Future Medicinal Chemistry, Volume 7, Issue 13 (2015)

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Future Medicinal Chemistry, Volume 7, Issue 13 (2015)

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Special Focus Issue: Frontiers in Nucleic Acid-Based Drug R&D – Foreword

Frontiers in Nucleic Acid-Based Drug Research and Development
Lun Quan Sun & Jonathan P Wong
Pages: 1619-1621
Published online: 14 Oct 2015
First Page PreviewforFrontiers in Nucleic Acid-Based Drug Research and Development | Full Text | References | PDF (1.1 MB)
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Editorial

Editorial
How can Novel Microscopic Approaches Shed Light on the Function of Nucleic Acid-Based Drugs?
Daniel Vocelle, Christina Chan & S Patrick Walton
Pages: 1623-1625
Published online: 18 Sep 2015
First Page PreviewforHow can Novel Microscopic Approaches Shed Light on the Function of Nucleic Acid-Based Drugs? | Full Text | References | PDF (947.8 KB)
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Free Access
Editorial
Exploring the Dark Matter of the Human Genome Using Oligonucleotide-Based Molecules
Concetta Avitabile, Luca Domenico D'Andrea & Alessandra Romanelli
Pages: 1627-1630
Published online: 18 Sep 2015
First Page PreviewforExploring the Dark Matter of the Human Genome Using Oligonucleotide-Based Molecules | Full Text | References | PDF (919.6 KB)
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Commentary

Editorial
Antisense Oligonucleotide Drugs for Duchenne Muscular Dystrophy: How Far Have We Come and What Does the Future Hold?
Ashley Guncay & Toshifumi Yokota
Pages: 1631-1635
Published online: 01 Oct 2015
First Page PreviewforAntisense Oligonucleotide Drugs for Duchenne Muscular Dystrophy: How Far Have We Come and What Does the Future Hold? | Full Text | References | PDF (1.1 MB)
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Editorial
Application of Modified Antisense Oligonucleotides and Sirnas as Antiviral Drugs
Anke Wagner, Claus-Thomas Bock, Henry Fechner & Jens Kurreck
Pages: 1637-1642
Published online: 18 Sep 2015
First Page PreviewforApplication of Modified Antisense Oligonucleotides and Sirnas as Antiviral Drugs | Full Text | References | PDF (1.1 MB)
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Preliminary Communication

Brief Report
Design, Synthesis and Cellular Metabolism Study of 4′-Selenonucleosides
Jinha Yu, Pramod K Sahu, Gyudong Kim, Shuhao Qu, Yoojin Choi, Jayoung Song, Sang Kook Lee, Minsoo Noh, Sunghyouk Park & Lak Shin Jeong
Pages: 1643-1655
Published online: 24 Sep 2015
AbstractforDesign, Synthesis and Cellular Metabolism Study of 4′-Selenonucleosides | Full Text | References | PDF (1.3 MB) | Supplemental
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Brief Report
Concise Postsynthetic Preparation of Oligonucleotide–Oligopeptide Conjugates Through Facile Disulfide Bond Formation
Mehrdad Dirin, Ernst Urban, Bodo Lachmann, Christian R Noe & Johannes Winkler
Pages: 1657-1673
Published online: 18 Sep 2015
AbstractforConcise Postsynthetic Preparation of Oligonucleotide–Oligopeptide Conjugates Through Facile Disulfide Bond Formation | Full Text | References | PDF (1.3 MB) | Supplemental
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Research Article

Article
Design, Synthesis and Antiviral Evaluation of 2′-C-Methyl Branched Guanosine Pronucleotides: The Discovery of IDX184, a Potent Liver-Targeted HCV Polymerase Inhibitor
Gwenaëlle Sizun, Claire Pierra, Jérôme Peyronnet, Eric Badaroux, Céline Rabeson, Samira Benzaria-Prad, Dominique Surleraux, Anna Giulia Loi, Chiara Musiu, Michel Liuzzi, Maria Seifer, David Standring, Jean-Pierre Sommadossi & Gilles Gosselin
Pages: 1675-1700
Published online: 01 Oct 2015
AbstractforDesign, Synthesis and Antiviral Evaluation of 2′-C-Methyl Branched Guanosine Pronucleotides: The Discovery of IDX184, a Potent Liver-Targeted HCV Polymerase Inhibitor | Full Text | References | PDF (1.6 MB) | Supplemental
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Special Report

Article
Dnazyme-Based Therapeutics for Cancer Treatment
Shujun Fu & Lun-Quan Sun
Pages: 1701-1707
Published online: 18 Sep 2015
AbstractforDnazyme-Based Therapeutics for Cancer Treatment | Full Text | References | PDF (871 KB)
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Review

Article
Nucleic Acid-Based Drugs Against Emerging Zoonotic Viruses
Jonathan P Wong
Pages: 1709-1719
Published online: 24 Sep 2015
AbstractforNucleic Acid-Based Drugs Against Emerging Zoonotic Viruses | Full Text | References | PDF (947.1 KB)
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Article
Therapeutic Oligonucleotides with Polyethylene Glycol Modifications
Johannes Winkler
Pages: 1721-1731
Published online: 29 Sep 2015
AbstractforTherapeutic Oligonucleotides with Polyethylene Glycol Modifications | Full Text | References | PDF (942.9 KB)
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Article
Polyamine–Oligonucleotide Conjugates: A Promising Direction for Nucleic Acid Tools and Therapeutics
Mirjam Menzi, Helen L Lightfoot & Jonathan Hall
Pages: 1733-1749
Published online: 01 Oct 2015
AbstractforPolyamine–Oligonucleotide Conjugates: A Promising Direction for Nucleic Acid Tools and Therapeutics | Full Text | References | PDF (2.3 MB)
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Article
Enhancing the Pharmacokinetic/Pharmacodynamic Properties of Therapeutic Nucleotides Using Lipid Nanoparticle Systems
Paulo JC Lin & Ying K Tam
Pages: 1751-1769
Published online: 24 Sep 2015
AbstractforEnhancing the Pharmacokinetic/Pharmacodynamic Properties of Therapeutic Nucleotides Using Lipid Nanoparticle Systems | Full Text | References | PDF (2.8 MB) | Supplemental
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Article
miRNA Therapeutics: A New Class of Drugs with Potential Therapeutic Applications in the Heart
Bianca C Bernardo, Jenny YY Ooi, Ruby CY Lin & Julie R McMullen
Pages: 1771-1792
Published online: 24 Sep 2015
AbstractformiRNA Therapeutics: A New Class of Drugs with Potential Therapeutic Applications in the Heart | Full Text | References | PDF (2.1 MB)
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Article
Mechanistic Principles of Antisense Targets for the Treatment of Spinal Muscular Atrophy
Natalia N Singh, Brian M Lee, Christine J DiDonato & Ravindra N Singh
Pages: 1793-1808
Published online: 18 Sep 2015
AbstractforMechanistic Principles of Antisense Targets for the Treatment of Spinal Muscular Atrophy | Full Text | References | PDF (2 MB)
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Article
Recent Progress for the Synthesis of Selected Carbocyclic Nucleosides
Maxime Bessières, Florian Chevrier, Vincent Roy & Luigi A Agrofoglio
Pages: 1809-1828
Published online: 29 Sep 2015
AbstractforRecent Progress for the Synthesis of Selected Carbocyclic Nucleosides | Full Text | References | PDF (1.8 MB)
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