Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 22, Issue 5 (2007)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 22, Issue 5 (2007)

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Editorial

Editorial
Editorial
Proceedings of the 15th Annual Conference of the Groupement des Pharmacochimistes de l'Arc Atlantique (GP2A) Guest Editors: Michael D. Threadgill, Guillaume Le Baut and Marc Le Borgne
Page: 517
Published online: 04 Oct 2008
CitationforEditorial | Full Text | PDF (29.9 KB)
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Research Article

Article
Influence of microwave irradiation on enzymatic properties: applications in enzyme chemistry
Barbara Rejasse, Sylvain Lamare, Marie-Dominique Legoy & Thierry Besson
Pages: 519-527
Published online: 04 Oct 2008
AbstractforInfluence of microwave irradiation on enzymatic properties: applications in enzyme chemistry | Full Text | References | PDF (219.5 KB)
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Article
The role of fluorine in medicinal chemistry
Review Article
Poonam Shah & Andrew D. Westwell
Pages: 527-540
Published online: 04 Oct 2008
AbstractforThe role of fluorine in medicinal chemistry | Full Text | References | PDF (306.9 KB)
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Article
Synthesis of new 4-(E)-alkenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents by Suzuki-Miyaura cross-coupling reactions
Jean Guillon, Isabelle Forfar, Vanessa Desplat, Solene Belisle Fabre, Denis Thiolat, Stephane Massip, Helene Carrie, Djavad Mossalayi & Christian Jarry
Pages: 541-549
Published online: 04 Oct 2008
AbstractforSynthesis of new 4-(E)-alkenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents by Suzuki-Miyaura cross-coupling reactions | Full Text | References | PDF (167.9 KB)
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Article
Crystal polymorphism of pharmaceuticals: probing crystal nucleation at the molecular level
Kevin P. Guiry, Joanne M. Kelleher, Simon E. Lawrence, Marie T. Mcauliffe, Humphrey A. Moynihan & Andrea L. Ryan
Pages: 550-555
Published online: 04 Oct 2008
AbstractforCrystal polymorphism of pharmaceuticals: probing crystal nucleation at the molecular level | Full Text | References | PDF (205.6 KB)
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Article
Quantitative structure-activity relationships studies of antioxidant hexahydropyridoindoles and flavonoid derivatives
Anne-Catherine Durand, Amaury Farce, Pascal Carato, Sebastien Dilly, Said Yous, Pascal Berthelot & Philippe Chavatte
Pages: 556-562
Published online: 04 Oct 2008
AbstractforQuantitative structure-activity relationships studies of antioxidant hexahydropyridoindoles and flavonoid derivatives | Full Text | References | PDF (125.1 KB)
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Article
Synthesis of new isoxazoles and dihydroisoxazoles and in vitro evaluation of their antifungal activity
Francis Chevreuil, Anne Landreau, Denis Séraphin, Gérald Larcher, Sabine Mallet, Jean-Philippe Bouchara & Pascal Richomme
Pages: 563-569
Published online: 04 Oct 2008
AbstractforSynthesis of new isoxazoles and dihydroisoxazoles and in vitro evaluation of their antifungal activity | Full Text | References | PDF (169.1 KB)
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Article
Biocatalytic synthesis of 4-pregnen-20,21-diol-3-one, a selective inhibitor of human 5α-reductase type II
Frank Hannemann, Rita Bernhardt & Joachim Jose
Pages: 570-576
Published online: 04 Oct 2008
AbstractforBiocatalytic synthesis of 4-pregnen-20,21-diol-3-one, a selective inhibitor of human 5α-reductase type II | Full Text | References | PDF (304.2 KB)
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Article
Synthesis and evaluation of the antimicrobial activity of novel quinazolinones
Maria De Fatima Pereira, Romain Chevrot, Eric Rosenfeld, Valerie Thiery & Thierry Besson
Pages: 577-583
Published online: 04 Oct 2008
AbstractforSynthesis and evaluation of the antimicrobial activity of novel quinazolinones | Full Text | References | PDF (122.5 KB)
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Article
Characterisation of recombinant human fatty aldehyde dehydrogenase: Implications for Sjögren-Larsson syndrome
Matthew D. Lloyd, Kieren D.E. Boardman, Andrew Smith, Daan M. van den Brink, Ronald J.A. Wanders & Michael D. Threadgill
Pages: 584-590
Published online: 04 Oct 2008
AbstractforCharacterisation of recombinant human fatty aldehyde dehydrogenase: Implications for Sjögren-Larsson syndrome | Full Text | References | PDF (201 KB) | Supplemental
