Molecular and Cellular Biology, Volume 21, Issue 15 (2001)

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Molecular and Cellular Biology, Volume 21, Issue 15 (2001)

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Transcriptional Regulation

Article
New Model for the Yeast RNA Polymerase I Transcription Cycle
Pavel Aprikian, Beth Moorefield & Ronald H. Reeder
Pages: 4847-4855
Published online: 28 Mar 2023
AbstractforNew Model for the Yeast RNA Polymerase I Transcription Cycle | Full Text | References | PDF (227.6 KB)
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Article
Ligand-Dependent Degradation of Retinoid X Receptors Does Not Require Transcriptional Activity or Coactivator Interactions
Deborah L. Osburn, Gang Shao, H. Martin Seidel & Ira G. Schulman
Pages: 4909-4918
Published online: 28 Mar 2023
AbstractforLigand-Dependent Degradation of Retinoid X Receptors Does Not Require Transcriptional Activity or Coactivator Interactions | Full Text | References | PDF (320.8 KB)
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Article
Self-Association of CIITA and Its Transactivation Potential
Tyler J. Sisk, Stacey Roys & Cheong-Hee Chang
Pages: 4919-4928
Published online: 28 Mar 2023
AbstractforSelf-Association of CIITA and Its Transactivation Potential | Full Text | References | PDF (408.5 KB)
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Article
Maf1p, a Negative Effector of RNA Polymerase III in Saccharomyces cerevisiae
Krzysztof Pluta, Olivier Lefebvre, Nancy C. Martin, Wieslaw J. Smagowicz, David R. Stanford, Steven R. Ellis, Anita K. Hopper, Andre Sentenac & Magdalena Boguta
Pages: 5031-5040
Published online: 28 Mar 2023
AbstractforMaf1p, a Negative Effector of RNA Polymerase III in Saccharomyces cerevisiae | Full Text | References | PDF (488.4 KB)
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Article
A Conserved α-Helical Motif Mediates the Interaction of Sp1-Like Transcriptional Repressors with the Corepressor mSin3A
Jin-San Zhang, Martin C. Moncrieffe, Joanna Kaczynski, Volker Ellenrieder, Franklyn G. Prendergast & Raul Urrutia
Pages: 5041-5049
Published online: 28 Mar 2023
AbstractforA Conserved α-Helical Motif Mediates the Interaction of Sp1-Like Transcriptional Repressors with the Corepressor mSin3A | Full Text | References | PDF (330.5 KB)
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Article
The TFIID Components Human TAFII140 andDrosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger
Yann-Gaël Gangloff, Jean-Christophe Pointud, Sylvie Thuault, Lucie Carré, Christophe Romier, Selen Muratoglu, Marjorie Brand, Laszlo Tora, Jean-Louis Couderc & Irwin Davidson
Pages: 5109-5121
Published online: 28 Mar 2023
AbstractforThe TFIID Components Human TAFII140 andDrosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger | Full Text | References | PDF (926.7 KB)
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Article
Mitotic Phosphorylation Prevents the Binding of HMGN Proteins to Chromatin
Marta Prymakowska-Bosak, Tom Misteli, Julio E. Herrera, Hitoshi Shirakawa, Yehudit Birger, Susan Garfield & Michael Bustin
Pages: 5169-5178
Published online: 28 Mar 2023
AbstractforMitotic Phosphorylation Prevents the Binding of HMGN Proteins to Chromatin | Full Text | References | PDF (1.2 MB)
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Article
The Novel Transcription Factor e(y)2 Interacts with TAFII40 and Potentiates Transcription Activation on Chromatin Templates
Sofia Georgieva, Elena Nabirochkina, F. Jeffrey Dilworth, Holger Eickhoff, Peter Becker, Làszlò Tora, Pavel Georgiev & Aleksey Soldatov
Pages: 5223-5231
Published online: 28 Mar 2023
AbstractforThe Novel Transcription Factor e(y)2 Interacts with TAFII40 and Potentiates Transcription Activation on Chromatin Templates | Full Text | References | PDF (1.7 MB)
