mAbs, Volume 4, Issue 1 (2012)

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mAbs, Volume 4, Issue 1 (2012)

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Editorial

Editorial
Which are the antibodies to watch in 2012?
Janice M. Reichert
Pages: 1-3
Published online: 01 Jan 2012
AbstractforWhich are the antibodies to watch in 2012? | Full Text | PDF (283.5 KB)
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Meeting Report

Meeting Report
World Bispecific Antibody Summit, September 27–28, 2011, Boston, MA
Eugen Dhimolea & Janice M. Reichert
Pages: 4-13
Published online: 01 Jan 2012
AbstractforWorld Bispecific Antibody Summit, September 27–28, 2011, Boston, MA | Full Text | References | PDF (244.7 KB)
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Meeting Report
Poster Sessions
September 27-28, 2011
Eugen Dhimolea & Janice M. Reichert
Pages: 14-16
Published online: 01 Jan 2012
First Page PreviewforPoster Sessions | Full Text | PDF (200.8 KB)
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Review

Review Article
Disulfide bond structures of IgG molecules
Structural variations, chemical modifications and possible impacts to stability and biological function
Hongcheng Liu & Kimberly May
Pages: 17-23
Published online: 01 Jan 2012
AbstractforDisulfide bond structures of IgG molecules | Full Text | References | PDF (768.1 KB)
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Report

Article
Analysis of host-cell proteins in biotherapeutic proteins by comprehensive online two-dimensional liquid chromatography/mass spectrometry
Catalin Doneanu, Alex Xenopoulos, Keith Fadgen, Jim Murphy, St. John Skilton, Holly Prentice, Martha Stapels & Weibin Chen
Pages: 24-44
Published online: 01 Jan 2012
AbstractforAnalysis of host-cell proteins in biotherapeutic proteins by comprehensive online two-dimensional liquid chromatography/mass spectrometry | Full Text | References | PDF (5 MB) | Supplemental
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Article
A recombinant triplebody with specificity for CD19 and HLA-DR mediates 
preferential binding to antigen double-positive cells by dual-targeting
Ingo Schubert, Christian Kellner, Christoph Stein, Markus Kügler, Michael Schwenkert, Domenica Saul, Bernhard Stockmeyer, Christian Berens, Fuat S. Oduncu, Andreas Mackensen & Georg H. Fey
Pages: 45-56
Published online: 01 Jan 2012
AbstractforA recombinant triplebody with specificity for CD19 and HLA-DR mediates 
preferential binding to antigen double-positive cells by dual-targeting | Full Text | References | PDF (1.2 MB) | Supplemental
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Article
Immunotoxins constructed with chimeric, short-lived anti-CD22 monoclonal antibodies induce less vascular leak without loss of cytotoxicity
Xiao-yun Liu, Laurentiu M. Pop, John Schindler & Ellen S. Vitetta
Pages: 57-68
Published online: 01 Jan 2012
AbstractforImmunotoxins constructed with chimeric, short-lived anti-CD22 monoclonal antibodies induce less vascular leak without loss of cytotoxicity | Full Text | References | PDF (1.9 MB) | Supplemental
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Article
Generation and characterization of human anti-human IL-21 neutralizing monoclonal antibodies
Mark F. Maurer, Ursula Garrigues, Stephen R. Jaspers, Brent Meengs, Mark W. Rixon, Brenda L. Stevens, Kenneth B. Lewis, Susan H. Julien, Thomas R. Bukowski, Anitra C. Wolf, Nels B. Hamacher, Mark Snavely & Stacey R. Dillon
Pages: 69-83
Published online: 01 Jan 2012
AbstractforGeneration and characterization of human anti-human IL-21 neutralizing monoclonal antibodies | Full Text | References | PDF (2.5 MB)
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Article
Analytical characterization of ch14.18
A mouse-human chimeric disialoganglioside-specific therapeutic antibody
Gopalan Soman, Abraham T. Kallarakal, Dennis Michiel, Xiaoyi Yang, Nirmala Saptharish, Hengguang Jiang, Steve Giardina, John Gilly & George Mitra
Pages: 84-100
Published online: 01 Jan 2012
AbstractforAnalytical characterization of ch14.18 | Full Text | References | PDF (3.1 MB)
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Article
Subcutaneous bioavailability of therapeutic antibodies as a function 
of FcRn binding affinity in mice
Rong Deng, Y. Gloria Meng, Kwame Hoyte, Jeff Lutman, Yanmei Lu, Suhasini Iyer, Laura E DeForge, Frank-Peter Theil, Paul J. Fielder & Saileta Prabhu
Pages: 101-109
Published online: 01 Jan 2012
AbstractforSubcutaneous bioavailability of therapeutic antibodies as a function 
of FcRn binding affinity in mice | Full Text | References | PDF (1.1 MB) | Supplemental
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Article
Tolerability, pharmacokinetics and pharmacodynamics of CMAB007, a humanized anti-immunoglobulin E monoclonal antibody, in healthy Chinese subjects
Bo Zhou, Birong Lin, Jing Li, Weizhu Qian, Sheng Hou, Dapeng Zhang, Geng Kou, Bohua Li, Hao Wang, Yongchuan Chen & Yajun Guo
Pages: 110-119
Published online: 01 Jan 2012
AbstractforTolerability, pharmacokinetics and pharmacodynamics of CMAB007, a humanized anti-immunoglobulin E monoclonal antibody, in healthy Chinese subjects | Full Text | References | PDF (997 KB) | Supplemental
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Article
New developments in malaria diagnostics
Monoclonal antibodies against Plasmodium dihydrofolate reductase–thymidylate synthase, heme detoxification protein and glutamate rich protein
Johanna H. Kattenberg, Inge Versteeg, Stephanie J. Migchelsen, Iveth J. González, Mark D. Perkins, Petra F. Mens & Henk D.F.H. Schallig
Pages: 120-126
Published online: 01 Jan 2012
AbstractforNew developments in malaria diagnostics | Full Text | References | PDF (847.3 KB)
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Editor's Corner

Editorial
2012 upcoming meetings
Janice M. Reichert
Pages: 127-128
Published online: 01 Jan 2012
Citationfor2012 upcoming meetings | Full Text | PDF (355.3 KB)
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Editorial
Note of appreciation to reviewers
Janice M. Reichert
Pages: 129-131
Published online: 01 Jan 2012
First Page PreviewforNote of appreciation to reviewers | Full Text | PDF (339.2 KB)
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