Leukemia & Lymphoma, Volume 60, Issue 5 (2019)

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Leukemia & Lymphoma, Volume 60, Issue 5 (2019)

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Commentary

Article Commentary
‘Looking beyond survival to define therapeutic value in acute myeloid leukemia’
Elihu Estey
Pages: 1107-1109
Published online: 10 Jan 2019
First Page Previewfor‘Looking beyond survival to define therapeutic value in acute myeloid leukemia’ | Full Text | References | PDF (298.4 KB) | EPUB | Supplemental
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Article Commentary
The optimal chemotherapy regimen for primary mediastinal B-cell lymphoma: we may never know
Peter Martin
Pages: 1110-1111
Published online: 08 Feb 2019
CitationforThe optimal chemotherapy regimen for primary mediastinal B-cell lymphoma: we may never know | Full Text | References | PDF (234.7 KB) | EPUB
  • 155 Views
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Article Commentary
Mutations and prognosis in myeloproliferative neoplasms
Ayalew Tefferi & Animesh Pardanani
Pages: 1112-1113
Published online: 14 Nov 2018
CitationforMutations and prognosis in myeloproliferative neoplasms | Full Text | References | PDF (244.5 KB) | EPUB
  • 266 Views
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Article Commentary
Immunophenotype switching in cutaneous T-cell lymphoma: nature or nurture?
Stephen M. Ansell
Pages: 1114-1115
Published online: 11 Jan 2019
CitationforImmunophenotype switching in cutaneous T-cell lymphoma: nature or nurture? | Full Text | References | PDF (233.7 KB) | EPUB
  • 124 Views
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Review

Review
Differentiating factors in treatment-free remission trials: impact of study design on results and clinical applications
Ellen K. Ritchie
Pages: 1116-1125
Published online: 27 Nov 2018
AbstractforDifferentiating factors in treatment-free remission trials: impact of study design on results and clinical applications | Full Text | References | PDF (741.7 KB) | EPUB
  • 308 Views
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Review
Leukemia and male infertility: past, present, and future
Yulia Michailov, Eitan Lunenfeld, Joseph Kapelushnik & Mahmoud Huleihel
Pages: 1126-1135
Published online: 03 Dec 2018
AbstractforLeukemia and male infertility: past, present, and future | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Original Article

Article
Clinical and biological characteristics of acute myeloid leukemia with 20–29% blasts: a retrospective single-center study
Chen Mei, Yanling Ren, Xinping Zhou, Li Ye, Liya Ma, Yingwan Luo, Peipei Lin, Weilai Xu, Chenxi Lu, Haiyang Yang, Wenjuan Yu, Liping Mao, Juying Wei, Jie Jin & Hongyan Tong
Pages: 1136-1145
Published online: 10 Oct 2018
AbstractforClinical and biological characteristics of acute myeloid leukemia with 20–29% blasts: a retrospective single-center study | Full Text | References | PDF (1.1 MB) | EPUB
  • 224 Views
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Article
Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy
Jorge Labrador, Elisa Luño, Edo Vellenga, Salut Brunet, José González-Campos, Maria C. Chillón, Aleksandra Holowiecka, Jordi Esteve, Juan Bergua, José D González-Sanmiguel, Cristina Gil, Mar Tormo, Olga Salamero, Felix Manso, Isolda Fernández, Javier de laSerna, María-José Moreno, Manuel Pérez-Encinas, Isabel Krsnik, Josep-Maria Ribera, Jose Cervera, María J. Calasanz, Blanca Boluda, Marta Sobas, Bob Lowenberg, Miguel A. Sanz & Pau Montesinos
Pages: 1146-1155
Published online: 11 Dec 2018
AbstractforClinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy | Full Text | References | PDF (3.4 MB) | EPUB
  • 505 Views
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Article
Granulocyte colony-stimulating factor and respiratory status of critically ill neutropenic patients with hematologic malignancies
Xavier Mignard, Lucie Biard, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar, Michael Darmon, Elie Azoulay & Lara Zafrani
Pages: 1156-1163
Published online: 02 Oct 2018
AbstractforGranulocyte colony-stimulating factor and respiratory status of critically ill neutropenic patients with hematologic malignancies | Full Text | References | PDF (1,006.3 KB) | EPUB | Supplemental
  • 237 Views
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Article
Acute myeloid leukemia in the elderly: what constitutes treatment value?