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Article
Drosophila Med6 Is Required for Elevated Expression of a Large but Distinct Set of Developmentally Regulated Genes
Byung Soo Gim, Jin Mo Park, Jeong Ho Yoon, Changwon Kang & Young-Joon Kim
Pages: 5242-5255
Published online: 28 Mar 2023
AbstractforDrosophila Med6 Is Required for Elevated Expression of a Large but Distinct Set of Developmentally Regulated Genes | Full Text | References | PDF (1.4 MB)
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Cell Growth and Development

Article
Transcription Factor AP-2α Is Preferentially Cleaved by Caspase 6 and Degraded by Proteasome during Tumor Necrosis Factor Alpha-Induced Apoptosis in Breast Cancer Cells
Okot Nyormoi, Zhi Wang, Dao Doan, Maribelis Ruiz, David McConkey & Menashe Bar-Eli
Pages: 4856-4867
Published online: 28 Mar 2023
AbstractforTranscription Factor AP-2α Is Preferentially Cleaved by Caspase 6 and Degraded by Proteasome during Tumor Necrosis Factor Alpha-Induced Apoptosis in Breast Cancer Cells | Full Text | References | PDF (340.8 KB)
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Article
Mutational Analysis of the Cy Motif from p21 Reveals Sequence Degeneracy and Specificity for Different Cyclin-Dependent Kinases
James A. Wohlschlegel, Brian T. Dwyer, David Y. Takeda & Anindya Dutta
Pages: 4868-4874
Published online: 28 Mar 2023
AbstractforMutational Analysis of the Cy Motif from p21 Reveals Sequence Degeneracy and Specificity for Different Cyclin-Dependent Kinases | Full Text | References | PDF (294.1 KB)
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Article
c-Myc Is Necessary for DNA Damage-Induced Apoptosis in the G2 Phase of the Cell Cycle
Susumu Adachi, Alvaro J. Obaya, Zhiyong Han, Noemi Ramos-Desimone, James H. Wyche & John M. Sedivy
Pages: 4929-4937
Published online: 28 Mar 2023
Abstractforc-Myc Is Necessary for DNA Damage-Induced Apoptosis in the G2 Phase of the Cell Cycle | Full Text | References | PDF (357.2 KB)
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Article
Cdc5 Interacts with the Wee1 Kinase in Budding Yeast
Clinton R. Bartholomew, Sung Ho Woo, Yun Shin Chung, Carolyn Jones & Christopher F. J. Hardy
Pages: 4949-4959
Published online: 28 Mar 2023
AbstractforCdc5 Interacts with the Wee1 Kinase in Budding Yeast | Full Text | References | PDF (583.2 KB)
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Article
Control of Cyclin-Dependent Kinase Inhibitor p27 Expression by Cap-Independent Translation
W. Keith Miskimins, Gang Wang, Michelle Hawkinson & Robin Miskimins
Pages: 4960-4967
Published online: 28 Mar 2023
AbstractforControl of Cyclin-Dependent Kinase Inhibitor p27 Expression by Cap-Independent Translation | Full Text | References | PDF (280.8 KB)
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Article
The Multisubstrate Adapter Gab1 Regulates Hepatocyte Growth Factor (Scatter Factor)–c-Met Signaling for Cell Survival and DNA Repair
Saijun Fan, Yong Xian Ma, Min Gao, Ren-Qi Yuan, Qinghui Meng, Itzhak D. Goldberg & Eliot M. Rosen
Pages: 4968-4984
Published online: 28 Mar 2023
AbstractforThe Multisubstrate Adapter Gab1 Regulates Hepatocyte Growth Factor (Scatter Factor)–c-Met Signaling for Cell Survival and DNA Repair | Full Text | References | PDF (852.7 KB)
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Article
NoBP, a Nuclear Fibroblast Growth Factor 3 Binding Protein, Is Cell Cycle Regulated and Promotes Cell Growth
Kerstin Reimers, Marianne Antoine, Marcus Zapatka, Volker Blecken, Clive Dickson & Paul Kiefer
Pages: 4996-5007
Published online: 28 Mar 2023
AbstractforNoBP, a Nuclear Fibroblast Growth Factor 3 Binding Protein, Is Cell Cycle Regulated and Promotes Cell Growth | Full Text | References | PDF (489.9 KB)
  • 28 Views
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Article
Mammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin
Atsuko Takano, Isao Usui, Tetsuro Haruta, Junko Kawahara, Tatsuhito Uno, Minoru Iwata & Masashi Kobayashi
Pages: 5050-5062
Published online: 28 Mar 2023
AbstractforMammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin | Full Text | References | PDF (516.5 KB)
  • 36 Views
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Article
Apoptosis Triggered by Myc-Induced Suppression of Bcl-XL or Bcl-2 Is Bypassed during Lymphomagenesis
Christine M. Eischen, David Woo, Martine F. Roussel & John L. Cleveland
Pages: 5063-5070
Published online: 28 Mar 2023
AbstractforApoptosis Triggered by Myc-Induced Suppression of Bcl-XL or Bcl-2 Is Bypassed during Lymphomagenesis | Full Text | References | PDF (267.4 KB)
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Article
Early Expressed Clb Proteins Allow Accumulation of Mitotic Cyclin by Inactivating Proteolytic Machinery during S Phase
Foong May Yeong, Hong Hwa Lim, Ya Wang & Uttam Surana
Pages: 5071-5081
Published online: 28 Mar 2023
AbstractforEarly Expressed Clb Proteins Allow Accumulation of Mitotic Cyclin by Inactivating Proteolytic Machinery during S Phase | Full Text | References | PDF (622.7 KB)
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Article
Identification of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 as Signaling Intermediates in the α6β4 Integrin-Dependent Activation of Phosphoinositide 3-OH Kinase and Promotion of Invasion
Leslie M. Shaw
Pages: 5082-5093
Published online: 28 Mar 2023
AbstractforIdentification of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 as Signaling Intermediates in the α6β4 Integrin-Dependent Activation of Phosphoinositide 3-OH Kinase and Promotion of Invasion | Full Text | References | PDF (448.7 KB)
  • 29 Views
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Article
Proteolysis of the Docking Protein HEF1 and Implications for Focal Adhesion Dynamics
Geraldine M. O'Neill & Erica A. Golemis
Pages: 5094-5108
Published online: 28 Mar 2023
AbstractforProteolysis of the Docking Protein HEF1 and Implications for Focal Adhesion Dynamics | Full Text | References | PDF (423.5 KB)
  • 15 Views
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Article
Smad Proteins and Hepatocyte Growth Factor Control Parallel Regulatory Pathways That Converge on β1-Integrin To Promote Normal Liver Development
Michael Weinstein, Satdarshan P. S. Monga, Ye Liu, Steven G. Brodie, Yi Tang, Cuiling Li, Lopa Mishra & Chu-Xia Deng
Pages: 5122-5131
Published online: 28 Mar 2023
AbstractforSmad Proteins and Hepatocyte Growth Factor Control Parallel Regulatory Pathways That Converge on β1-Integrin To Promote Normal Liver Development | Full Text | References | PDF (4.9 MB)
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Article
Axin Facilitates Smad3 Activation in the Transforming Growth Factor β Signaling Pathway
Masao Furuhashi, Ken Yagi, Hideki Yamamoto, Yoichi Furukawa, Shinji Shimada, Yusuke Nakamura, Akira Kikuchi, Kohei Miyazono & Mitsuyasu Kato
Pages: 5132-5141
Published online: 28 Mar 2023
AbstractforAxin Facilitates Smad3 Activation in the Transforming Growth Factor β Signaling Pathway | Full Text | References | PDF (1.1 MB)
  • 21 Views
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Article
Conformational Switch and Role of Phosphorylation in PAK Activation
Gretel Buchwald, Eva Hostinova, Markus G. Rudolph, Astrid Kraemer, Albert Sickmann, Helmut E. Meyer, Klaus Scheffzek & Alfred Wittinghofer
Pages: 5179-5189
Published online: 28 Mar 2023
AbstractforConformational Switch and Role of Phosphorylation in PAK Activation | Full Text | References | PDF (931.6 KB)
  • 28 Views
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Article
Identification of an Overlapping Binding Domain on Cdc20 for Mad2 and Anaphase-Promoting Complex: Model for Spindle Checkpoint Regulation
