Leukemia & Lymphoma, Volume 59, Issue 10 (2018)

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Leukemia & Lymphoma, Volume 59, Issue 10 (2018)

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Commentary

Article Commentary
Managing myeloma with limited resources in the era of novel drugs
Meletios A. Dimopoulos & Efstathios Kastritis
Pages: 2269-2270
Published online: 03 Jul 2018
CitationforManaging myeloma with limited resources in the era of novel drugs | Full Text | References | PDF (250.7 KB)
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Spontaneous remission in congenital leukemia
Jenna Rossoff, Imo Akpan & Leonidas C. Platanias
Pages: 2271-2272
Published online: 28 Nov 2018
CitationforSpontaneous remission in congenital leukemia | Full Text | References | PDF (240.9 KB) | Supplemental
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Review

The importance of FLT3 mutational analysis in acute myeloid leukemia
Mrinal M. Patnaik
Pages: 2273-2286
Published online: 22 Nov 2017
AbstractforThe importance of FLT3 mutational analysis in acute myeloid leukemia | Full Text | References | PDF (1.6 MB) | Supplemental
  • 21349 Views
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Open Access
Management of patients with chronic lymphocytic leukemia at high risk of relapse on ibrutinib therapy
Ayed O. Ayed & Sameer A. Parikh
Pages: 2287-2296
Published online: 08 Nov 2017
AbstractforManagement of patients with chronic lymphocytic leukemia at high risk of relapse on ibrutinib therapy | Full Text | References | PDF (965.8 KB) | Supplemental
  • 388 Views
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Targeting oncoproteins for degradation by small molecules in myeloid leukemia
Hu Lei, Weiwei Wang & Yingli Wu
Pages: 2297-2304
Published online: 04 Dec 2017
AbstractforTargeting oncoproteins for degradation by small molecules in myeloid leukemia | Full Text | References | PDF (880 KB) | Supplemental
  • 510 Views
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Recent advances in the management of multiple myeloma: clinical impact based on resource-stratification. Consensus statement of the Asian Myeloma Network at the 16th international myeloma workshop
Daryl Tan, Jae Hoon Lee, Wenming Chen, Kazuyuki Shimizu, Jian Hou, Kenshi Suzuki, Weerasak Nawarawong, Shang-Yi Huang, Chor Sang Chim, Kihyun Kim, Lalit Kumar, Pankaj Malhotra, Wee Joo Chng, Brian Durie & for the Asian Myeloma Network
Pages: 2305-2317
Published online: 02 Feb 2018
AbstractforRecent advances in the management of multiple myeloma: clinical impact based on resource-stratification. Consensus statement of the Asian Myeloma Network at the 16th international myeloma workshop | Full Text | References | PDF (998.9 KB) | Supplemental
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Original Article: Clinical