Chadi Nabhan, Siddhesh Kamat & Jonathan Karl Kish
Pages: 1164-1170
Published online: 08 Nov 2018
AbstractforAcute myeloid leukemia in the elderly: what constitutes treatment value? | Full Text | References | PDF (556.4 KB) | EPUB
  • 430 Views
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Article
Incidence and survival of T-cell acute lymphoblastic leukemia in the United States
Guru Subramanian Guru Murthy, Satish Kumar Pondaiah, Sameem Abedin & Ehab Atallah
Pages: 1171-1178
Published online: 08 Nov 2018
AbstractforIncidence and survival of T-cell acute lymphoblastic leukemia in the United States | Full Text | References | PDF (787.5 KB) | EPUB
  • 1189 Views
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Article
The relation of SF3B1 mutation and intracellular iron in myelodysplastic syndrome with less than 5% bone marrow blasts
Liya Ma, Yingwan Luo, Lingxu Jiang, Dan Shen, Jianhu Li, Weilai Xu, Chen Mei, Xinping Zhou, Yanlin Ren, Li Ye, Chenxi Lu, Jin Jie & Hongyan Tong
Pages: 1179-1186
Published online: 09 Nov 2018
AbstractforThe relation of SF3B1 mutation and intracellular iron in myelodysplastic syndrome with less than 5% bone marrow blasts | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 259 Views
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Article
Antithrombin supplementation did not impact the incidence of pegylated asparaginase-induced venous thromboembolism in adults with acute lymphoblastic leukemia
Jason Chen, Dat Ngo, Ibrahim Aldoss, Sepideh Shayani, Ni-Chun Tsai & Vinod Pullarkat
Pages: 1187-1192
Published online: 15 Oct 2018
AbstractforAntithrombin supplementation did not impact the incidence of pegylated asparaginase-induced venous thromboembolism in adults with acute lymphoblastic leukemia | Full Text | References | PDF (605.5 KB) | EPUB
  • 465 Views
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Article
The JAK inhibitor antcin H exhibits direct anticancer activity while enhancing chemotherapy against LMP1-expressed lymphoma
Yu-Fon Chen, Chien-Hsiang Chang, Zih-Ning Huang, Yu-Chu Su, Sue-Joan Chang & Jeng-Shiung Jan
Pages: 1193-1203
Published online: 02 Oct 2018
AbstractforThe JAK inhibitor antcin H exhibits direct anticancer activity while enhancing chemotherapy against LMP1-expressed lymphoma | Full Text | References | PDF (3.2 MB) | EPUB
  • 185 Views
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Article
Italian expert panel consensus statement on the optimal use of PD-1 blockade therapy in classical Hodgkin lymphoma
Pier Luigi Zinzani, Armando Santoro, Arturo Chiti, Secondo Lastoria, Antonio Pinto, Lugi Rigacci, Giovanni Barosi, Martina Pennisi & Paolo Corradini
Pages: 1204-1213
Published online: 15 Oct 2018
AbstractforItalian expert panel consensus statement on the optimal use of PD-1 blockade therapy in classical Hodgkin lymphoma | Full Text | References | PDF (755.8 KB) | EPUB
  • 347 Views
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Article
A novel approach to eliminate therapy-resistant mantle cell lymphoma: synergistic effects of Vorinostat with Palbociclib
Nagendra K. Chaturvedi, Nathan D. Hatch, Garrett L. Sutton, Matthew Kling, Julie M. Vose & Shantaram S. Joshi
Pages: 1214-1223
Published online: 14 Nov 2018
AbstractforA novel approach to eliminate therapy-resistant mantle cell lymphoma: synergistic effects of Vorinostat with Palbociclib | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 357 Views
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Article
Long-term results with the adapted LMB 96 protocol in children with B-cell non Hodgkin lymphoma treated in Iraq: comparison in two subsequent cohorts of patients