Yongke Zhang & Emma Lees
Pages: 5190-5199
Published online: 28 Mar 2023
AbstractforIdentification of an Overlapping Binding Domain on Cdc20 for Mad2 and Anaphase-Promoting Complex: Model for Spindle Checkpoint Regulation | Full Text | References | PDF (1.6 MB)
  • 13 Views
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Article
Chk2 Activation Dependence on Nbs1 after DNA Damage
Giacomo Buscemi, Camilla Savio, Laura Zannini, Francesca Miccichè, Debora Masnada, Makoto Nakanishi, Hiroshi Tauchi, Kenshi Komatsu, Shuki Mizutani, KumKum Khanna, Phil Chen, Patrick Concannon, Luciana Chessa & Domenico Delia
Pages: 5214-5222
Published online: 28 Mar 2023
AbstractforChk2 Activation Dependence on Nbs1 after DNA Damage | Full Text | References | PDF (851.8 KB)
  • 34 Views
  • 158 CrossRef citations
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Article
Impaired Abdominal Wall Development and Deficient Wound Healing in Mice Lacking Aortic Carboxypeptidase-Like Protein
Matthew D. Layne, Shaw-Fang Yet, Koji Maemura, Chung-Ming Hsieh, Merton Bernfield, Mark A. Perrella & Mu-En Lee
Pages: 5256-5261
Published online: 28 Mar 2023
AbstractforImpaired Abdominal Wall Development and Deficient Wound Healing in Mice Lacking Aortic Carboxypeptidase-Like Protein | Full Text | References | PDF (2.3 MB)
  • 64 Views
  • 73 CrossRef citations
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Article
Gα11 Signaling through ARF6 Regulates F-Actin Mobilization and GLUT4 Glucose Transporter Translocation to the Plasma Membrane
Avirup Bose, Andrew D. Cherniack, Stephen E. Langille, Sarah M. C. Nicoloro, Joanne M. Buxton, Jin G. Park, Anil Chawla & Michael P. Czech
Pages: 5262-5275
Published online: 28 Mar 2023
AbstractforGα11 Signaling through ARF6 Regulates F-Actin Mobilization and GLUT4 Glucose Transporter Translocation to the Plasma Membrane | Full Text | References | PDF (7.1 MB)
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Article
ADP-Ribosylation Factor 6 Delineates Separate Pathways Used by Endothelin 1 and Insulin for Stimulating Glucose Uptake in 3T3-L1 Adipocytes
J. Todd R. Lawrence & Morris J. Birnbaum
Pages: 5276-5285
Published online: 28 Mar 2023
AbstractforADP-Ribosylation Factor 6 Delineates Separate Pathways Used by Endothelin 1 and Insulin for Stimulating Glucose Uptake in 3T3-L1 Adipocytes | Full Text | References | PDF (502.3 KB)
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Dna Dynamics and Chromosome Structure

Article
Multifunctional Centromere Binding Factor 1 Is Essential for Chromosome Segregation in the Human Pathogenic YeastCandida glabrata
Tanja Stoyan, Gernot Gloeckner, Stephan Diekmann & John Carbon
Pages: 4875-4888
Published online: 28 Mar 2023
AbstractforMultifunctional Centromere Binding Factor 1 Is Essential for Chromosome Segregation in the Human Pathogenic YeastCandida glabrata | Full Text | References | PDF (553.9 KB)
  • 8 Views
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Article
Identification of rad27 Mutations That Confer Differential Defects in Mutation Avoidance, Repeat Tract Instability, and Flap Cleavage
Yali Xie, Yuan Liu, Juan Lucas Argueso, Leigh A. Henricksen, Hui-I Kao, Robert A. Bambara & Eric Alani
Pages: 4889-4899
Published online: 28 Mar 2023
AbstractforIdentification of rad27 Mutations That Confer Differential Defects in Mutation Avoidance, Repeat Tract Instability, and Flap Cleavage | Full Text | References | PDF (288.3 KB)
  • 12 Views
  • 49 CrossRef citations
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Article
DNA Replication Forks Pause at Silent Origins near the HML Locus in Budding Yeast
Yangzhou Wang, Marija Vujcic & David Kowalski
Pages: 4938-4948
Published online: 28 Mar 2023
AbstractforDNA Replication Forks Pause at Silent Origins near the HML Locus in Budding Yeast | Full Text | References | PDF (335.4 KB)