The mutational landscape of small lymphocytic lymphoma compared to non-early stage chronic lymphocytic leukemia
Alejandra Martínez-Trillos, Magda Pinyol, Julio Delgado, Marta Aymerich, Maria Rozman, Tycho Baumann, Marcos González-Díaz, Jesus M Hernández, Miguel Alcoceba, Anna Muntañola, Maria José Terol, Blanca Navarro, Eva Giné, Pedro Jares, Sílvia Beà, Alba Navarro, Dolors Colomer, Ferran Nadeu, Enrique Colado, Angel R. Payer, Tomás García-Cerecedo, Xosé S. Puente, Carlos López-Otin, Elias Campo, Armando López-Guillermo & Neus Villamor
Pages: 2318-2326
Published online: 08 Nov 2017
AbstractforThe mutational landscape of small lymphocytic lymphoma compared to non-early stage chronic lymphocytic leukemia | Full Text | References | PDF (1.2 MB) | Supplemental
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Reasons for initiation of treatment and predictors of response for patients with Rai stage 0/1 chronic lymphocytic leukemia (CLL) receiving first-line therapy: an analysis of the Connect® CLL cohort study
Christopher R. Flowers, Chadi Nabhan, Neil E. Kay, Anthony Mato, Nicole Lamanna, Charles M. Farber, Matthew S. Davids, Pavel Kiselev, Arlene S. Swern, Kristen Sullivan, E. Dawn Flick & Jeff P. Sharman
Pages: 2327-2335
Published online: 07 Feb 2018
AbstractforReasons for initiation of treatment and predictors of response for patients with Rai stage 0/1 chronic lymphocytic leukemia (CLL) receiving first-line therapy: an analysis of the Connect® CLL cohort study | Full Text | References | PDF (820.3 KB) | Supplemental
  • 2374 Views
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Open Access
The impact of time from diagnosis to treatment in diffuse large B-cell lymphoma
Colin Phipps, Yuh Shan Lee, Hao Ying, Chandramouli Nagarajan, Nicholas Grigoropoulos, Yunxin Chen, Tiffany Tang, Alan Z. Goh, Aditi Ghosh, Heng Joo Ng, Sathish Gopalakrishnan, Yvonne Loh, Soon Thye Lim, William Hwang, Daryl Tan & Yeow Tee Goh
Pages: 2336-2341
Published online: 18 Jan 2018
AbstractforThe impact of time from diagnosis to treatment in diffuse large B-cell lymphoma | Full Text | References | PDF (502.8 KB) | Supplemental
  • 320 Views
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Anti-leukemic treatment-induced neurotoxicity in long-term survivors of childhood acute lymphoblastic leukemia: impact of reduced central nervous system radiotherapy and intermediate- to high-dose methotrexate
Olga Zając-Spychała, Mikolaj Pawlak, Katarzyna Karmelita-Katulska, Jakub Pilarczyk, Katarzyna Jończyk-Potoczna, Agnieszka Przepióra, Katarzyna Derwich & Jacek Wachowiak
Pages: 2342-2351
Published online: 09 Feb 2018
AbstractforAnti-leukemic treatment-induced neurotoxicity in long-term survivors of childhood acute lymphoblastic leukemia: impact of reduced central nervous system radiotherapy and intermediate- to high-dose methotrexate | Full Text | References | PDF (1 MB) | Supplemental
  • 481 Views
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A real-world study of clofarabine and cytarabine combination therapy for patients with acute myeloid leukemia
Fiona He, Smarika Sapkota, Sarah Parker, Todd Defor, Erica Warlick, Celalettin Ustun, Craig Eckfeldt, Armin Rashidi, Andy Kurtzweil, Daniel Weisdorf & Nelli Bejanyan
Pages: 2352-2359
Published online: 07 Feb 2018
AbstractforA real-world study of clofarabine and cytarabine combination therapy for patients with acute myeloid leukemia | Full Text | References | PDF (928.4 KB) | Supplemental
  • 316 Views
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Levocarnitine for asparaginase-induced hepatic injury: a multi-institutional case series and review of the literature
Rachael R. Schulte, Manasi V. Madiwale, Allyson Flower, Jessica Hochberg, Michael J. Burke, Jennifer L. McNeer, Adam DuVall & Archie Bleyer
Pages: 2360-2368
Published online: 12 Feb 2018
AbstractforLevocarnitine for asparaginase-induced hepatic injury: a multi-institutional case series and review of the literature | Full Text | References | PDF (882.2 KB) | Supplemental
  • 1512 Views
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Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia
Andry Van de Louw, Ruchi J. Desai, Junjia Zhu & David F. Claxton
Pages: 2369-2376
Published online: 12 Feb 2018
AbstractforCharacteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia | Full Text | References | PDF (746.1 KB) | Supplemental
  • 410 Views
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Thromboembolic complications following aminocaproic acid use in patients with hematologic malignancies
Rebecca C. Juhl, Julianna V. F. Roddy, Tzu-Fei Wang, Junan Li & Jessica L. Elefritz
Pages: 2377-2382
Published online: 09 Feb 2018
AbstractforThromboembolic complications following aminocaproic acid use in patients with hematologic malignancies | Full Text | References | PDF (561.3 KB) | Supplemental
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Original Article: Research

