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Original Articles

Deoxynivalenol: Toxicology and Potential Effects on Humans

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Pages 39-69 | Published online: 14 Mar 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (64)

Silu Hou, Jingjiao Ma, Yuqiang Cheng, Hengan Wang, Jianhe Sun & Yaxian Yan. (2023) The toxicity mechanisms of DON to humans and animals and potential biological treatment strategies. Critical Reviews in Food Science and Nutrition 63:6, pages 790-812.
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Ehsan Feizollahi & M. S. Roopesh. (2022) Mechanisms of deoxynivalenol (DON) degradation during different treatments: a review. Critical Reviews in Food Science and Nutrition 62:21, pages 5903-5924.
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Geovana Dagostim Savi, Elton Torres Zanoni, Bianca Guimarães Furtado, Hilária Mendes de Souza, Rahisa Scussel, Ricardo Andrez Machado-de-Ávila & Elidio Angioletto. (2022) Mesoporous silica nanoparticles incorporated with zinc oxide as a novel antifungal agent against toxigenic fungi strains. Journal of Environmental Science and Health, Part B 57:3, pages 176-183.
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Amal Saad-Hussein, Kawther M. Soliman & Gehan Moubarz. (2022) 18S rRNA gene sequencing for environmental aflatoxigenic fungi and risk of hepatic carcinoma among exposed workers. Journal of Environmental Science and Health, Part A 57:3, pages 174-182.
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Dongya Shi, Yu Zhang, Jin Wang, Weichao Ren, Jie Zhang, Jane Ifunanya Mbadianya, Yuanye Zhu, Changjun Chen & Hongyu Ma. (2021) S-adenosyl-L-homocysteine hydrolase FgSah1 is required for fungal development and virulence in Fusarium graminearum. Virulence 12:1, pages 2171-2185.
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Larissa Tuanny Franco, Amin Mousavi Khaneghah, Sarah Hwa In Lee & Carlos Augusto Fernandes Oliveira. (2021) Biomonitoring of mycotoxin exposure using urinary biomarker approaches: a review. Toxin Reviews 40:4, pages 383-403.
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Li Han, Yuetao Li, Jinqing Jiang, Renfeng Li, Guoying Fan, Zhuang Lei, Haojie Wang, Ziliang Wang & Wenju Zhang. (2020) Preparation and characterisation of monoclonal antibodies against deoxynivalenol. Italian Journal of Animal Science 19:1, pages 560-568.
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Elem Tamirys dos Santos Caramês, Karim C. Piacentini, Lucas Teixeira Alves, Juliana Azevedo Lima Pallone & Liliana de Oliveira Rocha. (2020) NIR spectroscopy and chemometric tools to identify high content of deoxynivalenol in barley. Food Additives & Contaminants: Part A 37:9, pages 1542-1552.
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Esteban Valverde-Bogantes, Andreia Bianchini, Joshua R. Herr, Devin J. Rose, Stephen N. Wegulo & Heather E. Hallen-Adams. (2020) Recent population changes of Fusarium head blight pathogens: drivers and implications. Canadian Journal of Plant Pathology 42:3, pages 315-329.
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Sakshi Mishra, Sonal Srivastava, Jayant Dewangan, Aman Divakar & Srikanta Kumar Rath. (2020) Global occurrence of deoxynivalenol in food commodities and exposure risk assessment in humans in the last decade: a survey. Critical Reviews in Food Science and Nutrition 60:8, pages 1346-1374.
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Zhangsheng Hu, Yu Sun, Jiongjie Chen, Yurong Zhao, Han Qiao, Ruohong Chen, Xianhui Wen, Yiqun Deng & Jikai Wen. (2020) Deoxynivalenol globally affects the selection of 3’ splice sites in human cells by suppressing the splicing factors, U2AF1 and SF1. RNA Biology 17:4, pages 584-595.
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Kun Zhuang, Chen Zhang, Wei Zhang, Wei Xu, Qian Tao, Guozheng Wang, Yuehui Wang & Wenping Ding. (2020) Effect of different ozone treatments on the degradation of deoxynivalenol and flour quality in Fusarium-contaminated wheat. CyTA - Journal of Food 18:1, pages 776-784.