  • 19 Views
  • 28 CrossRef citations
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Article
exo1-Dependent Mutator Mutations: Model System for Studying Functional Interactions in Mismatch Repair
Neelam S. Amin, My-Nga Nguyen, Scott Oh & Richard D. Kolodner
Pages: 5142-5155
Published online: 28 Mar 2023
Abstractforexo1-Dependent Mutator Mutations: Model System for Studying Functional Interactions in Mismatch Repair | Full Text | References | PDF (541.3 KB)
  • 104 Views
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Article
Loss of Cell Cycle Checkpoint Control in Drosophila Rfc4 Mutants
Sue A. Krause, Marie-Louise Loupart, Sharron Vass, Stefan Schoenfelder, Steve Harrison & Margarete M. S. Heck
Pages: 5156-5168
Published online: 28 Mar 2023
AbstractforLoss of Cell Cycle Checkpoint Control in Drosophila Rfc4 Mutants | Full Text | References | PDF (3 MB)
  • 25 Views
  • 36 CrossRef citations
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Gene Expression

Article
Linking the 3′ Poly(A) Tail to the Subunit Joining Step of Translation Initiation: Relations of Pab1p, Eukaryotic Translation Initiation Factor 5B (Fun12p), and Ski2p-Slh1p
Anjanette Searfoss, Thomas E. Dever & Reed Wickner
Pages: 4900-4908
Published online: 28 Mar 2023
AbstractforLinking the 3′ Poly(A) Tail to the Subunit Joining Step of Translation Initiation: Relations of Pab1p, Eukaryotic Translation Initiation Factor 5B (Fun12p), and Ski2p-Slh1p | Full Text | References | PDF (233 KB)
  • 24 Views
  • 67 CrossRef citations
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Article
Analysis of smu-1, a Gene That Regulates the Alternative Splicing of unc-52 Pre-mRNA in Caenorhabditis elegans
Caroline A. Spike, Jocelyn E. Shaw & Robert K. Herman
Pages: 4985-4995
Published online: 28 Mar 2023
AbstractforAnalysis of smu-1, a Gene That Regulates the Alternative Splicing of unc-52 Pre-mRNA in Caenorhabditis elegans | Full Text | References | PDF (393.3 KB)
  • 22 Views
  • 35 CrossRef citations
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Article
Investigation of Elements Sufficient To Imprint the Mouse Air Promoter
Frank Sleutels & Denise P. Barlow
Pages: 5008-5017
Published online: 28 Mar 2023
AbstractforInvestigation of Elements Sufficient To Imprint the Mouse Air Promoter | Full Text | References | PDF (271.7 KB)
  • 5 Views
  • 20 CrossRef citations
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Article
Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation
Thanuja Krishnamoorthy, Graham D. Pavitt, Fan Zhang, Thomas E. Dever & Alan G. Hinnebusch
Pages: 5018-5030
Published online: 28 Mar 2023
AbstractforTight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation | Full Text | References | PDF (587.4 KB)
  • 84 Views
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Article
Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein
Kianoush Khaleghpour, Avak Kahvejian, Gregory De Crescenzo, Guylaine Roy, Yuri V. Svitkin, Hiroaki Imataka, Maureen O'Connor-McCourt & Nahum Sonenberg
Pages: 5200-5213
Published online: 28 Mar 2023
AbstractforDual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein | Full Text | References | PDF (1.2 MB)
  • 82 Views
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Article
Recognition of RNA Branch Point Sequences by the KH Domain of Splicing Factor 1 (Mammalian Branch Point Binding Protein) in a Splicing Factor Complex
Hadas Peled-Zehavi, J. Andrew Berglund, Michael Rosbash & Alan D. Frankel
Pages: 5232-5241
Published online: 28 Mar 2023
AbstractforRecognition of RNA Branch Point Sequences by the KH Domain of Splicing Factor 1 (Mammalian Branch Point Binding Protein) in a Splicing Factor Complex | Full Text | References | PDF (1.3 MB)
  • 24 Views
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