Bone marrow VEGFC expression is associated with multilineage dysplasia and several prognostic markers in adult acute myeloid leukemia, but not with survival
Vicent Guillem, Marisa Calabuig, Salut Brunet, Jordi Esteve, Lourdes Escoda, David Gallardo, Josep-Maria Ribera, María Paz Queipo de Llano, Montserrat Arnan, Carme Pedro, María Luz Amigo, Josep M. Martí-Tutusaus, Antoni García-Guiñón, Joan Bargay, Antonia Sampol, Olga Salamero, Llorenç Font, Carme Talarn, Montserrat Hoyos, Marina Díaz-Beyá, Ana Garrido, Blanca Navarro, Josep Nomdédeu, Jordi Sierra & Mar Tormo
Pages: 2383-2393
Published online: 18 Jan 2018
AbstractforBone marrow VEGFC expression is associated with multilineage dysplasia and several prognostic markers in adult acute myeloid leukemia, but not with survival | Full Text | References | PDF (1.4 MB) | Supplemental
  • 236 Views
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A 4-gene expression prognostic signature might guide post-remission therapy in patients with intermediate-risk cytogenetic acute myeloid leukemia
Montserrat Torrebadell, Marina Díaz-Beyá, Susana G. Kalko, Marta Pratcorona, Josep Nomdedeu, Alfons Navarro, Bernat Gel, Salut Brunet, Jorge Sierra, Mireia Camós & Jordi Esteve
Pages: 2394-2404
Published online: 02 Feb 2018
AbstractforA 4-gene expression prognostic signature might guide post-remission therapy in patients with intermediate-risk cytogenetic acute myeloid leukemia | Full Text | References | PDF (2.8 MB) | Supplemental
  • 334 Views
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SNF5 deficiency induces apoptosis resistance by repressing SATB1 expression in Sézary syndrome
Yang Li, Jin Wang, Minghang Yu, Yang Wang, Huilai Zhang, Jie Yin, Zexing Li, Ting Li, Han Yan, Fajin Li & Xi Wang
Pages: 2405-2413
Published online: 16 Jan 2018
AbstractforSNF5 deficiency induces apoptosis resistance by repressing SATB1 expression in Sézary syndrome | Full Text | References | PDF (1.8 MB) | Supplemental
  • 348 Views
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Vibsanol A induces differentiation of acute myeloid leukemia cells via activation of the PKC signaling pathway and induction of ROS
Meng Yang, Shuang Xing, Hong-Ling Ou, Lu Zhang, Xing Shen, Guo-Lin Xiong, Fang-Min Wang, He Xiao, Yan-Hong Tu, Yu-Wen Cong, Xin-Ru Wang & Zu-Yin Yu
Pages: 2414-2422
Published online: 16 Jan 2018
AbstractforVibsanol A induces differentiation of acute myeloid leukemia cells via activation of the PKC signaling pathway and induction of ROS | Full Text | References | PDF (1.5 MB) | Supplemental
  • 138 Views
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Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia
Luyun Peng, Yuanting Tang, Yingchi Zhang, Siqi Guo, Leiwen Peng, Lei Ye, Yuefang Wang & Yongmei Jiang
Pages: 2423-2430
Published online: 18 Oct 2017
AbstractforStructural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia | Full Text | References | PDF (1.1 MB) | Supplemental
  • 246 Views
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Original Article: Clinical

A role for bone turnover markers β-CrossLaps (CTX) and amino-terminal propeptide of type I collagen (PINP) as potential indicators for disease progression from MGUS to multiple myeloma
Sonia Vallet, Nicholas R. Hoyle, Robert A. Kyle, Klaus Podar & Martin Pecherstorfer
Pages: 2431-2438
Published online: 18 Jan 2018
AbstractforA role for bone turnover markers β-CrossLaps (CTX) and amino-terminal propeptide of type I collagen (PINP) as potential indicators for disease progression from MGUS to multiple myeloma | Full Text | References | PDF (927.5 KB) | Supplemental
  • 399 Views
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Original Article: Research