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Xin Yang, Jie Gao, Qing Liu & Dajin Yang. (2019) Co-occurrence of mycotoxins in maize and maize-derived food in China and estimation of dietary intake. Food Additives & Contaminants: Part B 12:2, pages 124-134.
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Maria Papageorgiou, Liz Wells, Courtney Williams, Kay L.M. White, Barbara De Santis, Yunru Liu, Francesca Debegnach, Brunella Miano, Giorgio Moretti, Stephanie Greetham, Carlo Brera, Stephen L. Atkin, Laura J. Hardie & Thozhukat Sathyapalan. (2018) Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach. Food Additives & Contaminants: Part A 35:10, pages 2032-2044.
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Allana Patrícia Santos Alexandre, Rafael Segundo Vela-Paredes, Amanda Silva Santos, Naiara Silva Costa, Solange Guidolin Canniatti-Brazaca, Maria Antonia Calori-Domingues & Pedro Esteves Duarte Augusto. (2018) Ozone treatment to reduce deoxynivalenol (DON) and zearalenone (ZEN) contamination in wheat bran and its impact on nutritional quality. Food Additives & Contaminants: Part A 35:6, pages 1189-1199.
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Geovana D. Savi, William A. Cardoso, Bianca G. Furtado, Tiago Bortolotto, Elton T. Zanoni, Rahisa Scussel, Lucas F. Rezende, Ricardo A. Machado-de-Ávila, Oscar R. K. Montedo & Elidio Angioletto. (2018) Antifungal activities against toxigenic Fusarium specie and deoxynivalenol adsorption capacity of ion-exchanged zeolites. Journal of Environmental Science and Health, Part B 53:3, pages 184-190.
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Huihui Wu, Xiao Sun, Zhaoqiang Zhang, Dongming Zhuang, Yu Wang, Xiaoxia Li, Guangfu Yu, Gang Lv, Na Wang, Qiaoling Li, Charles Howard Wang, Ailian Yu & Yinghui Zhao. (2018) Deoxynivalenol impairs proliferation and induces apoptosis in primary murine osteoblasts. Toxicological & Environmental Chemistry 100:2, pages 214-227.
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Dafeng Jiang, Jindong Chen, Fenghua Li, Wei Li, Lianlong Yu, Fengjia Zheng & Xiaolin Wang. (2018) Deoxynivalenol and its acetyl derivatives in bread and biscuits in Shandong province of China. Food Additives & Contaminants: Part B 11:1, pages 43-48.
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Hervé Robert, Delphine Payros, Philippe Pinton, Vassilia Théodorou, Muriel Mercier-Bonin & Isabelle P. Oswald. (2017) Impact of mycotoxins on the intestine: are mucus and microbiota new targets?. Journal of Toxicology and Environmental Health, Part B 20:5, pages 249-275.
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Allana P. S. Alexandre, Nanci Castanha, Maria A. Calori-Domingues & Pedro E. D. Augusto. (2017) Ozonation of whole wheat flour and wet milling effluent: Degradation of deoxynivalenol (DON) and rheological properties. Journal of Environmental Science and Health, Part B 52:7, pages 516-524.
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Yan Zhang, Jian Yang, Yang Lu, Dong-Yue Ma, Mu Ge Qi & Shuo Wang. (2017) A competitive direct enzyme-linked immunosorbent assay for the rapid detection of deoxynivalenol: development and application in agricultural products and feedstuff. Food and Agricultural Immunology 28:3, pages 516-527.
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Li Wang, Ying Wang, Huili Shao, Xiaohu Luo, Ren Wang, Yongfu Li, Yanan Li, Yingpeng Luo, Dongjie Zhang & Zhengxing Chen. (2017) In vivo toxicity assessment of deoxynivalenol-contaminated wheat after ozone degradation. Food Additives & Contaminants: Part A 34:1, pages 103-112.
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Wolfram Föllmann, Nurshad Ali, Meinolf Blaszkewicz & Gisela H. Degen. (2016) Biomonitoring of Mycotoxins in Urine: Pilot Study in Mill Workers. Journal of Toxicology and Environmental Health, Part A 79:22-23, pages 1015-1025.