Maria Luisa Moleti, Mazin Faisal Al-Jadiry, Wafa Ablahad Shateh, Amir Fadhil Al-Darraji, Sara Mohamed, Stefania Uccini, Alfonso Piciocchi, Robin Foà, Anna Maria Testi & Salma Al-Hadad
Pages: 1224-1233
Published online: 18 Apr 2019
AbstractforLong-term results with the adapted LMB 96 protocol in children with B-cell non Hodgkin lymphoma treated in Iraq: comparison in two subsequent cohorts of patients | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 156 Views
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Article
Inferior outcomes and treatment disparities in elderly patients with classical Hodgkin lymphoma: a national cancer data base analysis
Ajay Major, Matthew W. Jackson, Derek E. Smith, Manali Kamdar & Rachel Rabinovitch
Pages: 1234-1243
Published online: 03 Dec 2018
AbstractforInferior outcomes and treatment disparities in elderly patients with classical Hodgkin lymphoma: a national cancer data base analysis | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 297 Views
  • 10 CrossRef citations
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Article
IL-10 is overexpressed in human cutaneous T-cell lymphoma and is required for maximal tumor growth in a mouse model
Xuesong Wu, Daniel K. Hsu, Kang-Hsin Wang, Yuanshen Huang, Lindsay Mendoza, Youwen Zhou & Sam T. Hwang
Pages: 1244-1252
Published online: 02 Oct 2018
AbstractforIL-10 is overexpressed in human cutaneous T-cell lymphoma and is required for maximal tumor growth in a mouse model | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 481 Views
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Article
Association of insurance status with survival in patients with cutaneous T-cell lymphoma
Rui Tang, Chang Su, Harrison X. Bai, Zhuotong Zeng, Giorgos Karakousis, Paul J. Zhang, Guiying Zhang & Rong Xiao
Pages: 1253-1260
Published online: 16 Oct 2018
AbstractforAssociation of insurance status with survival in patients with cutaneous T-cell lymphoma | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 173 Views
  • 2 CrossRef citations
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Article
R-CHOP without radiation in frontline management of primary mediastinal B-cell lymphoma
Marcus Messmer, Hua-Ling Tsai, Ravi Varadhan, Lode J. Swinnen, Richard J. Jones, Richard F. Ambinder, Satish P. Shanbhag, Michael J. Borowitz & Nina Wagner-Johnston
Pages: 1261-1265
Published online: 18 Jan 2019
AbstractforR-CHOP without radiation in frontline management of primary mediastinal B-cell lymphoma | Full Text | References | PDF (427.6 KB) | EPUB
  • 477 Views
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Article
Suppression of minichromosome maintenance 7 expression sensitizes chronic lymphocytic leukemia cells to fludarabine
Yangyang Xu, Xiangxiang Zhou, Ying Li, Ya Zhang & Xin Wang
Pages: 1266-1274
Published online: 04 Feb 2019
AbstractforSuppression of minichromosome maintenance 7 expression sensitizes chronic lymphocytic leukemia cells to fludarabine | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 168 Views
  • 1 CrossRef citations
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Article
Health related quality of life for multiple myeloma patients according to treatment strategy after autologous stem cell transplant: a cross-sectional study using EORTC, EQ-5D and MY-20 scales
Jason Tay, Ravi Vij, Maxim Norkin, Francis Buadi, Tamila L. Kindwall-Keller, Jenna S. Roberts, Darrell J. White, Robert P. Wood, Sophee E. Blanthorn-Hazell, Adriana C. Rossi, Sujith Dhanasiri, Faiza Zafar, Kim Newhouse & Arleigh R. McCurdy
Pages: 1275-1282