ASXL1 mutations in AML are associated with specific clinical and cytogenetic characteristics
Katerina Kakosaiou, Fotios Panitsas, Aggeliki Daraki, Maria Pagoni, Paraskevi Apostolou, Agapi Ioannidou, Ioanna Vlachadami, Theodoros Marinakis, Chara Giatra, Diamantina Vasilatou, Constantina Sambani, Vassiliki Pappa & Kalliopi N. Manola
Pages: 2439-2446
Published online: 07 Feb 2018
AbstractforASXL1 mutations in AML are associated with specific clinical and cytogenetic characteristics | Full Text | References | PDF (875.9 KB) | Supplemental
  • 603 Views
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Quantitative assessment of the sensitivity of dormant AML cells to the BAD mimetics ABT-199 and ABT-737
Ning Yu, Claire Seedhouse, Nigel Russell & Monica Pallis
Pages: 2447-2453
Published online: 12 Feb 2018
AbstractforQuantitative assessment of the sensitivity of dormant AML cells to the BAD mimetics ABT-199 and ABT-737 | Full Text | References | PDF (765.6 KB) | Supplemental
  • 210 Views
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Letter to the Editor

Heterochronous occurrence of microsatellite instability in multiple myeloma – an implication for a role of defective DNA mismatch repair in myelomagenesis
Kaname Miyashita, Kei Fujii, Youko Suehiro, Kenichi Taguchi, Naokuni Uike, Mitsuaki A. Yoshida & Shinya Oda
Pages: 2454-2459
Published online: 31 Jan 2018
First Page PreviewforHeterochronous occurrence of microsatellite instability in multiple myeloma – an implication for a role of defective DNA mismatch repair in myelomagenesis | Full Text | References | PDF (1.3 MB) | Supplemental
  • 201 Views
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A case of diffuse large B-cell lymphoma with MYC gene cluster amplification related to chromothripsis
Minoru Kojima, Joaquim Carreras, Yara Yukie Kikuti, Masashi Miyaoka, Tomoki Kikuchi, Jun Amaki, Ai Sato, Daisuke Ogiya, Kiyoshi Ando & Naoya Nakamura
Pages: 2460-2464
Published online: 18 Jan 2018
First Page PreviewforA case of diffuse large B-cell lymphoma with MYC gene cluster amplification related to chromothripsis | Full Text | References | PDF (1.1 MB) | Supplemental
  • 193 Views
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Use and impact of herpes zoster prophylaxis in myeloma patients treated with proteasome inhibitors
Siyang Leng, Suzanne Lentzsch, Yanhan Shen, Wei-Yann Tsai, Jason Dennis Wright, Dawn Lauryn Hershman & Alfred I. Neugut
Pages: 2465-2469
Published online: 02 Feb 2018
First Page PreviewforUse and impact of herpes zoster prophylaxis in myeloma patients treated with proteasome inhibitors | Full Text | References | PDF (898.7 KB) | Supplemental
  • 328 Views
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Letter to Editor

Real-world data on first relapse of acute lymphoblastic leukemia in patients >55 years
Emma Bergfelt Lennmyr, Piotr Kozlowski, Lucia Ahlberg, Per Bernell, Erik Hulegårdh, Antonio Santamaria Izarra, Karin Karlsson, Beata Tomaszewska-Toporska, Maria Åström, Helene Hallböök & on behalf of the Swedish Adult Acute Lymphoblastic Leukemia Group, SVALL
Pages: 2470-2473
Published online: 18 Jan 2018
First Page PreviewforReal-world data on first relapse of acute lymphoblastic leukemia in patients >55 years | Full Text | References | PDF (722.9 KB) | Supplemental
  • 171 Views
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Letter to the Editor