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Adriana Palma de Almeida, Leda Conceição Antonia Lamardo, Luzia Shundo, Simone Alves da Silva, Sandra Aparecida Navas, Janete Alaburda, Valter Ruvieri & Myrna Sabino. (2016) Occurrence of deoxynivalenol in wheat flour, instant noodle and biscuits commercialised in Brazil. Food Additives & Contaminants: Part B 9:4, pages 251-255.
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Wondimeneh Taye, Amare Ayalew, Alemayehu Chala & Mashilla Dejene. (2016) Aflatoxin B1 and total fumonisin contamination and their producing fungi in fresh and stored sorghum grain in East Hararghe, Ethiopia. Food Additives & Contaminants: Part B 9:4, pages 237-245.
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Shohei Sakuda, Tomoya Yoshinari, Tomohiro Furukawa, Usuma Jermnak, Keiko Takagi, Kurin Iimura, Toshiyoshi Yamamoto, Michio Suzuki & Hiromichi Nagasawa. (2016) Search for aflatoxin and trichothecene production inhibitors and analysis of their modes of action. Bioscience, Biotechnology, and Biochemistry 80:1, pages 43-54.
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Marek Halenar, Marina Medvedova, Nora Maruniakova & Adriana Kolesarova. (2015) Assessment of a potential preventive ability of amygdalin in mycotoxin-induced ovarian toxicity. Journal of Environmental Science and Health, Part B 50:6, pages 411-416.
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M.M. Li, E.Q. Guan & K. Bian. (2015) Effect of ozone treatment on deoxynivalenol and quality evaluation of ozonised wheat. Food Additives & Contaminants: Part A 32:4, pages 544-553.
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Jun Liu, Steve O. Simmons & Ruoting Pei. (2014) Regulation of IL-8 Promoter Activity by Verrucarin A in Human Monocytic THP-1 Cells. Journal of Toxicology and Environmental Health, Part A 77:19, pages 1125-1140.
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Mohammad Ebrahem, Susanne Kersten, Hana Valenta, Gerhard Breves & Sven Dänicke. (2014) Residues of deoxynivalenol (DON) and its metabolite de-epoxy-DON in eggs, plasma and bile of laying hens of different genetic backgrounds. Archives of Animal Nutrition 68:5, pages 412-422.
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Mayra Carraro Di Gregorio, Diane Valganon de Neeff, Alessandra Vincenzi Jager, Carlos Humberto Corassin, Ágatha Cristina de Pinho Carão, Ricardo de Albuquerque, Antônio Carlos de Azevedo & Carlos Augusto Fernandes Oliveira. (2014) Mineral adsorbents for prevention of mycotoxins in animal feeds. Toxin Reviews 33:3, pages 125-135.
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Ricardo Assunção, Mariana Ferreira, Carla Martins, Irene Diaz, Beatriz Padilla, Didier Dupont, Mauro Bragança & Paula Alvito. (2014) Applicability of In Vitro Methods to Study Patulin Bioaccessibility and Its Effects on Intestinal Membrane Integrity. Journal of Toxicology and Environmental Health, Part A 77:14-16, pages 983-992.
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C. Viegas, R. Dias, A. Quintal Gomes, M. Meneses, R. Sabino & S. Viegas. (2014) Aspergillus flavus Contamination in Two Portuguese Wastewater Treatment Plants. Journal of Toxicology and Environmental Health, Part A 77:14-16, pages 796-805.
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C. Viegas, E. Carolino, R. Sabino, S. Viegas & C. Veríssimo. (2013) Fungal Contamination in Swine: A Potential Occupational Health Threat. Journal of Toxicology and Environmental Health, Part A 76:4-5, pages 272-280.
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W.A. Awad, K. Ghareeb & J. Böhm. (2012) The toxicity of Fusarium mycotoxin deoxynivalenol in poultry feeding. World's Poultry Science Journal 68:4, pages 651-668.
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Claudia Behm, Wolfram Föllmann & Gisela H. Degen. (2012) Cytotoxic Potency of Mycotoxins in Cultures of V79 Lung Fibroblast Cells. Journal of Toxicology and Environmental Health, Part A 75:19-20, pages 1226-1231.