Published online: 31 Oct 2018
AbstractforHealth related quality of life for multiple myeloma patients according to treatment strategy after autologous stem cell transplant: a cross-sectional study using EORTC, EQ-5D and MY-20 scales | Full Text | References | PDF (842.4 KB) | EPUB | Supplemental
  • 544 Views
  • 7 CrossRef citations
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Article
BIM deletion polymorphism accounts for lack of favorable outcome in Japanese females with follicular lymphoma
Yoshikazu Ito, Tomohiro Umezu, Kenichi Tadokoro, Yuu Saito, Seiichiro Katagiri, Tamiko Suguro, Michiyo Asano, Seiichiro Yoshizawa, Daigo Akahane, Yuko Tanaka, Hiroaki Fujimoto, Seiichi Okabe, Moritaka Gotoh, Tetsuzo Tauchi, Chiaki Kawana, Junko H. Ohyashiki, Naoya Nakamura & Kazuma Ohyashiki
Pages: 1283-1288
Published online: 27 Nov 2018
AbstractforBIM deletion polymorphism accounts for lack of favorable outcome in Japanese females with follicular lymphoma | Full Text | References | PDF (743.5 KB) | EPUB | Supplemental
  • 132 Views
  • 2 CrossRef citations
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Letter to the Editor

Letter
Mutation patterns in essential thrombocythemia, polycythemia vera and secondary myelofibrosis
Anne Wanquet, Frédéric Courtier, Arnaud Guille, Nadine Carbuccia, Séverine Garnier, José Adélaide, Véronique Gelsi-Boyer, Marie Joelle Mozziconacci, Jérôme Rey, Norbert Vey, Daniel Birnbaum & Anne Murati
Pages: 1289-1293
Published online: 02 Jan 2019
First Page PreviewforMutation patterns in essential thrombocythemia, polycythemia vera and secondary myelofibrosis | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 340 Views
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Letter
Coexpression of ETV6/MDS1/EVI1 and ETV6/EVI1 fusion transcripts in acute myeloid leukemia with t(3;12)(q26.2;p13) and thrombocytosis
Katsuya Yamamoto, Kimikazu Yakushijin, Hiroya Ichikawa, Atsuo Okamura, Shigeki Nagao, Seiji Kakiuchi, Keiji Kurata, Shinichiro Kawamoto, Keiji Matsui, Yuji Nakamachi, Jun Saegusa, Hiroshi Matsuoka & Hironobu Minami
Pages: 1294-1298
Published online: 11 Dec 2018
First Page PreviewforCoexpression of ETV6/MDS1/EVI1 and ETV6/EVI1 fusion transcripts in acute myeloid leukemia with t(3;12)(q26.2;p13) and thrombocytosis | Full Text | References | PDF (1,021.1 KB) | EPUB
  • 168 Views
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Letter
Effects of rapamycin in combination with fludarabine on primary chronic lymphocytic leukemia cells
Cecilia M. Rodriguez, Claudio Bussi, Daniela S. Arroyo, Dario Sastre, Viviana Heller, Carmen Stanganelli, Irma Slavutsky & Pablo Iribarren
Pages: 1299-1303
Published online: 08 Nov 2018
First Page PreviewforEffects of rapamycin in combination with fludarabine on primary chronic lymphocytic leukemia cells | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 79 Views
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Letter
Cryptic ETV6–PDGFRB fusion in a highly complex rearrangement of chromosomes 1, 5, and 12 due to a chromothripsis-like event in a myelodysplastic syndrome/myeloproliferative neoplasm
Zeba N. Singh, Stephanie Richards, Firas El Chaer, Vu H. Duong, Mary A. Gudipati, Elizabeth O. Waters, Sarah Koon, Matthew Webley, Beth Pitel, Nicole L. Hoppman, Maria R. Baer & Ying S. Zou
Pages: 1304-1307
Published online: 11 Jul 2018
First Page PreviewforCryptic ETV6–PDGFRB fusion in a highly complex rearrangement of chromosomes 1, 5, and 12 due to a chromothripsis-like event in a myelodysplastic syndrome/myeloproliferative neoplasm | Full Text | References | PDF (638 KB) | EPUB | Supplemental
