 25 Views
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Research Article

Article
Anti-proliferation evaluation of new derivatives of indole-6-carboxylate ester as receptor tyrosine kinase inhibitors
Mustafa M Allawi, Ammar A Razzak Mahmood, Lubna H Tahtamouni, Abdulrahman M Saleh, Sana I Kanaan, Khaled M Saleh, Mai F AlSakhen, Nisreen Himsawi & Salem R Yasin
Published online: 10 May 2024
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Corrigendum

Correction
Corrigendum
Published online: 01 Aug 2019
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Free Access