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S. Piekkola, P.C. Turner, M. Abdel-Hamid, S. Ezzat, M. El-Daly, S. El-Kafrawy, E. Savchenko, T. Poussa, J.C.S. Woo, H. Mykkänen & H. El-Nezami. (2012) Characterisation of aflatoxin and deoxynivalenol exposure among pregnant Egyptian women. Food Additives & Contaminants: Part A 29:6, pages 962-971.
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Zhui Tu, Yang Xu, Qinghua He, Jinheng Fu, Xia Liu & Yong Tao. (2012) Isolation and characterisation of deoxynivalenol affinity binders from a phage display library based on single-domain camelid heavy chain antibodies (VHHs). Food and Agricultural Immunology 23:2, pages 123-131.
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S.J. Hepworth, L.J. Hardie, L.K. Fraser, V.J. Burley, R.S. Mijal, C.P. Wild, R. Azad, P.A. Mckinney & P.C. Turner. (2012) Deoxynivalenol exposure assessment in a cohort of pregnant women from Bradford, UK. Food Additives & Contaminants: Part A 29:2, pages 269-276.
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G.J.H.M. van der Burgt, B.G.H. Timmermans, J.M.S. Scholberg & A.M. Osman. (2011) Fusarium head blight and deoxynivalenol contamination in wheat as affected by nitrogen fertilization. NJAS: Wageningen Journal of Life Sciences 58:3-4, pages 123-129.
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P.C. Turner, B.T. Ji, X.O. Shu, W. Zheng, W.H. Chow, Y.T. Gao & L.J. Hardie. (2011) A biomarker survey of urinary deoxynivalenol in China: the Shanghai Women's Health Study. Food Additives & Contaminants: Part A 28:9, pages 1220-1223.
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L. Ribonnet, E. van der Heiden, I. Nobels, A. Chaumont, A.-S. Remacle, S. De Saeger, Y.-J. Schneider, M.-L. Scippo, R. Blust, L. Pussemier & Y. Larondelle. (2011) Potential of an in vitro toolbox combined with exposure data as a first step for the risk assessment of dietary chemical contaminants. Food Additives & Contaminants: Part A 28:9, pages 1136-1158.
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F. Bensassi, I. Rjiba, A. Zarrouk, A. Rhouma, M.R. Hajlaoui & H. Bacha. (2011) Deoxynivalenol contamination in Tunisian barley in the 2009 harvest. Food Additives & Contaminants: Part B 4:3, pages 205-211.
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Ruoting Pei & Claudia K. Gunsch. (2011) Cytotoxic and proinflammatory response of RAW 264.7 cells to differentially fractionated fungal fragments. Toxicological & Environmental Chemistry 93:7, pages 1386-1398.
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C. J. Amuzie, B. M. Flannery, A. M. Ulrich & J. J. Pestka. (2011) Effects of Deoxynivalenol Consumption on Body Weight and Adiposity in the Diet-Induced Obese Mouse. Journal of Toxicology and Environmental Health, Part A 74:10, pages 658-667.
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Ionelia Taranu, DanielaE. Marin, Radu Burlacu, Phillipe Pinton, Virgil Damian & IsabelleP. Oswald. (2010) Comparative aspects of in vitro proliferation of human and porcine lymphocytes exposed to mycotoxins. Archives of Animal Nutrition 64:5, pages 383-393.
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Paul C. Turner, Kay L.M. White, Victoria J. Burley, Richard P. Hopton, Anita Rajendram, Julie Fisher, Janet E. Cade & Christopher P. Wild. (2010) A comparison of deoxynivalenol intake and urinary deoxynivalenol in UK adults. Biomarkers 15:6, pages 553-562.
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Breda Jakovac-Strajn, Katarina Pavšič-Vrtač, Igor Ujčič-Vrhovnik, Anton Vengušt & Gabrijela Tavčar-Kalcher. (2010) Microbiological and mycotoxicological contamination in Slovenian primary grain production. Toxicological & Environmental Chemistry 92:8, pages 1551-1563.
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J. Gilbert, R.M. Clear, T.J. Ward, D. Gaba, A. Tekauz, T.K. Turkington, S.M. Woods, T. Nowicki & K. O'Donnell. (2010) Relative aggressiveness and production of 3- or 15-acetyl deoxynivalenol and deoxynivalenol by Fusarium graminearum in spring wheat. Canadian Journal of Plant Pathology 32:2, pages 146-152.