  • 260 Views
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Letter
CD4+/CD8+ immunophenotype switching as a marker for intraocular and CNS involvement in mycosis fungoides
Muhammad Husnain, Nicholas Mackrides, Francisco Vega, Manuel Paez-Escamilla, Arnold M. Markoe, J. William Harbour & Izidore S. Lossos
Pages: 1308-1311
Published online: 14 Nov 2018
First Page PreviewforCD4+/CD8+ immunophenotype switching as a marker for intraocular and CNS involvement in mycosis fungoides | Full Text | References | PDF (1.2 MB) | EPUB
  • 252 Views
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Letter
Ofatumumab plus high dose methylprednisolone followed by ofatumumab plus alemtuzumab to achieve maximal cytoreduction prior to allogeneic transplantation for 17p deleted or TP53 mutated chronic lymphocytic leukemia
Matthew S. Davids, Haesook T. Kim, Lijian Yu, Guadalupe De Maeyer, Mikaela McDonough, Alexander R. Vartanov, Rachael Langey, Stacey M. Fernandes, Jeffrey M. Hellman, Karen Francoeur, Jon Arnason, Eric D. Jacobsen, Ann S. LaCasce, David C. Fisher & Jennifer R. Brown
Pages: 1312-1315
Published online: 15 Oct 2018
AbstractforOfatumumab plus high dose methylprednisolone followed by ofatumumab plus alemtuzumab to achieve maximal cytoreduction prior to allogeneic transplantation for 17p deleted or TP53 mutated chronic lymphocytic leukemia | Full Text | References | PDF (488.6 KB) | EPUB | Supplemental
  • 248 Views
  • 2 CrossRef citations
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Letter
Co-expression of AML1-ETO and PML-RARa following treatment of de novo acute myeloid leukemia with AML1-ETO
Shuling Zhang, Wei Zhou, Yanchun Li, Shuili Yu, Mingming Xue, Yanhong Qiao, Jinli Jian, Bei Liu & Degui Wang
Pages: 1316-1319
Published online: 17 Oct 2018
First Page PreviewforCo-expression of AML1-ETO and PML-RARa following treatment of de novo acute myeloid leukemia with AML1-ETO | Full Text | References | PDF (896.5 KB) | EPUB
  • 142 Views
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Letter
T-lymphoblastic lymphoma after previous thymoma: how NGS helps establishing the diagnosis and procures new insights
Quentin Le Clef, Guacimara Ortega-Sanchez, Stephan Dirnhofer & Alexandar Tzankov
Pages: 1320-1323
Published online: 10 Oct 2018
First Page PreviewforT-lymphoblastic lymphoma after previous thymoma: how NGS helps establishing the diagnosis and procures new insights | Full Text | References | PDF (1.4 MB) | EPUB
  • 172 Views
  • 3 CrossRef citations
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Letter
A multicenter report on the natural history of myelodysplastic syndromes in very old patients (aged over 85 years)
Laura S. McDonald, Peter McCarthy, Mohammad Khan, Patrick Hogan, Eileen Kelleher, Philip T. Murphy, John Quinn, Ronan Desmond, John McHugh, Melanie Strickland, Elizabeth O'Connell, Mary Cahill, Su W. Maung, Clodagh Keohane, Desmond O'Neill, Dan Ryan, Vitaliy Mykytiv & Helen Enright
Pages: 1324-1327
Published online: 11 Jan 2019
First Page PreviewforA multicenter report on the natural history of myelodysplastic syndromes in very old patients (aged over 85 years) | Full Text | References | PDF (501.8 KB) | EPUB
  • 106 Views
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Letter
Reduction of hospitalization and transfusion support in patients with acute promyelocytic leukemia treated with arsenic trioxide plus all-trans retinoic acid compared to chemotherapy plus all-trans retinoic acid
Francesco Autore, Patrizia Chiusolo, Federica Sorà, Sabrina Giammarco, Luca Laurenti, Idanna Innocenti, Elisabetta Metafuni, Nicola Piccirillo, Livio Pagano, Andrea Bacigalupo, Giuseppe Leone & Simona Sica
