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Original Articles

Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII)

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Pages 586-591 | Received 04 Aug 2014, Accepted 16 Aug 2014, Published online: 06 Nov 2014

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Aamer Saeed, Syeda Abida Ejaz, Maria Saeed, Pervaiz Ali Channar, Mubashir Aziz, Ammara Fayyaz, Seema Zargar, Tanveer A. Wani, Humidah Alanazi, Mona Alharbi & Jamshed Iqbal. (2023) Synthesis, Biochemical Characterization, and in-Silico Investigations of Acyl-3-(Ciprofloxacinyl) Thioureas as Inhibitors of Carbonic Anhydrase-II. Polycyclic Aromatic Compounds 43:10, pages 8946-8964.
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Hasan Küçükbay, Nesrin Buğday, F. Zehra Küçükbay, Andrea Ageli, Gianluca Bartolucci & Claudiu T. Supuran. (2020) Synthesis and human carbonic anhydrase I, II, VA, and XII inhibition with novel amino acid–sulphonamide conjugates. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 489-497.
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Ümit M. Koçyiğit, Sevgi Durna Daştan, Parham Taslimi, Taner Daştan & İlhami Gülçin. (2018) Inhibitory effects of some drugs on carbonic anhydrase enzyme purified from Kangal Akkaraman sheep in Sivas, Turkey. Journal of Biochemical and Molecular Toxicology 32:1, pages e22000.
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Aliye Altundas, Berna Gül, Murat Çankaya, Ali Atasever & İlhami Gülçin. (2017) Synthesis of 2-amino-3-cyanopyridine derivatives and investigation of their carbonic anhydrase inhibition effects. Journal of Biochemical and Molecular Toxicology 31:12, pages e21998.
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Umit M. Kocyigit, Yakup Budak, Fikret Eligüzel, Parham Taslimi, Deryanur Kılıç, İlhami Gulçin & Mustafa Ceylan. (2017) Synthesis and Carbonic Anhydrase Inhibition of Tetrabromo Chalcone Derivatives. Archiv der Pharmazie 350:12, pages 1700198.
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Srinivas Angapelly, P.V. Sri Ramya, Andrea Angeli, Sonia Del Prete, Clemente Capasso, Mohammed Arifuddin & Claudiu T. Supuran. (2017) Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors. Bioorganic & Medicinal Chemistry 25:20, pages 5726-5732.
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Claudiu T. Supuran. (2017) Bortezomib inhibits mammalian carbonic anhydrases. Bioorganic & Medicinal Chemistry 25:19, pages 5064-5067.
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Necla Öztaskın, Parham Taslimi, Ahmet Maraş, İlhami Gülcin & Süleyman Göksu. (2017) Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. Bioorganic Chemistry 74, pages 104-114.
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Umit M. Kocyigit, Parham Taslimi, Hayreddin Gezegen, İlhami Gulçin & Mustafa Ceylan. (2017) Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes. Journal of Biochemical and Molecular Toxicology 31:9, pages e21938.
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Parham Taslimi, Sabiya Osmanova, İlhami Gulçin, Sabira Sardarova, Vagif Farzaliyev, Afsun Sujayev, Ruya Kaya, Fatma Koc, Sukru Beydemir, Saleh H. Alwasel & Omer Irfan Kufrevioglu. (2017) Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base. Journal of Biochemical and Molecular Toxicology 31:9, pages e21931.
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Zübeyir Huyut, Şükrü Beydemir & İlhami Gülçin. (2017) Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes. Journal of Biochemical and Molecular Toxicology 31:9, pages e21930.
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Koray Oktay, Leyla Polat Kose, Kıvılcım Şendil, Mehmet Serdar Gültekin & İlhami Gülçın. (2017) Synthesis of 3-chloro-1-substituted aryl pyrrolidine-2,5-dione derivatives: discovery of potent human carbonic anhydrase inhibitors. Medicinal Chemistry Research 26:8, pages 1619-1627.
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Parham Taslimi, Afsun Sujayev, Emin Garibov, Nazar Nazarov, Zubeyir Huyut, Saleh H. Alwasel & İlhami Gulçin. (2017) Synthesis of new cyclic thioureas and evaluation of their metal-chelating activity, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibition profiles. Journal of Biochemical and Molecular Toxicology 31:7, pages e21897.
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Çetin Bayrak, Parham Taslimi, İlhami Gülçin & Abdullah Menzek. (2017) The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes. Bioorganic Chemistry 72, pages 359-366.
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Aydın Aktaş, Parham Taslimi, İlhami Gülçin & Yetkin Gök. (2017) Novel NHC Precursors: Synthesis, Characterization, and Carbonic Anhydrase and Acetylcholinesterase Inhibitory Properties. Archiv der Pharmazie 350:6, pages e201700045.
