Cancer Biology & Therapy, Volume 17, Issue 6 (2016)

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Cancer Biology & Therapy, Volume 17, Issue 6 (2016)

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Review

Review
Role of EZH2 histone methyltrasferase in melanoma progression and metastasis
Fade Mahmoud, Bradley Shields, Issam Makhoul, Laura F. Hutchins, Sara C. Shalin & Alan J. Tackett
Pages: 579-591
Published online: 17 Jun 2016
AbstractforRole of EZH2 histone methyltrasferase in melanoma progression and metastasis | Full Text | References | PDF (640.7 KB)
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Journal Club

Article
YAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: “Hippo-thetical”, new therapeutic targets?
Fiorina Kyritsi, Douglas K. Price & William D. Figg
Pages: 592-594
Published online: 20 May 2016
AbstractforYAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: “Hippo-thetical”, new therapeutic targets? | Full Text | References | PDF (259 KB)
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Bedside to Bench Report

Report
Combination targeted therapy of VEGFR inhibitor, sorafenib, with an mTOR inhibitor, sirolimus induced a remakable response of rapid progressive Uterine PEComa
Fang Gao, Chengsuo Huang, Yiping Zhang, Ruirui Sun, Yujie Zhang, Huijun Wang & Shu Zhang
Pages: 595-598
Published online: 04 May 2016
AbstractforCombination targeted therapy of VEGFR inhibitor, sorafenib, with an mTOR inhibitor, sirolimus induced a remakable response of rapid progressive Uterine PEComa | Full Text | References | PDF (469 KB)
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Report
Germline mutations in the VHL gene associated with 3 different renal lesions in a Chinese von Hippel-Lindau disease family
Ping Yuan, Qipeng Sun, Hao Liang, Wenjun Wang, Ling Li, Ye Wang, Huan Deng, Luhua Lai, Xiaoli Chen & Xiangfu Zhou
Pages: 599-603
Published online: 04 May 2016
AbstractforGermline mutations in the VHL gene associated with 3 different renal lesions in a Chinese von Hippel-Lindau disease family | Full Text | References | PDF (567.9 KB)
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Research Paper