Successful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide
Toshihiko Ando, Kensuke Kojima, Haruhiko Sano, Keisuke Kidoguchi, Kana Kusaba, Mariko Yoshimura, Masako Yokoo, Yasushi Kubota, Hideaki Nakamura, Yukari Takase, Shinichi Aishima & Shinya Kimura
Pages: 2474-2477
Published online: 31 Jan 2018
First Page PreviewforSuccessful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide | Full Text | References | PDF (650.8 KB) | Supplemental
  • 380 Views
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Octasomy 21 in a patient with secondary AML after CMML: the role of acquired NRAS mutations in triggering aneuploidy
Kathrin Thomay, Yvonne Lisa Behrens, Jana Lentes, Nicole Wittner, Verena Wittig, Doreen Rothe, Doris Steinemann, Brigitte Schlegelberger & Gudrun Göhring
Pages: 2478-2481
Published online: 31 Jan 2018
First Page PreviewforOctasomy 21 in a patient with secondary AML after CMML: the role of acquired NRAS mutations in triggering aneuploidy | Full Text | References | PDF (881.7 KB) | Supplemental
  • 121 Views
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Care at specialized cancer centers among young adults with acute lymphoblastic leukemia in California
Elysia Alvarez, Lori Muffly, Qian Li, Ann Brunson, Ted Wun, Lisa Chamberlain & Theresa Keegan
Pages: 2482-2484
Published online: 09 Feb 2018
First Page PreviewforCare at specialized cancer centers among young adults with acute lymphoblastic leukemia in California | Full Text | References | PDF (366 KB) | Supplemental
  • 134 Views
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Management of relapsed or refractory follicular lymphoma patients in daily practice – a French non-interventional study
Pierre Feugier, Pauline Brice, Marc Maynadié, Patricia Franchi-Rezgui, Maya Hacini, Guy Laurent, Etienne Suc, Olivier Fitoussi, Philippe Solal-Celigny, Ghandi Damaj, Corinne Haioun, Pierre Leconte, Fatima Lazreg, Frédéric Boissard, David Pau & Gilles Salles
Pages: 2485-2488
Published online: 28 Feb 2018
First Page PreviewforManagement of relapsed or refractory follicular lymphoma patients in daily practice – a French non-interventional study | Full Text | References | PDF (552.6 KB) | Supplemental
  • 356 Views
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A case of B-cell precursor acute lymphoblastic leukemia with IL3-IGH rearrangement revealed by thromboembolism and marked eosinophilia
Coralie Derrieux, Nicolas Freynet, Jamile Frayfer, Eric Delabesse, Emmanuelle Clappier, Sabine Defasque, Helene Broutier & Loïc Fouillard
Pages: 2489-2492
Published online: 09 Feb 2018
First Page PreviewforA case of B-cell precursor acute lymphoblastic leukemia with IL3-IGH rearrangement revealed by thromboembolism and marked eosinophilia | Full Text | References | PDF (1.2 MB) | Supplemental
  • 276 Views
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In silico analysis of anti-leukemia immune response and immune evasion in acute myeloid leukemia
Rosemarie Krupar, Cleopatra Schreiber, Anne Offermann, Claudia Lengerke, Andrew G. Sikora, Christoph Thorns & Sven Perner
Pages: 2493-2496
Published online: 12 Feb 2018
First Page PreviewforIn silico analysis of anti-leukemia immune response and immune evasion in acute myeloid leukemia | Full Text | References | PDF (599.7 KB) | Supplemental
  • 117 Views
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Deep spontaneous molecular remission in a patient with congenital acute myeloid leukemia expressing a novel MOZ-p300 fusion transcript
Yasuhiro Ikawa, Ryosei Nishimura, Hideaki Maeba, Toshihiro Fujiki, Rie Kuroda, Kazuhiro Noguchi, Masaki Fukuda, Shintaro Mase, Raita Araki, Yusuke Mitani, Tomohiko Sato, Kiminori Terui, Etsurou Ito, Issay Kitabayashi & Akihiro Yachie