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Article
Synthesis of prodrug-type anti-HIV agents conjugating a REVERSE transcriptase inhibitor to a HIV-1 integrase inhibitor by a spontaneously cleavable linker
Christine Fossey, Anh-Hoang Vu, Anamaria Vidu, Irina Zarafu, Daniel Laduree, Sylvie Schmidt, Geraldine Laumond & Anne-Marie Aubertin
Pages: 591-607
Published online: 04 Oct 2008
AbstractforSynthesis of prodrug-type anti-HIV agents conjugating a REVERSE transcriptase inhibitor to a HIV-1 integrase inhibitor by a spontaneously cleavable linker | Full Text | References | PDF (412.3 KB)
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Article
Synthesis and anti-HIV evaluation of hybrid-type prodrugs conjugating HIV integrase inhibitors with d4t by self-cleavable spacers containing an amino acid residue
Christine Fossey, Ngoc-Trinh Huynh, Anh-Hoang Vu, Anamaria Vidu, Irina Zarafu, Daniel Laduree, Sylvie Schmidt, Geraldine Laumond & Anne-Marie Aubertin
Pages: 608-619
Published online: 04 Oct 2008
AbstractforSynthesis and anti-HIV evaluation of hybrid-type prodrugs conjugating HIV integrase inhibitors with d4t by self-cleavable spacers containing an amino acid residue | Full Text | References | PDF (334.3 KB)
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Article
Synthesis of new 4-[2-(alkylamino)ethylthio]pyrrolo[1,2-a]quinoxaline and 5-[2-(alkylamino)ethylthio]pyrrolo[1,2-a]thieno[3,2-e]pyrazine derivatives, as potential bacterial multidrug resistance pump inhibitors
Céline Vidaillac, Jean Guillon, Stéphane Moreau, Corinne Arpin, Annie Lagardère, Stéphane Larrouture, Patrick Dallemagne, Daniel-Henri Caignard, Claudine Quentin & Christian Jarry
Pages: 620-631
Published online: 04 Oct 2008
AbstractforSynthesis of new 4-[2-(alkylamino)ethylthio]pyrrolo[1,2-a]quinoxaline and 5-[2-(alkylamino)ethylthio]pyrrolo[1,2-a]thieno[3,2-e]pyrazine derivatives, as potential bacterial multidrug resistance pump inhibitors | Full Text | References | PDF (207.2 KB)
  • 574 Views
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Article
Synthesis of new bisaryl cyclopentathiophene and thieno-cyclopentoxazolidine derivatives as potential cytotoxic agents
Ziad Omran, Patrick Dallemagne & Sylvain Rault
Pages: 632-637
Published online: 04 Oct 2008
AbstractforSynthesis of new bisaryl cyclopentathiophene and thieno-cyclopentoxazolidine derivatives as potential cytotoxic agents | Full Text | References | PDF (134.5 KB)
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Article
Difluoro analogue of UCS15A triggers activation of exogenously expressed c-Src in HCT 116 human colorectal carcinoma cells
Noor Atatreh, Jane Barraclough, Arkadiusz Welman, Christopher Cawthorne, Richard A. Bryce, Caroline Dive & Sally Freeman
Pages: 638-646
Published online: 04 Oct 2008
AbstractforDifluoro analogue of UCS15A triggers activation of exogenously expressed c-Src in HCT 116 human colorectal carcinoma cells | Full Text | References | PDF (2.8 MB)
  • 427 Views
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Article
Synthesis and PC3 androgen-independent prostate cells antiproliferative effect of fagaronine derivatives
Enguerran Vanquelef, Jean-Jacques Hélesbeux, Olivier Duval, Eric Debiton, Chantal Barthomeuf, Christian Jarry, Isabelle Forfar & Pascal Richomme
Pages: 647-654
Published online: 04 Oct 2008
AbstractforSynthesis and PC3 androgen-independent prostate cells antiproliferative effect of fagaronine derivatives | Full Text | References | PDF (184.3 KB)
  • 328 Views
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Article
Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells
Mary J. Meegan, Irene Barrett, Jochen Zimmermann, Andrew J.S. Knox, Daniela M. Zisterer & David G. Lloyd
Pages: 655-666
Published online: 04 Oct 2008
AbstractforBenzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells | Full Text | References | PDF (266.9 KB)
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Article
Synthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(α-azolylbenzyl)-1H-indoles as selective aromatase inhibitors
MARC LE BORGNE, PASCAL MARCHAND, MARIE-RENEE NOURRISSON, DENIS LOQUET, MARTINA PALZER, GUILLAUME LE BAUT & ROLF W. HARTMANN
Pages: 667-676
Published online: 04 Oct 2008
AbstractforSynthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(α-azolylbenzyl)-1H-indoles as selective aromatase inhibitors | Full Text | References | PDF (207.2 KB)
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