Article
Bcl-2 family member Mcl-1 expression is reduced under hypoxia by the E3 ligase FBW7 contributing to BNIP3 induced cell death in glioma cells
Yongqiang Chen, Elizabeth S. Henson, Wenyan Xiao, Epsita Shome, Meghan B. Azad, Teralee R. Burton, Michelle Queau, Akshay Sathya, David D. Eisenstat & Spencer B. Gibson
Pages: 604-613
Published online: 13 May 2016
AbstractforBcl-2 family member Mcl-1 expression is reduced under hypoxia by the E3 ligase FBW7 contributing to BNIP3 induced cell death in glioma cells | Full Text | References | PDF (984.3 KB) | Supplemental
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Article
The influence of miR-34a expression on stemness and cytotoxic susceptibility of breast cancer stem cells
Hongyao Zhang, Ning Li, Jiahui Zhang, Fengjiao Jin, Meihua Shan, Junfang Qin & Yue Wang
Pages: 614-624
Published online: 13 May 2016
AbstractforThe influence of miR-34a expression on stemness and cytotoxic susceptibility of breast cancer stem cells | Full Text | References | PDF (1.1 MB) | Supplemental
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Article
HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia
Nana Zhe, Shuya Chen, Zhen Zhou, Ping Liu, Xiaojing Lin, Meisheng Yu, Bingqing Cheng, Yaming Zhang & Jishi Wang
Pages: 625-634
Published online: 20 May 2016
AbstractforHIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia | Full Text | References | PDF (1 MB)
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Article
Diagnostic and prognostic significance of serum apolipoprotein C-I in triple-negative breast cancer based on mass spectrometry
Dongjian Song, Lifang Yue, Junjie Zhang, Shanshan Ma, Wei Zhao, Fei Guo, Yingzhong Fan, Heying Yang, Qiuliang Liu, Da Zhang, Ziqiang Xia, Pan Qin, Jia Jia, Ming Yue, Jiekai Yu, Shu Zheng, Fuquan Yang & Jiaxiang Wang
Pages: 635-647
Published online: 15 Jun 2016
AbstractforDiagnostic and prognostic significance of serum apolipoprotein C-I in triple-negative breast cancer based on mass spectrometry | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Iron depletion enhances the effect of sorafenib in hepatocarcinoma
Shinichi Urano, Toshiaki Ohara, Kazuhiro Noma, Ryoichi Katsube, Takayuki Ninomiya, Yasuko Tomono, Hiroshi Tazawa, Shunsuke Kagawa, Yasuhiro Shirakawa, Fumiaki Kimura, Kazuhiro Nouso, Akihiro Matsukawa, Kazuhide Yamamoto & Toshiyoshi Fujiwara
Pages: 648-656
Published online: 17 Jun 2016
AbstractforIron depletion enhances the effect of sorafenib in hepatocarcinoma | Full Text | References | PDF (921.5 KB) | Supplemental
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Article
Fibersol-2 induces apoptosis of Apc-deficient colorectal Cancer (SW480) cells and decreases polyp formation in Apc MIN mice
Sara Cuesta Sancho, Susan Losee Olson, Eui Young So, Kazuhiro Shimomura, Toru Ouchi & Fabian Preuss
Pages: 657-663
Published online: 17 Jun 2016
AbstractforFibersol-2 induces apoptosis of Apc-deficient colorectal Cancer (SW480) cells and decreases polyp formation in Apc MIN mice | Full Text | References | PDF (705.5 KB)
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Article
Selective effects of a fiber chimeric conditionally replicative adenovirus armed with hep27 gene on renal cancer cell
Lin Fang, Qian Cheng, Wenshun Liu, Jie Zhang, Yan Ge, Qi Zhang, Liantao Li, Junjie Liu & Junnian Zheng
Pages: 664-673
Published online: 17 Jun 2016
AbstractforSelective effects of a fiber chimeric conditionally replicative adenovirus armed with hep27 gene on renal cancer cell | Full Text | References | PDF (1.1 MB)
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Article
Prognostic evaluation of VEGFA genotypes and haplotypes in a cohort of Brazilian women with non metastatic breast cancer
Hayra de Andrade Vieira-Monteiro, Daniely Regina Freitas-Alves, Marcelo Sobral-Leite, João Marcos de Azevedo Delou, Sheyla Maria Torres Goulart-Citrangulo, Camila Telles do Nascimento, Thales Nascimento e Castro, Sérgio Koifman, Jamila Alessandra Perini & Rosane Vianna-Jorge
Pages: 674-683
Published online: 19 May 2016
AbstractforPrognostic evaluation of VEGFA genotypes and haplotypes in a cohort of Brazilian women with non metastatic breast cancer | Full Text | References | PDF (648 KB)
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Article
Molecular correlates and prognostic value of tmTNF-α expression in colorectal cancer of 5-Fluorouracil-Based Adjuvant Therapy
Xiaogai Li, Shihai Wang, HuiJun Ren, Junfen Ma, Xiaoxu Sun, Nan Li, Cailin Liu, Kaida Huang, Min Xu & Liang Ming
Pages: 684-692
Published online: 25 May 2016
AbstractforMolecular correlates and prognostic value of tmTNF-α expression in colorectal cancer of 5-Fluorouracil-Based Adjuvant Therapy | Full Text | References | PDF (751.4 KB)
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Article
Remarkable response in 2 cases of Advanced Poorly Differentiated Thyroid Carcinoma with liposomal doxorubicin plus cisplatin
Haiyan Yang, Zhongjian Chen, Meijuan Wu, Tao Lei, Haifeng Yu & Minghua Ge
Pages: 693-697
Published online: 14 Jun 2016
AbstractforRemarkable response in 2 cases of Advanced Poorly Differentiated Thyroid Carcinoma with liposomal doxorubicin plus cisplatin | Full Text | References | PDF (829.3 KB)
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Article
Combination therapy targeting both cancer stem-like cells and bulk tumor cells for improved efficacy of breast cancer treatment
Tao Wang, Radhika Narayanaswamy, Huilan Ren & Vladimir P. Torchilin
Pages: 698-707
Published online: 03 Jun 2016
AbstractforCombination therapy targeting both cancer stem-like cells and bulk tumor cells for improved efficacy of breast cancer treatment | Full Text | References | PDF (892.8 KB)
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