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Murat Bozdag, Ahmed Mahmoud Alafeefy, Abdul Malik Altamimi, Fabrizio Carta, Claudiu T. Supuran & Daniela Vullo. (2017) Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII. Bioorganic & Medicinal Chemistry 25:10, pages 2782-2788.
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Mustafa Ceylan, Umit M. Kocyigit, Necibe Canan Usta, Belma Gürbüzlü, Yusuf Temel, Saleh H. Alwasel & İlhami Gülçin. (2017) Synthesis, carbonic anhydrase I and II isoenzymes inhibition properties, and antibacterial activities of novel tetralone-based 1,4-benzothiazepine derivatives. Journal of Biochemical and Molecular Toxicology 31:4, pages e21872.
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Alaa A.-M. Abdel-Aziz, Andrea Angeli, Adel S. El-Azab, Mohamed A. Abu El-Enin & Claudiu T. Supuran. (2017) Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors. Bioorganic & Medicinal Chemistry 25:5, pages 1666-1671.
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Jekaterīna Ivanova, Agnese Balode, Raivis Žalubovskis, Janis Leitans, Andris Kazaks, Daniela Vullo, Kaspars Tars & Claudiu T. Supuran. (2017) 5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations. Bioorganic & Medicinal Chemistry 25:3, pages 857-863.
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Fevzi Topal, Ilhami Gulcin, Arif Dastan & Murat Guney. (2017) Novel eugenol derivatives: Potent acetylcholinesterase and carbonic anhydrase inhibitors. International Journal of Biological Macromolecules 94, pages 845-851.
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Murat Bozdag, Ahmed Mahmoud Alafeefy, Abdul Malik Altamimi, Daniela Vullo, Fabrizio Carta & Claudiu T. Supuran. (2017) Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity. Bioorganic & Medicinal Chemistry 25:2, pages 677-683.
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Sachin Kumar Bharatiy, Mousumi Hazra, Manish Paul, Swati Mohapatra, Deviprasad Samantaray, Ramesh Chandra Dubey, Shourjya Sanyal, Saurav Datta & Saugata Hazra. (2016) In Silico Designing of an Industrially Sustainable Carbonic Anhydrase Using Molecular Dynamics Simulation. ACS Omega 1:6, pages 1081-1103.
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Anastasia Karioti, Fabrizio Carta & Claudiu Supuran. (2016) Phenols and Polyphenols as Carbonic Anhydrase Inhibitors. Molecules 21:12, pages 1649.
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Kadir Aksu, Bünyamin Özgeriş, Parham Taslimi, Ali Naderi, İlhami Gülçin & Süleyman Göksu. (2016) Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines. Archiv der Pharmazie 349:12, pages 944-954.
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Umit M. Kocyigit, Osman Nuri Aslan, Ilhami Gulcin, Yusuf Temel & Mustafa Ceylan. (2016) Synthesis and Carbonic Anhydrase Inhibition of Novel 2-(4-(Aryl)thiazole-2-yl)-3a,4,7,7a-tetrahydro-1 H -4,7-methanoisoindole-1,3(2 H )-dione Derivatives . Archiv der Pharmazie 349:12, pages 955-963.
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Sonia Del Prete, Daniela Vullo, Viviana De Luca, Vincenzo Carginale, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2016) Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum. Bioorganic & Medicinal Chemistry Letters 26:17, pages 4184-4190.
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Claudiu T. Supuran. (2016) Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. Bioorganic & Medicinal Chemistry 24:18, pages 4406-4409.
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Murat Bozdag, Ahmed M. Alafeefy, Fabrizio Carta, Mariangela Ceruso, Abdul-Malek S. Al-Tamimi, Abdulla A. Al-Kahtani, Fatmah A.S. Alasmary & Claudiu T. Supuran. (2016) Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties. Bioorganic & Medicinal Chemistry 24:18, pages 4100-4107.
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Murat Kucuk & İlhami Gulcin. (2016) Purification and characterization of the carbonic anhydrase enzyme from Black Sea trout (Salmo trutta Labrax Coruhensis) kidney and inhibition effects of some metal ions on enzyme activity. Environmental Toxicology and Pharmacology 44, pages 134-139.
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Haydar Göksu, Meryem Topal, Ali Keskin, Mehmet S. Gültekin, Murat Çelik, İlhami Gülçin, Muhammet Tanc & Claudiu T. Supuran. (2016) 9,10-Dibromo- N -aryl-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-diones: Synthesis and Investigation of Their Effects on Carbonic Anhydrase Isozymes I, II, IX, and XII . Archiv der Pharmazie 349:6, pages 466-474.
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Bünyamin Özgeriş, Süleyman Göksu, Leyla Polat Köse, İlhami Gülçin, Ramin Ekhteiari Salmas, Serdar Durdagi, Ferhan Tümer & Claudiu T. Supuran. (2016) Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds. Bioorganic & Medicinal Chemistry 24:10, pages 2318-2329.
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