Pages: 2497-2499
Published online: 12 Feb 2018
First Page PreviewforDeep spontaneous molecular remission in a patient with congenital acute myeloid leukemia expressing a novel MOZ-p300 fusion transcript | Full Text | References | PDF (706.8 KB) | Supplemental
  • 239 Views
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Successful treatment of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation with bortezomib
Ling Cao, Liang Piu Koh & Yeh Ching Linn
Pages: 2500-2502
Published online: 18 Jan 2018
First Page PreviewforSuccessful treatment of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation with bortezomib | Full Text | References | PDF (841.4 KB) | Supplemental
  • 332 Views
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Retroperitoneal fibrosis as extramedullary hematopoiesis of a chronic myelomonocytic leukemia
Laure Ricard, Noémie Abisror, Nathalie Droin, Dorothée Selimoglu-Buet, Antoine Martin, Michael Soussan, Christophe Willekens, Christophe Deligny, Olivier Fain, Eric Solary, Arsène Mekinian & at the behalf MINHEMON (French network of dysimmune disorders associated to hemopathies)
Pages: 2503-2505
Published online: 25 Jan 2018
First Page PreviewforRetroperitoneal fibrosis as extramedullary hematopoiesis of a chronic myelomonocytic leukemia | Full Text | References | PDF (638.4 KB) | Supplemental
  • 168 Views
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A novel fusion of PDGFRB to TSC1, an intrinsic suppressor of mTOR-signaling pathway, in a chronic eosinophilic leukemia patient with t(5;9)(q32;q34)
Yue Zhang, Shiqiang Qu, Qianfei Wang, Jianyong Li, Zefeng Xu, Tiejun Qin, Gang Huang & Zhijian Xiao
Pages: 2506-2508
Published online: 31 Jan 2018
First Page PreviewforA novel fusion of PDGFRB to TSC1, an intrinsic suppressor of mTOR-signaling pathway, in a chronic eosinophilic leukemia patient with t(5;9)(q32;q34) | Full Text | References | PDF (688.6 KB) | Supplemental
  • 230 Views
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Mantle Cell Lymphoma with t(11;22) (q13;q11.2) an indolent clinical variant?
William D. Marrero, Alexis Cruz-Chacón & Fernando Cabanillas
Pages: 2509-2511
Published online: 07 Feb 2018
First Page PreviewforMantle Cell Lymphoma with t(11;22) (q13;q11.2) an indolent clinical variant? | Full Text | References | PDF (749.6 KB) | Supplemental
  • 186 Views
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Genetic markers of stable molecular remission in chronic myeloid leukemia after targeted therapy discontinuation
Svetlana A. Smirnikhina, Ekaterina Yu. Chelysheva, Alexander V. Lavrov, Konstantin S. Kochergin-Nikitsky, Ivan V. Mozgovoy, Elmira P. Adilgereeva, Oleg A. Shukhov, Anna N. Petrova, Anastasia V. Bykova, Adhamjon O. Abdullaev, Anna G. Turkina & Sergey I. Kutsev
Pages: 2512-2515
Published online: 09 Feb 2018
First Page PreviewforGenetic markers of stable molecular remission in chronic myeloid leukemia after targeted therapy discontinuation | Full Text | References | PDF (1.4 MB) | Supplemental
  • 166 Views
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Severe hypofibrinogenemia associated with imatinib and prednisone therapy in Philadelphia chromosome–positive acute lymphoblastic leukemia
Mariarita Sciumè, Nicola Stefano Fracchiolla & Agostino Cortelezzi
Pages: 2516-2517
Published online: 31 Jan 2018
CitationforSevere hypofibrinogenemia associated with imatinib and prednisone therapy in Philadelphia chromosome–positive acute lymphoblastic leukemia | Full Text | References | PDF (246.4 KB) | Supplemental
  • 189 Views
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