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R.P. Hopton, E. Turner, V.J. Burley, P.C. Turner & J. Fisher. (2010) Urine metabolite analysis as a function of deoxynivalenol exposure: an NMR-based metabolomics investigation. Food Additives & Contaminants: Part A 27:2, pages 255-261.
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Tapani Yli-Mattila, Tatiana Gagkaeva, Todd J. Ward, Takayuki Aoki, H. Corby Kistler & Kerry O’Donnell. (2009) A novel Asian clade within the Fusarium graminearum species complex includes a newly discovered cereal head blight pathogen from the Russian Far East. Mycologia 101:6, pages 841-852.
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H.E. Ok, H.-J. Chang, S.-W. Choi, T.Y. Cho, K.S. Oh & H.S. Chun. (2009) Occurrence and intake of deoxynivalenol in cereal-based products marketed in Korea during 2007–2008. Food Additives & Contaminants: Part B 2:2, pages 154-161.
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Hyun Ee Ok, Hyun Jung Kim, Tae Yong Cho, Keum Soon Oh & Hyang Sook Chun. (2009) Determination of Deoxynivalenol in Cereal-Based Foods and Estimation of Dietary Exposure. Journal of Toxicology and Environmental Health, Part A 72:21-22, pages 1424-1430.
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Xianai Wu, Marian Kohut, Joan Cunnick, Ted Bailey & Suzanne Hendrich. (2009) Deoxynivalenol suppresses circulating and splenic leukocyte subpopulations in BALB/c mice: dose response, time course and sex differences. Food Additives & Contaminants: Part A 26:7, pages 1070-1080.
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J.J. Pestka. (2008) Mechanisms of deoxynivalenol-induced gene expression and apoptosis. Food Additives & Contaminants: Part A 25:9, pages 1128-1140.
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Radka Borutova, Stefan Faix, Iveta Placha, Lubomira Gresakova, Klaudia Cobanova & Lubomir Leng. (2008) Effects of deoxynivalenol and zearalenone on oxidative stress and blood phagocytic activity in broilers. Archives of Animal Nutrition 62:4, pages 303-312.
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Paul C. Turner, Victoria J. Burley, Joseph A. Rothwell, Kay L.M. White, Janet E. Cade & Christopher P. Wild. (2008) Deoxynivalenol: Rationale for development and application of a urinary biomarker. Food Additives & Contaminants: Part A 25:7, pages 864-871.
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J. David Miller. (2008) Mycotoxins in small grains and maize: Old problems, new challenges. Food Additives & Contaminants: Part A 25:2, pages 219-230.
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Daniel Sudakin & Payam Fallah. (2008) Toxigenic fungi and mycotoxins in outdoor, recreational environments. Clinical Toxicology 46:8, pages 738-744.
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P. Batina, N. Hymery, R. Froquet, Y. Sibiril & D. Parent-Massin. (2008) Human myelotoxicity of two phycotoxins, okadaic acid and domoic acid. An study. Toxicological & Environmental Chemistry 90:1, pages 141-152.
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Makoto KIMURA, Takeshi TOKAI, Naoko TAKAHASHI-ANDO, Shuichi OHSATO & Makoto FUJIMURA. (2007) Molecular and Genetic Studies of Fusarium Trichothecene Biosynthesis: Pathways, Genes, and Evolution. Bioscience, Biotechnology, and Biochemistry 71:9, pages 2105-2123.
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Tanja Goyarts, Sven Dänicke, Hana Valenta & Karl-Heinz Ueberschär. (2007) Carry-over of toxins (deoxynivalenol and zearalenone) from naturally contaminated wheat to pigs. Food Additives & Contaminants 24:4, pages 369-380.
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Peter Have Rasmussen, Annette Petersen & Faranak Ghorbani. (2007) Annual variation of deoxynivalenol in Danish wheat flour 1998–2003 and estimated daily intake by the Danish population. Food Additives & Contaminants 24:3, pages 315-325.
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C. A. Landgren, S. Hendrich & M. L. Kohut. (2006) Low-Level Dietary Deoxynivalenol and Acute Exercise Stress Result in Immunotoxicity in BALB/c Mice. Journal of Immunotoxicology 3:4, pages 173-178.
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