Pages: 1328-1330
Published online: 11 Dec 2018
First Page PreviewforReduction of hospitalization and transfusion support in patients with acute promyelocytic leukemia treated with arsenic trioxide plus all-trans retinoic acid compared to chemotherapy plus all-trans retinoic acid | Full Text | References | PDF (298.9 KB) | EPUB | Supplemental
  • 93 Views
  • 2 CrossRef citations
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Letter
Secondary malignancies after treatment with single-agent vemurafenib in two patients with refractory hairy cell leukemia
Munveer S. Bhangoo & Alan Saven
Pages: 1331-1333
Published online: 15 Oct 2018
First Page PreviewforSecondary malignancies after treatment with single-agent vemurafenib in two patients with refractory hairy cell leukemia | Full Text | References | PDF (635.6 KB) | EPUB | Supplemental
  • 189 Views
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Letter
RUNX1 mutations in MDS, s-AML, and de novo AML: differences in accompanying genetic alterations and outcome
Anna Stengel, Wolfgang Kern, Manja Meggendorfer, Torsten Haferlach & Claudia Haferlach
Pages: 1334-1336
Published online: 18 Apr 2019
First Page PreviewforRUNX1 mutations in MDS, s-AML, and de novo AML: differences in accompanying genetic alterations and outcome | Full Text | References | PDF (305.7 KB) | EPUB
  • 347 Views
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Letter
Novel germline missense DDX41 variant in a patient with an adult-onset myeloid neoplasm with excess blasts without dysplasia
Filippo Pinto e Vairo, Alejandro Ferrer, Elizabeth Cathcart-Rake, Rebecca L. King, Matthew T. Howard, David S. Viswanatha, Eric W. Klee, Abhishek A. Mangaonkar & Mrinal M. Patnaik
Pages: 1337-1339
Published online: 08 Nov 2018
First Page PreviewforNovel germline missense DDX41 variant in a patient with an adult-onset myeloid neoplasm with excess blasts without dysplasia | Full Text | References | PDF (1 MB) | EPUB
  • 470 Views
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Letter
HBV reactivation in CLL patients with occult HBV infection treated with ibrutinib without viral prophylaxis
Idanna Innocenti, Francesca Morelli, Francesco Autore, Andrea Corbingi, Raffaella Pasquale, Federica Sorà, Maurizio Pompili & Luca Laurenti
Pages: 1340-1342
Published online: 07 Feb 2019
First Page PreviewforHBV reactivation in CLL patients with occult HBV infection treated with ibrutinib without viral prophylaxis | Full Text | References | PDF (298.3 KB) | EPUB
  • 419 Views
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Letter
Phase II trial of Lestaurtinib, a JAK2 inhibitor, in patients with myelofibrosis
John Mascarenhas, Maria R. Baer, Craig Kessler, Elizabeth Hexner, Douglas Tremblay, Leah Price, Lonette Sandy, Rona Weinberg, Heike Pahl, Lewis R. Silverman, Judith D. Goldberg, Heidi Kosiorek, Amylou C. Dueck & Ronald Hoffman
Pages: 1343-1345
Published online: 22 Jan 2019
First Page PreviewforPhase II trial of Lestaurtinib, a JAK2 inhibitor, in patients with myelofibrosis | Full Text | References | PDF (560.9 KB) | EPUB
  • 382 Views
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Letter
CD19 directed CARs in acute lymphoblastic leukemia: state of the art and beyond
Alfonso Quintás-Cardama
Pages: 1346-1348
Published online: 16 Jan 2019
First Page PreviewforCD19 directed CARs in acute lymphoblastic leukemia: state of the art and beyond | Full Text | References | PDF (298.3 KB) | EPUB
  • 136 Views
  • 3 CrossRef citations
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